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Protein

Semaphorin-3G

Gene

Sema3g

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Has chemorepulsive activities for sympathetic axons. Ligand of NRP2.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-3G
Gene namesi
Name:Sema3g
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:3041242. Sema3g.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 780758Semaphorin-3GPRO_0000257792Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi44 – 441N-linked (GlcNAc...)Sequence analysis
Disulfide bondi105 ↔ 116By similarity
Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence analysis
Disulfide bondi134 ↔ 143By similarity
Disulfide bondi270 ↔ 382By similarity
Disulfide bondi294 ↔ 342By similarity
Disulfide bondi522 ↔ 540By similarity
Disulfide bondi603 ↔ 655By similarity
Glycosylationi652 – 6521N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ4LFA9.
PaxDbiQ4LFA9.
PeptideAtlasiQ4LFA9.
PRIDEiQ4LFA9.

PTM databases

iPTMnetiQ4LFA9.
PhosphoSiteiQ4LFA9.

Expressioni

Tissue specificityi

Highly expressed in lung and kidney. Weakly expressed in brain.

Gene expression databases

BgeeiENSMUSG00000021904.
GenevisibleiQ4LFA9. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000087643.

Structurei

3D structure databases

ProteinModelPortaliQ4LFA9.
SMRiQ4LFA9. Positions 29-675.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 519488SemaPROSITE-ProRule annotationAdd
BLAST
Domaini569 – 671103Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Belongs to the semaphorin family.Curated
Contains 1 Sema domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiKOG3611. Eukaryota.
ENOG410XQZC. LUCA.
GeneTreeiENSGT00760000118854.
HOGENOMiHOG000039964.
HOVERGENiHBG055071.
InParanoidiQ4LFA9.
KOiK06840.
OMAiTEHNSTF.
OrthoDBiEOG091G01WA.
PhylomeDBiQ4LFA9.
TreeFamiTF316102.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013151. Immunoglobulin.
IPR016201. Plexin-like_fold.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PfamiPF00047. ig. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4LFA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPSAWAICC LLGSLLFHVG IPSPGPSPSV PRLRLSYRDL LSTNRSAIFL
60 70 80 90 100
GPRGSLDLQV MYLDEYRDRL FLGSRDALYS LRLDQAWPDP REVLWLPQPG
110 120 130 140 150
QKVECVRKGK DPLTECANFV RVLQPHNRTH LLACGTGAFQ PICTFITVGH
160 170 180 190 200
RGEHVLRLDA SSVENGRGRC PHEPSRPFAS TFVGGELYTG LTADFLGREA
210 220 230 240 250
MIFRSGGPRP ALRSDSDQSL LHEPRFVMAA RIPDNSDRDD DKVYFFFSET
260 270 280 290 300
VPSPDGGPGH VTISRVGRVC VNDAGGQRVL VNKWSTFLKA RLVCSVPGPG
310 320 330 340 350
GAETHFDQLE DVFLLWPKAG KSLEVYALFS TVSAVFQGFA VCVYHMVDIW
360 370 380 390 400
EVFNGPFAHR DGPQHQWGPY GGKVPFPRPG VCPSKMTAQP GRPFGSTKDY
410 420 430 440 450
PDEVLQFVRD HPLMFQPVRP RRGRPVLVKT HLAQRLRQIV VDRVEAEDGT
460 470 480 490 500
YDVIFLGTDS GSVLKVIALQ GGGLTEPEEV VLEELQVFKV PTPITEMEIS
510 520 530 540 550
VKRQTLYVGS PLGVARLQLH QCETYGSACA ECCLARDPYC AWDGTACARY
560 570 580 590 600
RPSSGKRRFR RQDIRHGNPA VQCLGQGQSQ NKAASGLMTR VFGTEHNSTF
610 620 630 640 650
LECLPKSPQA AVRWFLQRPG DKGTDQVKTD ERVVQTAQGL LFRRLSRHDA
660 670 680 690 700
GNYTCTTLEH GFSQTVVRFA LEVIAAVQLD SLFLRESRLE EPSAWGSLAS
710 720 730 740 750
ASPKTWYKDI LQLTGFANLP RVDEYCERVW CRGVGERSGS FRGKGKQAKG
760 770 780
KSWAGLELGK KMKSRVLAEH NRTPREVEAT
Length:780
Mass (Da):86,695
Last modified:August 2, 2005 - v1
Checksum:i433F4D96F53CB4A5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti385 – 3851K → R in BAE23363 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB127607 mRNA. Translation: BAE06156.1.
AK137463 mRNA. Translation: BAE23363.1.
CCDSiCCDS26908.1.
RefSeqiNP_001020550.1. NM_001025379.1.
UniGeneiMm.27812.

Genome annotation databases

EnsembliENSMUST00000090180; ENSMUSP00000087643; ENSMUSG00000021904.
GeneIDi218877.
KEGGimmu:218877.
UCSCiuc007sxe.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB127607 mRNA. Translation: BAE06156.1.
AK137463 mRNA. Translation: BAE23363.1.
CCDSiCCDS26908.1.
RefSeqiNP_001020550.1. NM_001025379.1.
UniGeneiMm.27812.

3D structure databases

ProteinModelPortaliQ4LFA9.
SMRiQ4LFA9. Positions 29-675.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000087643.

PTM databases

iPTMnetiQ4LFA9.
PhosphoSiteiQ4LFA9.

Proteomic databases

MaxQBiQ4LFA9.
PaxDbiQ4LFA9.
PeptideAtlasiQ4LFA9.
PRIDEiQ4LFA9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090180; ENSMUSP00000087643; ENSMUSG00000021904.
GeneIDi218877.
KEGGimmu:218877.
UCSCiuc007sxe.1. mouse.

Organism-specific databases

CTDi56920.
MGIiMGI:3041242. Sema3g.

Phylogenomic databases

eggNOGiKOG3611. Eukaryota.
ENOG410XQZC. LUCA.
GeneTreeiENSGT00760000118854.
HOGENOMiHOG000039964.
HOVERGENiHBG055071.
InParanoidiQ4LFA9.
KOiK06840.
OMAiTEHNSTF.
OrthoDBiEOG091G01WA.
PhylomeDBiQ4LFA9.
TreeFamiTF316102.

Miscellaneous databases

PROiQ4LFA9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021904.
GenevisibleiQ4LFA9. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013151. Immunoglobulin.
IPR016201. Plexin-like_fold.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PfamiPF00047. ig. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSEM3G_MOUSE
AccessioniPrimary (citable) accession number: Q4LFA9
Secondary accession number(s): Q3UVA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: August 2, 2005
Last modified: September 7, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.