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Q4P8U8

- KEX1_USTMA

UniProt

Q4P8U8 - KEX1_USTMA

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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei198 – 1981By similarity
Active sitei397 – 3971By similarity
Active sitei455 – 4551By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:UM03465
OrganismiUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Taxonomic identifieri237631 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeUstilago
ProteomesiUP000000561: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 657Pheromone-processing carboxypeptidase KEX1PRO_0000411950
Signal peptidei1 – ?Sequence Analysis

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi432 – 4321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi444 – 4441N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5270.UM03465.1.

Structurei

3D structure databases

ProteinModelPortaliQ4P8U8.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini? – 539LumenalSequence Analysis
Topological domaini561 – 65797CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei540 – 56021HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi502 – 5065Poly-Gly
Compositional biasi619 – 6235Poly-Asp

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2939.
HOGENOMiHOG000208879.
InParanoidiQ4P8U8.
KOiK01288.
OMAiKACHEEL.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4P8U8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLLDPREVL LRRGIPIPAA ASFHVPGLPD LHAESSSSTA LAHPLQMSAG
60 70 80 90 100
YLPARPIEAD GQPKDNAHLF FLLLRARHVP AKRKLIIWFN GGPGCSSFDG
110 120 130 140 150
AMMEVGAWRM DGKGGLVWVK DGASWNEYAD ILFLDQPAGT GFSYVNTNAY
160 170 180 190 200
TKSLPQAADE VVHFLEQFVQ VYPEYSRDVE LEYGSQGSGV DVYLAGESFA
210 220 230 240 250
GQYIPYTAKA IVKSPKPPVS LKGIAIGNGF IDPKSQYGTE LETMVQKNIW
260 270 280 290 300
TTSSGEYKHV AGLVKACHEE LDKSNQREIG KCELILQTII ASTTTKTQGA
310 320 330 340 350
SGYTCINVYD VRLSDSSPAC GMNWPTTLPA MYDYLRRPDV RKALHVDEHH
360 370 380 390 400
KPEAWVECNA NVGSAMRTDT TSPPSVQLLP ELLDSGVKVL LFAGEEDLIC
410 420 430 440 450
NAIGVQRAAE NLEWGGAKGF DDKQPAQDWY VNGTHAGTWR TARNLTYVGI
460 470 480 490 500
KGASHMVGVD KPIESHDMIV RFMGIDYMKV AGPNALIPSR VGNEPDRVLI
510 520 530 540 550
TGGGGGIAQI GKDGSRVIPG SGKTEEEVAE EARWRAYYDA GSFALMVLLI
560 570 580 590 600
AVGIGTWLLL RARKQRRLNR NRIGRGGALR LATTTELGAS RSTTGNGDTD
610 620 630 640 650
ETSNNHELER LVGGKHVEDD DDDVEEHIFN VGDEDLSDSN GENGPPVVKA

RHTGSQR
Length:657
Mass (Da):71,455
Last modified:July 19, 2005 - v1
Checksum:i700D1FEB7CCC422C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACP01000116 Genomic DNA. Translation: EAK84603.1.
RefSeqiXP_759612.1. XM_754519.1.

Genome annotation databases

EnsemblFungiiUM03465T0; UM03465P0; UM03465.
GeneIDi3631559.
KEGGiuma:UM03465.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACP01000116 Genomic DNA. Translation: EAK84603.1 .
RefSeqi XP_759612.1. XM_754519.1.

3D structure databases

ProteinModelPortali Q4P8U8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5270.UM03465.1.

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii UM03465T0 ; UM03465P0 ; UM03465 .
GeneIDi 3631559.
KEGGi uma:UM03465.1.

Phylogenomic databases

eggNOGi COG2939.
HOGENOMi HOG000208879.
InParanoidi Q4P8U8.
KOi K01288.
OMAi KACHEEL.
OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis."
    Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J., Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H., Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G., Snetselaar K., McCann M., Perez-Martin J.
    , Feldbruegge M., Basse C.W., Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L., Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L., Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N., Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B., Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J., Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P., Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G., Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A., Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M., Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M., Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E., Birren B.W.
    Nature 444:97-101(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 521 / FGSC 9021.

Entry informationi

Entry nameiKEX1_USTMA
AccessioniPrimary (citable) accession number: Q4P8U8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 19, 2005
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3