ID   AARD_HUMAN              Reviewed;         155 AA.
AC   Q4LEZ3; A5PKU8;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   24-JAN-2024, entry version 102.
DE   RecName: Full=Alanine and arginine-rich domain-containing protein;
GN   Name=AARD; Synonyms=C8orf85;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Ishikawa S.K., Shimizu A., Yamazaki S., Asakawa S., Shimizu N.;
RT   "Novel gene containing alanine and arginine rich domain on human chromosome
RT   8.";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-96.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q4LEZ3; Q7L2Z9: CENPQ; NbExp=3; IntAct=EBI-5463075, EBI-2350265;
CC       Q4LEZ3; Q86XR8-3: CEP57; NbExp=3; IntAct=EBI-5463075, EBI-11752486;
CC       Q4LEZ3; Q4V328: GRIPAP1; NbExp=3; IntAct=EBI-5463075, EBI-717919;
CC       Q4LEZ3; Q2KHM9: KIAA0753; NbExp=3; IntAct=EBI-5463075, EBI-2805604;
CC       Q4LEZ3; Q2M2I5: KRT24; NbExp=3; IntAct=EBI-5463075, EBI-2952736;
CC       Q4LEZ3; Q7Z3Y8: KRT27; NbExp=6; IntAct=EBI-5463075, EBI-3044087;
CC       Q4LEZ3; P61968: LMO4; NbExp=3; IntAct=EBI-5463075, EBI-2798728;
CC       Q4LEZ3; O15481: MAGEB4; NbExp=3; IntAct=EBI-5463075, EBI-751857;
CC       Q4LEZ3; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-5463075, EBI-741158;
CC       Q4LEZ3; Q16623: STX1A; NbExp=3; IntAct=EBI-5463075, EBI-712466;
CC       Q4LEZ3; P32856-2: STX2; NbExp=3; IntAct=EBI-5463075, EBI-11956649;
CC       Q4LEZ3; Q13190: STX5; NbExp=3; IntAct=EBI-5463075, EBI-714206;
CC       Q4LEZ3; Q9UBB9: TFIP11; NbExp=3; IntAct=EBI-5463075, EBI-1105213;
CC       Q4LEZ3; Q9BZW7: TSGA10; NbExp=3; IntAct=EBI-5463075, EBI-744794;
CC       Q4LEZ3; A5D8V6: VPS37C; NbExp=3; IntAct=EBI-5463075, EBI-2559305;
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DR   EMBL; AB181519; BAE03184.1; -; mRNA.
DR   EMBL; BC142621; AAI42622.1; -; mRNA.
DR   CCDS; CCDS34935.1; -.
DR   RefSeq; NP_001020528.1; NM_001025357.2.
DR   AlphaFoldDB; Q4LEZ3; -.
DR   SMR; Q4LEZ3; -.
DR   BioGRID; 137412; 15.
DR   IntAct; Q4LEZ3; 15.
DR   STRING; 9606.ENSP00000367528; -.
DR   GlyGen; Q4LEZ3; 1 site, 1 O-linked glycan (1 site).
DR   BioMuta; AARD; -.
DR   DMDM; 121944377; -.
DR   MassIVE; Q4LEZ3; -.
DR   PaxDb; 9606-ENSP00000367528; -.
DR   PeptideAtlas; Q4LEZ3; -.
DR   ProteomicsDB; 62246; -.
DR   Antibodypedia; 74104; 2 antibodies from 2 providers.
DR   DNASU; 441376; -.
DR   Ensembl; ENST00000378279.4; ENSP00000367528.3; ENSG00000205002.4.
DR   GeneID; 441376; -.
DR   KEGG; hsa:441376; -.
DR   MANE-Select; ENST00000378279.4; ENSP00000367528.3; NM_001025357.3; NP_001020528.1.
DR   UCSC; uc003yof.4; human.
DR   AGR; HGNC:33842; -.
DR   CTD; 441376; -.
DR   GeneCards; AARD; -.
DR   HGNC; HGNC:33842; AARD.
DR   HPA; ENSG00000205002; Tissue enhanced (testis, urinary bladder).
DR   neXtProt; NX_Q4LEZ3; -.
DR   OpenTargets; ENSG00000205002; -.
DR   PharmGKB; PA164717502; -.
DR   VEuPathDB; HostDB:ENSG00000205002; -.
DR   eggNOG; ENOG502SG9F; Eukaryota.
DR   GeneTree; ENSGT00390000007815; -.
DR   HOGENOM; CLU_142929_0_0_1; -.
DR   InParanoid; Q4LEZ3; -.
DR   OMA; SELLEMH; -.
DR   OrthoDB; 4640955at2759; -.
DR   PhylomeDB; Q4LEZ3; -.
DR   TreeFam; TF339066; -.
DR   PathwayCommons; Q4LEZ3; -.
DR   SignaLink; Q4LEZ3; -.
DR   BioGRID-ORCS; 441376; 14 hits in 1137 CRISPR screens.
DR   GenomeRNAi; 441376; -.
DR   Pharos; Q4LEZ3; Tdark.
DR   PRO; PR:Q4LEZ3; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   RNAct; Q4LEZ3; Protein.
DR   Bgee; ENSG00000205002; Expressed in left testis and 90 other cell types or tissues.
DR   PANTHER; PTHR32289:SF2; ALANINE AND ARGININE-RICH DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR32289; PROTEIN FAM167A; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..155
FT                   /note="Alanine and arginine-rich domain-containing protein"
FT                   /id="PRO_0000337036"
FT   VARIANT         96
FT                   /note="G -> R (in dbSNP:rs16889283)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_043570"
SQ   SEQUENCE   155 AA;  17575 MW;  4D991ECA38D29531 CRC64;
     MGPGDFRRCR ERISQGLQGL PGRAELWFPP RPACDFFGDG RSTDIQEEAL AASPLLEDLR
     RRLTRAFQWA VQRAISRRVQ EAAAAAAARE EQSWTGVEAT LARLRAELVE MHFQNHQLAR
     TLLDLNMKVQ QLKKEYELEI TSDSQSPKDD AANPE
//