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Protein

Serine/threonine-protein kinase SSN3

Gene

SSN3

Organism
Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The srb8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei201ATPPROSITE-ProRule annotation1
Active sitei304Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi72 – 80ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Kinase, Repressor, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SSN3 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
Cyclin-dependent kinase 8
Gene namesi
Name:SSN3
Synonyms:CDK8
ORF Names:UMAG_12208
OrganismiUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Taxonomic identifieri237631 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeUstilago
Proteomesi
  • UP000000561 Componentsi: Chromosome 8, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:UMAG_12208.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003129511 – 713Serine/threonine-protein kinase SSN3Add BLAST713

Interactioni

Subunit structurei

Component of the srb8-11 complex, a regulatory module of the Mediator complex.By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 484Protein kinasePROSITE-ProRule annotationAdd BLAST419

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiQ4P9T2.
KOiK02208.
OrthoDBiEOG092C2FL8.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4P9T2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDQIRASGY FYSQTDDPFA AAFWSQFQDP HVLAARHIPA DSSASAAMKA
60 70 80 90 100
YREYRDRVRK PVLATYTILG FLSSGTYGRV YKARLRTPPQ LASSSGTAGI
110 120 130 140 150
ANANAGTGSG TATVGSGAST AKKRGGLLQQ HQLLDSPSSS LHATPKSVAD
160 170 180 190 200
GAGVGVNGTP SASPSLSASL GTSTANAPGG SDNTLQLSSN ELPDTQIYAI
210 220 230 240 250
KKFKPDSKET DATIYTGISQ SAMREISLNR ELSHVNIVTL HQVMLEDKAI
260 270 280 290 300
YMVFEYAEHD LLQIIHYHST ALRAPIPLAV LKSLLWQLIN GVAYLHANWI
310 320 330 340 350
LHRDLKPANI LVTSQGVVKI GDLGLARLYS SPLQSLYNGD KVVVTIWYRA
360 370 380 390 400
PELLLGARHY TTAIDMWSVG CIWGELLALR PMFKGEEAKM DPKTKAAPFQ
410 420 430 440 450
TDQLKRIVEV LGTPNKDRWP AIESMPDYKG WWPHLRLDNY PKTLSRWYAT
460 470 480 490 500
RNKGDDGYEL FNSLLQYDPE QRLTANQALE HAWFTAQDPK PTANAFSSLA
510 520 530 540 550
KPHATYPNRR VIQDDMDPKM KSNYVPPIKS HHMQPWHQVN LNSSQPHRLA
560 570 580 590 600
QLMYQQEQMR HQQMQTQAPA PAPAQPPAAT AVTGRLGHAV GAGSSAVGTA
610 620 630 640 650
ANVGGPAAPP PIAIGSTAGT GGAIGIQSSA ASTAPSQHMY NNNPLITIAG
660 670 680 690 700
TNGGTISNPA TVRSSHSIGS TESITPTTSS QPIPAQPSSA PLARTTNLVA
710
TATRNQQRKR QRN
Length:713
Mass (Da):77,024
Last modified:September 16, 2015 - v2
Checksum:i5674199753DF565A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM003147 Genomic DNA. Translation: KIS68558.1.
RefSeqiXP_011389845.1. XM_011391543.1.

Genome annotation databases

EnsemblFungiiKIS68558; KIS68558; UMAG_12208.
GeneIDi23567961.
KEGGiuma:UMAG_12208.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM003147 Genomic DNA. Translation: KIS68558.1.
RefSeqiXP_011389845.1. XM_011391543.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiKIS68558; KIS68558; UMAG_12208.
GeneIDi23567961.
KEGGiuma:UMAG_12208.

Organism-specific databases

EuPathDBiFungiDB:UMAG_12208.

Phylogenomic databases

InParanoidiQ4P9T2.
KOiK02208.
OrthoDBiEOG092C2FL8.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSSN3_USTMA
AccessioniPrimary (citable) accession number: Q4P9T2
Secondary accession number(s): A0A0D1CPR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 16, 2015
Last modified: November 30, 2016
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.