Reviewed, UniProtKB/Swiss-Prot Q4PB36 (SET1_USTMA)

Names and origin

Protein names

Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-4 specific
    EC=2.1.1.43
Alternative name(s):
    COMPASS component SET1
    SET domain-containing protein 1

Gene names

Name:	SET1
ORF Names:	UM02677

Organism

Ustilago maydis (Smut fungus) [Complete proteome]

Taxonomic identifier

5270 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Basidiomycota › Ustilaginomycotina › Ustilaginomycetes › Ustilaginales › Ustilaginaceae › Ustilago

Protein attributes

Sequence length	1468 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation By similarity.
Catalytic activity	S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.
Subunit structure	Component of the COMPASS (Set1C) complex By similarity.
Subcellular location	Nucleus Probable.
Sequence similarities	Contains 1 post-SET domain. Contains 1 SET domain.

Ontologies

Keywords
Cellular component	Chromosomal protein Nucleus
Ligand	RNA-binding S-adenosyl-L-methionine
Molecular function	Chromatin regulator Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	chromosome Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW histone-lysine N-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1468	1468	Histone-lysine N-methyltransferase, H3 lysine-4 specific		PRO_0000269777
Regions
	Domain	1326 – 1448	123	SET
	Domain	1453 – 1468	16	Post-SET
	Compositional bias	27 – 275	249	Arg-rich
	Compositional bias	641 – 685	45	Pro-rich

Sequences

	Sequence		Length	Mass (Da)
	Q4PB36-1 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: 7CC6632973149DF9	FASTA	1,468	164,530
	10 20 30 40 50 60 MPYSSQQNGY TSASTSRLSE QTSSHSRSSR EDRHLTEKGR RPPSPEARHR SDRDYDRRRS 70 80 90 100 110 120 TEYVRDDDYR RSSRSSHDSR YADAYDHWRS ARSAYSPTPR DDRRDEARND LSSTKRHRSP 130 140 150 160 170 180 EHSTSRLRHR SPESAHRRQN GTANRLDSKP DRGGDRKTGE ALDSGRSRWS QRAYEYDDWR 190 200 210 220 230 240 NERPSARYER YRHDREPHRS RREDEYETKR SRDDSNGNSI YAPTRRSRSR SRSRSRSRDR 250 260 270 280 290 300 YRSRDHSRER RRERSRDRSN GTYSSRDDRR PKADRSAHTI KRDEHSTRLN GTSEDSKDLR 310 320 330 340 350 360 HESQRRVSAS VQSASEGPAS TPVARAVYIK HAEVDQEAPA PPTTRDYHSC PQRWPDQADS 370 380 390 400 410 420 AVRASSAPNG SATAPSRSDR PPANGSSGRH SPRSLPTREK AEEARTSSTR RPSSQTNDNV 430 440 450 460 470 480 NNSRDPLTQR KATSERSFGH VLLPHELPVE CRGKNYMATA TYKEGVKSIY KSAADKHLVD 490 500 510 520 530 540 VDTRDPRRLG KKSSRYRESL HSASFRWDSN SRGKKPLPPP RNLVLTNLSG LLQPHQILLH 550 560 570 580 590 600 ILPHGRIESS KLEIDPKIGQ SLGIFRVTFA HDFDEHGKPL ESMPAGQNPQ HGAKVAKAAC 610 620 630 640 650 660 LALNGRMIGQ TRAQAFLDRD GEVIAERIKA KLAENEHKLR PTIVPPAPPA AASSSPATPS 670 680 690 700 710 720 TTKQSMPPPQ VPRGPKVFMP AAPSPSYASS PASARANTDR YEYSATSHSR YRSSYEESRK 730 740 750 760 770 780 LASSETYHRR RGTEEYDTYN RSKPYADAQV PAGSRSETRK DIKRPDEEIL NELRDKKRPY 790 800 810 820 830 840 VHIPRPKNCD IDVTSVEAQL RSTAPIWVRE GQKGFYAAFH TSKEANQCKV VNETLTIGGY 850 860 870 880 890 900 TLQVDVRSAP SQHAPSQQIR TPSGKHASVP LSMPAPPKQE RKAIDTGLRP PTADEKLKVD 910 920 930 940 950 960 WSAAELQDAV FRMLQKELAD TFVRDVKSRV VGPYLTAYLK PDGEGGKMLA KATMKKPVIP 970 980 990 1000 1010 1020 TSINDHGTTL FEATGEARLP SFRKLAGAHP KKKASDADTT TSQAKRDQTD AKKKRGHTHR 1030 1040 1050 1060 1070 1080 SKVHRDRDVS SSENESDDME RGMVVAARRN SYTRSKSSTK RRGAAAWLLE ASDAEAGTDD 1090 1100 1110 1120 1130 1140 VDSTETDALS RSVSASVEPT GEEQIEVDVG AKAKKIPKVK AATVSKKKGT TAARKKLDVA 1150 1160 1170 1180 1190 1200 PPEAVVEADQ GSETATPETD VPIKTAAAKA KVKPAKTSAK AKSALVDPFE AGLVEDSEDC 1210 1220 1230 1240 1250 1260 HYLRLALEHL SRTGELASEH TLPDEIELEV EAEEQAMAAG GIPKHSTGSA RTEGYYRIPP 1270 1280 1290 1300 1310 1320 EQKAMHLPDR NKATEDVDTS SNAQILQSAR NNRADSRRLV LGIEQHKRET ATDTDIFKFN 1330 1340 1350 1360 1370 1380 QLRTRKKQLK FAKSPIHDWG LYAMELIPAG DMVIEYVGEV VRQQVADERE KQYERQGNFS 1390 1400 1410 1420 1430 1440 TYLFRVDDDL VVDATHKGNI ARLMNHCCTP NCNAKILTLN GEKRIVLFAK TAIRAGEELT 1450 1460 YDYKFQSSAD DEDAIPCLCG SPGCRRFL

References

[1]

"Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis." Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J., Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H., Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G., Snetselaar K., McCann M., Perez-Martin J. , Feldbruegge M., Basse C.W., Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L., Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L., Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N., Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B., Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J., Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P., Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G., Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A., Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M., Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M., Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E., Birren B.W. Nature 444:97-101(2006) [PubMed: 17080091] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 521.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACP01000088 Genomic DNA. Translation: EAK83847.1.
RefSeq	XP_758824.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3630740.
KEGG	uma:UM02677.1.
Enzyme and pathway databases
BRENDA	2.1.1.43. 2320.
Family and domain databases
InterPro	IPR015722. MLL. IPR003616. Post-SET_Zn_bd. IPR001214. SET. [Graphical view]
PANTHER	PTHR22884:SF10. MLL. 1 hit.
Pfam	PF00856. SET. 1 hit. [Graphical view]
SMART	SM00508. PostSET. 1 hit. SM00317. SET. 1 hit. [Graphical view]
PROSITE	PS50868. POST_SET. 1 hit. PS50280. SET. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SET1_USTMA

Accession

Primary (citable) accession number: Q4PB36

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	July 19, 2005
Last modified:	June 16, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)