Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q4PF83

- NTE1_USTMA

UniProt

Q4PF83 - NTE1_USTMA

Protein

Lysophospholipase NTE1

Gene

NTE1

Organism
Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (19 Jul 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

    Enzyme regulationi

    Inhibited by organophosphorus esters.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei1577 – 15771By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi863 – 1158296cNMP 1Add
    BLAST
    Nucleotide bindingi1166 – 1285120cNMP 2Add
    BLAST

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid catabolic process Source: UniProtKB-KW
    2. phosphatidylcholine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysophospholipase NTE1 (EC:3.1.1.5)
    Alternative name(s):
    Intracellular phospholipase B
    Neuropathy target esterase homolog
    Gene namesi
    Name:NTE1
    ORF Names:UM01230
    OrganismiUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
    Taxonomic identifieri237631 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeUstilago
    ProteomesiUP000000561: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 18831883Lysophospholipase NTE1PRO_0000295331Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5270.UM01230.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4PF83.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7575CytoplasmicBy similarityAdd
    BLAST
    Topological domaini97 – 1037LumenalBy similarity
    Topological domaini125 – 18831759CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei76 – 9621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei104 – 12421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1544 – 1708165PatatinAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1575 – 15795GXSXG

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi7 – 5347Ala-richAdd
    BLAST
    Compositional biasi1008 – 10136Poly-Ser

    Sequence similaritiesi

    Belongs to the NTE family.Curated
    Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 patatin domain.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0664.
    HOGENOMiHOG000048680.
    KOiK14676.
    OMAiASENDRS.
    OrthoDBiEOG70W3NS.

    Family and domain databases

    Gene3Di2.60.120.10. 5 hits.
    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 5 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4PF83-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQVPVASPA SWSSVASAAA AAVSAATSAS SSLAASVDEP AATTATAATA     50
    SYADERNPLI ALFDGLLRVV LASLNLIRIL ATFSTITVPS LVYAILHYSL 100
    TLQLNFPSLA LLFLTSLISA FIWLRYRHLN KYERLREVPI TRDEGFNLNP 150
    DVASPGGDND RGSFHNYLDD FLQAIRIFGF LEKPVFHELA RHLQTRRLVA 200
    GDSLSLDTDF SFYIVIDGHV QVYAPLPSAT ASAVGQDSVE DEDDSGYQLL 250
    NEVESGGTLS SLFTILSLFT EDVKLSFDDH DDPHLAPPHP AYPAMDRLNN 300
    SSAANHLGRG NNATAPTSPY SSAFNPPSQT AAQLQLNAAA LRNVPAAIST 350
    EGAVERLGGS AAVRSTSKSS HARTASSGTA SATVQDGDTS TIMDPLEQND 400
    DGVTSSLYHA PDLQMPPAQA AAPFSHFAPS YHPSPAGTPI SSLPGSTHSP 450
    YFRGRATSIH ALHEAAGGPN TPGSILSAMS SSAHGHYHPQ ADYLPRQGAG 500
    TVARATVDTT LAVIPAEAFK RLTKKFPNAA AHIVQVILAR LSRVTFHTAH 550
    KYLGLTKEVM RTEKSINDLA CFPLPSEFYE KGGMDKLRHR FLPQPNSKRE 600
    TTVDDDYFRD FQEWTSISQR SSTPVPGSKD DTKDAATSSP PKVRIASDLP 650
    SLTTSSKQSN QKPTSSRISA ARTPWGHPDP PLKTPTARNM VGPGDLLSMA 700
    SLSQDGWYTT GFDMHSAQPT PRAKPRSVSK LEPFHGPLPH PVDDSTDGTS 750
    PLSGASPIPI RKGSSTMYHQ GEAIGTDRPF ANIGLPHFDI KNEVMDCIAK 800
    SIGLAQAAHS PLAPSYQASP HINAQDSLLQ RSVFKSAFGS LSMLDAAMAE 850
    EESSITGTNS SMAGHGHSGF HPSDFENEVE IKFFPAGSTL VKAGESRAGL 900
    FYVIDGFLDV LLPAEANELE EEDRLKPNMN HKSAKTDASS GSSRQNRPGS 950
    HRKDSSSASL RAGLLDERNL READVSLPQR RGTEADRISS NGDGNSGSVH 1000
    RPAMREGSSS STSYGTPAGL RKKPTESAKV GNALDGTGGA GSSSRRKPSH 1050
    VSSGSGATTM PRHPDATNSN MAFTAKQPVL HPSLHQQQPL RGKPSQQSSQ 1100
    RSKDGKRSIF TVGRGGIAGY LSSLLGTASY VDITAKTDVY VGFLPAHALE 1150
    RIMERRPIVL LTLCKRLLSL LPPLILHIDS SLDWQQVNAG QVIYREDDPS 1200
    DSFFIVINGR LRAITEKTNG IEVHNEYGQG DSVGELDVIT NSRRRTTLHA 1250
    IRDSELAKMP STLFNAISVR HPAITIQISR IIARRVRTEL VRSKQEGAAL 1300
    GAPIPGLPDL GRNNLNLKTV AIVPVTRQVP VIDFAAKLQT AFDDTIGGRA 1350
    IFLDQSSVMG VLGRHAFSRM GKLKLAGWLA DLEQKYRLVV YVVDTPVSSA 1400
    WSQTSIRQAD CVLMVGFGDE PAMGEYERLL MSVKTTARKE LVLLHPERSV 1450
    PPGSTREWLK NRPWVHAHHH VEMPGLTGSH AGAAISTGGD PKAVKALRNL 1500
    KQKLETSLQR YRKTMTPLSA SGRPHHASDF ARLARRLCGM SIGLVLGGGG 1550
    ARGCAHLGVI RALEERGIPI DMVGGTSIGS LVGGLYAREA EMVSTFGRAK 1600
    RFAGRMASLW RFASDLTYPV VSYTTGHEFN RGVFKAIQET HIEDMWIPFF 1650
    CNTTNITWSR MEVHTSGYAW RYIRGSMTLA GLIPPLVDEG NMLVDGGYVD 1700
    NLPVTVMLAM GARSVFAVDV GSIDDTSPRA YGDTLSGWWV LLNRWNPWSD 1750
    ASKIPSIPDI QGRLTYVSSV KTLEEAKKVK GCFYMRMPVE EFGTLAFGRF 1800
    DMIYEKGYKA AVELLDGWDA EGKLPSGTER EDFEDDWEDG DEYEEYEVYT 1850
    DDESGVGGGV RKIRKKRRRT RRKAGISARR NSI 1883
    Length:1,883
    Mass (Da):203,826
    Last modified:July 19, 2005 - v1
    Checksum:iAF91BC38E34B0FF5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACP01000043 Genomic DNA. Translation: EAK81837.1.
    RefSeqiXP_757377.1. XM_752284.1.

    Genome annotation databases

    EnsemblFungiiUM01230T0; UM01230P0; UM01230.
    GeneIDi3629272.
    KEGGiuma:UM01230.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACP01000043 Genomic DNA. Translation: EAK81837.1 .
    RefSeqi XP_757377.1. XM_752284.1.

    3D structure databases

    ProteinModelPortali Q4PF83.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5270.UM01230.1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii UM01230T0 ; UM01230P0 ; UM01230 .
    GeneIDi 3629272.
    KEGGi uma:UM01230.1.

    Phylogenomic databases

    eggNOGi COG0664.
    HOGENOMi HOG000048680.
    KOi K14676.
    OMAi ASENDRS.
    OrthoDBi EOG70W3NS.

    Family and domain databases

    Gene3Di 2.60.120.10. 5 hits.
    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 5 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis."
      Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J., Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H., Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G., Snetselaar K., McCann M., Perez-Martin J.
      , Feldbruegge M., Basse C.W., Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L., Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L., Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N., Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B., Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J., Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P., Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G., Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A., Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M., Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M., Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E., Birren B.W.
      Nature 444:97-101(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 521 / FGSC 9021.

    Entry informationi

    Entry nameiNTE1_USTMA
    AccessioniPrimary (citable) accession number: Q4PF83
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3