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Protein
Submitted name:

PIK4CA variant protein

Gene

PIK4CA variant protein

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotation, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
PIK4CA variant proteinImported
Gene namesi
Name:PIK4CA variant proteinImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162399305.

PTM / Processingi

Proteomic databases

PaxDbiQ4LE69.
PRIDEiQ4LE69.

Expressioni

Gene expression databases

BgeeiQ4LE69.
GenevisibleiQ4LE69. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000458238.

Structurei

3D structure databases

ProteinModelPortaliQ4LE69.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1549 – 1737189PIK helicalInterPro annotationAdd
BLAST
Domaini1864 – 2121258PI3K/PI4KInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.SAAS annotation
Contains PI3K/PI4K domain.SAAS annotation
Contains PIK helical domain.SAAS annotation

Phylogenomic databases

eggNOGiKOG0902. Eukaryota.
COG5032. LUCA.
HOGENOMiHOG000007272.
HOVERGENiHBG052742.
KOiK00888.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 5 hits.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view]
SMARTiSM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 6 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q4LE69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GRSRARSGEP AGSAAAREVM AAAPARGGGG GGGGGGGCSG SGSSASRGFY
60 70 80 90 100
FNTVLSLARS LAVQRPASLE KVQKLLCMCP VDFHGIFQLD ERRRDAVIAL
110 120 130 140 150
GIFLIESDLQ HKDCVVPYLL RLLKGLPKVY WVEESTARKG RGALPVAESF
160 170 180 190 200
SFCLVTLLSD VAYRDPSLRD EILEVLLQVL HVLLGMCQAL EIQDKEYLCK
210 220 230 240 250
YAIPCLIGIS RAFGRYSNME ESLLSKLFPK IPPHSLRVLE ELEGVRRRSF
260 270 280 290 300
NDFRSILPSN LLTVCQEGTL KRKTSSVSSI SQVSPERGMP PPSSPGGSAF
310 320 330 340 350
HYFEASCLPD GTALEPEYYF STISSSFSVS PLFNGVTYKE FNIPLEMLRE
360 370 380 390 400
LLNLVKKIVE EAVLKSLDAI VASVMEANPS ADLYYTSFSD PLYLTMFKML
410 420 430 440 450
RDTLYYMKDL PTSFVKEIHD FVLEQFNTSQ GELQKILHDA DRIHNELSPL
460 470 480 490 500
KLRCQANAAC VDLMVWAVKD EQGAENLCIK LSEKLQSKTS SKVIIAHLPL
510 520 530 540 550
LICCLQGLGR LCERFPVVVH SVTPSLRDFL VIPSPVLVKL YKYHSQYHTV
560 570 580 590 600
AGNDIKISVT NEHSESTLNV MSGKKSQPSM YEQLRDIAID NICRCLKAGL
610 620 630 640 650
TVDPVIVEAF LASLSNRLYI SQESDKDAHL IPDHTIRALG HIAVALRDTP
660 670 680 690 700
KVMEPILQIL QQKFCQPPSP LDVLIIDQLG CLVITGNQYI YQEVWNLFQQ
710 720 730 740 750
ISVKASSVVY SATKDYKDHG YRHCSLAVIN ALANIAANIQ DEHLVDELLM
760 770 780 790 800
NLLELFVQLG LEGKRASERA SEKGPALKAS SSAGNLGVLI PVIAVLTRRL
810 820 830 840 850
PPIKEAKPRL QKLFRDFWLY SVLMGFAVEG SGLWPEEWYE GVCEIATKSP
860 870 880 890 900
LLTFPSKEPL RSVLQYNSAM KNDTVTPAEL SELRSTIINL LDPPPEVSAL
910 920 930 940 950
INKLDFAMST YLLSVYRLEY MRVLRSTDPD RFQVMFCYFE DKAIQKDKSG
960 970 980 990 1000
MMQCVIAVAD KVFDAFLNMM ADKAKTKENE EELERHAQFL LVNFNHIHKR
1010 1020 1030 1040 1050
IRRVADKYLS GLVDKFPHLL WSGTVLKTML DILQTLSLSL SADIHKDQPY
1060 1070 1080 1090 1100
YDIPDAPYRI TVPDTYEARE SIVKDFAARC GMILQEAMKW APTVTKSHLQ
1110 1120 1130 1140 1150
EYLNKHQNWV SGLSQHTGLA MATESILHFA GYNKQNTTLG ATQLSERPAC
1160 1170 1180 1190 1200
VKKDYSNFMA SLNLRNRYAG EVYGMIRFSG TTGQMSDLNK MMVQDLHSAL
1210 1220 1230 1240 1250
DRSHPQHYTQ AMFKLTAMLI SSKDCDPQLL HHLCWGPLRM FNEHGMETAL
1260 1270 1280 1290 1300
ACWEWLLAGK DGVEVPFMRE MAGAWHMTVE QKFGLFSAEI KEADPLAASE
1310 1320 1330 1340 1350
ASQPKPCPPE VTPHYIWIDF LVQRFEIAKY CSSDQVEIFS SLLQRSMSLN
1360 1370 1380 1390 1400
IGGAKGSMNR HVAAIGPRFK LLTLGLSLLH ADVVPNATIR NVLREKIYST
1410 1420 1430 1440 1450
AFDYFSCPPK FPTQGEKRLR EDISIMIKFW TAMFSDKKYL TASQLVPPDN
1460 1470 1480 1490 1500
QDTRSNLDIT VGSRQQATQG WINTYPLSSG MSTISKKSGM SKKTNRGSQL
1510 1520 1530 1540 1550
HKYYMKRRTL LLSLLATEIE RLITWYNPLS APELELDQAG ENSVANWRSK
1560 1570 1580 1590 1600
YISLSEKQWK DNVNLAWSIS PYLAVQLPAR FKNTEAIGNE VTRLVRLDPG
1610 1620 1630 1640 1650
AVSDVPEAIK FLVTWHTIDA DAPELSHVLC WAPTDPPTGL SYFSSMYPPH
1660 1670 1680 1690 1700
PLTAQYGVKV LRSFPPDAIL FYIPQIVQAL RYDKMGYVRE YILWAASKSQ
1710 1720 1730 1740 1750
LLAHQFIWNM KTNIYLDEEG HQKDPDIGDL LDQLVEEITG SLSGPAKDFY
1760 1770 1780 1790 1800
QREFDFFNKI TNVSAIIKPY PKGDERKKAC LSALSEVKVQ PGCYLPSNPE
1810 1820 1830 1840 1850
AIVLDIDYKS GTPMQSAAKA PYLAKFKVKR CGVSELEKEG LRCRSDSEDE
1860 1870 1880 1890 1900
CSTQEADGQK ISWQAAIFKV GDDCRQDMLA LQIIDLFKNI FQLVGLDLFV
1910 1920 1930 1940 1950
FPYRVVATAP GCGVIECIPD CTSRDQLGRQ TDFGMYDYFT RQYGDESTLA
1960 1970 1980 1990 2000
FQQARYNFIR SMAAYSLLLF LLQIKDRHNG NIMLDKKGHI IHIDFGFMFE
2010 2020 2030 2040 2050
SSPGGNLGWE PDIKLTDEMV MIMGGKMEAT PFKWFMEMCV RGYLAVRPYM
2060 2070 2080 2090 2100
DAVVSLVTLM LDTGLPCFRG QTIKLLKHRF SPNMTEREAA NFIMKVIQSC
2110 2120
FLSNRSRTYD MIQYYQNDIP Y
Length:2,121
Mass (Da):238,697
Last modified:August 2, 2005 - v1
Checksum:i5B3CEC2D4645DFB6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB210002 mRNA. Translation: BAE06084.1.
RefSeqiNP_477352.3. NM_058004.3.
UniGeneiHs.529438.
Hs.731386.

Genome annotation databases

GeneIDi5297.
KEGGihsa:5297.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB210002 mRNA. Translation: BAE06084.1.
RefSeqiNP_477352.3. NM_058004.3.
UniGeneiHs.529438.
Hs.731386.

3D structure databases

ProteinModelPortaliQ4LE69.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000458238.

Proteomic databases

PaxDbiQ4LE69.
PRIDEiQ4LE69.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5297.
KEGGihsa:5297.

Organism-specific databases

CTDi5297.
PharmGKBiPA162399305.

Phylogenomic databases

eggNOGiKOG0902. Eukaryota.
COG5032. LUCA.
HOGENOMiHOG000007272.
HOVERGENiHBG052742.
KOiK00888.

Miscellaneous databases

ChiTaRSiPI4KA. human.
GenomeRNAii5297.

Gene expression databases

BgeeiQ4LE69.
GenevisibleiQ4LE69. HS.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 5 hits.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view]
SMARTiSM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 6 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method."
    Nakajima D., Saito K., Yamakawa H., Kikuno R.F., Nakayama M., Ohara R., Okazaki N., Koga H., Nagase T., Ohara O.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiQ4LE69_HUMAN
AccessioniPrimary (citable) accession number: Q4LE69
Entry historyi
Integrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: June 8, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.