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Q4P9T2 (SSN3_USTMA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase SSN3

EC=2.7.11.22
EC=2.7.11.23
Alternative name(s):
Cyclin-dependent kinase 8
Gene names
Name:SSN3
Synonyms:CDK8
ORF Names:UM03131
OrganismUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) [Reference proteome]
Taxonomic identifier237631 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeUstilago

Protein attributes

Sequence length654 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The srb8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactor

Magnesium By similarity.

Subunit structure

Component of the srb8-11 complex, a regulatory module of the Mediator complex By similarity.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 654654Serine/threonine-protein kinase SSN3
PRO_0000312951

Regions

Domain90 – 508419Protein kinase
Nucleotide binding96 – 1049ATP By similarity

Sites

Active site3281Proton acceptor By similarity
Binding site2251ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4P9T2 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: 5D4C711CB031535C

FASTA65471,536
        10         20         30         40         50         60 
MNTQEPYASG STASGASTSA QRTCMSDQIR ASGYFYSQTD DPFAAAFWSQ FQDPHVLAAR 

        70         80         90        100        110        120 
HIPADSSASA AMKAYREYRD RVRKPVLATY TILGFLSSGT YGRVYKARLR TPPQLASSSG 

       130        140        150        160        170        180 
TAGIANANAG TGSGTATVGS GASTAKKRGG LLQQHQLLDS PSSSLHATPK SVADGAGVGV 

       190        200        210        220        230        240 
NGTPSASPSL SASLGTSTAN APGGSDNTLQ LSSNELPDTQ IYAIKKFKPD SKETDATIYT 

       250        260        270        280        290        300 
GISQSAMREI SLNRELSHVN IVTLHQVMLE DKAIYMVFEY AEHDLLQIIH YHSTALRAPI 

       310        320        330        340        350        360 
PLAVLKSLLW QLINGVAYLH ANWILHRDLK PANILVTSQG VVKIGDLGLA RLYSSPLQSL 

       370        380        390        400        410        420 
YNGDKVVVTI WYRAPELLLG ARHYTTAIDM WSVGCIWGEL LALRPMFKGE EAKMDPKTKA 

       430        440        450        460        470        480 
APFQTDQLKR IVEVLGTPNK DRWPAIESMP DYKGWWPHLR LDNYPKTLSR WYATRNKGDD 

       490        500        510        520        530        540 
GYELFNSLLQ YDPEQRLTAN QALEHAWFTA QDPKPTANAF SSLAKPHATY PNRRVIQDDM 

       550        560        570        580        590        600 
DPKMKSNYVP PIKSHHMQPW HQARATHVST GADEASADAD AGSSSGSGPT SGCNGSDGQT 

       610        620        630        640        650 
GPCGWSGQFR SGNSGQCRRS GGTATDRDRE YRWHRRRDRH TKLGRKHRSF TAHV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACP01000108 Genomic DNA. Translation: EAK84361.1.
RefSeqXP_759278.1. XM_754185.1.

3D structure databases

ProteinModelPortalQ4P9T2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5270.UM03131.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiUM03131T0; UM03131P0; UM03131.
GeneID3631219.
KEGGuma:UM03131.1.

Phylogenomic databases

eggNOGCOG0515.
KOK02208.
OMARRVTHED.
OrthoDBEOG7K3TWD.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 2 hits.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSSN3_USTMA
AccessionPrimary (citable) accession number: Q4P9T2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 19, 2005
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families