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Q4PF83

- NTE1_USTMA

UniProt

Q4PF83 - NTE1_USTMA

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Protein

Lysophospholipase NTE1

Gene

NTE1

Organism
Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1577 – 15771By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi863 – 1158296cNMP 1Add
BLAST
Nucleotide bindingi1166 – 1285120cNMP 2Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
  2. phosphatidylcholine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase NTE1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:NTE1
ORF Names:UM01230
OrganismiUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Taxonomic identifieri237631 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeUstilago
ProteomesiUP000000561: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18831883Lysophospholipase NTE1PRO_0000295331Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5270.UM01230.1.

Structurei

3D structure databases

ProteinModelPortaliQ4PF83.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7575CytoplasmicBy similarityAdd
BLAST
Topological domaini97 – 1037LumenalBy similarity
Topological domaini125 – 18831759CytoplasmicBy similarityAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei76 – 9621HelicalSequence AnalysisAdd
BLAST
Transmembranei104 – 12421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1544 – 1708165PatatinAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1575 – 15795GXSXG

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi7 – 5347Ala-richAdd
BLAST
Compositional biasi1008 – 10136Poly-Ser

Sequence similaritiesi

Belongs to the NTE family.Curated
Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 patatin domain.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000048680.
InParanoidiQ4PF83.
KOiK14676.
OMAiASENDRS.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 5 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4PF83-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQVPVASPA SWSSVASAAA AAVSAATSAS SSLAASVDEP AATTATAATA
60 70 80 90 100
SYADERNPLI ALFDGLLRVV LASLNLIRIL ATFSTITVPS LVYAILHYSL
110 120 130 140 150
TLQLNFPSLA LLFLTSLISA FIWLRYRHLN KYERLREVPI TRDEGFNLNP
160 170 180 190 200
DVASPGGDND RGSFHNYLDD FLQAIRIFGF LEKPVFHELA RHLQTRRLVA
210 220 230 240 250
GDSLSLDTDF SFYIVIDGHV QVYAPLPSAT ASAVGQDSVE DEDDSGYQLL
260 270 280 290 300
NEVESGGTLS SLFTILSLFT EDVKLSFDDH DDPHLAPPHP AYPAMDRLNN
310 320 330 340 350
SSAANHLGRG NNATAPTSPY SSAFNPPSQT AAQLQLNAAA LRNVPAAIST
360 370 380 390 400
EGAVERLGGS AAVRSTSKSS HARTASSGTA SATVQDGDTS TIMDPLEQND
410 420 430 440 450
DGVTSSLYHA PDLQMPPAQA AAPFSHFAPS YHPSPAGTPI SSLPGSTHSP
460 470 480 490 500
YFRGRATSIH ALHEAAGGPN TPGSILSAMS SSAHGHYHPQ ADYLPRQGAG
510 520 530 540 550
TVARATVDTT LAVIPAEAFK RLTKKFPNAA AHIVQVILAR LSRVTFHTAH
560 570 580 590 600
KYLGLTKEVM RTEKSINDLA CFPLPSEFYE KGGMDKLRHR FLPQPNSKRE
610 620 630 640 650
TTVDDDYFRD FQEWTSISQR SSTPVPGSKD DTKDAATSSP PKVRIASDLP
660 670 680 690 700
SLTTSSKQSN QKPTSSRISA ARTPWGHPDP PLKTPTARNM VGPGDLLSMA
710 720 730 740 750
SLSQDGWYTT GFDMHSAQPT PRAKPRSVSK LEPFHGPLPH PVDDSTDGTS
760 770 780 790 800
PLSGASPIPI RKGSSTMYHQ GEAIGTDRPF ANIGLPHFDI KNEVMDCIAK
810 820 830 840 850
SIGLAQAAHS PLAPSYQASP HINAQDSLLQ RSVFKSAFGS LSMLDAAMAE
860 870 880 890 900
EESSITGTNS SMAGHGHSGF HPSDFENEVE IKFFPAGSTL VKAGESRAGL
910 920 930 940 950
FYVIDGFLDV LLPAEANELE EEDRLKPNMN HKSAKTDASS GSSRQNRPGS
960 970 980 990 1000
HRKDSSSASL RAGLLDERNL READVSLPQR RGTEADRISS NGDGNSGSVH
1010 1020 1030 1040 1050
RPAMREGSSS STSYGTPAGL RKKPTESAKV GNALDGTGGA GSSSRRKPSH
1060 1070 1080 1090 1100
VSSGSGATTM PRHPDATNSN MAFTAKQPVL HPSLHQQQPL RGKPSQQSSQ
1110 1120 1130 1140 1150
RSKDGKRSIF TVGRGGIAGY LSSLLGTASY VDITAKTDVY VGFLPAHALE
1160 1170 1180 1190 1200
RIMERRPIVL LTLCKRLLSL LPPLILHIDS SLDWQQVNAG QVIYREDDPS
1210 1220 1230 1240 1250
DSFFIVINGR LRAITEKTNG IEVHNEYGQG DSVGELDVIT NSRRRTTLHA
1260 1270 1280 1290 1300
IRDSELAKMP STLFNAISVR HPAITIQISR IIARRVRTEL VRSKQEGAAL
1310 1320 1330 1340 1350
GAPIPGLPDL GRNNLNLKTV AIVPVTRQVP VIDFAAKLQT AFDDTIGGRA
1360 1370 1380 1390 1400
IFLDQSSVMG VLGRHAFSRM GKLKLAGWLA DLEQKYRLVV YVVDTPVSSA
1410 1420 1430 1440 1450
WSQTSIRQAD CVLMVGFGDE PAMGEYERLL MSVKTTARKE LVLLHPERSV
1460 1470 1480 1490 1500
PPGSTREWLK NRPWVHAHHH VEMPGLTGSH AGAAISTGGD PKAVKALRNL
1510 1520 1530 1540 1550
KQKLETSLQR YRKTMTPLSA SGRPHHASDF ARLARRLCGM SIGLVLGGGG
1560 1570 1580 1590 1600
ARGCAHLGVI RALEERGIPI DMVGGTSIGS LVGGLYAREA EMVSTFGRAK
1610 1620 1630 1640 1650
RFAGRMASLW RFASDLTYPV VSYTTGHEFN RGVFKAIQET HIEDMWIPFF
1660 1670 1680 1690 1700
CNTTNITWSR MEVHTSGYAW RYIRGSMTLA GLIPPLVDEG NMLVDGGYVD
1710 1720 1730 1740 1750
NLPVTVMLAM GARSVFAVDV GSIDDTSPRA YGDTLSGWWV LLNRWNPWSD
1760 1770 1780 1790 1800
ASKIPSIPDI QGRLTYVSSV KTLEEAKKVK GCFYMRMPVE EFGTLAFGRF
1810 1820 1830 1840 1850
DMIYEKGYKA AVELLDGWDA EGKLPSGTER EDFEDDWEDG DEYEEYEVYT
1860 1870 1880
DDESGVGGGV RKIRKKRRRT RRKAGISARR NSI
Length:1,883
Mass (Da):203,826
Last modified:July 19, 2005 - v1
Checksum:iAF91BC38E34B0FF5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACP01000043 Genomic DNA. Translation: EAK81837.1.
RefSeqiXP_757377.1. XM_752284.1.

Genome annotation databases

EnsemblFungiiUM01230T0; UM01230P0; UM01230.
GeneIDi3629272.
KEGGiuma:UM01230.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACP01000043 Genomic DNA. Translation: EAK81837.1 .
RefSeqi XP_757377.1. XM_752284.1.

3D structure databases

ProteinModelPortali Q4PF83.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5270.UM01230.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii UM01230T0 ; UM01230P0 ; UM01230 .
GeneIDi 3629272.
KEGGi uma:UM01230.1.

Phylogenomic databases

eggNOGi COG0664.
HOGENOMi HOG000048680.
InParanoidi Q4PF83.
KOi K14676.
OMAi ASENDRS.
OrthoDBi EOG70W3NS.

Family and domain databases

Gene3Di 2.60.120.10. 5 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis."
    Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J., Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H., Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G., Snetselaar K., McCann M., Perez-Martin J.
    , Feldbruegge M., Basse C.W., Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L., Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L., Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N., Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B., Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J., Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P., Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G., Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A., Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M., Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M., Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E., Birren B.W.
    Nature 444:97-101(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 521 / FGSC 9021.

Entry informationi

Entry nameiNTE1_USTMA
AccessioniPrimary (citable) accession number: Q4PF83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 19, 2005
Last modified: October 29, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3