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Q4P8U8

- KEX1_USTMA

UniProt

Q4P8U8 - KEX1_USTMA

Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (19 Jul 2005)
      Previous versions | rss
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    Functioni

    Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei198 – 1981By similarity
    Active sitei397 – 3971By similarity
    Active sitei455 – 4551By similarity

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    MEROPSiS10.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
    Alternative name(s):
    Carboxypeptidase D
    Gene namesi
    Name:KEX1
    ORF Names:UM03465
    OrganismiUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
    Taxonomic identifieri237631 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeUstilago
    ProteomesiUP000000561: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 657Pheromone-processing carboxypeptidase KEX1PRO_0000411950
    Signal peptidei1 – ?Sequence Analysis

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi432 – 4321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi444 – 4441N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi5270.UM03465.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4P8U8.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini? – 539LumenalSequence Analysis
    Topological domaini561 – 65797CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei540 – 56021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi502 – 5065Poly-Gly
    Compositional biasi619 – 6235Poly-Asp

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2939.
    HOGENOMiHOG000208879.
    KOiK01288.
    OMAiKACHEEL.
    OrthoDBiEOG7TJ3SJ.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q4P8U8-1 [UniParc]FASTAAdd to Basket

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    MPLLDPREVL LRRGIPIPAA ASFHVPGLPD LHAESSSSTA LAHPLQMSAG    50
    YLPARPIEAD GQPKDNAHLF FLLLRARHVP AKRKLIIWFN GGPGCSSFDG 100
    AMMEVGAWRM DGKGGLVWVK DGASWNEYAD ILFLDQPAGT GFSYVNTNAY 150
    TKSLPQAADE VVHFLEQFVQ VYPEYSRDVE LEYGSQGSGV DVYLAGESFA 200
    GQYIPYTAKA IVKSPKPPVS LKGIAIGNGF IDPKSQYGTE LETMVQKNIW 250
    TTSSGEYKHV AGLVKACHEE LDKSNQREIG KCELILQTII ASTTTKTQGA 300
    SGYTCINVYD VRLSDSSPAC GMNWPTTLPA MYDYLRRPDV RKALHVDEHH 350
    KPEAWVECNA NVGSAMRTDT TSPPSVQLLP ELLDSGVKVL LFAGEEDLIC 400
    NAIGVQRAAE NLEWGGAKGF DDKQPAQDWY VNGTHAGTWR TARNLTYVGI 450
    KGASHMVGVD KPIESHDMIV RFMGIDYMKV AGPNALIPSR VGNEPDRVLI 500
    TGGGGGIAQI GKDGSRVIPG SGKTEEEVAE EARWRAYYDA GSFALMVLLI 550
    AVGIGTWLLL RARKQRRLNR NRIGRGGALR LATTTELGAS RSTTGNGDTD 600
    ETSNNHELER LVGGKHVEDD DDDVEEHIFN VGDEDLSDSN GENGPPVVKA 650
    RHTGSQR 657
    Length:657
    Mass (Da):71,455
    Last modified:July 19, 2005 - v1
    Checksum:i700D1FEB7CCC422C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACP01000116 Genomic DNA. Translation: EAK84603.1.
    RefSeqiXP_759612.1. XM_754519.1.

    Genome annotation databases

    EnsemblFungiiUM03465T0; UM03465P0; UM03465.
    GeneIDi3631559.
    KEGGiuma:UM03465.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACP01000116 Genomic DNA. Translation: EAK84603.1 .
    RefSeqi XP_759612.1. XM_754519.1.

    3D structure databases

    ProteinModelPortali Q4P8U8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5270.UM03465.1.

    Protein family/group databases

    MEROPSi S10.007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii UM03465T0 ; UM03465P0 ; UM03465 .
    GeneIDi 3631559.
    KEGGi uma:UM03465.1.

    Phylogenomic databases

    eggNOGi COG2939.
    HOGENOMi HOG000208879.
    KOi K01288.
    OMAi KACHEEL.
    OrthoDBi EOG7TJ3SJ.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis."
      Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J., Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H., Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G., Snetselaar K., McCann M., Perez-Martin J.
      , Feldbruegge M., Basse C.W., Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L., Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L., Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N., Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B., Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J., Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P., Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G., Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A., Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M., Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M., Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E., Birren B.W.
      Nature 444:97-101(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 521 / FGSC 9021.

    Entry informationi

    Entry nameiKEX1_USTMA
    AccessioniPrimary (citable) accession number: Q4P8U8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3