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Protein

Histone acetyltransferase type B catalytic subunit

Gene

HAT1

Organism
Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.By similarity

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei275Proton donor/acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Chromatin regulator, Transferase
Biological processDNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase type B catalytic subunit (EC:2.3.1.48By similarity)
Gene namesi
Name:HAT1
ORF Names:UMAG_02567
OrganismiUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Taxonomic identifieri237631 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeUstilago
Proteomesi
  • UP000000561 Componentsi: Chromosome 6, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:UMAG_02567.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002277271 – 448Histone acetyltransferase type B catalytic subunitAdd BLAST448

Interactioni

Subunit structurei

Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei198Interaction with histone H4 N-terminusBy similarity1

GO - Molecular functioni

Protein-protein interaction databases

STRINGi5270.UM02567P0.

Structurei

3D structure databases

ProteinModelPortaliQ4PBE6.
SMRiQ4PBE6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni39 – 41Interaction with histone H4 N-terminusBy similarity3
Regioni224 – 226Interaction with histone H4 N-terminusBy similarity3
Regioni240 – 242Acetyl-CoA bindingBy similarity3
Regioni247 – 253Acetyl-CoA bindingBy similarity7

Sequence similaritiesi

Belongs to the HAT1 family.Curated

Phylogenomic databases

HOGENOMiHOG000074728.
InParanoidiQ4PBE6.
KOiK11303.
OMAiMAHQIFG.
OrthoDBiEOG092C3YYH.

Family and domain databases

Gene3Di1.10.10.390. 1 hit.
3.90.360.10. 1 hit.
InterProiView protein in InterPro
IPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR019467. Hat1_N.
IPR037113. Hat1_N_sf.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
IPR013523. Hist_AcTrfase_HAT1_C.
PANTHERiPTHR12046. PTHR12046. 1 hit.
PfamiView protein in Pfam
PF00583. Acetyltransf_1. 1 hit.
PF10394. Hat1_N. 1 hit.
PIRSFiPIRSF038084. HAT-B_cat. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4PBE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDSWSSNST TSTAIRLVGS PYGTDSPFQP TFTYPIYGEA ETIYGYEGLA
60 70 80 90 100
IKLSVASGSL VPLLEVTYRA KNEATTAEID DVEGKIKEFL APDFLSTSSP
110 120 130 140 150
SAMEEFETVV KADKEFRPLG DKVHSYTRGK VDKGKAKSST ASLASSTLSA
160 170 180 190 200
SDPNARVFEI YRSTWHTPGF REYHRRMQLF TLLFIEGASY IQEDETNWEF
210 220 230 240 250
FTLYEKVSRD DKQTWHFMGY TSLYKFWCWP DSSRIRLSQF VILPPFQKQG
260 270 280 290 300
HGGALYTTVY DQIRERANVT ELTVEDPSED FDRLRDGNDL RRLLAPGGFA
310 320 330 340 350
DSAKAQNKLH APLDKEWIES QRLQHKLAPR QWSRVLEMVQ LMNLDTTDHE
360 370 380 390 400
QVKQYRLQVK ARIYRQNKDI LMQLEKQQQR SKLQETFEGV VEEYGDMVGV
410 420 430 440
DVEDLLDDGP SGTGALYGAD EEEDQEQGQG DRHYSNGNGP PRKMARLA
Length:448
Mass (Da):51,083
Last modified:July 19, 2005 - v1
Checksum:i4BBAE5DC8D52776A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM003145 Genomic DNA. Translation: KIS69219.1.
RefSeqiXP_011388972.1. XM_011390670.1.

Genome annotation databases

EnsemblFungiiKIS69219; KIS69219; UMAG_02567.
GeneIDi23563283.
KEGGiuma:UMAG_02567.

Similar proteinsi

Entry informationi

Entry nameiHAT1_USTMA
AccessioniPrimary (citable) accession number: Q4PBE6
Secondary accession number(s): A0A0D1DYT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: July 19, 2005
Last modified: October 25, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families