ID   SET1_USTMA              Reviewed;        1468 AA.
AC   Q4PB36;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   16-JUN-2009, entry version 35.
DE   RecName: Full=Histone-lysine N-methyltransferase, H3 lysine-4 specific;
DE            EC=2.1.1.43;
DE   AltName: Full=COMPASS component SET1;
DE   AltName: Full=SET domain-containing protein 1;
GN   Name=SET1; ORFNames=UM02677;
OS   Ustilago maydis (Smut fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX   NCBI_TaxID=5270;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=521;
RX   PubMed=17080091; DOI=10.1038/nature05248;
RA   Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T.,
RA   Saville B.J., Banuett F., Kronstad J.W., Gold S.E., Mueller O.,
RA   Perlin M.H., Woesten H.A.B., de Vries R., Ruiz-Herrera J.,
RA   Reynaga-Pena C.G., Snetselaar K., McCann M., Perez-Martin J.,
RA   Feldbruegge M., Basse C.W., Steinberg G., Ibeas J.I., Holloman W.,
RA   Guzman P., Farman M.L., Stajich J.E., Sentandreu R.,
RA   Gonzalez-Prieto J.M., Kennell J.C., Molina L., Schirawski J.,
RA   Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N., Scherer M.,
RA   Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B., Meng S.,
RA   Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA   Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA   Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA   Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA   Chen F., Vysotskaia V., Mannhaupt G., Gueldener U.,
RA   Muensterkoetter M., Haase D., Oesterheld M., Mewes H.-W.,
RA   Mauceli E.W., DeCaprio D., Wade C.M., Butler J., Young S.K.,
RA   Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E., Birren B.W.;
RT   "Insights from the genome of the biotrophic fungal plant pathogen
RT   Ustilago maydis.";
RL   Nature 444:97-101(2006).
CC   -!- FUNCTION: Catalytic component of the COMPASS (Set1C) complex that
CC       specifically mono-, di- and trimethylates histone H3 to form
CC       H3K4me1/2/3, which subsequently plays a role in telomere length
CC       maintenance and transcription elongation regulation (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + histone L-lysine =
CC       S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.
CC   -!- SUBUNIT: Component of the COMPASS (Set1C) complex (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus (Probable).
CC   -!- SIMILARITY: Contains 1 post-SET domain.
CC   -!- SIMILARITY: Contains 1 SET domain.
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DR   EMBL; AACP01000088; EAK83847.1; -; Genomic_DNA.
DR   RefSeq; XP_758824.1; -.
DR   GeneID; 3630740; -.
DR   KEGG; uma:UM02677.1; -.
DR   BRENDA; 2.1.1.43; 2320.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
DR   InterPro; IPR015722; MLL.
DR   InterPro; IPR003616; Post-SET_Zn_bd.
DR   InterPro; IPR001214; SET.
DR   PANTHER; PTHR22884:SF10; MLL; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00508; PostSET; 1.
DR   SMART; SM00317; SET; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Chromosomal protein; Complete proteome;
KW   Methyltransferase; Nucleus; RNA-binding; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN         1   1468       Histone-lysine N-methyltransferase, H3
FT                                lysine-4 specific.
FT                                /FTId=PRO_0000269777.
FT   DOMAIN     1326   1448       SET.
FT   DOMAIN     1453   1468       Post-SET.
FT   COMPBIAS     27    275       Arg-rich.
FT   COMPBIAS    641    685       Pro-rich.
SQ   SEQUENCE   1468 AA;  164530 MW;  7CC6632973149DF9 CRC64;
     MPYSSQQNGY TSASTSRLSE QTSSHSRSSR EDRHLTEKGR RPPSPEARHR SDRDYDRRRS
     TEYVRDDDYR RSSRSSHDSR YADAYDHWRS ARSAYSPTPR DDRRDEARND LSSTKRHRSP
     EHSTSRLRHR SPESAHRRQN GTANRLDSKP DRGGDRKTGE ALDSGRSRWS QRAYEYDDWR
     NERPSARYER YRHDREPHRS RREDEYETKR SRDDSNGNSI YAPTRRSRSR SRSRSRSRDR
     YRSRDHSRER RRERSRDRSN GTYSSRDDRR PKADRSAHTI KRDEHSTRLN GTSEDSKDLR
     HESQRRVSAS VQSASEGPAS TPVARAVYIK HAEVDQEAPA PPTTRDYHSC PQRWPDQADS
     AVRASSAPNG SATAPSRSDR PPANGSSGRH SPRSLPTREK AEEARTSSTR RPSSQTNDNV
     NNSRDPLTQR KATSERSFGH VLLPHELPVE CRGKNYMATA TYKEGVKSIY KSAADKHLVD
     VDTRDPRRLG KKSSRYRESL HSASFRWDSN SRGKKPLPPP RNLVLTNLSG LLQPHQILLH
     ILPHGRIESS KLEIDPKIGQ SLGIFRVTFA HDFDEHGKPL ESMPAGQNPQ HGAKVAKAAC
     LALNGRMIGQ TRAQAFLDRD GEVIAERIKA KLAENEHKLR PTIVPPAPPA AASSSPATPS
     TTKQSMPPPQ VPRGPKVFMP AAPSPSYASS PASARANTDR YEYSATSHSR YRSSYEESRK
     LASSETYHRR RGTEEYDTYN RSKPYADAQV PAGSRSETRK DIKRPDEEIL NELRDKKRPY
     VHIPRPKNCD IDVTSVEAQL RSTAPIWVRE GQKGFYAAFH TSKEANQCKV VNETLTIGGY
     TLQVDVRSAP SQHAPSQQIR TPSGKHASVP LSMPAPPKQE RKAIDTGLRP PTADEKLKVD
     WSAAELQDAV FRMLQKELAD TFVRDVKSRV VGPYLTAYLK PDGEGGKMLA KATMKKPVIP
     TSINDHGTTL FEATGEARLP SFRKLAGAHP KKKASDADTT TSQAKRDQTD AKKKRGHTHR
     SKVHRDRDVS SSENESDDME RGMVVAARRN SYTRSKSSTK RRGAAAWLLE ASDAEAGTDD
     VDSTETDALS RSVSASVEPT GEEQIEVDVG AKAKKIPKVK AATVSKKKGT TAARKKLDVA
     PPEAVVEADQ GSETATPETD VPIKTAAAKA KVKPAKTSAK AKSALVDPFE AGLVEDSEDC
     HYLRLALEHL SRTGELASEH TLPDEIELEV EAEEQAMAAG GIPKHSTGSA RTEGYYRIPP
     EQKAMHLPDR NKATEDVDTS SNAQILQSAR NNRADSRRLV LGIEQHKRET ATDTDIFKFN
     QLRTRKKQLK FAKSPIHDWG LYAMELIPAG DMVIEYVGEV VRQQVADERE KQYERQGNFS
     TYLFRVDDDL VVDATHKGNI ARLMNHCCTP NCNAKILTLN GEKRIVLFAK TAIRAGEELT
     YDYKFQSSAD DEDAIPCLCG SPGCRRFL
//