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Q4PF83 (NTE1_USTMA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Lysophospholipase NTE1

EC=3.1.1.5
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene names
Name:NTE1
ORF Names:UM01230
OrganismUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) [Reference proteome]
Taxonomic identifier237631 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeUstilago

Protein attributes

Sequence length1883 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulation

Inhibited by organophosphorus esters By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the NTE family.

Contains 2 cyclic nucleotide-binding domains.

Contains 1 patatin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 18831883Lysophospholipase NTE1
PRO_0000295331

Regions

Topological domain1 – 7575Cytoplasmic By similarity
Transmembrane76 – 9621Helical; Potential
Topological domain97 – 1037Lumenal By similarity
Transmembrane104 – 12421Helical; Potential
Topological domain125 – 18831759Cytoplasmic By similarity
Domain1544 – 1708165Patatin
Nucleotide binding863 – 1158296cNMP 1
Nucleotide binding1166 – 1285120cNMP 2
Motif1575 – 15795GXSXG
Compositional bias7 – 5347Ala-rich
Compositional bias1008 – 10136Poly-Ser

Sites

Active site15771 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4PF83 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: AF91BC38E34B0FF5

FASTA1,883203,826
        10         20         30         40         50         60 
MSQVPVASPA SWSSVASAAA AAVSAATSAS SSLAASVDEP AATTATAATA SYADERNPLI 

        70         80         90        100        110        120 
ALFDGLLRVV LASLNLIRIL ATFSTITVPS LVYAILHYSL TLQLNFPSLA LLFLTSLISA 

       130        140        150        160        170        180 
FIWLRYRHLN KYERLREVPI TRDEGFNLNP DVASPGGDND RGSFHNYLDD FLQAIRIFGF 

       190        200        210        220        230        240 
LEKPVFHELA RHLQTRRLVA GDSLSLDTDF SFYIVIDGHV QVYAPLPSAT ASAVGQDSVE 

       250        260        270        280        290        300 
DEDDSGYQLL NEVESGGTLS SLFTILSLFT EDVKLSFDDH DDPHLAPPHP AYPAMDRLNN 

       310        320        330        340        350        360 
SSAANHLGRG NNATAPTSPY SSAFNPPSQT AAQLQLNAAA LRNVPAAIST EGAVERLGGS 

       370        380        390        400        410        420 
AAVRSTSKSS HARTASSGTA SATVQDGDTS TIMDPLEQND DGVTSSLYHA PDLQMPPAQA 

       430        440        450        460        470        480 
AAPFSHFAPS YHPSPAGTPI SSLPGSTHSP YFRGRATSIH ALHEAAGGPN TPGSILSAMS 

       490        500        510        520        530        540 
SSAHGHYHPQ ADYLPRQGAG TVARATVDTT LAVIPAEAFK RLTKKFPNAA AHIVQVILAR 

       550        560        570        580        590        600 
LSRVTFHTAH KYLGLTKEVM RTEKSINDLA CFPLPSEFYE KGGMDKLRHR FLPQPNSKRE 

       610        620        630        640        650        660 
TTVDDDYFRD FQEWTSISQR SSTPVPGSKD DTKDAATSSP PKVRIASDLP SLTTSSKQSN 

       670        680        690        700        710        720 
QKPTSSRISA ARTPWGHPDP PLKTPTARNM VGPGDLLSMA SLSQDGWYTT GFDMHSAQPT 

       730        740        750        760        770        780 
PRAKPRSVSK LEPFHGPLPH PVDDSTDGTS PLSGASPIPI RKGSSTMYHQ GEAIGTDRPF 

       790        800        810        820        830        840 
ANIGLPHFDI KNEVMDCIAK SIGLAQAAHS PLAPSYQASP HINAQDSLLQ RSVFKSAFGS 

       850        860        870        880        890        900 
LSMLDAAMAE EESSITGTNS SMAGHGHSGF HPSDFENEVE IKFFPAGSTL VKAGESRAGL 

