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Protein
Submitted name:

PIK3CA variant protein

Gene

PIK3CA variant protein

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotation, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
PIK3CA variant proteinImported
Gene namesi
Name:PIK3CA variant proteinImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ4LE51.
PeptideAtlasiQ4LE51.
PRIDEiQ4LE51.

Expressioni

Gene expression databases

BgeeiQ4LE51.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000263967.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 10690PI3K-ABDInterPro annotationAdd
BLAST
Domaini188 – 290103PI3K-RBDInterPro annotationAdd
BLAST
Domaini331 – 488158C2 PI3K-typeInterPro annotationAdd
BLAST
Domaini518 – 695178PIK helicalInterPro annotationAdd
BLAST
Domaini798 – 1069272PI3K/PI4KInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.SAAS annotation
Contains PI3K/PI4K domain.SAAS annotation
Contains PIK helical domain.SAAS annotation

Phylogenomic databases

eggNOGiKOG0904. Eukaryota.
COG5032. LUCA.
HOGENOMiHOG000252911.
HOVERGENiHBG052721.
KOiK00922.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003113. PI3K_adapt-bd_dom.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF02192. PI3K_p85B. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view]
SMARTiSM00142. PI3K_C2. 1 hit.
SM00143. PI3K_p85B. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51544. PI3K_ABD. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q4LE51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
TMPPRPSSGE LWGIHLMPPR ILVECLLPNG MIVTLECLRE ATLITIKHEL
60 70 80 90 100
FKEARKYPLH QLLQDESSYI FVSVTQEAER EEFFDETRRL CDLRLFQPFL
110 120 130 140 150
KVIEPVGNRE EKILNREIGF AIGMPVCEFD MVKDPEVQDF RRNILNVCKE
160 170 180 190 200
AVDLRDLNSP HSRAMYVYPP NVESSPELPK HIYNKLDKGQ IIVVIWVIVS
210 220 230 240 250
PNNDKQKYTL KINHDCVPEQ VIAEAIRKKT RSMLLSSEQL KLCVLEYQGK
260 270 280 290 300
YILKVCGCDE YFLEKYPLSQ YKYIRSCIML GRMPNLMLMA KESLYSQLPM
310 320 330 340 350
DCFTMPSYSR RISTATPYMN GETSTKSLWV INSALRIKIL CATYVNVNIR
360 370 380 390 400
DIDKIYVRTG IYHGGEPLCD NVNTQRVPCS NPRWNEWLNY DIYIPDLPRA
410 420 430 440 450
ARLCLSICSV KGRKGAKEEH CPLAWGNINL FDYTDTLVSG KMALNLWPVP
460 470 480 490 500
HGLEDLLNPI GVTGSNPNKE TPCLELEFDW FSSVVKFPDM SVIEEHANWS
510 520 530 540 550
VSREAGFSYS HAGLSNRLAR DNELRENDKE QLKAISTRDP LSEITEQEKD
560 570 580 590 600
FLWSHRHYCV TIPEILPKLL LSVKWNSRDE VAQMYCLVKD WPPIKPEQAM
610 620 630 640 650
ELLDCNYPDP MVRGFAVRCL EKYLTDDKLS QYLIQLVQVL KYEQYLDNLL
660 670 680 690 700
VRFLLKKALT NQRIGHFFFW HLKSEMHNKT VSQRFGLLLE SYCRACGMYL
710 720 730 740 750
KHLNRQVEAM EKLINLTDIL KQEKKDETQK VQMKFLVEQM RRPDFMDALQ
760 770 780 790 800
GFLSPLNPAH QLGNLRLEEC RIMSSAKRPL WLNWENPDIM SELLFQNNEI
810 820 830 840 850
IFKNGDDLRQ DMLTLQIIRI MENIWQNQGL DLRMLPYGCL SIGDCVGLIE
860 870 880 890 900
VVRNSHTIMQ IQCKGGLKGA LQFNSHTLHQ WLKDKNKGEI YDAAIDLFTR
910 920 930 940 950
SCAGYCVATF ILGIGDRHNS NIMVKDDGQL FHIDFGHFLD HKKKKFGYKR
960 970 980 990 1000
ERVPFVLTQD FLIVISKGAQ ECTKTREFER FQEMCYKAYL AIRQHANLFI
1010 1020 1030 1040 1050
NLFSMMLGSG MPELQSFDDI AYIRKTLALD KTEQEALEYF MKQMNDAHHG
1060
GWTTKMDWIF HTIKQHALN
Length:1,069
Mass (Da):124,385
Last modified:August 2, 2005 - v1
Checksum:i68624049DF9E4352
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB210020 mRNA. Translation: BAE06102.1.
RefSeqiNP_006209.2. NM_006218.3.
XP_006713721.1. XM_006713658.2.
XP_011511196.1. XM_011512894.1.
UniGeneiHs.553498.
Hs.715194.

Genome annotation databases

GeneIDi5290.
KEGGihsa:5290.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB210020 mRNA. Translation: BAE06102.1.
RefSeqiNP_006209.2. NM_006218.3.
XP_006713721.1. XM_006713658.2.
XP_011511196.1. XM_011512894.1.
UniGeneiHs.553498.
Hs.715194.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000263967.

Proteomic databases

PaxDbiQ4LE51.
PeptideAtlasiQ4LE51.
PRIDEiQ4LE51.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5290.
KEGGihsa:5290.

Organism-specific databases

CTDi5290.

Phylogenomic databases

eggNOGiKOG0904. Eukaryota.
COG5032. LUCA.
HOGENOMiHOG000252911.
HOVERGENiHBG052721.
KOiK00922.

Miscellaneous databases

ChiTaRSiPIK3CA. human.
GenomeRNAii5290.

Gene expression databases

BgeeiQ4LE51.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003113. PI3K_adapt-bd_dom.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF02192. PI3K_p85B. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view]
SMARTiSM00142. PI3K_C2. 1 hit.
SM00143. PI3K_p85B. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51544. PI3K_ABD. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method."
    Nakajima D., Saito K., Yamakawa H., Kikuno R.F., Nakayama M., Ohara R., Okazaki N., Koga H., Nagase T., Ohara O.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiQ4LE51_HUMAN
AccessioniPrimary (citable) accession number: Q4LE51
Entry historyi
Integrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: July 6, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.