Reviewed, UniProtKB/Swiss-Prot Q4P0K0 (ATG1_USTMA)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein kinase ATG1
    EC=2.7.11.1
Alternative name(s):
    Autophagy-related protein 1

Gene names

Name:	ATG1
ORF Names:	UM06363

Organism

Ustilago maydis (Smut fungus) [Complete proteome]

Taxonomic identifier

5270 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Basidiomycota › Ustilaginomycotina › Ustilaginomycetes › Ustilaginales › Ustilaginaceae › Ustilago

Protein attributes

Sequence length	990 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Serine/threonine protein kinase probably involved in the cytoplasm to vacuole transport (Cvt) and in autophagy, where it may be required for the formation of autophagosomes By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 990	990	Serine/threonine-protein kinase ATG1		PRO_0000085653
Regions
	Domain	15 – 334	320	Protein kinase
	Nucleotide binding	21 – 29	9	ATP By similarity
Sites
	Active site	165	1	Proton acceptor By similarity
	Binding site	44	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4P0K0-1 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: FFABEF71CB4590EF	FASTA	990	106,540
	10 20 30 40 50 60 MSKSSTGRDE RIGDFVIENE IGKGSFAVVH KGYRLQPREP VAIKIVIRKK LTPKLLDNLE 70 80 90 100 110 120 GEIAILKAIH HPNIVELKEC LKTEHQIYLV MAFCASGDLA QYIKKRFDIY ERAGMAEPDS 130 140 150 160 170 180 LTKGFKPTYP HPVDGGLNET IVRSILTQLA AALEFMRARD IVHRDIKPQN LLLQPPDAAF 190 200 210 220 230 240 LALGNPREIP QMKVADFGFA RHLSVNTLAE TLCGSPLYMA PEILRFEKYD AKADLWSVGA 250 260 270 280 290 300 VLFEMTVGKP PFRAANHVEL LKRIERGEDK IKFPDERSAG SLAREAARRQ ELGEAPLPPP 310 320 330 340 350 360 HPVSEDVKIL IRQLLRQRPV SRMSFDDFFA SPVISDFKAF IRPRAQPEAV ERYEDLQRSE 370 380 390 400 410 420 RSVIIPSSGI KHVSVSSIEA STQQPGVQPP VSTATSPPAL ESRSTQEASP KAITGETIAP 430 440 450 460 470 480 NKTPREDARP PRTLPRAFSA KYVTGEPPQP EDLEKRVPPT MTRTPSSPGI PEGSLLSGER 490 500 510 520 530 540 DEAPQATTEH FGSSKGGEDS FLGKEYVLIE KQSVEVNALA DELAASPQSR LGLASRRPSR 550 560 570 580 590 600 LSRLSSGPLP SAPGASPPTA PPTILSSKPI RIANNTNTAS TGAFALPPGS RPSSFPRRAS 610 620 630 640 650 660 LSSSGSPSTR QGGQVITNMD AVASTQSNRR DGNASSFPKD EVSVLGQRLA GFGLSGSGVG 670 680 690 700 710 720 GGPSSALAKA ISMASLRLFG VPSGVSLRDA AALVRTRAQR RGIARATDSL DEAEMTLLST 730 740 750 760 770 780 LEDLGQKAFV LSEFADSKLA HFFPDGPHQL SQELDSSTAT SGISPSRNSV QGSARRVGSI 790 800 810 820 830 840 SSSSSSAVDP VAAEAASAEA LMLYVRSLAF LQRAITLTKR HVESRSRPGV PAVTSAELND 850 860 870 880 890 900 VVQWLRARFN EVYDKADFAR SRCSELPESA QQVDKLIFDK AVEVARAAAT DELENNREGS 910 920 930 940 950 960 GWDPSHCLLA YETANSMLSS LLDPGEDAMS LSEGSILMID GYVKSINKRL WTLQEQFGGG 970 980 990 VGAVGAAGAS PVGVDAEARP GVSRSRTESP

References

[1]

"Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis." Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J., Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H., Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G., Snetselaar K., McCann M., Perez-Martin J. , Feldbruegge M., Basse C.W., Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L., Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L., Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N., Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B., Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J., Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P., Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G., Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A., Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M., Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M., Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E., Birren B.W. Nature 444:97-101(2006) [PubMed: 17080091] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 521.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AACP01000247 Genomic DNA. Translation: EAK87220.1.
RefSeq	XP_762510.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3634510.
KEGG	uma:UM06363.1.
Phylogenomic databases
OMA	AVERYED.
Enzyme and pathway databases
BRENDA	2.7.11.1. 2320.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG1_USTMA

Accession

Primary (citable) accession number: Q4P0K0

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
Last sequence update:	July 19, 2005
Last modified:	November 3, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)