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Protein

Ras-related protein Rab-27A

Gene

RAB27A

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 24GTPBy similarity9
Nucleotide bindingi74 – 78GTPBy similarity5
Nucleotide bindingi133 – 136GTPBy similarity4
Nucleotide bindingi163 – 165GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processExocytosis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SSC-6798695 Neutrophil degranulation
R-SSC-8873719 RAB geranylgeranylation
R-SSC-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-27A
Gene namesi
Name:RAB27A
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002362432 – 221Ras-related protein Rab-27AAdd BLAST220

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1
Disulfide bondi123 ↔ 188By similarity
Lipidationi219S-geranylgeranyl cysteineBy similarity1
Modified residuei221Cysteine methyl esterBy similarity1
Lipidationi221S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Disulfide bond, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiQ4LE85
PeptideAtlasiQ4LE85
PRIDEiQ4LE85

Expressioni

Gene expression databases

BgeeiENSSSCG00000004612

Interactioni

Subunit structurei

Binds SYTL1, SYTL2, SLAC2B, MYRIP, SYTL3, SYTL4 and SYTL5. Interacts with RPH3A and RPH3A. Binds MLPH. Interacts with UNC13D. Does not interact with the BLOC-3 complex (heterodimer of HPS1 and HPS4) (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000004969

Structurei

3D structure databases

ProteinModelPortaliQ4LE85
SMRiQ4LE85
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi38 – 46Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0081 Eukaryota
ENOG410XQ3T LUCA
GeneTreeiENSGT00890000139330
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ4LE85
KOiK07885
OMAiLVMQRIQ
OrthoDBiEOG091G0I51
TreeFamiTF312895

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4LE85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDGDYDYLI KFLALGDSGV GKTSVLYQYT DGKFNSKFIT TVGIDFREKR
60 70 80 90 100
VVYRANGPDG AIGRGQRIHL QLWDTAGQER FRSLTTAFFR DAMGFLLLFD
110 120 130 140 150
LTNEQSFLNV RNWISQLQMH AYCENPDIVL CGNKSDLEDQ RVVKEEEARG
160 170 180 190 200
LAEKYGIPYF ETSAANGTNV SLAIETLLDL IMKRMERCVD KSWIPEGVVR
210 220
SNGHTSADPL NEEKEKGSCG C
Length:221
Mass (Da):24,889
Last modified:August 2, 2005 - v1
Checksum:i7A958EE0014657FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209958 mRNA Translation: BAE03308.1
RefSeqiNP_001027528.1, NM_001032357.1
XP_005659637.1, XM_005659580.2
XP_005659638.1, XM_005659581.2
XP_005659639.1, XM_005659582.2
XP_005659640.1, XM_005659583.2
XP_005659641.1, XM_005659584.2
XP_005659642.1, XM_005659585.2
XP_013848417.1, XM_013992963.1
XP_013848418.1, XM_013992964.1
XP_013848419.1, XM_013992965.1
XP_013848420.1, XM_013992966.1
XP_013848422.1, XM_013992968.1
UniGeneiSsc.54872

Genome annotation databases

EnsembliENSSSCT00000005093; ENSSSCP00000004969; ENSSSCG00000004612
ENSSSCT00000037937; ENSSSCP00000047735; ENSSSCG00000004612
ENSSSCT00000038357; ENSSSCP00000041641; ENSSSCG00000004612
ENSSSCT00000041011; ENSSSCP00000059014; ENSSSCG00000004612
ENSSSCT00000055502; ENSSSCP00000046520; ENSSSCG00000004612
ENSSSCT00000057291; ENSSSCP00000033260; ENSSSCG00000004612
ENSSSCT00000059651; ENSSSCP00000031594; ENSSSCG00000004612
ENSSSCT00000060087; ENSSSCP00000048461; ENSSSCG00000004612
GeneIDi606749
KEGGissc:606749

Similar proteinsi

Entry informationi

Entry nameiRB27A_PIG
AccessioniPrimary (citable) accession number: Q4LE85
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: August 2, 2005
Last modified: February 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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