Reviewed, UniProtKB/Swiss-Prot Q4P7H2 (CWC27_USTMA)

Names and origin

Protein names

Recommended name:
    Peptidyl-prolyl isomerase CWC27
    EC=5.2.1.8

Gene names

Name:	CWC27
ORF Names:	UM03941

Organism

Ustilago maydis (Smut fungus) [Complete proteome]

Taxonomic identifier

5270 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Basidiomycota › Ustilaginomycotina › Ustilaginomycetes › Ustilaginales › Ustilaginaceae › Ustilago

Protein attributes

Sequence length	485 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in pre-mRNA splicing By similarity.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Subunit structure	Associated with the spliceosome By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the cyclophilin-type PPIase family. CWC27 subfamily. Contains 1 PPIase cyclophilin-type domain.

Ontologies

Keywords
Biological process	mRNA processing mRNA splicing
Cellular component	Cytoplasm Nucleus Spliceosome
Molecular function	Isomerase Rotamase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	RNA splicing Inferred from electronic annotation. Source: UniProtKB-KW mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW protein folding Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell spliceosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 485	485	Peptidyl-prolyl isomerase CWC27		PRO_0000064187
Regions
	Domain	11 – 167	157	PPIase cyclophilin-type

Sequences

	Sequence		Length	Mass (Da)
	Q4P7H2-1 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: B3F21234EC915BAE	FASTA	485	54,023
	10 20 30 40 50 60 MTSQYVTEPP SSGLVDLVTS KGTISIALFP TQAPLACRNF LTLALEGFYD NLVFHRLIPN 70 80 90 100 110 120 FILQTGDPSA TGTGGESIYG EPFPIESHSR LKFNRRGLLG MAANQDRTNE SQFFLTLDAT 130 140 150 160 170 180 PELTGKHTLM GKVEGKSIYT LVELVEGVEL VDGDRPRYPI KLHEVRVVEN PFDDLQPRTT 190 200 210 220 230 240 KKQRIAEERR KKHEMETRVA EEQKRKRSKA KKNTGLLSFG AEEEAEDEVA LKGPKSSHDL 250 260 270 280 290 300 LKDDKHLSRQ TIETSKSTKA NTPAVSANIS SKEKRFLAQS SSSTTPPAVT KQASKDGTSD 310 320 330 340 350 360 APHPTATLKS EHSGPSDQKA SSSTGRDFLA SQRAKYLSSS HPSTAKQDDS YSALLSFQSR 370 380 390 400 410 420 LRTRPSSTTP IAKPLPSVGV DEVEEEAGEY GASDDDDDWR SHRLDAGGQP LVAGQNAGKD 430 440 450 460 470 480 TLEDYEVLDP RDHTDRERNP KAESSRDGKR GRDWVEHDRK YQNDRSRRHR EHDKHPQQRR QRSII

References

[1]

"Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis." Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J., Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H., Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G., Snetselaar K., McCann M., Perez-Martin J. , Feldbruegge M., Basse C.W., Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L., Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L., Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N., Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B., Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J., Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P., Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G., Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A., Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M., Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M., Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E., Birren B.W. Nature 444:97-101(2006) [PubMed: 17080091] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 521.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACP01000136 Genomic DNA. Translation: EAK85086.1.
RefSeq	XP_760088.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3632039.
KEGG	uma:UM03941.1.
Enzyme and pathway databases
BRENDA	5.2.1.8. 2320.
Family and domain databases
InterPro	IPR002130. PPIase_cyclophilin. [Graphical view]
Gene3D	G3DSA:2.40.100.10. PPIase_cyclophilin. 1 hit.
Pfam	PF00160. Pro_isomerase. 1 hit. [Graphical view]
PRINTS	PR00153. CSAPPISMRASE.
PROSITE	PS00170. CSA_PPIASE_1. 1 hit. PS50072. CSA_PPIASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CWC27_USTMA

Accession

Primary (citable) accession number: Q4P7H2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	July 19, 2005
Last modified:	June 16, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)