ID Q4LE62_HUMAN Unreviewed; 1258 AA. AC Q4LE62; DT 02-AUG-2005, integrated into UniProtKB/TrEMBL. DT 02-AUG-2005, sequence version 1. DT 22-FEB-2023, entry version 101. DE SubName: Full=PPFIA2 variant protein {ECO:0000313|EMBL:BAE06091.1}; DE Flags: Fragment; GN Name=PPFIA2 variant protein {ECO:0000313|EMBL:BAE06091.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAE06091.1}; RN [1] {ECO:0000313|EMBL:BAE06091.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Brain {ECO:0000313|EMBL:BAE06091.1}; RA Nakajima D., Saito K., Yamakawa H., Kikuno R.F., Nakayama M., Ohara R., RA Okazaki N., Koga H., Nagase T., Ohara O.; RT "Preparation of a set of expression-ready clones of mammalian long cDNAs RT encoding large proteins by the ORF trap cloning method."; RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the liprin family. Liprin-alpha subfamily. CC {ECO:0000256|ARBA:ARBA00007026}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB210009; BAE06091.1; -; mRNA. DR RefSeq; NP_001207402.1; NM_001220473.2. DR RefSeq; NP_001207403.1; NM_001220474.2. DR RefSeq; NP_001207404.1; NM_001220475.2. DR RefSeq; NP_001207405.1; NM_001220476.2. DR RefSeq; XP_016875575.1; XM_017020086.1. DR AlphaFoldDB; Q4LE62; -. DR IntAct; Q4LE62; 1. DR DNASU; 8499; -. DR GeneID; 8499; -. DR CTD; 8499; -. DR OrthoDB; 2906732at2759; -. DR BioGRID-ORCS; 8499; 16 hits in 1149 CRISPR screens. DR ChiTaRS; PPFIA2; human. DR GenomeRNAi; 8499; -. DR GO; GO:0005737; C:cytoplasm; IEA:UniProt. DR CDD; cd09562; SAM_liprin-alpha1_2_3_4_repeat1; 1. DR CDD; cd09565; SAM_liprin-alpha1_2_3_4_repeat2; 1. DR CDD; cd09568; SAM_liprin-alpha1_2_3_4_repeat3; 1. DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 3. DR InterPro; IPR029515; Liprin. DR InterPro; IPR037620; Liprin-alpha_SAM_rpt_1. DR InterPro; IPR037621; Liprin-alpha_SAM_rpt_2. DR InterPro; IPR037622; Liprin-alpha_SAM_rpt_3. DR InterPro; IPR001660; SAM. DR InterPro; IPR013761; SAM/pointed_sf. DR PANTHER; PTHR12587; LAR INTERACTING PROTEIN LIP -RELATED PROTEIN; 1. DR PANTHER; PTHR12587:SF6; LIPRIN-ALPHA-2; 1. DR Pfam; PF00536; SAM_1; 2. DR Pfam; PF07647; SAM_2; 1. DR SMART; SM00454; SAM; 3. DR SUPFAM; SSF47769; SAM/Pointed domain; 3. DR SUPFAM; SSF57997; Tropomyosin; 1. DR PROSITE; PS50105; SAM_DOMAIN; 3. DR Genevisible; Q4LE62; HS. PE 2: Evidence at transcript level; KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils}. FT DOMAIN 909..975 FT /note="SAM" FT /evidence="ECO:0000259|PROSITE:PS50105" FT DOMAIN 1038..1095 FT /note="SAM" FT /evidence="ECO:0000259|PROSITE:PS50105" FT DOMAIN 1119..1188 FT /note="SAM" FT /evidence="ECO:0000259|PROSITE:PS50105" FT REGION 18..40 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 242..276 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 449..474 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 720..748 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 801..845 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 46..73 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 114..155 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 206..240 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 516..546 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 661..702 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 21..40 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 245..271 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 720..738 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 801..831 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:BAE06091.1" SQ SEQUENCE 1258 AA; 143321 MW; C9676A074BF3FE15 CRC64; RSKDPKSQTL AMMCEVMPTI NEDTPMSQRG SQSSGSDSDS HFEQLMVNML DERDRLLDTL RETQESLSLA QQRLQDVIYD RDSLQRQLNS ALPQDIESLT GGLAGSKGAD PPEFAALTKE LNACREQLLE KEEEISELKA ERNNTRLLLE HLECLVSRHE RSLRMTVVKR QAQSPSGVSS EVEVLKALKS LFEHHKALDE KVRERLRVSL ERVSALEEEL AAANQEIVAL REQNVHIQRK MASSEGSTES EHLEGMEPGQ KVHEKRLSNG SIDSTDETSQ IVELQELLEK QNYEMAQMKE RLAALSSRVG EVEQEAETAR KDLIKTEEMN TKYQRDIREA MAQKEDMEER ITTLEKRYLS AQRESTSIHD MNDKLENELA NKEAILRQME EKNRQLQERL ELAEQKLQQT MRKAETLPEV EAELAQRIAA LTKAEERHGN IEERMRHLEG QLEEKNQELQ RARQREKMNE EHNKRLSDTV DRLLTESNER LQLHLKERMA ALEEKNVLIQ ESETFRKNLE ESLHDKERLA EEIEKLRSEL DQLKMRTGSL IEPTIPRTHL DTSAELRYSV GSLVDSQSDY RTTKVIRRPR RGRMGVRRDE PKVKSLGDHE WNRTQQIGVL SSHPFESDTE MSDIDDDDRE TIFSSMDLLS PSGHSDAQTL AMMLQEQLDA INKEIRLIQE EKESTELRAE EIENRVASVS LEGLNLARVH PGTSITASVT ASSLASSSPP SGHSTPKLTP RSPAREMDRM GVMTLPSDLR KHRRKIAVVE EDGREDKATI KCETSPPPTP RALRMTHTLP SSYHNDARSS LSVSLEPESL GLGSANSSQD SLHKAPKKKG IKSSIGRLFG KKEKARLGQL RGFMETEAAA QESLGLGKLG TQAEKDRRLK KKHELLEEAR RKGLPFAQWD GPTVVAWLEL WLGMPAWYVA ACRANVKSGA IMSALSDTEI QREIGISNPL HRLKLRLAIQ EMVSLTSPSA PPTSRTPSGN VWVTHEEMEN LAAPAKTKES EEGSWAQCPV FLQTLAYGDM NHEWIGNEWL PSLGLPQYRS YFMECLVDAR MLDHLTKKDL RVHLKMVDSF HRTSLQYGIM CLKRLNYDRK ELERRREASQ HEIKDVLVWS NDRVIRWIQA IGLREYANNI LESGVHGSLI ALDENFDYSS LALLLQIPTQ NTQARQILER EYNNLLALGT ERRLDESDDK NFRRGSTWRR QFPPREVHGI SMMPGSSETL PAGFRLTTTS GQSRKMTTDD GVFSVYST //