       910        920        930        940        950        960 
FYVIDGFLDV LLPAEANELE EEDRLKPNMN HKSAKTDASS GSSRQNRPGS HRKDSSSASL 

       970        980        990       1000       1010       1020 
RAGLLDERNL READVSLPQR RGTEADRISS NGDGNSGSVH RPAMREGSSS STSYGTPAGL 

      1030       1040       1050       1060       1070       1080 
RKKPTESAKV GNALDGTGGA GSSSRRKPSH VSSGSGATTM PRHPDATNSN MAFTAKQPVL 

      1090       1100       1110       1120       1130       1140 
HPSLHQQQPL RGKPSQQSSQ RSKDGKRSIF TVGRGGIAGY LSSLLGTASY VDITAKTDVY 

      1150       1160       1170       1180       1190       1200 
VGFLPAHALE RIMERRPIVL LTLCKRLLSL LPPLILHIDS SLDWQQVNAG QVIYREDDPS 

      1210       1220       1230       1240       1250       1260 
DSFFIVINGR LRAITEKTNG IEVHNEYGQG DSVGELDVIT NSRRRTTLHA IRDSELAKMP 

      1270       1280       1290       1300       1310       1320 
STLFNAISVR HPAITIQISR IIARRVRTEL VRSKQEGAAL GAPIPGLPDL GRNNLNLKTV 

      1330       1340       1350       1360       1370       1380 
AIVPVTRQVP VIDFAAKLQT AFDDTIGGRA IFLDQSSVMG VLGRHAFSRM GKLKLAGWLA 

      1390       1400       1410       1420       1430       1440 
DLEQKYRLVV YVVDTPVSSA WSQTSIRQAD CVLMVGFGDE PAMGEYERLL MSVKTTARKE 

      1450       1460       1470       1480       1490       1500 
LVLLHPERSV PPGSTREWLK NRPWVHAHHH VEMPGLTGSH AGAAISTGGD PKAVKALRNL 

      1510       1520       1530       1540       1550       1560 
KQKLETSLQR YRKTMTPLSA SGRPHHASDF ARLARRLCGM SIGLVLGGGG ARGCAHLGVI 

      1570       1580       1590       1600       1610       1620 
RALEERGIPI DMVGGTSIGS LVGGLYAREA EMVSTFGRAK RFAGRMASLW RFASDLTYPV 

      1630       1640       1650       1660       1670       1680 
VSYTTGHEFN RGVFKAIQET HIEDMWIPFF CNTTNITWSR MEVHTSGYAW RYIRGSMTLA 

      1690       1700       1710       1720       1730       1740 
GLIPPLVDEG NMLVDGGYVD NLPVTVMLAM GARSVFAVDV GSIDDTSPRA YGDTLSGWWV 

      1750       1760       1770       1780       1790       1800 
LLNRWNPWSD ASKIPSIPDI QGRLTYVSSV KTLEEAKKVK GCFYMRMPVE EFGTLAFGRF 

      1810       1820       1830       1840       1850       1860 
DMIYEKGYKA AVELLDGWDA EGKLPSGTER EDFEDDWEDG DEYEEYEVYT DDESGVGGGV 

      1870       1880 
RKIRKKRRRT RRKAGISARR NSI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACP01000043 Genomic DNA. Translation: EAK81837.1.
RefSeqXP_757377.1. XM_752284.1.

3D structure databases

ProteinModelPortalQ4PF83.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5270.UM01230.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiUM01230T0; UM01230P0; UM01230.
GeneID3629272.
KEGGuma:UM01230.1.

Phylogenomic databases

eggNOGCOG0664.
HOGENOMHOG000048680.
KOK14676.
OMAASENDRS.
OrthoDBEOG70W3NS.

Family and domain databases

Gene3D2.60.120.10. 5 hits.
InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNTE1_USTMA
AccessionPrimary (citable) accession number: Q4PF83
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 19, 2005
Last modified: February 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families