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Q4MTG0 (ODPA_BACCE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Pyruvate dehydrogenase E1 component subunit alpha

EC=1.2.4.1
Gene names
Name:pdhA
ORF Names:BCE_G9241_3962
OrganismBacillus cereus
Taxonomic identifier1396 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length371 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. UniProtKB P21873

Catalytic activity

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2. UniProtKB P21873

Cofactor

Thiamine pyrophosphate By similarity. UniProtKB P21873

Subunit structure

Heterodimer of an alpha and a beta chain.

Induction

By acid stress. Under acid-stress, this protein is expressed at a higher level in wild-type B.cereus than in the acid-sensitive mutant strain NB1. Ref.2

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.2
Chain2 – 371370Pyruvate dehydrogenase E1 component subunit alpha
PRO_0000271255

Sequences

Sequence LengthMass (Da)Tools
Q4MTG0 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 884A8A94D6084451

FASTA37141,441
        10         20         30         40         50         60 
MGTKTKKTLF NVDEQMKAIA AQFETLQILN EKGEVVNEAA MPELSDDQLK ELMRRMVYTR 

        70         80         90        100        110        120 
VLDQRSISLN RQGRLGFYAP TAGQEASQLA SHFALEAEDF ILPGYRDVPQ LVWHGLPLYQ 

       130        140        150        160        170        180 
AFLFSRGHFM GNQMPENVNA LAPQIIIGAQ IIQTAGVALG MKLRGKKSVA ITYTGDGGAS 

       190        200        210        220        230        240 
QGDFYEGMNF AGAFKAPAIF VVQNNRYAIS TPVEKQSAAK TVAQKAVAAG IYGIQVDGMD 

       250        260        270        280        290        300 
PLAVYAATAF ARERAVNGEG PTLIETLTFR YGPHTMAGDD PTRYRTKDIE NEWEQKDPIV 

       310        320        330        340        350        360 
RFRAFLENKG LWSQEVEEKV IEEAKEDIKQ AIAKADQAPK QKVTDLMEIM YEKMPYNLAE 

       370 
QYEIYKEKES K 

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References

[1]"Identification of anthrax toxin genes in a Bacillus cereus associated with an illness resembling inhalation anthrax."
Hoffmaster A.R., Ravel J., Rasko D.A., Chapman G.D., Chute M.D., Marston C.K., De B.K., Sacchi C.T., Fitzgerald C., Mayer L.W., Maiden M.C.J., Priest F.G., Barker M., Jiang L., Cer R.Z., Rilstone J., Peterson S.N., Weyant R.S. expand/collapse author list , Galloway D.R., Read T.D., Popovic T., Fraser C.M.
Proc. Natl. Acad. Sci. U.S.A. 101:8449-8454(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: G9241.
[2]"Acid stress in the food pathogen Bacillus cereus."
Browne N., Dowds B.C.A.
J. Appl. Microbiol. 92:404-414(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-21, INDUCTION.
Strain: NCIMB 11796 / DSM 626.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAEK01000007 Genomic DNA. Translation: EAL15457.1.

3D structure databases

ProteinModelPortalQ4MTG0.
SMRQ4MTG0. Positions 10-371.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEAL15457; EAL15457; BCE_G9241_3962.
PATRIC24955467. VBIBacCer116370_1693.

Family and domain databases

Gene3D3.40.50.970. 1 hit.
InterProIPR001017. DH_E1.
IPR017596. Pyrv_DH_E1_asu_subgrp-x.
IPR029061. THDP-binding.
[Graphical view]
PfamPF00676. E1_dh. 1 hit.
[Graphical view]
SUPFAMSSF52518. SSF52518. 1 hit.
TIGRFAMsTIGR03181. PDH_E1_alph_x. 1 hit.
ProtoNetSearch...

Entry information

Entry nameODPA_BACCE
AccessionPrimary (citable) accession number: Q4MTG0
Secondary accession number(s): P83068, P83070
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 36 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program