Reviewed,
UniProtKB/Swiss-Prot Q4MVY3 (K6PF_BACCE)
Last modified
June 16, 2009.
Version 20.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: 6-phosphofructokinase Short name=Phosphofructokinase EC=2.7.1.11 Alternative name(s): Phosphohexokinase | ||||||
| Gene names |
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| Organism | Bacillus cereus | ||||||
| Taxonomic identifier | 1396 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group |
Protein attributes
| Sequence length | 319 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. HAMAP MF_00339 |
| Pathway | Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. HAMAP MF_00339 |
| Subunit structure | Homotetramer By similarity. |
| Subcellular location | Cytoplasm By similarity. |
| Induction | By salt stress. Ref.2 |
| Sequence similarities | Belongs to the phosphofructokinase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Glycolysis Stress response |
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Magnesium Metal-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| Technical term | Allosteric enzyme Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | fructose 6-phosphate metabolic process Inferred from electronic annotation. Source: InterPro glycolysisInferred from electronic annotation. Source: HAMAP response to stressInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | 6-phosphofructokinase complex Inferred from electronic annotation. Source: InterPro |
| Molecular function | 6-phosphofructokinase activity Inferred from electronic annotation. Source: HAMAP ATP bindingInferred from electronic annotation. Source: UniProtKB-KW magnesium ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 319 | 319 | 6-phosphofructokinase HAMAP MF_00339 | PRO_0000271249 | |||||
Regions | |||||||||
| Nucleotide binding | 21 – 25 | 5 | ATP By similarity | ||||||
| Nucleotide binding | 154 – 158 | 5 | ATP By similarity | ||||||
| Nucleotide binding | 171 – 187 | 17 | ATP By similarity | ||||||
Sites | |||||||||
| Active site | 127 | 1 | Proton acceptor By similarity | ||||||
| Metal binding | 185 | 1 | Magnesium; via carbonyl oxygen By similarity | ||||||
| Metal binding | 187 | 1 | Magnesium By similarity | ||||||
| Binding site | 162 | 1 | Substrate By similarity | ||||||
| Binding site | 243 | 1 | Substrate By similarity | ||||||
| Binding site | 249 | 1 | Substrate By similarity | ||||||
| Binding site | 252 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | "Identification of anthrax toxin genes in a Bacillus cereus associated with an illness resembling inhalation anthrax." Hoffmaster A.R., Ravel J., Rasko D.A., Chapman G.D., Chute M.D., Marston C.K., De B.K., Sacchi C.T., Fitzgerald C., Mayer L.W., Maiden M.C.J., Priest F.G., Barker M., Jiang L., Cer R.Z., Rilstone J., Peterson S.N., Weyant R.S. Fraser C.M.Proc. Natl. Acad. Sci. U.S.A. 101:8449-8454(2004) [PubMed: 15155910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: G9241. |
| [2] | "Heat and salt stress in the food pathogen Bacillus cereus." Browne N., Dowds B.C.A. J. Appl. Microbiol. 91:1085-1094(2001) [PubMed: 11851817] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-10, INDUCTION. Strain: NCIMB 11796 / DSM 626. |
Cross-references
Sequence databases | |
|---|---|
| AAEK01000003 Genomic DNA. Translation: EAL16121.1. | |
3D structure databases | |
| SMR | Q4MVY3. Positions 1-319. |
| ModBase | Search... |
Enzyme and pathway databases | |
| BRENDA | 2.7.1.11. 604. |
Family and domain databases | |
| HAMAP | MF_00339. [Tree] |
| InterPro | IPR012003. ATP_PFK_prok. IPR012828. PFKA_ATP. IPR000023. Phosphofructokinase. IPR015912. Phosphofructokinase_CS. [Graphical view] |
| Pfam | PF00365. PFK. 1 hit. [Graphical view] |
| PIRSF | PIRSF000532. ATP_PFK_prok. 1 hit. |
| PRINTS | PR00476. PHFRCTKINASE. |
| ProDom | PD000707. Ppfruckinase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR02482. PFKA_ATP. 1 hit. |
| PROSITE | PS00433. PHOSPHOFRUCTOKINASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | K6PF_BACCE | ||||||||
| Accession | Primary (citable) accession number: Q4MVY3 Secondary accession number(s): P83066 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


