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Protein

Alanine and arginine-rich domain-containing protein

Gene

AARD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-32285-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine and arginine-rich domain-containing protein
Gene namesi
Name:AARD
Synonyms:C8orf85
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:33842. AARD.

Pathology & Biotechi

Organism-specific databases

DisGeNETi441376.
OpenTargetsiENSG00000205002.
PharmGKBiPA164717502.

Polymorphism and mutation databases

BioMutaiAARD.
DMDMi121944377.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003370361 – 155Alanine and arginine-rich domain-containing proteinAdd BLAST155

Proteomic databases

PaxDbiQ4LEZ3.
PeptideAtlasiQ4LEZ3.
PRIDEiQ4LEZ3.

Expressioni

Gene expression databases

BgeeiENSG00000205002.

Organism-specific databases

HPAiHPA068290.

Interactioni

Protein-protein interaction databases

IntActiQ4LEZ3. 9 interactors.
STRINGi9606.ENSP00000367528.

Structurei

3D structure databases

ProteinModelPortaliQ4LEZ3.
SMRiQ4LEZ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi60 – 105Ala/Arg-richAdd BLAST46

Phylogenomic databases

eggNOGiENOG410J1H4. Eukaryota.
ENOG41119RY. LUCA.
GeneTreeiENSGT00390000007815.
HOGENOMiHOG000033743.
HOVERGENiHBG101169.
InParanoidiQ4LEZ3.
OMAiFQWAVQR.
OrthoDBiEOG091G0ZAU.
PhylomeDBiQ4LEZ3.
TreeFamiTF339066.

Sequencei

Sequence statusi: Complete.

Q4LEZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPGDFRRCR ERISQGLQGL PGRAELWFPP RPACDFFGDG RSTDIQEEAL
60 70 80 90 100
AASPLLEDLR RRLTRAFQWA VQRAISRRVQ EAAAAAAARE EQSWTGVEAT
110 120 130 140 150
LARLRAELVE MHFQNHQLAR TLLDLNMKVQ QLKKEYELEI TSDSQSPKDD

AANPE
Length:155
Mass (Da):17,575
Last modified:August 2, 2005 - v1
Checksum:i4D991ECA38D29531
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04357096G → R.1 PublicationCorresponds to variant rs16889283dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB181519 mRNA. Translation: BAE03184.1.
BC142621 mRNA. Translation: AAI42622.1.
CCDSiCCDS34935.1.
RefSeqiNP_001020528.1. NM_001025357.2.
UniGeneiHs.437551.

Genome annotation databases

EnsembliENST00000378279; ENSP00000367528; ENSG00000205002.
GeneIDi441376.
KEGGihsa:441376.
UCSCiuc003yof.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB181519 mRNA. Translation: BAE03184.1.
BC142621 mRNA. Translation: AAI42622.1.
CCDSiCCDS34935.1.
RefSeqiNP_001020528.1. NM_001025357.2.
UniGeneiHs.437551.

3D structure databases

ProteinModelPortaliQ4LEZ3.
SMRiQ4LEZ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ4LEZ3. 9 interactors.
STRINGi9606.ENSP00000367528.

Polymorphism and mutation databases

BioMutaiAARD.
DMDMi121944377.

Proteomic databases

PaxDbiQ4LEZ3.
PeptideAtlasiQ4LEZ3.
PRIDEiQ4LEZ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378279; ENSP00000367528; ENSG00000205002.
GeneIDi441376.
KEGGihsa:441376.
UCSCiuc003yof.4. human.

Organism-specific databases

CTDi441376.
DisGeNETi441376.
GeneCardsiAARD.
HGNCiHGNC:33842. AARD.
HPAiHPA068290.
neXtProtiNX_Q4LEZ3.
OpenTargetsiENSG00000205002.
PharmGKBiPA164717502.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1H4. Eukaryota.
ENOG41119RY. LUCA.
GeneTreeiENSGT00390000007815.
HOGENOMiHOG000033743.
HOVERGENiHBG101169.
InParanoidiQ4LEZ3.
OMAiFQWAVQR.
OrthoDBiEOG091G0ZAU.
PhylomeDBiQ4LEZ3.
TreeFamiTF339066.

Enzyme and pathway databases

BioCyciZFISH:G66-32285-MONOMER.

Miscellaneous databases

GenomeRNAii441376.
PROiQ4LEZ3.

Gene expression databases

BgeeiENSG00000205002.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiAARD_HUMAN
AccessioniPrimary (citable) accession number: Q4LEZ3
Secondary accession number(s): A5PKU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 2, 2005
Last modified: November 30, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.