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Q4PBS8

- PMIP_USTMA

UniProt

Q4PBS8 - PMIP_USTMA

Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 2 (10 Jun 2008)
      Previous versions | rss
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    Functioni

    Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.By similarity

    Catalytic activityi

    Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

    Cofactori

    Binds 1 zinc ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi644 – 6441Zinc; catalyticPROSITE-ProRule annotation
    Active sitei645 – 6451PROSITE-ProRule annotation
    Metal bindingi648 – 6481Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi651 – 6511Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. metalloendopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial intermediate peptidase (EC:3.4.24.59)
    Short name:
    MIP
    Alternative name(s):
    Octapeptidyl aminopeptidase
    Gene namesi
    Name:OCT1
    ORF Names:UM02435
    OrganismiUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
    Taxonomic identifieri237631 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeUstilago
    ProteomesiUP000000561: Unassembled WGS sequence

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4040MitochondrionSequence AnalysisAdd
    BLAST
    Chaini41 – 863823Mitochondrial intermediate peptidasePRO_0000338595Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5270.UM02435.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4PBS8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M3 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0339.
    HOGENOMiHOG000076521.
    KOiK01410.
    OrthoDBiEOG71GB4R.

    Family and domain databases

    Gene3Di1.10.1370.10. 2 hits.
    1.20.1050.40. 1 hit.
    3.40.390.10. 2 hits.
    InterProiIPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR024080. Neurolysin/TOP_N.
    IPR001567. Pept_M3A_M3B.
    [Graphical view]
    PfamiPF01432. Peptidase_M3. 1 hit.
    [Graphical view]
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q4PBS8-1 [UniParc]FASTAAdd to Basket

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    MSRLPTLLSN ISAPAASKAL DRYESKRIHS RSFSSSLAAQ RVQRPTSAGP    50
    ILTNPISDHE KDNDELRSLF DAPPTSSSAN HLRSSGPSTG LFEIPSLTSP 100
    QNFLVLAQQT LARAQLLVDR IDRAGSADAS TAQGIKELKE VVRNLDRLSD 150
    LLCGVIDMAE LVRNAHPDPE WAEAANAAYE YLCGYMNVLN THTGLYSVLK 200
    NILSIKEVAE TLSKEATAVA QVFLRDFEKS GIHLPPAERE RFVQLSDEIL 250
    VLGRGFLQDI AGNDASDDFA RIASAQADAD KSDMVGLPTH WLEDVNPTIL 300
    KAVRASAITD TDGLLTFSAA DQPWVFQTLL KYAPDERARK VAFRAANYGS 350
    QAQVQRLERL LKARAELATL TGASSYAEMA LGDKMAKEPQ NVEEFLRALT 400
    KHHRPRASHD LDKLRRLKHN ATVSEPAQNT RQSTFNTNST LPEFAPWDRD 450
    MYTEQHFRSA SLSNVQPLSP YLSVGSVFAG LSRLFSALYG IRFRASMVAP 500
    GEVWSEGAGD VMKVEVLDES EGARGTSGSA EGLIGTIYAD LWSREGKPGG 550
    AAHYTVRCSR RVDKDDEAGD FTYGRAEDGR VVRPQDLGGE GCGNPLQAPT 600
    FEQRERPGRY QLPVVVLMCD FARPGNANQG PCLLGWHEVE TLFHEMGHAI 650
    HSMIGRTSYH NVSGTRCATD FVELPSILME HFVSSPQVVH LLARHHSTGA 700
    SLPFEHLSSH LAASKSLEGL DTYHQILLAR LDQLYHSQLA ASPSFSSTTT 750
    YSDLDRQMHL PGAPNLSYTE GAHPQVRFGH LFGYGSTYYS YLLDRVIASK 800
    VWNHLFANNP LDRYAGQVFK NQCLKYGGGK DPWHILADVL NEDSVRQGDS 850
    RAMQQVGKWG IEC 863
    Length:863
    Mass (Da):95,030
    Last modified:June 10, 2008 - v2
    Checksum:i88FF232FA6308458
    GO

    Sequence cautioni

    The sequence EAK83473.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACP01000083 Genomic DNA. Translation: EAK83473.1. Different initiation.
    RefSeqiXP_758582.1. XM_753489.1.

    Genome annotation databases

    GeneIDi3630533.
    KEGGiuma:UM02435.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACP01000083 Genomic DNA. Translation: EAK83473.1 . Different initiation.
    RefSeqi XP_758582.1. XM_753489.1.

    3D structure databases

    ProteinModelPortali Q4PBS8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5270.UM02435.1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3630533.
    KEGGi uma:UM02435.1.

    Phylogenomic databases

    eggNOGi COG0339.
    HOGENOMi HOG000076521.
    KOi K01410.
    OrthoDBi EOG71GB4R.

    Family and domain databases

    Gene3Di 1.10.1370.10. 2 hits.
    1.20.1050.40. 1 hit.
    3.40.390.10. 2 hits.
    InterProi IPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR024080. Neurolysin/TOP_N.
    IPR001567. Pept_M3A_M3B.
    [Graphical view ]
    Pfami PF01432. Peptidase_M3. 1 hit.
    [Graphical view ]
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis."
      Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J., Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H., Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G., Snetselaar K., McCann M., Perez-Martin J.
      , Feldbruegge M., Basse C.W., Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L., Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L., Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N., Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B., Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J., Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P., Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G., Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A., Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M., Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M., Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E., Birren B.W.
      Nature 444:97-101(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 521 / FGSC 9021.

    Entry informationi

    Entry nameiPMIP_USTMA
    AccessioniPrimary (citable) accession number: Q4PBS8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: June 10, 2008
    Last modified: October 1, 2014
    This is version 52 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3