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Q4P2Q7 (3HAO_USTMA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-hydroxyanthranilate 3,4-dioxygenase

EC=1.13.11.6
Alternative name(s):
3-hydroxyanthranilate oxygenase
Short name=3-HAO
3-hydroxyanthranilic acid dioxygenase
Short name=HAD
Biosynthesis of nicotinic acid protein 1
Gene names
Name:BNA1
ORF Names:UM05606
OrganismUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) [Reference proteome]
Taxonomic identifier237631 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeUstilago

Protein attributes

Sequence length181 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity. HAMAP-Rule MF_03019

Catalytic activity

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde. HAMAP-Rule MF_03019

Cofactor

Fe2+ ion By similarity. HAMAP-Rule MF_03019

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3. HAMAP-Rule MF_03019

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_03019.

Sequence similarities

Belongs to the 3-HAO family.

Ontologies

Keywords
   Biological processPyridine nucleotide biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionDioxygenase
Oxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_process'de novo' NAD biosynthetic process from tryptophan

Inferred from electronic annotation. Source: EnsemblFungi

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function3-hydroxyanthranilate 3,4-dioxygenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 1811813-hydroxyanthranilate 3,4-dioxygenase HAMAP-Rule MF_03019
PRO_0000361995

Sites

Metal binding501Iron; catalytic By similarity
Metal binding561Iron; catalytic By similarity
Metal binding951Iron; catalytic By similarity
Binding site461Dioxygen By similarity
Binding site561Substrate By similarity
Binding site991Substrate By similarity
Binding site1091Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4P2Q7 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: 75124AC34209CF79

FASTA18120,640
        10         20         30         40         50         60 
MPFPLPLNFP KWLSENEHLL QPPVGNFCLF RTRDYTVMAV GGPNARSDYH YQPTEEFFYQ 

        70         80         90        100        110        120 
YKGDMLLKVI DEDGKFQDIP IKQGEMFMLP AHTPHSPVRF ANTVGIVVER TRPDGSPDAM 

       130        140        150        160        170        180 
RWYCPNKEAH GETPTLVKEV HFQCTDLGTQ LKPIIDAWVN DEAGRQCSHC GYTQGARELP 


A 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACP01000203 Genomic DNA. Translation: EAK86472.1.
RefSeqXP_761753.1. XM_756660.1.

3D structure databases

ProteinModelPortalQ4P2Q7.
SMRQ4P2Q7. Positions 3-177.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5270.UM05606.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiUM05606T0; UM05606P0; UM05606.
GeneID3633705.
KEGGuma:UM05606.1.

Phylogenomic databases

eggNOGNOG77058.
KOK00452.
OMAHINQTPE.
OrthoDBEOG7QK0Q0.

Enzyme and pathway databases

UniPathwayUPA00253; UER00330.

Family and domain databases

Gene3D2.60.120.10. 1 hit.
HAMAPMF_00825. 3_HAO.
InterProIPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERPTHR15497. PTHR15497. 1 hit.
PfamPF06052. 3-HAO. 1 hit.
[Graphical view]
SUPFAMSSF51182. SSF51182. 1 hit.
TIGRFAMsTIGR03037. anthran_nbaC. 1 hit.
ProtoNetSearch...

Entry information

Entry name3HAO_USTMA
AccessionPrimary (citable) accession number: Q4P2Q7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: July 19, 2005
Last modified: February 19, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways