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Protein

Histone deacetylase

Gene

TP02_0039

Organism
Theileria parva (East coast fever infection agent)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei95SubstrateUniRule annotation1
Active sitei137Proton acceptorUniRule annotation1
Binding sitei145Substrate; via carbonyl oxygenUniRule annotation1
Metal bindingi172Divalent metal cationUniRule annotation1
Metal bindingi174Divalent metal cationUniRule annotation1
Metal bindingi260Divalent metal cationUniRule annotation1
Binding sitei299SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation)
Gene namesi
Ordered Locus Names:TP02_0039Imported
OrganismiTheileria parva (East coast fever infection agent)Imported
Taxonomic identifieri5875 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaPiroplasmidaTheileriidaeTheileria
Proteomesi
  • UP000001949 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiPiroplasmaDB:TP02_0039.

Subcellular locationi

  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi333668.XP_764608.1.

Structurei

3D structure databases

ProteinModelPortaliQ4N698.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 313Hist_deacetylInterPro annotationAdd BLAST292

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1342. Eukaryota.
COG0123. LUCA.
HOGENOMiHOG000225180.
InParanoidiQ4N698.
KOiK06067.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiView protein in Pfam
PF00850. Hist_deacetyl. 1 hit.
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

Q4N698-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKRVSYFYD PDVGSFYYGP GHPMKPQRIR MAHALVLSYD LYRHMEIFRP
60 70 80 90 100
HKAVEPELLS FHDSEYVHFL SGVSPENYRD FTYQLKRFNV GEATDCPVFD
110 120 130 140 150
GLYVFQQSCS GASIDAAHRL NNQQADICVN WSGGLHHAKR SEASGFCYLN
160 170 180 190 200
DIVLGILELL KYHARVMYID IDVHHGDGVE EAFYVTHRVM TISFHKFGNF
210 220 230 240 250
FPGTGDVTDV GVSSGKYYSV NVPLNDGIDD ESFVDLFKVV VGKCVEVYCP
260 270 280 290 300
GAIVLQCGAD SLTGDRLGRF NLTIKGHAAC VQYVRSLNIP LLVLGGGGYT
310 320 330 340 350
IRNVARCWAY ETGVILNKHT DMSNQISLND YYDYYAPDFQ LHLTPSQMTN
360 370 380 390 400
YNTKEHLDKI KVKILDNLRY VEKSPGVQFA HVPPDFLTRD DDVDDDLQKQ
410 420 430 440
VFDEGGGRTS LSTRKRISLI TSSHKLRRRD YKGELYDLPD RDDQIPI
Length:447
Mass (Da):50,781
Last modified:August 2, 2005 - v1
Checksum:i3C88C204C274BDB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAGK01000002 Genomic DNA. Translation: EAN32325.1.
RefSeqiXP_764608.1. XM_759515.1.

Genome annotation databases

EnsemblProtistsiEAN32325; EAN32325; TP02_0039.
GeneIDi3501619.
KEGGitpv:TP02_0039.

Similar proteinsi

Entry informationi

Entry nameiQ4N698_THEPA
AccessioniPrimary (citable) accession number: Q4N698
Entry historyiIntegrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: August 30, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported