Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

ATP2B2 variant protein

Gene

ATP2B2 variant protein

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
ATP2B2 variant proteinImported
Gene namesi
Name:ATP2B2 variant proteinImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei163 – 18220HelicalSequence analysisAdd
BLAST
Transmembranei369 – 39022HelicalSequence analysisAdd
BLAST
Transmembranei410 – 43627HelicalSequence analysisAdd
BLAST
Transmembranei922 – 94019HelicalSequence analysisAdd
BLAST
Transmembranei998 – 101821HelicalSequence analysisAdd
BLAST
Transmembranei1030 – 105122HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25108.

PTM / Processingi

Proteomic databases

PaxDbiQ4LE63.
PeptideAtlasiQ4LE63.
PRIDEiQ4LE63.

Expressioni

Gene expression databases

BgeeiENSG00000157087.
GenevisibleiQ4LE63. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000324172.

Structurei

3D structure databases

ProteinModelPortaliQ4LE63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini59 – 13577Cation_ATPase_NInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. [View classification]SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0204. Eukaryota.
ENOG410XNNC. LUCA.
HOGENOMiHOG000265623.
HOVERGENiHBG061286.
KOiK05850.

Family and domain databases

Gene3Di1.20.1110.10. 3 hits.
InterProiIPR022141. ATP_Ca_trans_C.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006408. P-type_ATPase_IIB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF12424. ATP_Ca_trans_C. 1 hit.
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 2 hits.
PF08282. Hydrolase_3. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01517. ATPase-IIB_Ca. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q4LE63-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PLGPARARTA ANMGDMTNSD FYSKNQRNES SHGGEFGCTM EELRSLMELR
60 70 80 90 100
GTEAVVKIKE TYGDTEAICR RLKTSPVEGL PGTAPDLEKR KQIFGQNFIP
110 120 130 140 150
PKKPKTFLQL VWEALQDVTL IILEIAAIIS LGLSFYHPPG EGNEGCATAQ
160 170 180 190 200
GGAEDEGEAE AGWIEGAAIL LSVICVVLVT AFNDWSKEKQ FRGLQSRIEQ
210 220 230 240 250
EQKFTVVRAG QVVQIPVAEI VVGDIAQVKY GDLLPADGLF IQGNDLKIDE
260 270 280 290 300
SSLTGESDQV RKSVDKDPML LSGTHVMEGS GRMLVTAVGV NSQTGIIFTL
310 320 330 340 350
LGAGGEEEEK KDKKAKQQDG AAAMEMQPLK SAEGGDADDR KKASMHKKEK
360 370 380 390 400
SVLQGKLTKL AVQIGKAGLV MSAITVIILV LYFTVDTFVV NKKPWLPECT
410 420 430 440 450
PVYVQYFVKF FIIGVTVLVV AVPEGLPLAV TISLAYSVKK MMKDNNLVRH
460 470 480 490 500
LDACETMGNA TAICSDKTGT LTTNRMTVVQ AYVGDVHYKE IPDPSSINTK
510 520 530 540 550
TMELLINAIA INSAYTTKIL PPEKEGALPR QVGNKTECGL LGFVLDLKQD
560 570 580 590 600
YEPVRSQMPE EKLYKVYTFN SVRKSMSTVI KLPDESFRMY SKGASEIVLK
610 620 630 640 650
KCCKILNGAG EPRVFRPRDR DEMVKKVIEP MACDGLRTIC VAYRDFPSSP
660 670 680 690 700
EPDWDNENDI LNELTCICVV GIEDPVRPEV PEAIRKCQRA GITVRMVTGD
710 720 730 740 750
NINTARAIAI KCGIIHPGED FLCLEGKEFN RRIRNEKGEI EQERIDKIWP
760 770 780 790 800
KLRVLARSSP TDKHTLVKGI IDSTHTEQRQ VVAVTGDGTN DGPALKKADV
810 820 830 840 850
GFAMGIAGTD VAKEASDIIL TDDNFSSIVK AVMWGRNVYD SISKFLQFQL
860 870 880 890 900
TVNVVAVIVA FTGACITQDS PLKAVQMLWV NLIMDTFASL ALATEPPTET
910 920 930 940 950
LLLRKPYGRN KPLISRTMMK NILGHAVYQL ALIFTLLFVG EKMFQIDSGR
960 970 980 990 1000
NAPLHSPPSE HYTIIFNTFV MMQLFNEINA RKIHGERNVF DGIFRNPIFC
1010 1020 1030 1040 1050
TIVLGTFAIQ IVIVQFGGKP FSCSPLQLDQ WMWCIFIGLG ELVWGQVIAT
1060 1070 1080 1090 1100
IPTSRLKFLK EAGRLTQKEE IPEEELNEDV EEIDHAEREL RRGQILWFRG
1110 1120 1130 1140 1150
LNRIQTQIRV VKAFRSSLYE GLEKPESRTS IHNFMAHPEF RIEDSQPHIP
1160 1170 1180 1190 1200
LIDDTDLEED AALKQNSSPP SSLNKNNSAI DSGINLTTDT SKSATSSSPG
1210
SPIHSLETSL
Length:1,210
Mass (Da):133,770
Last modified:August 2, 2005 - v1
Checksum:i57832447CF2C571B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB210008 mRNA. Translation: BAE06090.1.
RefSeqiNP_001001331.1. NM_001001331.2.
NP_001674.2. NM_001683.3.
UniGeneiHs.268942.

Genome annotation databases

GeneIDi491.
KEGGihsa:491.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB210008 mRNA. Translation: BAE06090.1.
RefSeqiNP_001001331.1. NM_001001331.2.
NP_001674.2. NM_001683.3.
UniGeneiHs.268942.

3D structure databases

ProteinModelPortaliQ4LE63.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000324172.

Proteomic databases

PaxDbiQ4LE63.
PeptideAtlasiQ4LE63.
PRIDEiQ4LE63.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi491.
KEGGihsa:491.

Organism-specific databases

CTDi491.
PharmGKBiPA25108.

Phylogenomic databases

eggNOGiKOG0204. Eukaryota.
ENOG410XNNC. LUCA.
HOGENOMiHOG000265623.
HOVERGENiHBG061286.
KOiK05850.

Miscellaneous databases

ChiTaRSiATP2B2. human.
GenomeRNAii491.

Gene expression databases

BgeeiENSG00000157087.
GenevisibleiQ4LE63. HS.

Family and domain databases

Gene3Di1.20.1110.10. 3 hits.
InterProiIPR022141. ATP_Ca_trans_C.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006408. P-type_ATPase_IIB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF12424. ATP_Ca_trans_C. 1 hit.
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 2 hits.
PF08282. Hydrolase_3. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01517. ATPase-IIB_Ca. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ4LE63_HUMAN
AccessioniPrimary (citable) accession number: Q4LE63
Entry historyi
Integrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: September 7, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.