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Protein

Alanine and arginine-rich domain-containing protein

Gene

AARD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine and arginine-rich domain-containing protein
Gene namesi
Name:AARD
Synonyms:C8orf85
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:33842. AARD.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164717502.

Polymorphism and mutation databases

BioMutaiAARD.
DMDMi121944377.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 155155Alanine and arginine-rich domain-containing proteinPRO_0000337036Add
BLAST

Proteomic databases

PaxDbiQ4LEZ3.
PRIDEiQ4LEZ3.

Expressioni

Gene expression databases

BgeeiQ4LEZ3.

Organism-specific databases

HPAiHPA068290.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000367528.

Structurei

3D structure databases

ProteinModelPortaliQ4LEZ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi60 – 10546Ala/Arg-richAdd
BLAST

Phylogenomic databases

eggNOGiNOG133760.
GeneTreeiENSGT00390000007815.
HOGENOMiHOG000033743.
HOVERGENiHBG101169.
InParanoidiQ4LEZ3.
OMAiFQWAVQR.
OrthoDBiEOG7XWPQ8.
PhylomeDBiQ4LEZ3.
TreeFamiTF339066.

Sequencei

Sequence statusi: Complete.

Q4LEZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPGDFRRCR ERISQGLQGL PGRAELWFPP RPACDFFGDG RSTDIQEEAL
60 70 80 90 100
AASPLLEDLR RRLTRAFQWA VQRAISRRVQ EAAAAAAARE EQSWTGVEAT
110 120 130 140 150
LARLRAELVE MHFQNHQLAR TLLDLNMKVQ QLKKEYELEI TSDSQSPKDD

AANPE
Length:155
Mass (Da):17,575
Last modified:August 2, 2005 - v1
Checksum:i4D991ECA38D29531
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti96 – 961G → R.1 Publication
Corresponds to variant rs16889283 [ dbSNP | Ensembl ].
VAR_043570

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB181519 mRNA. Translation: BAE03184.1.
BC142621 mRNA. Translation: AAI42622.1.
CCDSiCCDS34935.1.
RefSeqiNP_001020528.1. NM_001025357.2.
UniGeneiHs.437551.

Genome annotation databases

EnsembliENST00000378279; ENSP00000367528; ENSG00000205002.
GeneIDi441376.
KEGGihsa:441376.
UCSCiuc003yof.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB181519 mRNA. Translation: BAE03184.1.
BC142621 mRNA. Translation: AAI42622.1.
CCDSiCCDS34935.1.
RefSeqiNP_001020528.1. NM_001025357.2.
UniGeneiHs.437551.

3D structure databases

ProteinModelPortaliQ4LEZ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000367528.

Polymorphism and mutation databases

BioMutaiAARD.
DMDMi121944377.

Proteomic databases

PaxDbiQ4LEZ3.
PRIDEiQ4LEZ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378279; ENSP00000367528; ENSG00000205002.
GeneIDi441376.
KEGGihsa:441376.
UCSCiuc003yof.3. human.

Organism-specific databases

CTDi441376.
GeneCardsiGC08P117951.
HGNCiHGNC:33842. AARD.
HPAiHPA068290.
neXtProtiNX_Q4LEZ3.
PharmGKBiPA164717502.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG133760.
GeneTreeiENSGT00390000007815.
HOGENOMiHOG000033743.
HOVERGENiHBG101169.
InParanoidiQ4LEZ3.
OMAiFQWAVQR.
OrthoDBiEOG7XWPQ8.
PhylomeDBiQ4LEZ3.
TreeFamiTF339066.

Miscellaneous databases

GenomeRNAii441376.
NextBioi110120.
PROiQ4LEZ3.

Gene expression databases

BgeeiQ4LEZ3.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Novel gene containing alanine and arginine rich domain on human chromosome 8."
    Ishikawa S.K., Shimizu A., Yamazaki S., Asakawa S., Shimizu N.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-96.

Entry informationi

Entry nameiAARD_HUMAN
AccessioniPrimary (citable) accession number: Q4LEZ3
Secondary accession number(s): A5PKU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 2, 2005
Last modified: June 24, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.