Q4P4G2 (LCMT1_USTMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leucine carboxyl methyltransferase 1
EC=2.1.1.233

Alternative name(s):
Protein phosphatase methyltransferase 1
[Phosphatase 2A protein]-leucine-carboxy methyltransferase 1

Gene names

Name:	PPM1
ORF Names:	UM05001

Organism

Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) [Reference proteome]

Taxonomic identifier

237631 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Basidiomycota › Ustilaginomycotina › Ustilaginomycetes › Ustilaginales › Ustilaginaceae › Ustilago › Ustilago maydis

Protein attributes

Sequence length	536 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues By similarity.
Catalytic activity	S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine = S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester.
Sequence similarities	Belongs to the methyltransferase superfamily. LCMT family.

Ontologies

Keywords
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	methyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 536	536	Leucine carboxyl methyltransferase 1		PRO_0000226133
Regions
	Region	305 – 306	2	S-adenosyl-L-methionine binding By similarity
Sites
	Binding site	185	1	S-adenosyl-L-methionine By similarity
	Binding site	210	1	S-adenosyl-L-methionine; via carbonyl oxygen By similarity
	Binding site	237	1	S-adenosyl-L-methionine By similarity
	Binding site	343	1	S-adenosyl-L-methionine; via carbonyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4P4G2 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: A47193E42A9FF345	FASTA	536	58,631
	10 20 30 40 50 60 MQRDTSLRDP FATEDESSAS EIGRAPERRL RIPQNQLRNA DERCEIRSPQ PVPGPGLPRS 70 80 90 100 110 120 IAVRTETAAT SKDAPAPAPS LRLSLGLPRS RTKAHSGQTS DATNITSTAR QADDAVRNTD 130 140 150 160 170 180 SDALLSRLSA LKLGYLPSEP FTQEFSSTLP SNGGHPTGRS GFPQPHHPGS SIRRSPLINI 190 200 210 220 230 240 GTYLRCSTID AEVESFLRQG CEQKQIISVG AGSDSRYWRI MADTDLSRRL HHYVEIDFEE 250 260 270 280 290 300 NTSQKLSRIL KSPILRASLD TNSSVYGVPL SHLSQFSLGV PCHTGSESRQ FDVIRSSKYS 310 320 330 340 350 360 LLAADVRSLH PDTPSAERID LEHLLGPAST GLDSTLPTLI LFECVLAYIA PDRADWLIRH 370 380 390 400 410 420 LGQRFAAVQA LSYDIALAGD AHPSAKAVAC VSSESESSEC GQTVGTADSA ISTSTTVASP 430 440 450 460 470 480 APPSRFGRVM LQNLELIRIR SALNVASRHI KMRKLSLPGA RAYPTIHAQS QRFAQAWSDS 490 500 510 520 530 QALQIETSGR SLFSIWSDLG AEQRSRLSRL EGLDEVEEID MLLQHYCIVQ ARRQRP

References

[1]

"Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis." Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J., Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H., Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G., Snetselaar K., McCann M., Perez-Martin J. , Feldbruegge M., Basse C.W., Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L., Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L., Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N., Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B., Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J., Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P., Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G., Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A., Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M., Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M., Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E., Birren B.W. Nature 444:97-101(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 521 / FGSC 9021.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACP01000185 Genomic DNA. Translation: EAK85819.1.
RefSeq	XP_761148.1. XM_756055.1.
3D structure databases
ProteinModelPortal	Q4P4G2.
ModBase	Search...
Protein-protein interaction databases
STRING	5270.UM05001.1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	UM05001T0; UM05001P0; UM05001.
GeneID	3633117.
KEGG	uma:UM05001.1.
Phylogenomic databases
eggNOG	NOG251911.
KO	K00599.
OrthoDB	EOG4ZW8MC.
Family and domain databases
InterPro	IPR007213. LCM_MeTrfase. IPR021121. LCM_MeTrfase_euk. [Graphical view]
PANTHER	PTHR13600. PTHR13600. 1 hit.
Pfam	PF04072. LCM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LCMT1_USTMA

Accession

Primary (citable) accession number: Q4P4G2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	July 19, 2005
Last modified:	April 3, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program