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Protein

Mitochondrial glycine transporter

Gene

UMAG_10880

Organism
Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial glycine transporterUniRule annotation
Alternative name(s):
Solute carrier family 25 member 38 homologUniRule annotation
Gene namesi
ORF Names:UMAG_10880
OrganismiUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Taxonomic identifieri237631 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeUstilago
Proteomesi
  • UP000000561 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:UMAG_10880

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei41 – 66Helical; Name=1UniRule annotationAdd BLAST26
Transmembranei112 – 138Helical; Name=2UniRule annotationAdd BLAST27
Transmembranei170 – 195Helical; Name=3UniRule annotationAdd BLAST26
Transmembranei226 – 249Helical; Name=4UniRule annotationAdd BLAST24
Transmembranei270 – 296Helical; Name=5UniRule annotationAdd BLAST27
Transmembranei349 – 367Helical; Name=6UniRule annotationAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004252671 – 399Mitochondrial glycine transporterAdd BLAST399

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati35 – 137Solcar 1UniRule annotationAdd BLAST103
Repeati164 – 251Solcar 2UniRule annotationAdd BLAST88
Repeati266 – 374Solcar 3UniRule annotationAdd BLAST109

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ4PDL5
KOiK15118
OrthoDBiEOG092C3NVU

Family and domain databases

Gene3Di1.50.40.10, 2 hits
HAMAPiMF_03064 SLC25A38, 1 hit
InterProiView protein in InterPro
IPR030847 Hem25/SLC25A38
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 2 hits

Sequencei

Sequence statusi: Complete.

Q4PDL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATASSSDDA GAAMSISIAN SSKRPIATTK TAASIPPYAT LAFGALSGFA
60 70 80 90 100
SCVLLQPFDL LKTRLQQLDH RPLSPVSNKS ISKPQYASRT QKLVAITKDI
110 120 130 140 150
VHTHGYQGLW RGTAPTVIRN VPGVALYFYS VSHLRSVASQ RQIPLISVAI
160 170 180 190 200
PSDASSNTST LAKLSTTGNL LTGAVARVTV GFILSPVTVV KARFESSNFS
210 220 230 240 250
AATERTLLSS MREIRAQSGF RGFFQGFTAT ALRDAPYAGL YLALYEACKT
260 270 280 290 300
NLAGLSRSMD GGLGTGNWMV VSASGLLAGT LATLLTHPFD IIKTRMQTTP
310 320 330 340 350
ADTLHQIALA HDPKSTLSPS VLRDSLKPSV WGMTKHLWAS SGPRALLDGL
360 370 380 390
GLRCARKAAS SAIGWSIFER GRSWYTEREA SSSAQEAGTG TRLLDHKQV
Length:399
Mass (Da):42,473
Last modified:February 19, 2014 - v2
Checksum:i10741CB2DE8A3AE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM003142 Genomic DNA Translation: KIS70633.1
RefSeqiXP_011388010.1, XM_011389708.1

Genome annotation databases

EnsemblFungiiKIS70633; KIS70633; UMAG_10880
GeneIDi23566850
KEGGiuma:UMAG_10880

Similar proteinsi

Entry informationi

Entry nameiS2538_USTMA
AccessioniPrimary (citable) accession number: Q4PDL5
Secondary accession number(s): A0A0D1CW78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 19, 2014
Last sequence update: February 19, 2014
Last modified: April 25, 2018
This is version 76 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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