Reviewed, UniProtKB/Swiss-Prot Q4PBY6 (CCPR_USTMA)

Names and origin

Protein names

Recommended name:
    Cytochrome c peroxidase, mitochondrial
      Short name=CCP
    EC=1.11.1.5

Gene names

Name:	CCP1
ORF Names:	UM02377

Organism

Ustilago maydis (Smut fungus) [Complete proteome]

Taxonomic identifier

5270 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Basidiomycota › Ustilaginomycotina › Ustilaginomycetes › Ustilaginales › Ustilaginaceae › Ustilago

Protein attributes

Sequence length	398 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Destroys radicals which are normally produced within the cells and which are toxic to biological systems By similarity.
Catalytic activity	2 ferrocytochrome c + H2O2 = 2 ferricytochrome c + 2 H2O.
Cofactor	Binds 1 heme B (iron-protoporphyrin IX) group per subunit By similarity.
Subunit structure	Forms a one-to-one complex with cytochrome c By similarity.
Subcellular location	Mitochondrion matrix By similarity.
Sequence similarities	Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase Peroxidase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to oxidative stress Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	cytochrome-c peroxidase activity Inferred from electronic annotation. Source: EC heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 34	34	Mitochondrion Potential
	Chain	35 – 398	364	Cytochrome c peroxidase, mitochondrial		PRO_0000045296
Sites
	Active site	145	1	Proton acceptor By similarity
	Active site	284	1	Tryptophan radical intermediate By similarity
	Metal binding	268	1	Iron (heme axial ligand)
	Site	141	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4PBY6-1 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: 81C9947C2D71B3D3	FASTA	398	43,162
	10 20 30 40 50 60 MASLRTGLRV AQPLRASARN FATRPSIRSS VRHYSSPAPG SPPPPQPSSS SSTSKVLLTS 70 80 90 100 110 120 VAIAAAAGGA FLAFGRDDKV SILGVGANGA NKFQGSKGSV GPATTSAHSK ADYQAVYNAI 130 140 150 160 170 180 AEQLEANPDY DDGSYGPVLV RLAWHASGTY DKNSNTGGSN GATMRFAPES EHGANAGLGA 190 200 210 220 230 240 ARDFMEKIHQ KFPWITYSDL WTLGGVAAIQ ELGGPKIPWR PGRKDATADK CTPDGRLPDG 250 260 270 280 290 300 DKGPDHLRYI FYKMGFNDQE IVALSGAHAL GRCHTDRSGF DGPWTFAPTS FTNEYFNLLM 310 320 330 340 350 360 NEKWNIRKWN GPPQFEDKST KSLMMLMTDM ALVQDPSFKK HVQRYAKSED EFFNDFRSAY 370 380 390 AKLLELGVPA ENFKAFETKL DGGKPFEFAT SAEQENAN

References

[1]

"Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis." Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J., Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H., Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G., Snetselaar K., McCann M., Perez-Martin J. , Feldbruegge M., Basse C.W., Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L., Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L., Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N., Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B., Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J., Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P., Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G., Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A., Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M., Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M., Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E., Birren B.W. Nature 444:97-101(2006) [PubMed: 17080091] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 521.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACP01000083 Genomic DNA. Translation: EAK83415.1.
RefSeq	XP_758524.1.
3D structure databases
ModBase	Search...
Protein family/group databases
PeroxiBase	2328. UmCcP02.
Genome annotation databases
GeneID	3630421.
KEGG	uma:UM02377.1.
Phylogenomic databases
OMA	Q4PBY6. ATMRFAP.
Enzyme and pathway databases
BRENDA	1.11.1.5. 2320.
Family and domain databases
InterPro	IPR002207. Asc_perxdse. IPR002016. Haem_peroxidase_pln/fun/bac. IPR019794. Peroxidases_AS. IPR019793. Peroxidases_heam-ligand_BS. [Graphical view]
Pfam	PF00141. peroxidase. 1 hit. [Graphical view]
PRINTS	PR00459. ASPEROXIDASE. PR00458. PEROXIDASE.
PROSITE	PS00435. PEROXIDASE_1. 1 hit. PS00436. PEROXIDASE_2. 1 hit. PS50873. PEROXIDASE_4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CCPR_USTMA

Accession

Primary (citable) accession number: Q4PBY6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	July 19, 2005
Last modified:	June 16, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)