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Q4LEZ3

- AARD_HUMAN

UniProt

Q4LEZ3 - AARD_HUMAN

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Protein

Alanine and arginine-rich domain-containing protein

Gene

AARD

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. lung development Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine and arginine-rich domain-containing protein
Gene namesi
Name:AARD
Synonyms:C8orf85
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:33842. AARD.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164717502.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 155155Alanine and arginine-rich domain-containing proteinPRO_0000337036Add
BLAST

Proteomic databases

PaxDbiQ4LEZ3.
PRIDEiQ4LEZ3.

Expressioni

Gene expression databases

BgeeiQ4LEZ3.
GenevestigatoriQ4LEZ3.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000367528.

Structurei

3D structure databases

ProteinModelPortaliQ4LEZ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi60 – 10546Ala/Arg-richAdd
BLAST

Phylogenomic databases

eggNOGiNOG133760.
GeneTreeiENSGT00390000007815.
HOGENOMiHOG000033743.
HOVERGENiHBG101169.
InParanoidiQ4LEZ3.
OMAiFQWAVQR.
OrthoDBiEOG7XWPQ8.
PhylomeDBiQ4LEZ3.
TreeFamiTF339066.

Sequencei

Sequence statusi: Complete.

Q4LEZ3 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGPGDFRRCR ERISQGLQGL PGRAELWFPP RPACDFFGDG RSTDIQEEAL
60 70 80 90 100
AASPLLEDLR RRLTRAFQWA VQRAISRRVQ EAAAAAAARE EQSWTGVEAT
110 120 130 140 150
LARLRAELVE MHFQNHQLAR TLLDLNMKVQ QLKKEYELEI TSDSQSPKDD

AANPE
Length:155
Mass (Da):17,575
Last modified:August 2, 2005 - v1
Checksum:i4D991ECA38D29531
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti96 – 961G → R.1 Publication
Corresponds to variant rs16889283 [ dbSNP | Ensembl ].
VAR_043570

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB181519 mRNA. Translation: BAE03184.1.
BC142621 mRNA. Translation: AAI42622.1.
CCDSiCCDS34935.1.
RefSeqiNP_001020528.1. NM_001025357.2.
UniGeneiHs.437551.

Genome annotation databases

EnsembliENST00000378279; ENSP00000367528; ENSG00000205002.
GeneIDi441376.
KEGGihsa:441376.
UCSCiuc003yof.3. human.

Polymorphism databases

DMDMi121944377.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB181519 mRNA. Translation: BAE03184.1 .
BC142621 mRNA. Translation: AAI42622.1 .
CCDSi CCDS34935.1.
RefSeqi NP_001020528.1. NM_001025357.2.
UniGenei Hs.437551.

3D structure databases

ProteinModelPortali Q4LEZ3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000367528.

Polymorphism databases

DMDMi 121944377.

Proteomic databases

PaxDbi Q4LEZ3.
PRIDEi Q4LEZ3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000378279 ; ENSP00000367528 ; ENSG00000205002 .
GeneIDi 441376.
KEGGi hsa:441376.
UCSCi uc003yof.3. human.

Organism-specific databases

CTDi 441376.
GeneCardsi GC08P117951.
HGNCi HGNC:33842. AARD.
neXtProti NX_Q4LEZ3.
PharmGKBi PA164717502.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG133760.
GeneTreei ENSGT00390000007815.
HOGENOMi HOG000033743.
HOVERGENi HBG101169.
InParanoidi Q4LEZ3.
OMAi FQWAVQR.
OrthoDBi EOG7XWPQ8.
PhylomeDBi Q4LEZ3.
TreeFami TF339066.

Miscellaneous databases

GenomeRNAii 441376.
NextBioi 110120.
PROi Q4LEZ3.

Gene expression databases

Bgeei Q4LEZ3.
Genevestigatori Q4LEZ3.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel gene containing alanine and arginine rich domain on human chromosome 8."
    Ishikawa S.K., Shimizu A., Yamazaki S., Asakawa S., Shimizu N.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-96.

Entry informationi

Entry nameiAARD_HUMAN
AccessioniPrimary (citable) accession number: Q4LEZ3
Secondary accession number(s): A5PKU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 2, 2005
Last modified: October 29, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3