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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei198 – 1981By similarity
Active sitei397 – 3971By similarity
Active sitei455 – 4551By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

ESTHERiustma-q4p8u8. Carboxypeptidase_S10.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:UM03465
OrganismiUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Taxonomic identifieri237631 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeUstilago

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini? – 539LumenalSequence Analysis
Transmembranei540 – 56021HelicalSequence AnalysisAdd
BLAST
Topological domaini561 – 65797CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 657Pheromone-processing carboxypeptidase KEX1PRO_0000411950
Signal peptidei1 – ?Sequence Analysis

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi432 – 4321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi444 – 4441N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ4P8U8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi502 – 5065Poly-Gly
Compositional biasi619 – 6235Poly-Asp

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2939.
HOGENOMiHOG000208879.
InParanoidiQ4P8U8.
OMAiKACHEEL.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4P8U8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLLDPREVL LRRGIPIPAA ASFHVPGLPD LHAESSSSTA LAHPLQMSAG
60 70 80 90 100
YLPARPIEAD GQPKDNAHLF FLLLRARHVP AKRKLIIWFN GGPGCSSFDG
110 120 130 140 150
AMMEVGAWRM DGKGGLVWVK DGASWNEYAD ILFLDQPAGT GFSYVNTNAY
160 170 180 190 200
TKSLPQAADE VVHFLEQFVQ VYPEYSRDVE LEYGSQGSGV DVYLAGESFA
210 220 230 240 250
GQYIPYTAKA IVKSPKPPVS LKGIAIGNGF IDPKSQYGTE LETMVQKNIW
260 270 280 290 300
TTSSGEYKHV AGLVKACHEE LDKSNQREIG KCELILQTII ASTTTKTQGA
310 320 330 340 350
SGYTCINVYD VRLSDSSPAC GMNWPTTLPA MYDYLRRPDV RKALHVDEHH
360 370 380 390 400
KPEAWVECNA NVGSAMRTDT TSPPSVQLLP ELLDSGVKVL LFAGEEDLIC
410 420 430 440 450
NAIGVQRAAE NLEWGGAKGF DDKQPAQDWY VNGTHAGTWR TARNLTYVGI
460 470 480 490 500
KGASHMVGVD KPIESHDMIV RFMGIDYMKV AGPNALIPSR VGNEPDRVLI
510 520 530 540 550
TGGGGGIAQI GKDGSRVIPG SGKTEEEVAE EARWRAYYDA GSFALMVLLI
560 570 580 590 600
AVGIGTWLLL RARKQRRLNR NRIGRGGALR LATTTELGAS RSTTGNGDTD
610 620 630 640 650
ETSNNHELER LVGGKHVEDD DDDVEEHIFN VGDEDLSDSN GENGPPVVKA

RHTGSQR
Length:657
Mass (Da):71,455
Last modified:July 19, 2005 - v1
Checksum:i700D1FEB7CCC422C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACP01000116 Genomic DNA. Translation: EAK84603.1.
RefSeqiXP_011389921.1. XM_011391619.1.

Genome annotation databases

GeneIDi23563908.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACP01000116 Genomic DNA. Translation: EAK84603.1.
RefSeqiXP_011389921.1. XM_011391619.1.

3D structure databases

ProteinModelPortaliQ4P8U8.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERiustma-q4p8u8. Carboxypeptidase_S10.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi23563908.

Phylogenomic databases

eggNOGiCOG2939.
HOGENOMiHOG000208879.
InParanoidiQ4P8U8.
OMAiKACHEEL.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis."
    Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J., Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H., Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G., Snetselaar K., McCann M., Perez-Martin J.
    , Feldbruegge M., Basse C.W., Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L., Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L., Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N., Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B., Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J., Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P., Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G., Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A., Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M., Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M., Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E., Birren B.W.
    Nature 444:97-101(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 521 / FGSC 9021.

Entry informationi

Entry nameiKEX1_USTMA
AccessioniPrimary (citable) accession number: Q4P8U8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 19, 2005
Last modified: July 22, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.