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Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi670Zinc; catalyticPROSITE-ProRule annotation1
Active sitei671PROSITE-ProRule annotation1
Metal bindingi674Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi677Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM03.006

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
ORF Names:UMAG_02435
OrganismiUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Taxonomic identifieri237631 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeUstilago
Proteomesi
  • UP000000561 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:UMAG_02435

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 30MitochondrionSequence analysisAdd BLAST30
ChainiPRO_000033859531 – 889Mitochondrial intermediate peptidaseAdd BLAST859

Structurei

3D structure databases

ProteinModelPortaliQ4PBS8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000076521
InParanoidiQ4PBS8
KOiK01410
OMAiVENTAWQ
OrthoDBiEOG092C0JU2

Family and domain databases

CDDicd06457 M3A_MIP, 1 hit
Gene3Di1.10.1370.10, 2 hits
InterProiView protein in InterPro
IPR033851 M3A_MIP
IPR024077 Neurolysin/TOP_dom2
IPR001567 Pept_M3A_M3B
PANTHERiPTHR11804:SF5 PTHR11804:SF5, 1 hit
PfamiView protein in Pfam
PF01432 Peptidase_M3, 1 hit
PROSITEiView protein in PROSITE
PS00142 ZINC_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4PBS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTSKNAQR AAASVAHSYH VCLARRMSRL PTLLSNISAP AASKALDRYE
60 70 80 90 100
SKRIHSRSFS SSLAAQRVQR PTSAGPILTN PISDHEKDND ELRSLFDAPP
110 120 130 140 150
TSSSANHLRS SGPSTGLFEI PSLTSPQNFL VLAQQTLARA QLLVDRIDRA
160 170 180 190 200
GSADASTAQG IKELKEVVRN LDRLSDLLCG VIDMAELVRN AHPDPEWAEA
210 220 230 240 250
ANAAYEYLCG YMNVLNTHTG LYSVLKNILS IKEVAETLSK EATAVAQVFL
260 270 280 290 300
RDFEKSGIHL PPAERERFVQ LSDEILVLGR GFLQDIAGND ASDDFARIAS
310 320 330 340 350
AQADADKSDM VGLPTHWLED VNPTILKAVR ASAITDTDGL LTFSAADQPW
360 370 380 390 400
VFQTLLKYAP DERARKVAFR AANYGSQAQV QRLERLLKAR AELATLTGAS
410 420 430 440 450
SYAEMALGDK MAKEPQNVEE FLRALTKHHR PRASHDLDKL RRLKHNATVS
460 470 480 490 500
EPAQNTRQST FNTNSTLPEF APWDRDMYTE QHFRSASLSN VQPLSPYLSV
510 520 530 540 550
GSVFAGLSRL FSALYGIRFR ASMVAPGEVW SEGAGDVMKV EVLDESEGAR
560 570 580 590 600
GTSGSAEGLI GTIYADLWSR EGKPGGAAHY TVRCSRRVDK DDEAGDFTYG
610 620 630 640 650
RAEDGRVVRP QDLGGEGCGN PLQAPTFEQR ERPGRYQLPV VVLMCDFARP
660 670 680 690 700
GNANQGPCLL GWHEVETLFH EMGHAIHSMI GRTSYHNVSG TRCATDFVEL
710 720 730 740 750
PSILMEHFVS SPQVVHLLAR HHSTGASLPF EHLSSHLAAS KSLEGLDTYH
760 770 780 790 800
QILLARLDQL YHSQLAASPS FSSTTTYSDL DRQMHLPGAP NLSYTEGAHP
810 820 830 840 850
QVRFGHLFGY GSTYYSYLLD RVIASKVWNH LFANNPLDRY AGQVFKNQCL
860 870 880
KYGGGKDPWH ILADVLNEDS VRQGDSRAMQ QVGKWGIEC
Length:889
Mass (Da):97,799
Last modified:September 16, 2015 - v3
Checksum:i7376E7069CBE7367
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM003144 Genomic DNA Translation: KIS69921.1
RefSeqiXP_011388723.1, XM_011390421.1

Genome annotation databases

EnsemblFungiiKIS69921; KIS69921; UMAG_02435
GeneIDi23563181
KEGGiuma:UMAG_02435

Similar proteinsi

Entry informationi

Entry nameiPMIP_USTMA
AccessioniPrimary (citable) accession number: Q4PBS8
Secondary accession number(s): A0A0D1E1U7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: September 16, 2015
Last modified: March 28, 2018
This is version 76 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health