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Q4PBS8

- PMIP_USTMA

UniProt

Q4PBS8 - PMIP_USTMA

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Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi644 – 6441Zinc; catalyticPROSITE-ProRule annotation
Active sitei645 – 6451PROSITE-ProRule annotation
Metal bindingi648 – 6481Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi651 – 6511Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
ORF Names:UM02435
OrganismiUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Taxonomic identifieri237631 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeUstilago
ProteomesiUP000000561: Unassembled WGS sequence

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4040MitochondrionSequence AnalysisAdd
BLAST
Chaini41 – 863823Mitochondrial intermediate peptidasePRO_0000338595Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5270.UM02435.1.

Structurei

3D structure databases

ProteinModelPortaliQ4PBS8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0339.
HOGENOMiHOG000076521.
InParanoidiQ4PBS8.
KOiK01410.
OrthoDBiEOG71GB4R.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 2 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4PBS8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRLPTLLSN ISAPAASKAL DRYESKRIHS RSFSSSLAAQ RVQRPTSAGP
60 70 80 90 100
ILTNPISDHE KDNDELRSLF DAPPTSSSAN HLRSSGPSTG LFEIPSLTSP
110 120 130 140 150
QNFLVLAQQT LARAQLLVDR IDRAGSADAS TAQGIKELKE VVRNLDRLSD
160 170 180 190 200
LLCGVIDMAE LVRNAHPDPE WAEAANAAYE YLCGYMNVLN THTGLYSVLK
210 220 230 240 250
NILSIKEVAE TLSKEATAVA QVFLRDFEKS GIHLPPAERE RFVQLSDEIL
260 270 280 290 300
VLGRGFLQDI AGNDASDDFA RIASAQADAD KSDMVGLPTH WLEDVNPTIL
310 320 330 340 350
KAVRASAITD TDGLLTFSAA DQPWVFQTLL KYAPDERARK VAFRAANYGS
360 370 380 390 400
QAQVQRLERL LKARAELATL TGASSYAEMA LGDKMAKEPQ NVEEFLRALT
410 420 430 440 450
KHHRPRASHD LDKLRRLKHN ATVSEPAQNT RQSTFNTNST LPEFAPWDRD
460 470 480 490 500
MYTEQHFRSA SLSNVQPLSP YLSVGSVFAG LSRLFSALYG IRFRASMVAP
510 520 530 540 550
GEVWSEGAGD VMKVEVLDES EGARGTSGSA EGLIGTIYAD LWSREGKPGG
560 570 580 590 600
AAHYTVRCSR RVDKDDEAGD FTYGRAEDGR VVRPQDLGGE GCGNPLQAPT
610 620 630 640 650
FEQRERPGRY QLPVVVLMCD FARPGNANQG PCLLGWHEVE TLFHEMGHAI
660 670 680 690 700
HSMIGRTSYH NVSGTRCATD FVELPSILME HFVSSPQVVH LLARHHSTGA
710 720 730 740 750
SLPFEHLSSH LAASKSLEGL DTYHQILLAR LDQLYHSQLA ASPSFSSTTT
760 770 780 790 800
YSDLDRQMHL PGAPNLSYTE GAHPQVRFGH LFGYGSTYYS YLLDRVIASK
810 820 830 840 850
VWNHLFANNP LDRYAGQVFK NQCLKYGGGK DPWHILADVL NEDSVRQGDS
860
RAMQQVGKWG IEC
Length:863
Mass (Da):95,030
Last modified:June 10, 2008 - v2
Checksum:i88FF232FA6308458
GO

Sequence cautioni

The sequence EAK83473.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACP01000083 Genomic DNA. Translation: EAK83473.1. Different initiation.
RefSeqiXP_758582.1. XM_753489.1.

Genome annotation databases

GeneIDi3630533.
KEGGiuma:UM02435.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACP01000083 Genomic DNA. Translation: EAK83473.1 . Different initiation.
RefSeqi XP_758582.1. XM_753489.1.

3D structure databases

ProteinModelPortali Q4PBS8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5270.UM02435.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3630533.
KEGGi uma:UM02435.1.

Phylogenomic databases

eggNOGi COG0339.
HOGENOMi HOG000076521.
InParanoidi Q4PBS8.
KOi K01410.
OrthoDBi EOG71GB4R.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 2 hits.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis."
    Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J., Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H., Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G., Snetselaar K., McCann M., Perez-Martin J.
    , Feldbruegge M., Basse C.W., Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L., Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L., Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N., Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B., Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J., Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P., Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G., Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A., Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M., Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M., Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E., Birren B.W.
    Nature 444:97-101(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 521 / FGSC 9021.

Entry informationi

Entry nameiPMIP_USTMA
AccessioniPrimary (citable) accession number: Q4PBS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: October 29, 2014
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3