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Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi670 – 6701Zinc; catalyticPROSITE-ProRule annotation
Active sitei671 – 6711PROSITE-ProRule annotation
Metal bindingi674 – 6741Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi677 – 6771Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM03.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
ORF Names:UMAG_02435
OrganismiUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Taxonomic identifieri237631 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeUstilago
Proteomesi
  • UP000000561 Componentsi: Chromosome 5, Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3030MitochondrionSequence analysisAdd
BLAST
Chaini31 – 889859Mitochondrial intermediate peptidasePRO_0000338595Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ4PBS8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000076521.
InParanoidiQ4PBS8.
KOiK01410.
OMAiANAAYEY.
OrthoDBiEOG092C0JU2.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 2 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4PBS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTSKNAQR AAASVAHSYH VCLARRMSRL PTLLSNISAP AASKALDRYE
60 70 80 90 100
SKRIHSRSFS SSLAAQRVQR PTSAGPILTN PISDHEKDND ELRSLFDAPP
110 120 130 140 150
TSSSANHLRS SGPSTGLFEI PSLTSPQNFL VLAQQTLARA QLLVDRIDRA
160 170 180 190 200
GSADASTAQG IKELKEVVRN LDRLSDLLCG VIDMAELVRN AHPDPEWAEA
210 220 230 240 250
ANAAYEYLCG YMNVLNTHTG LYSVLKNILS IKEVAETLSK EATAVAQVFL
260 270 280 290 300
RDFEKSGIHL PPAERERFVQ LSDEILVLGR GFLQDIAGND ASDDFARIAS
310 320 330 340 350
AQADADKSDM VGLPTHWLED VNPTILKAVR ASAITDTDGL LTFSAADQPW
360 370 380 390 400
VFQTLLKYAP DERARKVAFR AANYGSQAQV QRLERLLKAR AELATLTGAS
410 420 430 440 450
SYAEMALGDK MAKEPQNVEE FLRALTKHHR PRASHDLDKL RRLKHNATVS
460 470 480 490 500
EPAQNTRQST FNTNSTLPEF APWDRDMYTE QHFRSASLSN VQPLSPYLSV
510 520 530 540 550
GSVFAGLSRL FSALYGIRFR ASMVAPGEVW SEGAGDVMKV EVLDESEGAR
560 570 580 590 600
GTSGSAEGLI GTIYADLWSR EGKPGGAAHY TVRCSRRVDK DDEAGDFTYG
610 620 630 640 650
RAEDGRVVRP QDLGGEGCGN PLQAPTFEQR ERPGRYQLPV VVLMCDFARP
660 670 680 690 700
GNANQGPCLL GWHEVETLFH EMGHAIHSMI GRTSYHNVSG TRCATDFVEL
710 720 730 740 750
PSILMEHFVS SPQVVHLLAR HHSTGASLPF EHLSSHLAAS KSLEGLDTYH
760 770 780 790 800
QILLARLDQL YHSQLAASPS FSSTTTYSDL DRQMHLPGAP NLSYTEGAHP
810 820 830 840 850
QVRFGHLFGY GSTYYSYLLD RVIASKVWNH LFANNPLDRY AGQVFKNQCL
860 870 880
KYGGGKDPWH ILADVLNEDS VRQGDSRAMQ QVGKWGIEC
Length:889
Mass (Da):97,799
Last modified:September 16, 2015 - v3
Checksum:i7376E7069CBE7367
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM003144 Genomic DNA. Translation: KIS69921.1.
RefSeqiXP_011388723.1. XM_011390421.1.

Genome annotation databases

GeneIDi23563181.
KEGGiuma:UMAG_02435.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM003144 Genomic DNA. Translation: KIS69921.1.
RefSeqiXP_011388723.1. XM_011390421.1.

3D structure databases

ProteinModelPortaliQ4PBS8.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiM03.006.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi23563181.
KEGGiuma:UMAG_02435.

Phylogenomic databases

HOGENOMiHOG000076521.
InParanoidiQ4PBS8.
KOiK01410.
OMAiANAAYEY.
OrthoDBiEOG092C0JU2.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 2 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPMIP_USTMA
AccessioniPrimary (citable) accession number: Q4PBS8
Secondary accession number(s): A0A0D1E1U7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: September 16, 2015
Last modified: September 7, 2016
This is version 66 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.