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Q4PBE6 (HAT1_USTMA) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone acetyltransferase type B catalytic subunit

EC=2.3.1.48
Gene names
Name:HAT1
ORF Names:UM02567
OrganismUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) [Reference proteome]
Taxonomic identifier237631 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeUstilago

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair By similarity.

Catalytic activity

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Subunit structure

Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the HAT1 family.

Ontologies

Keywords
   Biological processDNA damage
DNA repair
   Cellular componentCytoplasm
Nucleus
   Molecular functionAcyltransferase
Chromatin regulator
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA repair

Inferred from electronic annotation. Source: UniProtKB-KW

chromatin silencing at telomere

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

histone acetyltransferase complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionhistone acetyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 448448Histone acetyltransferase type B catalytic subunit
PRO_0000227727

Sequences

Sequence LengthMass (Da)Tools
Q4PBE6 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: 4BBAE5DC8D52776A

FASTA44851,083
        10         20         30         40         50         60 
MKDSWSSNST TSTAIRLVGS PYGTDSPFQP TFTYPIYGEA ETIYGYEGLA IKLSVASGSL 

        70         80         90        100        110        120 
VPLLEVTYRA KNEATTAEID DVEGKIKEFL APDFLSTSSP SAMEEFETVV KADKEFRPLG 

       130        140        150        160        170        180 
DKVHSYTRGK VDKGKAKSST ASLASSTLSA SDPNARVFEI YRSTWHTPGF REYHRRMQLF 

       190        200        210        220        230        240 
TLLFIEGASY IQEDETNWEF FTLYEKVSRD DKQTWHFMGY TSLYKFWCWP DSSRIRLSQF 

       250        260        270        280        290        300 
VILPPFQKQG HGGALYTTVY DQIRERANVT ELTVEDPSED FDRLRDGNDL RRLLAPGGFA 

       310        320        330        340        350        360 
DSAKAQNKLH APLDKEWIES QRLQHKLAPR QWSRVLEMVQ LMNLDTTDHE QVKQYRLQVK 

       370        380        390        400        410        420 
ARIYRQNKDI LMQLEKQQQR SKLQETFEGV VEEYGDMVGV DVEDLLDDGP SGTGALYGAD 

       430        440 
EEEDQEQGQG DRHYSNGNGP PRKMARLA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACP01000086 Genomic DNA. Translation: EAK83737.1.
RefSeqXP_758714.1. XM_753621.1.

3D structure databases

ProteinModelPortalQ4PBE6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5270.UM02567.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiUM02567T0; UM02567P0; UM02567.
GeneID3630647.
KEGGuma:UM02567.1.

Phylogenomic databases

eggNOGNOG326277.
HOGENOMHOG000074728.
KOK11303.
OMAHISYDEK.
OrthoDBEOG7HTHSD.

Family and domain databases

Gene3D1.10.10.390. 1 hit.
3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
IPR013523. Hist_AcTrfase_HAT1_C.
[Graphical view]
PANTHERPTHR12046. PTHR12046. 1 hit.
PfamPF10394. Hat1_N. 1 hit.
[Graphical view]
PIRSFPIRSF038084. HAT-B_cat. 1 hit.
SUPFAMSSF55729. SSF55729. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHAT1_USTMA
AccessionPrimary (citable) accession number: Q4PBE6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: July 19, 2005
Last modified: November 13, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families