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Protein
Submitted name:

UNC13B variant protein

Gene

UNC13B variant protein

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
UNC13B variant proteinImported
Gene namesi
Name:UNC13B variant proteinImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37203.

PTM / Processingi

Proteomic databases

PaxDbiQ4LE73.
PRIDEiQ4LE73.

Expressioni

Gene expression databases

GenevisibleiQ4LE73. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000367756.

Structurei

3D structure databases

ProteinModelPortaliQ4LE73.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini506 – 55651Phorbol-ester/DAG-typeInterPro annotationAdd
BLAST
Domaini630 – 72293C2InterPro annotationAdd
BLAST
Domaini1042 – 1185144MHD1 (MUNC13 homology domain 1)InterPro annotationAdd
BLAST
Domaini1292 – 1434143MHD2 (MUNC13 homology domain 2)InterPro annotationAdd
BLAST
Domaini1468 – 155992C2InterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 2 C2 domains.UniRule annotation

Phylogenomic databases

eggNOGiKOG1011. Eukaryota.
ENOG410XS5D. LUCA.
HOGENOMiHOG000231404.
HOVERGENiHBG057340.
KOiK15293.

Family and domain databases

Gene3Di2.60.40.150. 3 hits.
InterProiIPR000008. C2_dom.
IPR010439. CAPS_dom.
IPR014770. Munc13_1.
IPR014772. Munc13_dom-2.
IPR019558. Munc13_subgr_dom-2.
IPR002219. PE/DAG-bd.
IPR027080. Unc-13.
[Graphical view]
PANTHERiPTHR10480. PTHR10480. 1 hit.
PfamiPF00130. C1_1. 1 hit.
PF00168. C2. 3 hits.
PF06292. DUF1041. 1 hit.
PF10540. Membr_traf_MHD. 1 hit.
[Graphical view]
PRINTSiPR00360. C2DOMAIN.
SMARTiSM00109. C1. 1 hit.
SM00239. C2. 3 hits.
SM01145. DUF1041. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 3 hits.
PROSITEiPS50004. C2. 2 hits.
PS51258. MHD1. 1 hit.
PS51259. MHD2. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q4LE73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
REQSRHLLRG KRERSGAAGA RQRLARSSAM SLLCVRVKRA KFQGSPDKFN
60 70 80 90 100
TYVTLKVQNV KSTTVAVRGD QPSWEQDFMF EISRLDLGLS VEVWNKGLIW
110 120 130 140 150
DTMVGTVWIA LKTIRQSDEE GPGEWSTLEA ETLMKDDEIC GTRNPTPHKI
160 170 180 190 200
LLDTRFELPF DIPEEEARYW TYKWEQINAL GADNEYSSQE ESQRKPLPTA
210 220 230 240 250
AAQCSFEDPD SAVDDRDSDY RSETSNSFPP PYHTASQPNA SVHQFPVPVR
260 270 280 290 300
SPQQLLLQGS SRDSCNDSMQ SYDLDYPERR AISPTSSSRY GSSCNVSQGS
310 320 330 340 350
SQLSELDQYH EQDDDHRETD SIHSCHSSHS LSRDGQAGFG EQEKPLEVTG
360 370 380 390 400
QAEKEAACEP KEMKEDATTH PPPDLVLQKD HFLGPQESFP EENASSPFTQ
410 420 430 440 450
ARAHWIRAVT KVRLQLQEIP DDGDPSLPQW LPEGPAGGLY GIDSMPDLRR
460 470 480 490 500
KKPLPLVSDL SLVQSRKAGI TSAMATRTSL KDEELKSHVY KKTLQALIYP
510 520 530 540 550
ISCTTPHNFE VWTATTPTYC YECEGLLWGI ARQGMRCSEC GVKCHEKCQD
560 570 580 590 600
LLNADCLQRA AEKSCKHGAE DRTQNIIMAM KDRMKIRERN KPEIFEVIRD
610 620 630 640 650
VFTVNKAAHV QQMKTVKQSV LDGTSKWSAK ITITVVCAQG LQAKDKTGSS
660 670 680 690 700
DPYVTVQVSK TKKRTKTIFG NLNPVWEEKF HFECHNSSDR IKVRVWDEDD
710 720 730 740 750
DIKSRVKQRL KRESDDFLGQ TIIEVRTLSG EMDVWYNLEK RTDKSAVSGA
760 770 780 790 800
IRLQISVEIK GEEKVAPYHV QYTCLHENLF HYLTDIQGSG GVRIPEARGD
810 820 830 840 850
DAWKVYFDET AQEIVDEFAM RYGIESIYQA MTHFACLSSK YMCPGVPAVM
860 870 880 890 900
STLLANINAY YAHTTASTNV SASDRFAASN FGKERFVKLL DQLHNSLRID
910 920 930 940 950
LSTYRNNFPA GSPERLQDLK STVDLLTSIT FFRMKVQELQ SPPRASQVVK
960 970 980 990 1000
DCVKACLNST YEYIFNNCHD LYSRQYQLKQ ELPPEEQGPS IRNLDFWPKL
1010 1020 1030 1040 1050
ITLIVSIIEE DKNSYTPVLN QFPQELNVGK VSAEVMWHLF AQDMKYALEE
1060 1070 1080 1090 1100
HEKDHLCKSA DYMNLHFKVK WLHNEYVRDL PVLQGQVPEY PAWFEQFVLQ
1110 1120 1130 1140 1150
WLDENEDVSL EFLRGALERD KKDGFQQTSE HALFSCSVVD VFTQLNQSFE
1160 1170 1180 1190 1200
IIRKLECPDP SILAHYMRRF AKTIGKVLMQ YADILSKDFP AYCTKEKLPC
1210 1220 1230 1240 1250
ILMNNVQQLR VQLEKMFEAM GGKELDLEAA DSLKELQVKL NTVLDELSMV
1260 1270 1280 1290 1300
FGNSFQVRID ECVRQMADIL GQVRGTGNAS PDARASAAQD ADSVLRPLMD
1310 1320 1330 1340 1350
FLDGNLTLFA TVCEKTVLKR VLKELWRVVM NTMERMIVLP PLTDQTGTQL
1360 1370 1380 1390 1400
IFTAAKELSH LSKLKDHMVR EETRNLTPKQ CAVLDLALDT IKQYFHAGGN
1410 1420 1430 1440 1450
GLKKTFLEKS PDLQSLRYAL SLYTQTTDTL IKTFVRSQTT QGSGVDDPVG
1460 1470 1480 1490 1500
EVSIQVDLFT HPGTGEHKVT VKVVAANDLK WQTAGMFRPF VEVTMVGPHQ
1510 1520 1530 1540 1550
SDKKRKFTTK SKSNNWAPKY NETFHFLLGN EEGPESYELQ ICVKDYYFAR
1560 1570 1580 1590 1600
EDRVLGLAVM PLRDVTAKGS CACWCPLGRK IHMDETGLTI LRILSQRSND
1610 1620
EVAREFVKLK SESRSTEEGS
Length:1,620
Mass (Da):183,982
Last modified:August 2, 2005 - v1
Checksum:iB79410CA32B65F4C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209998 mRNA. Translation: BAE06080.1.
RefSeqiNP_006368.3. NM_006377.3.
UniGeneiHs.493791.

Genome annotation databases

GeneIDi10497.
KEGGihsa:10497.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209998 mRNA. Translation: BAE06080.1.
RefSeqiNP_006368.3. NM_006377.3.
UniGeneiHs.493791.

3D structure databases

ProteinModelPortaliQ4LE73.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000367756.

Proteomic databases

PaxDbiQ4LE73.
PRIDEiQ4LE73.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi10497.
KEGGihsa:10497.

Organism-specific databases

CTDi10497.
PharmGKBiPA37203.

Phylogenomic databases

eggNOGiKOG1011. Eukaryota.
ENOG410XS5D. LUCA.
HOGENOMiHOG000231404.
HOVERGENiHBG057340.
KOiK15293.

Miscellaneous databases

ChiTaRSiUNC13B. human.
GenomeRNAii10497.

Gene expression databases

GenevisibleiQ4LE73. HS.

Family and domain databases

Gene3Di2.60.40.150. 3 hits.
InterProiIPR000008. C2_dom.
IPR010439. CAPS_dom.
IPR014770. Munc13_1.
IPR014772. Munc13_dom-2.
IPR019558. Munc13_subgr_dom-2.
IPR002219. PE/DAG-bd.
IPR027080. Unc-13.
[Graphical view]
PANTHERiPTHR10480. PTHR10480. 1 hit.
PfamiPF00130. C1_1. 1 hit.
PF00168. C2. 3 hits.
PF06292. DUF1041. 1 hit.
PF10540. Membr_traf_MHD. 1 hit.
[Graphical view]
PRINTSiPR00360. C2DOMAIN.
SMARTiSM00109. C1. 1 hit.
SM00239. C2. 3 hits.
SM01145. DUF1041. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 3 hits.
PROSITEiPS50004. C2. 2 hits.
PS51258. MHD1. 1 hit.
PS51259. MHD2. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ4LE73_HUMAN
AccessioniPrimary (citable) accession number: Q4LE73
Entry historyi
Integrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: September 7, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.