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Reviewed, UniProtKB/Swiss-Prot Q4P2Q7 (3HAO_USTMA)

Last modified November 3, 2009. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    3-hydroxyanthranilate 3,4-dioxygenase
    EC=1.13.11.6
Alternative name(s):
    3-hydroxyanthranilic acid dioxygenase
      Short name=HAD
    3-hydroxyanthranilate oxygenase
      Short name=3-HAO
    Biosynthesis of nicotinic acid protein 1
Gene names
Name: BNA1
ORF Names: UM05606
OrganismUstilago maydis (Smut fungus) [Complete proteome]
Taxonomic identifier5270 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeUstilago

Protein attributes

Sequence length181 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity.

Catalytic activity

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.

Cofactor

Fe2+ ion By similarity.

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the 3-HAO family.

Ontologies

Keywords
   Biological processPyridine nucleotide biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionDioxygenase
Oxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

pyridine nucleotide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-hydroxyanthranilate 3,4-dioxygenase activity

Inferred from electronic annotation. Source: EC

iron ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 1811813-hydroxyanthranilate 3,4-dioxygenase
PRO_0000361995

Sites

Metal binding501Iron; catalytic By similarity
Metal binding561Iron; catalytic By similarity
Metal binding951Iron; catalytic By similarity
Metal binding1241Divalent metal cation By similarity
Metal binding1671Divalent metal cation By similarity
Metal binding1701Divalent metal cation By similarity
Binding site461Dioxygen By similarity
Binding site561Substrate By similarity
Binding site991Substrate By similarity
Binding site1091Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4P2Q7-1 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: 75124AC34209CF79

FASTA18120,640
        10         20         30         40         50         60 
MPFPLPLNFP KWLSENEHLL QPPVGNFCLF RTRDYTVMAV GGPNARSDYH YQPTEEFFYQ 

        70         80         90        100        110        120 
YKGDMLLKVI DEDGKFQDIP IKQGEMFMLP AHTPHSPVRF ANTVGIVVER TRPDGSPDAM 

       130        140        150        160        170        180 
RWYCPNKEAH GETPTLVKEV HFQCTDLGTQ LKPIIDAWVN DEAGRQCSHC GYTQGARELP 


A 

« Hide

Cross-references

Sequence databases

AACP01000203 Genomic DNA. Translation: EAK86472.1.
RefSeqXP_761753.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ4P2Q7.

Genome annotation databases

GeneID3633705.
KEGGuma:UM05606.1.

Phylogenomic databases

OMARHSPQRP.

Family and domain databases

InterProIPR010329. 3hydroanth_dOase.
[Graphical view]
PfamPF06052. 3-HAO. 1 hit.
[Graphical view]
TIGRFAMsTIGR03037. anthran_nbaC. 1 hit.
ProtoNetSearch...

Entry information

Entry name3HAO_USTMA
AccessionPrimary (citable) accession number: Q4P2Q7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: July 19, 2005
Last modified: November 3, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents