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Protein

Lysophospholipase NTE1

Gene

NTE1

Organism
Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1577NucleophilePROSITE-ProRule annotation1
Active sitei1695Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi863 – 1158cNMP 1Add BLAST296
Nucleotide bindingi1166 – 1285cNMP 2Add BLAST120

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase NTE1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:NTE1
ORF Names:UMAG_01230
OrganismiUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Taxonomic identifieri237631 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeUstilago
Proteomesi
  • UP000000561 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:UMAG_01230

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 75CytoplasmicBy similarityAdd BLAST75
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Topological domaini97 – 103LumenalBy similarity7
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Topological domaini125 – 1883CytoplasmicBy similarityAdd BLAST1759

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002953311 – 1883Lysophospholipase NTE1Add BLAST1883

Proteomic databases

PRIDEiQ4PF83

Interactioni

Protein-protein interaction databases

STRINGi5270.UM01230P0

Structurei

3D structure databases

ProteinModelPortaliQ4PF83
SMRiQ4PF83
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1544 – 1708PNPLAPROSITE-ProRule annotationAdd BLAST165

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1548 – 1553GXGXXGPROSITE-ProRule annotation6
Motifi1575 – 1579GXSXGPROSITE-ProRule annotation5
Motifi1695 – 1697DGA/GPROSITE-ProRule annotation3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi7 – 53Ala-richAdd BLAST47
Compositional biasi1008 – 1013Poly-Ser6

Sequence similaritiesi

Belongs to the NTE family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000048680
InParanoidiQ4PF83
KOiK14676
OMAiQETHIED
OrthoDBiEOG092C0BAH

Family and domain databases

CDDicd00038 CAP_ED, 2 hits
Gene3Di2.60.120.10, 2 hits
InterProiView protein in InterPro
IPR016035 Acyl_Trfase/lysoPLipase
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR001423 LysoPLipase_patatin_CS
IPR002641 PNPLA_dom
IPR014710 RmlC-like_jellyroll
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
PF01734 Patatin, 1 hit
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SUPFAMiSSF51206 SSF51206, 5 hits
SSF52151 SSF52151, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 2 hits
PS51635 PNPLA, 1 hit
PS01237 UPF0028, 1 hit

Sequencei

Sequence statusi: Complete.

