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Q4P8U8 (KEX1_USTMA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase KEX1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:KEX1
ORF Names:UM03465
OrganismUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) [Reference proteome]
Taxonomic identifier237631 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeUstilago

Protein attributes

Sequence length657 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentGolgi apparatus
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – ? Potential
Chain? – 657Pheromone-processing carboxypeptidase KEX1PRO_0000411950

Regions

Topological domain? – 539Lumenal Potential
Transmembrane540 – 56021Helical; Potential
Topological domain561 – 65797Cytoplasmic Potential
Compositional bias502 – 5065Poly-Gly
Compositional bias619 – 6235Poly-Asp

Sites

Active site1981 By similarity
Active site3971 By similarity
Active site4551 By similarity

Amino acid modifications

Glycosylation4321N-linked (GlcNAc...) Potential
Glycosylation4441N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q4P8U8 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: 700D1FEB7CCC422C

FASTA65771,455
        10         20         30         40         50         60 
MPLLDPREVL LRRGIPIPAA ASFHVPGLPD LHAESSSSTA LAHPLQMSAG YLPARPIEAD 

        70         80         90        100        110        120 
GQPKDNAHLF FLLLRARHVP AKRKLIIWFN GGPGCSSFDG AMMEVGAWRM DGKGGLVWVK 

       130        140        150        160        170        180 
DGASWNEYAD ILFLDQPAGT GFSYVNTNAY TKSLPQAADE VVHFLEQFVQ VYPEYSRDVE 

       190        200        210        220        230        240 
LEYGSQGSGV DVYLAGESFA GQYIPYTAKA IVKSPKPPVS LKGIAIGNGF IDPKSQYGTE 

       250        260        270        280        290        300 
LETMVQKNIW TTSSGEYKHV AGLVKACHEE LDKSNQREIG KCELILQTII ASTTTKTQGA 

       310        320        330        340        350        360 
SGYTCINVYD VRLSDSSPAC GMNWPTTLPA MYDYLRRPDV RKALHVDEHH KPEAWVECNA 

       370        380        390        400        410        420 
NVGSAMRTDT TSPPSVQLLP ELLDSGVKVL LFAGEEDLIC NAIGVQRAAE NLEWGGAKGF 

       430        440        450        460        470        480 
DDKQPAQDWY VNGTHAGTWR TARNLTYVGI KGASHMVGVD KPIESHDMIV RFMGIDYMKV 

       490        500        510        520        530        540 
AGPNALIPSR VGNEPDRVLI TGGGGGIAQI GKDGSRVIPG SGKTEEEVAE EARWRAYYDA 

       550        560        570        580        590        600 
GSFALMVLLI AVGIGTWLLL RARKQRRLNR NRIGRGGALR LATTTELGAS RSTTGNGDTD 

       610        620        630        640        650 
ETSNNHELER LVGGKHVEDD DDDVEEHIFN VGDEDLSDSN GENGPPVVKA RHTGSQR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACP01000116 Genomic DNA. Translation: EAK84603.1.
RefSeqXP_759612.1. XM_754519.1.

3D structure databases

ProteinModelPortalQ4P8U8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5270.UM03465.1.

Protein family/group databases

MEROPSS10.007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiUM03465T0; UM03465P0; UM03465.
GeneID3631559.
KEGGuma:UM03465.1.

Phylogenomic databases

eggNOGCOG2939.
HOGENOMHOG000208879.
KOK01288.
OMAKACHEEL.
OrthoDBEOG7TJ3SJ.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
SUPFAMSSF53474. SSF53474. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKEX1_USTMA
AccessionPrimary (citable) accession number: Q4P8U8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 19, 2005
Last modified: June 11, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries