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Q4P0S6

- LCPS_USTMA

UniProt

Q4P0S6 - LCPS_USTMA

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Protein
Bifunctional lycopene cyclase/phytoene synthase
Gene
UM06287
Organism
Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase) By similarity.

Catalytic activityi

Carotenoid psi-end group = carotenoid beta-end group.
2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

Pathwayi

GO - Molecular functioni

  1. geranylgeranyl-diphosphate geranylgeranyltransferase activity Source: UniProtKB-EC
  2. intramolecular lyase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. carotenoid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Transferase

Keywords - Biological processi

Carotenoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00799; UER00773.
UPA00802.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional lycopene cyclase/phytoene synthase
Including the following 2 domains:
Lycopene beta-cyclase (EC:5.5.1.19)
Alternative name(s):
Lycopene cyclase
Phytoene synthase (EC:2.5.1.32)
Gene namesi
ORF Names:UM06287
OrganismiUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Taxonomic identifieri237631 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeUstilago
ProteomesiUP000000561: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4121Helical; Reviewed prediction
Add
BLAST
Transmembranei48 – 6821Helical; Reviewed prediction
Add
BLAST
Transmembranei92 – 11423Helical; Reviewed prediction
Add
BLAST
Transmembranei129 – 14921Helical; Reviewed prediction
Add
BLAST
Transmembranei156 – 17621Helical; Reviewed prediction
Add
BLAST
Transmembranei183 – 20321Helical; Reviewed prediction
Add
BLAST
Transmembranei231 – 25121Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 690690Bifunctional lycopene cyclase/phytoene synthase
PRO_0000409246Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5270.UM06287.1.

Structurei

3D structure databases

ProteinModelPortaliQ4P0S6.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 255255Lycopene beta-cyclase
Add
BLAST
Regioni262 – 686425Phytoene synthase
Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the lycopene beta-cyclase family.
In the C-terminal section; belongs to the phytoene/squalene synthase family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47964.
KOiK17841.
OMAiYMEIGRV.
OrthoDBiEOG7RBZJ2.

Family and domain databases

Gene3Di1.10.600.10. 2 hits.
InterProiIPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamiPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 3 hits.
TIGRFAMsiTIGR03462. CarR_dom_SF. 2 hits.
PROSITEiPS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4P0S6-1 [UniParc]FASTAAdd to Basket

« Hide

MTSLDEPSQD WPACTLSYRH FHLLWTLPVC GVLLVIARPF LTKLDRAKLI    50
LLPIIAFVWT TPWDNLIVRN RAWSYHRHCI WFTIGYVPIE EYFYFIIQSL 100
ISTLWCTLIT RWTLPNLYLT PSTPARRPLA PFAVATCVVC FVLGLQASVP 150
ATHTYYFGMI SWWSSMPLAL LLWGSIDFVR NMGVGAGFIP FAISVLGPTL 200
YLWSSDIYAL RRGTWHINQA TSLNIFPIPD LPIEEMLFFL VTNVILVSAC 250
FTFDRCVAIC RLSAPDHQPP LSPSYLPLGS LATYTKLWAA FVRSDRSSLP 300
TSCASASVEP QDLSASLQVL RAASKSFNAA SLLLPWDLRT DLGCLYAFCR 350
VADDLVDDHA QELQAKAKNL DVVRDIVDAV YADSIVDRKQ HLSTPIGERL 400
RILLASAALS DKIKQDTRAA ATSIAPLTQY IPKRLWYEML QGYSADLRFQ 450
HQDARQRTRL QSMDDLVEYS QCVAGVVGEM CIRVILGRCG STVPLDLEVD 500
RKIALRASKT IEQSINVKPL DLNRTADVHT LLYEARRMGV SLQLVNIARD 550
VVPDSVELRR CYLPADMFDK EEDDGMYEAL LKGRVALPRH ASKLVHGAEE 600
QGVVRPQDVR KYALRLLEIS QRLYDESYPS LRQIPNRPAR AGLKAACSVY 650
AAIGKRIQAQ TEDEISSGRR ARMSNLDRIL RAISAVYFDV 690
Length:690
Mass (Da):77,749
Last modified:July 19, 2005 - v1
Checksum:iE52BB51A2F576BC5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACP01000242 Genomic DNA. Translation: EAK82916.1.
RefSeqiXP_762434.1. XM_757341.1.

Genome annotation databases

EnsemblFungiiUM06287T0; UM06287P0; UM06287.
GeneIDi3634467.
KEGGiuma:UM06287.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACP01000242 Genomic DNA. Translation: EAK82916.1 .
RefSeqi XP_762434.1. XM_757341.1.

3D structure databases

ProteinModelPortali Q4P0S6.
ModBasei Search...

Protein-protein interaction databases

STRINGi 5270.UM06287.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii UM06287T0 ; UM06287P0 ; UM06287 .
GeneIDi 3634467.
KEGGi uma:UM06287.1.

Phylogenomic databases

eggNOGi NOG47964.
KOi K17841.
OMAi YMEIGRV.
OrthoDBi EOG7RBZJ2.

Enzyme and pathway databases

UniPathwayi UPA00799 ; UER00773 .
UPA00802 .

Family and domain databases

Gene3Di 1.10.600.10. 2 hits.
InterProi IPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view ]
Pfami PF00494. SQS_PSY. 1 hit.
[Graphical view ]
SUPFAMi SSF48576. SSF48576. 3 hits.
TIGRFAMsi TIGR03462. CarR_dom_SF. 2 hits.
PROSITEi PS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis."
    Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J., Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H., Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G., Snetselaar K., McCann M., Perez-Martin J.
    , Feldbruegge M., Basse C.W., Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L., Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L., Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N., Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B., Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J., Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P., Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G., Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A., Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M., Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M., Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E., Birren B.W.
    Nature 444:97-101(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 521 / FGSC 9021.

Entry informationi

Entry nameiLCPS_USTMA
AccessioniPrimary (citable) accession number: Q4P0S6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: July 19, 2005
Last modified: March 19, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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