Q4PF83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQVPVASPA SWSSVASAAA AAVSAATSAS SSLAASVDEP AATTATAATA
60 70 80 90 100
SYADERNPLI ALFDGLLRVV LASLNLIRIL ATFSTITVPS LVYAILHYSL
110 120 130 140 150
TLQLNFPSLA LLFLTSLISA FIWLRYRHLN KYERLREVPI TRDEGFNLNP
160 170 180 190 200
DVASPGGDND RGSFHNYLDD FLQAIRIFGF LEKPVFHELA RHLQTRRLVA
210 220 230 240 250
GDSLSLDTDF SFYIVIDGHV QVYAPLPSAT ASAVGQDSVE DEDDSGYQLL
260 270 280 290 300
NEVESGGTLS SLFTILSLFT EDVKLSFDDH DDPHLAPPHP AYPAMDRLNN
310 320 330 340 350
SSAANHLGRG NNATAPTSPY SSAFNPPSQT AAQLQLNAAA LRNVPAAIST
360 370 380 390 400
EGAVERLGGS AAVRSTSKSS HARTASSGTA SATVQDGDTS TIMDPLEQND
410 420 430 440 450
DGVTSSLYHA PDLQMPPAQA AAPFSHFAPS YHPSPAGTPI SSLPGSTHSP
460 470 480 490 500
YFRGRATSIH ALHEAAGGPN TPGSILSAMS SSAHGHYHPQ ADYLPRQGAG
510 520 530 540 550
TVARATVDTT LAVIPAEAFK RLTKKFPNAA AHIVQVILAR LSRVTFHTAH
560 570 580 590 600
KYLGLTKEVM RTEKSINDLA CFPLPSEFYE KGGMDKLRHR FLPQPNSKRE
610 620 630 640 650
TTVDDDYFRD FQEWTSISQR SSTPVPGSKD DTKDAATSSP PKVRIASDLP
660 670 680 690 700
SLTTSSKQSN QKPTSSRISA ARTPWGHPDP PLKTPTARNM VGPGDLLSMA
710 720 730 740 750
SLSQDGWYTT GFDMHSAQPT PRAKPRSVSK LEPFHGPLPH PVDDSTDGTS
760 770 780 790 800
PLSGASPIPI RKGSSTMYHQ GEAIGTDRPF ANIGLPHFDI KNEVMDCIAK
810 820 830 840 850
SIGLAQAAHS PLAPSYQASP HINAQDSLLQ RSVFKSAFGS LSMLDAAMAE
860 870 880 890 900
EESSITGTNS SMAGHGHSGF HPSDFENEVE IKFFPAGSTL VKAGESRAGL
910 920 930 940 950
FYVIDGFLDV LLPAEANELE EEDRLKPNMN HKSAKTDASS GSSRQNRPGS
960 970 980 990 1000
HRKDSSSASL RAGLLDERNL READVSLPQR RGTEADRISS NGDGNSGSVH
1010 1020 1030 1040 1050
RPAMREGSSS STSYGTPAGL RKKPTESAKV GNALDGTGGA GSSSRRKPSH
1060 1070 1080 1090 1100
VSSGSGATTM PRHPDATNSN MAFTAKQPVL HPSLHQQQPL RGKPSQQSSQ
1110 1120 1130 1140 1150
RSKDGKRSIF TVGRGGIAGY LSSLLGTASY VDITAKTDVY VGFLPAHALE
1160 1170 1180 1190 1200
RIMERRPIVL LTLCKRLLSL LPPLILHIDS SLDWQQVNAG QVIYREDDPS
1210 1220 1230 1240 1250
DSFFIVINGR LRAITEKTNG IEVHNEYGQG DSVGELDVIT NSRRRTTLHA
1260 1270 1280 1290 1300
IRDSELAKMP STLFNAISVR HPAITIQISR IIARRVRTEL VRSKQEGAAL
1310 1320 1330 1340 1350
GAPIPGLPDL GRNNLNLKTV AIVPVTRQVP VIDFAAKLQT AFDDTIGGRA
1360 1370 1380 1390 1400
IFLDQSSVMG VLGRHAFSRM GKLKLAGWLA DLEQKYRLVV YVVDTPVSSA
1410 1420 1430 1440 1450
WSQTSIRQAD CVLMVGFGDE PAMGEYERLL MSVKTTARKE LVLLHPERSV
1460 1470 1480 1490 1500
PPGSTREWLK NRPWVHAHHH VEMPGLTGSH AGAAISTGGD PKAVKALRNL
1510 1520 1530 1540 1550
KQKLETSLQR YRKTMTPLSA SGRPHHASDF ARLARRLCGM SIGLVLGGGG
1560 1570 1580 1590 1600
ARGCAHLGVI RALEERGIPI DMVGGTSIGS LVGGLYAREA EMVSTFGRAK
1610 1620 1630 1640 1650
RFAGRMASLW RFASDLTYPV VSYTTGHEFN RGVFKAIQET HIEDMWIPFF
1660 1670 1680 1690 1700
CNTTNITWSR MEVHTSGYAW RYIRGSMTLA GLIPPLVDEG NMLVDGGYVD
1710 1720 1730 1740 1750
NLPVTVMLAM GARSVFAVDV GSIDDTSPRA YGDTLSGWWV LLNRWNPWSD
1760 1770 1780 1790 1800
ASKIPSIPDI QGRLTYVSSV KTLEEAKKVK GCFYMRMPVE EFGTLAFGRF
1810 1820 1830 1840 1850
DMIYEKGYKA AVELLDGWDA EGKLPSGTER EDFEDDWEDG DEYEEYEVYT
1860 1870 1880
DDESGVGGGV RKIRKKRRRT RRKAGISARR NSI
Length:1,883
Mass (Da):203,826
Last modified:July 19, 2005 - v1
Checksum:iAF91BC38E34B0FF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM003141 Genomic DNA Translation: KIS71330.1
RefSeqiXP_011387164.1, XM_011388862.1

Genome annotation databases

EnsemblFungiiKIS71330; KIS71330; UMAG_01230
GeneIDi23562320
KEGGiuma:UMAG_01230

Similar proteinsi

Entry informationi

Entry nameiNTE1_USTMA
AccessioniPrimary (citable) accession number: Q4PF83
Secondary accession number(s): A0A0D1EAB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 19, 2005
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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