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Protein
Submitted name:

PIK3CA variant protein

Gene

PIK3CA variant protein

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinasePROSITE-ProRule annotationSAAS annotation, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
PIK3CA variant proteinImported
Gene namesi
Name:PIK3CA variant proteinImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

PTM / Processingi

Proteomic databases

PRIDEiQ4LE51

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 106PI3K-ABDInterPro annotationAdd BLAST90
Domaini188 – 290PI3K-RBDInterPro annotationAdd BLAST103
Domaini331 – 488C2 PI3K-typeInterPro annotationAdd BLAST158
Domaini518 – 695PIK helicalInterPro annotationAdd BLAST178
Domaini798 – 1069PI3K/PI4KInterPro annotationAdd BLAST272

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili710 – 730Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0904 Eukaryota
COG5032 LUCA
HOGENOMiHOG000252911
HOVERGENiHBG052721
KOiK00922

Family and domain databases

CDDicd05175 PI3Kc_IA_alpha, 1 hit
Gene3Di1.10.1070.11, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR003113 PI3K_adapt-bd_dom
IPR002420 PI3K_C2_dom
IPR000341 PI3K_Ras-bd_dom
IPR008290 PI3K_Vps34
IPR037704 PI3Kalpha_dom
IPR015433 PI_Kinase
IPR001263 PInositide-3_kin_accessory_dom
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR10048 PTHR10048, 1 hit
PfamiView protein in Pfam
PF00454 PI3_PI4_kinase, 1 hit
PF00792 PI3K_C2, 1 hit
PF02192 PI3K_p85B, 1 hit
PF00794 PI3K_rbd, 1 hit
PF00613 PI3Ka, 1 hit
PIRSFiPIRSF000587 PI3K_Vps34, 3 hits
SMARTiView protein in SMART
SM00142 PI3K_C2, 1 hit
SM00143 PI3K_p85B, 1 hit
SM00144 PI3K_rbd, 1 hit
SM00145 PI3Ka, 1 hit
SM00146 PI3Kc, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF54236 SSF54236, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51544 PI3K_ABD, 1 hit
PS51547 PI3K_C2, 1 hit
PS51546 PI3K_RBD, 1 hit
PS51545 PIK_HELICAL, 1 hit

Sequencei

Sequence statusi: Fragment.

Q4LE51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
TMPPRPSSGE LWGIHLMPPR ILVECLLPNG MIVTLECLRE ATLITIKHEL
60 70 80 90 100
FKEARKYPLH QLLQDESSYI FVSVTQEAER EEFFDETRRL CDLRLFQPFL
110 120 130 140 150
KVIEPVGNRE EKILNREIGF AIGMPVCEFD MVKDPEVQDF RRNILNVCKE
160 170 180 190 200
AVDLRDLNSP HSRAMYVYPP NVESSPELPK HIYNKLDKGQ IIVVIWVIVS
210 220 230 240 250
PNNDKQKYTL KINHDCVPEQ VIAEAIRKKT RSMLLSSEQL KLCVLEYQGK
260 270 280 290 300
YILKVCGCDE YFLEKYPLSQ YKYIRSCIML GRMPNLMLMA KESLYSQLPM
310 320 330 340 350
DCFTMPSYSR RISTATPYMN GETSTKSLWV INSALRIKIL CATYVNVNIR
360 370 380 390 400
DIDKIYVRTG IYHGGEPLCD NVNTQRVPCS NPRWNEWLNY DIYIPDLPRA
410 420 430 440 450
ARLCLSICSV KGRKGAKEEH CPLAWGNINL FDYTDTLVSG KMALNLWPVP
460 470 480 490 500
HGLEDLLNPI GVTGSNPNKE TPCLELEFDW FSSVVKFPDM SVIEEHANWS
510 520 530 540 550
VSREAGFSYS HAGLSNRLAR DNELRENDKE QLKAISTRDP LSEITEQEKD
560 570 580 590 600
FLWSHRHYCV TIPEILPKLL LSVKWNSRDE VAQMYCLVKD WPPIKPEQAM
610 620 630 640 650
ELLDCNYPDP MVRGFAVRCL EKYLTDDKLS QYLIQLVQVL KYEQYLDNLL
660 670 680 690 700
VRFLLKKALT NQRIGHFFFW HLKSEMHNKT VSQRFGLLLE SYCRACGMYL
710 720 730 740 750
KHLNRQVEAM EKLINLTDIL KQEKKDETQK VQMKFLVEQM RRPDFMDALQ
760 770 780 790 800
GFLSPLNPAH QLGNLRLEEC RIMSSAKRPL WLNWENPDIM SELLFQNNEI
810 820 830 840 850
IFKNGDDLRQ DMLTLQIIRI MENIWQNQGL DLRMLPYGCL SIGDCVGLIE
860 870 880 890 900
VVRNSHTIMQ IQCKGGLKGA LQFNSHTLHQ WLKDKNKGEI YDAAIDLFTR
910 920 930 940 950
SCAGYCVATF ILGIGDRHNS NIMVKDDGQL FHIDFGHFLD HKKKKFGYKR
960 970 980 990 1000
ERVPFVLTQD FLIVISKGAQ ECTKTREFER FQEMCYKAYL AIRQHANLFI
1010 1020 1030 1040 1050
NLFSMMLGSG MPELQSFDDI AYIRKTLALD KTEQEALEYF MKQMNDAHHG
1060
GWTTKMDWIF HTIKQHALN
Length:1,069
Mass (Da):124,385
Last modified:August 2, 2005 - v1
Checksum:i68624049DF9E4352
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB210020 mRNA Translation: BAE06102.1
RefSeqiNP_006209.2, NM_006218.3
XP_006713721.1, XM_006713658.3
XP_011511196.1, XM_011512894.2
UniGeneiHs.553498
Hs.715194
Hs.732394

Genome annotation databases

GeneIDi5290
KEGGihsa:5290

Similar proteinsi

Entry informationi

Entry nameiQ4LE51_HUMAN
AccessioniPrimary (citable) accession number: Q4LE51
Entry historyiIntegrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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