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Q4P0S6 (LCPS_USTMA) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Bifunctional lycopene cyclase/phytoene synthase

Including the following 2 domains:

  1. Lycopene beta-cyclase
    EC=5.5.1.19
    Alternative name(s):
    Lycopene cyclase
  2. Phytoene synthase
    EC=2.5.1.32
Gene names
ORF Names:UM06287
OrganismUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) [Reference proteome]
Taxonomic identifier237631 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeUstilago

Protein attributes

Sequence length690 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase) By similarity.

Catalytic activity

Carotenoid psi-end group = carotenoid beta-end group.

2 geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate.

Pathway

Carotenoid biosynthesis; beta-carotene biosynthesis.

Carotenoid biosynthesis; phytoene biosynthesis; all-trans-phytoene from geranylgeranyl diphosphate: step 1/1.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

In the N-terminal section; belongs to the lycopene beta-cyclase family.

In the C-terminal section; belongs to the phytoene/squalene synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 690690Bifunctional lycopene cyclase/phytoene synthase
PRO_0000409246

Regions

Transmembrane21 – 4121Helical; Potential
Transmembrane48 – 6821Helical; Potential
Transmembrane92 – 11423Helical; Potential
Transmembrane129 – 14921Helical; Potential
Transmembrane156 – 17621Helical; Potential
Transmembrane183 – 20321Helical; Potential
Transmembrane231 – 25121Helical; Potential
Region1 – 255255Lycopene beta-cyclase
Region262 – 686425Phytoene synthase

Sequences

Sequence LengthMass (Da)Tools
Q4P0S6 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: E52BB51A2F576BC5

FASTA69077,749
        10         20         30         40         50         60 
MTSLDEPSQD WPACTLSYRH FHLLWTLPVC GVLLVIARPF LTKLDRAKLI LLPIIAFVWT 

        70         80         90        100        110        120 
TPWDNLIVRN RAWSYHRHCI WFTIGYVPIE EYFYFIIQSL ISTLWCTLIT RWTLPNLYLT 

       130        140        150        160        170        180 
PSTPARRPLA PFAVATCVVC FVLGLQASVP ATHTYYFGMI SWWSSMPLAL LLWGSIDFVR 

       190        200        210        220        230        240 
NMGVGAGFIP FAISVLGPTL YLWSSDIYAL RRGTWHINQA TSLNIFPIPD LPIEEMLFFL 

       250        260        270        280        290        300 
VTNVILVSAC FTFDRCVAIC RLSAPDHQPP LSPSYLPLGS LATYTKLWAA FVRSDRSSLP 

       310        320        330        340        350        360 
TSCASASVEP QDLSASLQVL RAASKSFNAA SLLLPWDLRT DLGCLYAFCR VADDLVDDHA 

       370        380        390        400        410        420 
QELQAKAKNL DVVRDIVDAV YADSIVDRKQ HLSTPIGERL RILLASAALS DKIKQDTRAA 

       430        440        450        460        470        480 
ATSIAPLTQY IPKRLWYEML QGYSADLRFQ HQDARQRTRL QSMDDLVEYS QCVAGVVGEM 

       490        500        510        520        530        540 
CIRVILGRCG STVPLDLEVD RKIALRASKT IEQSINVKPL DLNRTADVHT LLYEARRMGV 

       550        560        570        580        590        600 
SLQLVNIARD VVPDSVELRR CYLPADMFDK EEDDGMYEAL LKGRVALPRH ASKLVHGAEE 

       610        620        630        640        650        660 
QGVVRPQDVR KYALRLLEIS QRLYDESYPS LRQIPNRPAR AGLKAACSVY AAIGKRIQAQ 

       670        680        690 
TEDEISSGRR ARMSNLDRIL RAISAVYFDV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACP01000242 Genomic DNA. Translation: EAK82916.1.
RefSeqXP_762434.1. XM_757341.1.

3D structure databases

ProteinModelPortalQ4P0S6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5270.UM06287.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiUM06287T0; UM06287P0; UM06287.
GeneID3634467.
KEGGuma:UM06287.1.

Phylogenomic databases

eggNOGNOG47964.
KOK17841.
OMAYMEIGRV.
OrthoDBEOG7RBZJ2.

Enzyme and pathway databases

UniPathwayUPA00799; UER00773.
UPA00802.

Family and domain databases

Gene3D1.10.600.10. 2 hits.
InterProIPR017825. Lycopene_cyclase_dom.
IPR002060. Squ/phyt_synthse.
IPR019845. Squalene/phytoene_synthase_CS.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamPF00494. SQS_PSY. 1 hit.
[Graphical view]
SUPFAMSSF48576. SSF48576. 3 hits.
TIGRFAMsTIGR03462. CarR_dom_SF. 2 hits.
PROSITEPS01044. SQUALEN_PHYTOEN_SYN_1. 1 hit.
PS01045. SQUALEN_PHYTOEN_SYN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLCPS_USTMA
AccessionPrimary (citable) accession number: Q4P0S6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: July 19, 2005
Last modified: March 19, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways