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Protein
Submitted name:

NUMA1 variant protein

Gene

NUMA1 variant protein

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Submitted name:
NUMA1 variant proteinImported
Gene namesi
Name:NUMA1 variant proteinImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31844.

PTM / Processingi

Proteomic databases

PaxDbiQ4LE64.
PeptideAtlasiQ4LE64.
PRIDEiQ4LE64.

Expressioni

Gene expression databases

BgeeiQ4LE64.
GenevisibleiQ4LE64. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000377298.

Structurei

3D structure databases

ProteinModelPortaliQ4LE64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili222 – 25635Sequence analysisAdd
BLAST
Coiled coili284 – 32542Sequence analysisAdd
BLAST
Coiled coili333 – 40674Sequence analysisAdd
BLAST
Coiled coili421 – 45535Sequence analysisAdd
BLAST
Coiled coili474 – 49724Sequence analysisAdd
BLAST
Coiled coili506 – 783278Sequence analysisAdd
BLAST
Coiled coili795 – 82935Sequence analysisAdd
BLAST
Coiled coili834 – 86835Sequence analysisAdd
BLAST
Coiled coili873 – 92856Sequence analysisAdd
BLAST
Coiled coili973 – 104674Sequence analysisAdd
BLAST
Coiled coili1072 – 110635Sequence analysisAdd
BLAST
Coiled coili1128 – 116235Sequence analysisAdd
BLAST
Coiled coili1177 – 121135Sequence analysisAdd
BLAST
Coiled coili1219 – 128163Sequence analysisAdd
BLAST
Coiled coili1286 – 134156Sequence analysisAdd
BLAST
Coiled coili1373 – 141139Sequence analysisAdd
BLAST
Coiled coili1415 – 144935Sequence analysisAdd
BLAST
Coiled coili1468 – 151750Sequence analysisAdd
BLAST
Coiled coili1522 – 154928Sequence analysisAdd
BLAST
Coiled coili1578 – 1699122Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410IFJ8. Eukaryota.
ENOG41125FF. LUCA.
HOGENOMiHOG000113889.
HOVERGENiHBG052694.
KOiK16808.

Family and domain databases

InterProiIPR026650. NUMA1.
[Graphical view]
PANTHERiPTHR18902:SF24. PTHR18902:SF24. 7 hits.

Sequencei

Sequence statusi: Fragment.

Q4LE64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LSGITKMTLH ATRGAALLSW VNSLHVADPV EAVLQLQDCS IFIKIIDRIH
60 70 80 90 100
GTEEGQQILK QPVSERLDFV CSFLQKNRKH PSSPECLVSA QKVLEGSELE
110 120 130 140 150
LAKMTMLLLY HSTMSSKSPR DWEQFEYKIQ AELAVILKFV LDHEDGLNLN
160 170 180 190 200
EDLENFLQKA PVPSTCSSTF PEELSPPSHQ AKREIRFLEL QKVASSSSGN
210 220 230 240 250
NFLSGSPASP MGDILQTPQF QMRRLKKQLA DERSNRDELE LELAENRKLL
260 270 280 290 300
TEKDAQIAMM QQRIDRLALL NEKQAASPLE PKELEELRDK NESLTMRLHE
310 320 330 340 350
TLKQCQDLKT EKSQMDRKIN QLSEENGDLS FKLREFASHL QQLQDALNEL
360 370 380 390 400
TEEHSKATQE WLEKQAQLEK ELSAALQDKK CLEEKNEILQ GKLSQLEEHL
410 420 430 440 450
SQLQDNPPQE KGEVLGDVLQ LETLKQEAAT LAANNTQLQA RVEMLETERG
460 470 480 490 500
QQEAKLLAER GHFEEEKQQL SSLITDLQSS ISNLSQAKEE LEQASQAHGA
510 520 530 540 550
RLTAQVASLT SELTTLNATI QQQDQELAGL KQQAKEKQAQ LAQTLQQQEQ
560 570 580 590 600
ASQGLRHQVE QLSSSLKQKE QQLKEVAEKQ EATRQDHAQQ LATAAEEREA
610 620 630 640 650
SLRERDAALK QLEALEKEKA AKLEILQQQL QVANEARDSA QTSVTQAQRE
660 670 680 690 700
KAELSRKVEE LQACVETARQ EQHEAQAQVA ELELQLRSEQ QKATEKERVA
710 720 730 740 750
QEKDQLQEQL QALKESLKVT KGSLEEEKRR AADALEEQQR CISELKAETR
760 770 780 790 800
SLVEQHKRER KELEEERAGR KGLEARLQQL GEAHQAETEV LRRELAEAMA
810 820 830 840 850
AQHTAESECE QLVKEVAAWR ERYEDSQQEE AQYGAMFQEQ LMTLKEECEK
860 870 880 890 900
ARQELQEAKE KVAGIESHSE LQISRQQNEL AELHANLARA LQQVQEKEVR
910 920 930 940 950
AQKLADDLST LQEKMAATSK EVARLETLVR KAGEQQETAS RELVKEPARA
960 970 980 990 1000
GDRQPEWLEE QQGRQFCSTQ AALQAMEREA EQMGNELERL RAALMESQGQ
1010 1020 1030 1040 1050
QQEERGQQER EVARLTQERG RAQADLALEK AARAELEMRL QNALNEQRVE
1060 1070 1080 1090 1100
FATLQEALAH ALTEKEGKDQ ELAKLRGLEA AQIKELEELR QTVKQLKEQL
1110 1120 1130 1140 1150
AKKEKEHASG SGAQSEAAGR TEPTGPKLEA LRAEVSKLEQ QCQKQQEQAD
1160 1170 1180 1190 1200
SLERSLEAER ASRAERDSAL ETLQGQLEEK AQELGHSQSA LASAQRELAA
1210 1220 1230 1240 1250
FRTKVQDHSK AEDEWKAQVA RGRQEAERKN SLISSLEEEV SILNRQVLEK
1260 1270 1280 1290 1300
EGESKELKRL VMAESEKSQK LEERLRLLQA ETASNSARAA ERSSALREEV
1310 1320 1330 1340 1350
QSLREEAEKQ RVASENLRQE LTSQAERAEE LGQELKAWQE KFFQKEQALS
1360 1370 1380 1390 1400
TLQLEHTSTQ ALVSELLPAK HLCQQLQAEQ AAAEKRHREE LEQSKQAAGG
1410 1420 1430 1440 1450
LRAELLRAQR ELGELIPLRQ KVAEQERTAQ QLRAEKASYA EQLSMLKKAH
1460 1470 1480 1490 1500
GLLAEENRGL GERANLGRQF LEVELDQARE KYVQELAAVR ADAETRLAEV
1510 1520 1530 1540 1550
QREAQSTARE LEVMTAKYEG AKVKVLEERQ RFQEERQKLT AQVEQLEVFQ
1560 1570 1580 1590 1600
REQTKQVEEL SKKLADSDQA SKVQQQKLKA VQAQGGESQQ EAQRLQAQLN
1610 1620 1630 1640 1650
ELQAQLSQKE QAAEHYKLQM EKAKTHYDAK KQQNQELQEQ LRSLEQLQKE
1660 1670 1680 1690 1700
NKELRAEAER LGHELQQAGL KTKEAEQTCR HLTAQVRSLE AQVAHADQQL
1710 1720 1730 1740 1750
RDLGKFQVAT DALKSREPQA KPQLDLSIDS LDLSCEEGTP LSITSKLPRT
1760 1770 1780 1790 1800
QPDGTSVPGE PASPISQRLP PKVESLESLY FTPIPARSQA PLESSLDSLG
1810 1820 1830 1840 1850
DVFLDSGRKT RSARRRTTQI INITMTKKLD VEEPDSANSS FYSTRSAPAS
1860 1870 1880 1890 1900
QASLRATSST QSLARLGSPD YGNSALLSLP GYRPTTRSSA RRSQAGVSSG
1910 1920 1930 1940 1950
APPGRNSFYM GTCQDEPEQL DDWNRIAELQ QRNRVCPPHL KTCYPLESRP
1960 1970 1980 1990 2000
SLSLGTITDE EMKTGDPQET LRRASMQPIQ IAEGTGITTR QQRKRVSLEP
2010 2020 2030 2040 2050
HQGPGTPESK KATSCFPRPM TPRDRHEGRK QSTTEAQKKA APASTKQADR
2060 2070 2080 2090 2100
RQSMAFSILN TPKKLGNSLL RRGASKKALS KASPNTRSGT RRSPRIATTT
2110 2120
ASAATAAAIG ATPRAKGKAK H
Length:2,121
Mass (Da):238,859
Last modified:August 2, 2005 - v1
Checksum:i32080FE79C65BA1D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB210007 mRNA. Translation: BAE06089.1.
RefSeqiNP_001273490.1. NM_001286561.1.
NP_006176.2. NM_006185.3.
XP_006718627.1. XM_006718564.1.
UniGeneiHs.325978.
Hs.591967.

Genome annotation databases

GeneIDi4926.
KEGGihsa:4926.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB210007 mRNA. Translation: BAE06089.1.
RefSeqiNP_001273490.1. NM_001286561.1.
NP_006176.2. NM_006185.3.
XP_006718627.1. XM_006718564.1.
UniGeneiHs.325978.
Hs.591967.

3D structure databases

ProteinModelPortaliQ4LE64.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000377298.

Proteomic databases

PaxDbiQ4LE64.
PeptideAtlasiQ4LE64.
PRIDEiQ4LE64.

Protocols and materials databases

DNASUi4926.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4926.
KEGGihsa:4926.

Organism-specific databases

CTDi4926.
PharmGKBiPA31844.

Phylogenomic databases

eggNOGiENOG410IFJ8. Eukaryota.
ENOG41125FF. LUCA.
HOGENOMiHOG000113889.
HOVERGENiHBG052694.
KOiK16808.

Miscellaneous databases

ChiTaRSiNUMA1. human.
GenomeRNAii4926.

Gene expression databases

BgeeiQ4LE64.
GenevisibleiQ4LE64. HS.

Family and domain databases

InterProiIPR026650. NUMA1.
[Graphical view]
PANTHERiPTHR18902:SF24. PTHR18902:SF24. 7 hits.
ProtoNetiSearch...

Publicationsi

  1. "Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method."
    Nakajima D., Saito K., Yamakawa H., Kikuno R.F., Nakayama M., Ohara R., Okazaki N., Koga H., Nagase T., Ohara O.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiQ4LE64_HUMAN
AccessioniPrimary (citable) accession number: Q4LE64
Entry historyi
Integrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: July 6, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.