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Protein
Submitted name:

APC variant protein

Gene

APC variant protein

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ4LE70.

Names & Taxonomyi

Protein namesi
Submitted name:
APC variant proteinImported
Gene namesi
Name:APC variant proteinImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24875.

PTM / Processingi

Proteomic databases

PaxDbiQ4LE70.
PeptideAtlasiQ4LE70.
PRIDEiQ4LE70.

Expressioni

Gene expression databases

BgeeiQ4LE70.
GenevisibleiQ4LE70. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000257430.

Structurei

3D structure databases

ProteinModelPortaliQ4LE70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 5752APC_N_CCInterPro annotationAdd
BLAST
Domaini2226 – 2577352APC_basicInterPro annotationAdd
BLAST
Domaini2672 – 2845174EB1_bindingInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili8 – 5649Sequence analysisAdd
BLAST
Coiled coili136 – 17035Sequence analysisAdd
BLAST
Coiled coili1873 – 189624Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG2122. Eukaryota.
ENOG410XR2V. LUCA.
HOGENOMiHOG000033986.
HOVERGENiHBG004264.
KOiK02085.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR026836. APC.
IPR009240. APC_15aa_rpt.
IPR009234. APC_basic_dom.
IPR026831. APC_dom.
IPR026818. Apc_fam.
IPR032038. APC_N.
IPR009223. APC_rpt.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR009232. EB1-bd.
IPR009224. SAMP.
[Graphical view]
PANTHERiPTHR12607. PTHR12607. 2 hits.
PTHR12607:SF11. PTHR12607:SF11. 2 hits.
PfamiPF05972. APC_15aa. 3 hits.
PF05956. APC_basic. 1 hit.
PF05923. APC_crr. 7 hits.
PF16689. APC_N_CC. 1 hit.
PF00514. Arm. 2 hits.
PF05937. EB1_binding. 1 hit.
PF05924. SAMP. 3 hits.
[Graphical view]
SMARTiSM00185. ARM. 7 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF58050. SSF58050. 1 hit.
SSF82931. SSF82931. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q4LE70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PRMAAASYDQ LLKQVEALKM ENSNLRQELE DNSNHLTKLE TEASNMKEVL
60 70 80 90 100
KQLQGSIEDE AMASSGQIDL LERLKELNLD SSNFPGVKLR SKMSLRSYGS
110 120 130 140 150
REGSVSSRSG ECSPVPMGSF PRRGFVNGSR ESTGYLEELE KERSLLLADL
160 170 180 190 200
DKEEKEKDWY YAQLQNLTKR IDSLPLTENF SLQTDMTRRQ LEYEARQIRV
210 220 230 240 250
AMEEQLGTCQ DMEKRAQRRI ARIQQIEKDI LRIRQLLQSQ ATEAERSSQN
260 270 280 290 300
KHETGSHDAE RQNEGQGVGE INMATSGNGQ GSTTRMDHET ASVLSSSSTH
310 320 330 340 350
SAPRRLTSHL GTKVEMVYSL LSMLGTHDKD DMSRTLLAMS SSQDSCISMR
360 370 380 390 400
QSGCLPLLIQ LLHGNDKDSV LLGNSRGSKE ARARASAALH NIIHSQPDDK
410 420 430 440 450
RGRREIRVLH LLEQIRAYCE TCWEWQEAHE PGMDQDKNPM PAPVEHQICP
460 470 480 490 500
AVCVLMKLSF DEEHRHAMNE LGGLQAIAEL LQVDCEMYGL TNDHYSITLR
510 520 530 540 550
RYAGMALTNL TFGDVANKAT LCSMKGCMRA LVAQLKSESE DLQQVIASVL
560 570 580 590 600
RNLSWRADVN SKKTLREVGS VKALMECALE VKKESTLKSV LSALWNLSAH
610 620 630 640 650
CTENKADICA VDGALAFLVG TLTYRSQTNT LAIIESGGGI LRNVSSLIAT
660 670 680 690 700
NEDHRQILRE NNCLQTLLQH LKSHSLTIVS NACGTLWNLS ARNPKDQEAL
710 720 730 740 750
WDMGAVSMLK NLIHSKHKMI AMGSAAALRN LMANRPAKYK DANIMSPGSS
760 770 780 790 800
LPSLHVRKQK ALEAELDAQH LSETFDNIDN LSPKASHRSK QRHKQSLYGD
810 820 830 840 850
YVFDTNRHDD NRSDNFNTGN MTVLSPYLNT TVLPSSSSSR GSLDSSRSEK
860 870 880 890 900
DRSLERERGI GLGNYHPATE NPGTSSKRGL QISTTAAQIA KVMEEVSAIH
910 920 930 940 950
TSQEDRSSGS TTELHCVTDE RNALRRSSAA HTHSNTYNFT KSENSNRTCS
960 970 980 990 1000
MPYAKLEYKR SSNDSLNSVS SSDGYGKRGQ MKPSIESYSE DDESKFCSYG
1010 1020 1030 1040 1050
QYPADLAHKI HSANHMDDND GELDTPINYS LKYSDEQLNS GRQSPSQNER
1060 1070 1080 1090 1100
WARPKHIIED EIKQSEQRQS RNQSTTYPVY TESTDDKHLK FQPHFGQQEC
1110 1120 1130 1140 1150
VSPYRSRGAN GSETNRVGSN HGINQNVSQS LCQEDDYEDD KPTNYSERYS
1160 1170 1180 1190 1200
EEEQHEEEER PTNYSIKYNE EKRHVDQPID YSLKYATDIP SSQKQSFSFS
1210 1220 1230 1240 1250
KSSSGQSSKT EHMSSSSENT STPSSNAKRQ NQLHPSSAQS RSGQPQKAAT
1260 1270 1280 1290 1300
CKVSSINQET IQTYCVEDTP ICFSRCSSLS SLSSAEDEIG CNQTTQEADS
1310 1320 1330 1340 1350
ANTLQIAEIK EKIGTRSAED PVSEVPAVSQ HPRTKSSRLQ GSSLSSESAR
1360 1370 1380 1390 1400
HKAVEFSSGA KSPSKSGAQT PKSPPEHYVQ ETPLMFSRCT SVSSLDSFES
1410 1420 1430 1440 1450
RSIASSVQSE PCSGMVSGII SPSDLPDSPG QTMPPSRSKT PPPPPQTAQT
1460 1470 1480 1490 1500
KREVPKNKAP TAEKRESGPK QAAVNAAVQR VQVLPDADTL LHFATESTPD
1510 1520 1530 1540 1550
GFSCSSSLSA LSLDEPFIQK DVELRIMPPV QENDNGNETE SEQPKESNEN
1560 1570 1580 1590 1600
QEKEAEKTID SEKDLLDDSD DDDIEILEEC IISAMPTKSS RKAKKPAQTA
1610 1620 1630 1640 1650
SKLPPPVARK PSQLPVYKLL PSQNRLQPQK HVSFTPGDDM PRVYCVEGTP
1660 1670 1680 1690 1700
INFSTATSLS DLTIESPPNE LAAGEGVRGG AQSGEFEKRD TIPTEGRSTD
1710 1720 1730 1740 1750
EAQGGKTSSV TIPELDDNKA EEGDILAECI NSAMPKGKSH KPFRVKKIMD
1760 1770 1780 1790 1800
QVQQASASSS APNKNQLDGK KKKPTSPVKP IPQNTEYRTR VRKNADSKNN
1810 1820 1830 1840 1850
LNAERVFSDN KDSKKQNLKN NSKVFNDKLP NNEDRVRGSF AFDSPHHYTP
1860 1870 1880 1890 1900
IEGTPYCFSR NDSLSSLDFD DDDVDLSREK AELRKAKENK ESEAKVTSHT
1910 1920 1930 1940 1950
ELTSNQQSAN KTQAIAKQPI NRGQPKPILQ KQSTFPQSSK DIPDRGAATD
1960 1970 1980 1990 2000
EKLQNFAIEN TPVCFSHNSS LSSLSDIDQE NNNKENEPIK ETEPPDSQGE
2010 2020 2030 2040 2050
PSKPQASGYA PKSFHVEDTP VCFSRNSSLS SLSIDSEDDL LQECISSAMP
2060 2070 2080 2090 2100
KKKKPSRLKG DNEKHSPRNM GGILGEDLTL DLKDIQRPDS EHGLSPDSEN
2110 2120 2130 2140 2150
FDWKAIQEGA NSIVSSLHQA AAAACLSRQA SSDSDSILSL KSGISLGSPF
2160 2170 2180 2190 2200
HLTPDQEEKP FTSNKGPRIL KPGEKSTLET KKIESESKGI KGGKKVYKSL
2210 2220 2230 2240 2250
ITGKVRSNSE ISGQMKQPLQ ANMPSISRGR TMIHIPGVRN SSSSTSPVSK
2260 2270 2280 2290 2300
KGPPLKTPAS KSPSEGQTAT TSPRGAKPSV KSELSPVARQ TSQIGGSSKA
2310 2320 2330 2340 2350
PSRSGSRDST PSRPAQQPLS RPIQSPGRNS ISPGRNGISP PNKLSQLPRT
2360 2370 2380 2390 2400
SSPSTASTKS SGSGKMSYTS PGRQMSQQNL TKQTGLSKNA SSIPRSESAS
2410 2420 2430 2440 2450
KGLNQMNNGN GANKKVELSR MSSTKSSGSE SDRSERPVLV RQSTFIKEAP
2460 2470 2480 2490 2500
SPTLRRKLEE SASFESLSPS SRPASPTRSQ AQTPVLSPSL PDMSLSTHSS
2510 2520 2530 2540 2550
VQAGGWRKLP PNLSPTIEYN DGRPAKRHDI ARSHSESPSR LPINRSGTWK
2560 2570 2580 2590 2600
REHSKHSSSL PRVSTWRRTG SSSSILSASS ESSEKAKSED EKHVNSISGT
2610 2620 2630 2640 2650
KQSKENQVSA KGTWRKIKEN EFSPTNSTSQ TVSSGATNGA ESKTLIYQMA
2660 2670 2680 2690 2700
PAVSKTEDVW VRIEDCPINN PRSGRSPTGN TPPVIDSVSE KANPNIKDSK
2710 2720 2730 2740 2750
DNQAKQNVGN GSVPMRTVGL ENRLNSFIQV DAPDQKGTEI KPGQNNPVPV
2760 2770 2780 2790 2800
SETNESSIVE RTPFSSSSSS KHSSPSGTVA ARVTPFNYNP SPRKSSADST
2810 2820 2830 2840
SARPSQIPTP VNNNTKKRDS KTDSTESSGT QSPKRHSGSY LVTSV
Length:2,845
Mass (Da):311,899
Last modified:August 2, 2005 - v1
Checksum:iB83A16839FB61181
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB210001 mRNA. Translation: BAE06083.1.
RefSeqiNP_000029.2. NM_000038.5.
NP_001120982.1. NM_001127510.2.
NP_001120983.2. NM_001127511.2.
UniGeneiHs.158932.

Genome annotation databases

GeneIDi324.
KEGGihsa:324.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB210001 mRNA. Translation: BAE06083.1.
RefSeqiNP_000029.2. NM_000038.5.
NP_001120982.1. NM_001127510.2.
NP_001120983.2. NM_001127511.2.
UniGeneiHs.158932.

3D structure databases

ProteinModelPortaliQ4LE70.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000257430.

Proteomic databases

PaxDbiQ4LE70.
PeptideAtlasiQ4LE70.
PRIDEiQ4LE70.

Protocols and materials databases

DNASUi324.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi324.
KEGGihsa:324.

Organism-specific databases

CTDi324.
PharmGKBiPA24875.

Phylogenomic databases

eggNOGiKOG2122. Eukaryota.
ENOG410XR2V. LUCA.
HOGENOMiHOG000033986.
HOVERGENiHBG004264.
KOiK02085.

Enzyme and pathway databases

SignaLinkiQ4LE70.

Miscellaneous databases

ChiTaRSiAPC. human.
GenomeRNAii324.

Gene expression databases

BgeeiQ4LE70.
GenevisibleiQ4LE70. HS.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR026836. APC.
IPR009240. APC_15aa_rpt.
IPR009234. APC_basic_dom.
IPR026831. APC_dom.
IPR026818. Apc_fam.
IPR032038. APC_N.
IPR009223. APC_rpt.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR009232. EB1-bd.
IPR009224. SAMP.
[Graphical view]
PANTHERiPTHR12607. PTHR12607. 2 hits.
PTHR12607:SF11. PTHR12607:SF11. 2 hits.
PfamiPF05972. APC_15aa. 3 hits.
PF05956. APC_basic. 1 hit.
PF05923. APC_crr. 7 hits.
PF16689. APC_N_CC. 1 hit.
PF00514. Arm. 2 hits.
PF05937. EB1_binding. 1 hit.
PF05924. SAMP. 3 hits.
[Graphical view]
SMARTiSM00185. ARM. 7 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF58050. SSF58050. 1 hit.
SSF82931. SSF82931. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method."
    Nakajima D., Saito K., Yamakawa H., Kikuno R.F., Nakayama M., Ohara R., Okazaki N., Koga H., Nagase T., Ohara O.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiQ4LE70_HUMAN
AccessioniPrimary (citable) accession number: Q4LE70
Entry historyi
Integrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: July 6, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.