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Protein

Semaphorin-3G

Gene

Sema3g

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Has chemorepulsive activities for sympathetic axons. Ligand of NRP2.1 Publication

GO - Molecular functioni

  • neuropilin binding Source: GO_Central
  • signaling receptor binding Source: UniProtKB

GO - Biological processi

  • negative chemotaxis Source: GO_Central
  • negative regulation of axon extension Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-3G
Gene namesi
Name:Sema3g
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:3041242 Sema3g

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000025779223 – 780Semaphorin-3GAdd BLAST758

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi44N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi105 ↔ 116By similarity
Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi134 ↔ 143By similarity
Disulfide bondi270 ↔ 382By similarity
Disulfide bondi294 ↔ 342By similarity
Disulfide bondi522 ↔ 540By similarity
Disulfide bondi603 ↔ 655By similarity
Glycosylationi652N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ4LFA9
PaxDbiQ4LFA9
PeptideAtlasiQ4LFA9
PRIDEiQ4LFA9

PTM databases

iPTMnetiQ4LFA9
PhosphoSitePlusiQ4LFA9

Expressioni

Tissue specificityi

Highly expressed in lung and kidney. Weakly expressed in brain.

Gene expression databases

BgeeiENSMUSG00000021904
GenevisibleiQ4LFA9 MM

Interactioni

GO - Molecular functioni

  • neuropilin binding Source: GO_Central
  • signaling receptor binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000087643

Structurei

3D structure databases

ProteinModelPortaliQ4LFA9
SMRiQ4LFA9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 519SemaPROSITE-ProRule annotationAdd BLAST488
Domaini569 – 671Ig-like C2-typeAdd BLAST103

Sequence similaritiesi

Belongs to the semaphorin family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiKOG3611 Eukaryota
ENOG410XQZC LUCA
GeneTreeiENSGT00760000118854
HOGENOMiHOG000039964
HOVERGENiHBG055071
InParanoidiQ4LFA9
KOiK06840
OMAiEAMIFRS
OrthoDBiEOG091G01WA
PhylomeDBiQ4LFA9
TreeFamiTF316102

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013151 Immunoglobulin
IPR016201 PSI
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036 PTHR11036, 1 hit
PfamiView protein in Pfam
PF00047 ig, 1 hit
PF01403 Sema, 1 hit
SMARTiView protein in SMART
SM00423 PSI, 1 hit
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51004 SEMA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4LFA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPSAWAICC LLGSLLFHVG IPSPGPSPSV PRLRLSYRDL LSTNRSAIFL
60 70 80 90 100
GPRGSLDLQV MYLDEYRDRL FLGSRDALYS LRLDQAWPDP REVLWLPQPG
110 120 130 140 150
QKVECVRKGK DPLTECANFV RVLQPHNRTH LLACGTGAFQ PICTFITVGH
160 170 180 190 200
RGEHVLRLDA SSVENGRGRC PHEPSRPFAS TFVGGELYTG LTADFLGREA
210 220 230 240 250
MIFRSGGPRP ALRSDSDQSL LHEPRFVMAA RIPDNSDRDD DKVYFFFSET
260 270 280 290 300
VPSPDGGPGH VTISRVGRVC VNDAGGQRVL VNKWSTFLKA RLVCSVPGPG
310 320 330 340 350
GAETHFDQLE DVFLLWPKAG KSLEVYALFS TVSAVFQGFA VCVYHMVDIW
360 370 380 390 400
EVFNGPFAHR DGPQHQWGPY GGKVPFPRPG VCPSKMTAQP GRPFGSTKDY
410 420 430 440 450
PDEVLQFVRD HPLMFQPVRP RRGRPVLVKT HLAQRLRQIV VDRVEAEDGT
460 470 480 490 500
YDVIFLGTDS GSVLKVIALQ GGGLTEPEEV VLEELQVFKV PTPITEMEIS
510 520 530 540 550
VKRQTLYVGS PLGVARLQLH QCETYGSACA ECCLARDPYC AWDGTACARY
560 570 580 590 600
RPSSGKRRFR RQDIRHGNPA VQCLGQGQSQ NKAASGLMTR VFGTEHNSTF
610 620 630 640 650
LECLPKSPQA AVRWFLQRPG DKGTDQVKTD ERVVQTAQGL LFRRLSRHDA
660 670 680 690 700
GNYTCTTLEH GFSQTVVRFA LEVIAAVQLD SLFLRESRLE EPSAWGSLAS
710 720 730 740 750
ASPKTWYKDI LQLTGFANLP RVDEYCERVW CRGVGERSGS FRGKGKQAKG
760 770 780
KSWAGLELGK KMKSRVLAEH NRTPREVEAT
Length:780
Mass (Da):86,695
Last modified:August 2, 2005 - v1
Checksum:i433F4D96F53CB4A5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti385K → R in BAE23363 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB127607 mRNA Translation: BAE06156.1
AK137463 mRNA Translation: BAE23363.1
CCDSiCCDS26908.1
RefSeqiNP_001020550.1, NM_001025379.1
UniGeneiMm.27812

Genome annotation databases

EnsembliENSMUST00000090180; ENSMUSP00000087643; ENSMUSG00000021904
GeneIDi218877
KEGGimmu:218877
UCSCiuc007sxe.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSEM3G_MOUSE
AccessioniPrimary (citable) accession number: Q4LFA9
Secondary accession number(s): Q3UVA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: August 2, 2005
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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