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Protein
Submitted name:

EPHB2 variant protein

Gene

EPHB2 variant protein

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei671ATPUniRule annotation1
Active sitei764Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi645 – 653ATPUniRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotation, Transferase, Tyrosine-protein kinaseSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
EPHB2 variant proteinImported
Gene namesi
Name:EPHB2 variant proteinImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei561 – 583HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 36Sequence analysisAdd BLAST36
ChainiPRO_500424090637 – 1004Sequence analysisAdd BLAST968

Proteomic databases

PaxDbiQ4LE53.

Expressioni

Gene expression databases

BgeeiENSG00000133216.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000363763.

Structurei

3D structure databases

ProteinModelPortaliQ4LE53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 220Eph LBD (Eph ligand-binding)InterPro annotationAdd BLAST183
Domaini342 – 452Fibronectin type-IIIInterPro annotationAdd BLAST111
Domaini453 – 548Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini639 – 902Protein kinaseInterPro annotationAdd BLAST264
Domaini931 – 995SAM (sterile alpha motif)InterPro annotationAdd BLAST65

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0196. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000233856.
HOVERGENiHBG062180.
KOiK05111.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di1.10.150.50. 1 hit.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR027936. Eph_TM.
IPR001090. Ephrin_rcpt_lig-bd_dom.
IPR003961. FN3_dom.
IPR008979. Galactose-bd-like.
IPR009030. Growth_fac_rcpt_.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016257. Tyr_kinase_ephrin_rcpt.
IPR001426. Tyr_kinase_rcpt_V_CS.
[Graphical view]
PfamiPF14575. EphA2_TM. 1 hit.
PF01404. Ephrin_lbd. 1 hit.
PF07699. Ephrin_rec_like. 1 hit.
PF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00615. EPH_lbd. 1 hit.
SM01411. Ephrin_rec_like. 1 hit.
SM00060. FN3. 2 hits.
SM00454. SAM. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS51550. EPH_LBD. 1 hit.
PS50853. FN3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q4LE53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PGRPGPAAPR PEAPGSAAMA LRRLGAALLL LPLLAAVEET LMDSTTATAE
60 70 80 90 100
LGWMVHPPSG WEEVSGYDEN MNTIRTYQVC NVFESSQNNW LRTKFIRRRG
110 120 130 140 150
AHRIHVEMKF SVRDCSSIPS VPGSCKETFN LYYYEADFDS ATKTFPNWME
160 170 180 190 200
NPWVKVDTIA ADESFSQVDL GGRVMKINTE VRSFGPVSRS GFYLAFQDYG
210 220 230 240 250
GCMSLIAVRV FYRKCPRIIQ NGAIFQETLS GAESTSLVAA RGSCIANAEE
260 270 280 290 300
VDVPIKLYCN GDGEWLVPIG RCMCKAGFEA VENGTVCRGC PSGTFKANQG
310 320 330 340 350
DEACTHCPIN SRTTSEGATN CVCRNGYYRA DLDPLDMPCT TIPSAPQAVI
360 370 380 390 400
SSVNETSLML EWTPPRDSGG REDLVYNIIC KSCGSGRGAC TRCGDNVQYA
410 420 430 440 450
PRQLGLTEPR IYISDLLAHT QYTFEIQAVN GVTDQSPFSP QFASVNITTN
460 470 480 490 500
QAAPSAVSIM HQVSRTVDSI TLSWSQPDQP NGVILDYELQ YYEKELSEYN
510 520 530 540 550
ATAIKSPTNT VTVQGLKAGA IYVFQVRART VAGYGRYSGK MYFQTMTEAE
560 570 580 590 600
YQTSIQEKLP LIIGSSAAGL VFLIAVVVIA IVCNRRGFER ADSEYTDKLQ
610 620 630 640 650
HYTSGHMTPG MKIYIDPFTY EDPNEAVREF AKEIDISCVK IEQVIGAGEF
660 670 680 690 700
GEVCSGHLKL PGKREIFVAI KTLKSGYTEK QRRDFLSEAS IMGQFDHPNV
710 720 730 740 750
IHLEGVVTKS TPVMIITEFM ENGSLDSFLR QNDGQFTVIQ LVGMLRGIAA
760 770 780 790 800
GMKYLADMNY VHRDLAARNI LVNSNLVCKV SDFGLSRFLE DDTSDPTYTS
810 820 830 840 850
ALGGKIPIRW TAPEAIQYRK FTSASDVWSY GIVMWEVMSY GERPYWDMTN
860 870 880 890 900
QDVINAIEQD YRLPPPMDCP SALHQLMLDC WQKDRNHRPK FGQIVNTLDK
910 920 930 940 950
MIRNPNSLKA MAPLSSGINL PLLDRTIPDY TSFNTVDEWL EAIKMGQYKE
960 970 980 990 1000
SFANAGFTSF DVVSQMMMED ILRVGVTLAG HQKKILNSIQ VMRAQMNQIQ

SVEV
Length:1,004
Mass (Da):111,512
Last modified:August 2, 2005 - v1
Checksum:i0CBA9D22B278CA49
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB210018 mRNA. Translation: BAE06100.1.
RefSeqiNP_001296121.1. NM_001309192.1.
NP_001296122.1. NM_001309193.1.
NP_004433.2. NM_004442.7.
NP_059145.2. NM_017449.4.
UniGeneiHs.380705.
Hs.523329.

Genome annotation databases

GeneIDi2048.
KEGGihsa:2048.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB210018 mRNA. Translation: BAE06100.1.
RefSeqiNP_001296121.1. NM_001309192.1.
NP_001296122.1. NM_001309193.1.
NP_004433.2. NM_004442.7.
NP_059145.2. NM_017449.4.
UniGeneiHs.380705.
Hs.523329.

3D structure databases

ProteinModelPortaliQ4LE53.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000363763.

Proteomic databases

PaxDbiQ4LE53.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2048.
KEGGihsa:2048.

Organism-specific databases

CTDi2048.

Phylogenomic databases

eggNOGiKOG0196. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000233856.
HOVERGENiHBG062180.
KOiK05111.

Miscellaneous databases

ChiTaRSiEPHB2. human.
GenomeRNAii2048.

Gene expression databases

BgeeiENSG00000133216.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di1.10.150.50. 1 hit.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR027936. Eph_TM.
IPR001090. Ephrin_rcpt_lig-bd_dom.
IPR003961. FN3_dom.
IPR008979. Galactose-bd-like.
IPR009030. Growth_fac_rcpt_.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016257. Tyr_kinase_ephrin_rcpt.
IPR001426. Tyr_kinase_rcpt_V_CS.
[Graphical view]
PfamiPF14575. EphA2_TM. 1 hit.
PF01404. Ephrin_lbd. 1 hit.
PF07699. Ephrin_rec_like. 1 hit.
PF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00615. EPH_lbd. 1 hit.
SM01411. Ephrin_rec_like. 1 hit.
SM00060. FN3. 2 hits.
SM00454. SAM. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS51550. EPH_LBD. 1 hit.
PS50853. FN3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ4LE53_HUMAN
AccessioniPrimary (citable) accession number: Q4LE53
Entry historyi
Integrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: November 30, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.