Unreviewed, UniProtKB/TrEMBL Q4LE43 (Q4LE43_HUMAN)

Names and origin

Protein names

Submitted name:
    PLCG1 variant protein EMBL BAE06110.1

Gene names

Name:

PLCG1 variant protein EMBL BAE06110.1

Organism

Homo sapiens (Human) EMBL BAE06110.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1412 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Contains 1 C2 domain. Contains 1 PH domain. Contains 1 PI-PLC X-box domain. Contains 1 PI-PLC Y-box domain. Contains 1 SH3 domain. Contains 3 PH domains.

Ontologies

Keywords
Domain	SH3 domain RuleBase RU003338V3
Ligand	Calcium RuleBase RU000331V1
Molecular function	Transducer Spearmint SPM001192
Gene Ontology (GO)
Biological process	intracellular signaling cascade Inferred from electronic annotation. Source: InterPro lipid metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoinositide phospholipase C activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from electronic annotation. Source: InterPro signal transducer activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAE06110.1

Sequences

	Sequence		Length	Mass (Da)
	Q4LE43-1 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 6B3233E8A77FAD3D	FASTA	1,412	161,303
	10 20 30 40 50 60 ESSAGLRAGW VDRERRALPP PSRLRPRLRP VWGSRGAGAA GRRAGVLPTG ARAPLFPAPK 70 80 90 100 110 120 RGGASGQPRP AALRPRPVSA CRSRRRVPLV CRLSLSPNLS RRRCACSRAV LACAAAAPSV 130 140 150 160 170 180 GAMAGAASPC ANGCGPGAPS DAEVLHLCRS LEVGTVMTLF YSKKSQRPER KTFQVKLETR 190 200 210 220 230 240 QITWSRGADK IEGAIDIREI KEIRPGKTSR DFDRYQEDPA FRPDQSHCFV ILYGMEFRLK 250 260 270 280 290 300 TLSLQATSED EVNMWIKGLT WLMEDTLQAP TPLQIERWLR KQFYSVDRNR EDRISAKDLK 310 320 330 340 350 360 NMLSQVNYRV PNMRFLRERL TDLEQRSGDI TYGQFAQLYR SLMYSAQKTM DLPFLEASTL 370 380 390 400 410 420 RAGERPELCR VSLPEFQQFL LDYQGELWAV DRLQVQEFML SFLRDPLREI EEPYFFLDEF 430 440 450 460 470 480 VTFLFSKENS VWNSQLDAVC PDTMNNPLSH YWISSSHNTY LTGDQFSSES SLEAYARCLR 490 500 510 520 530 540 MGCRCIELDC WDGPDGMPVI YHGHTLTTKI KFSDVLHTIK EHAFVASEYP VILSIEDHCS 550 560 570 580 590 600 IAQQRNMAQY FKKVLGDTLL TKPVEISADG LPSPNQLKRK ILIKHKKLAE GSAYEEVPTS 610 620 630 640 650 660 MMYSENDISN SIKNGILYLE DPVNHEWYPH YFVLTSSKIY YSEETSSDQG NEDEEEPKEV 670 680 690 700 710 720 SSSTELHSNE KWFHGKLGAG RDGRHIAERL LTEYCIETGA PDGSFLVRES ETFVGDYTLS 730 740 750 760 770 780 FWRNGKVQHC RIHSRQDAGT PKFFLTDNLV FDSLYDLITH YQQVPLRCNE FEMRLSEPVP 790 800 810 820 830 840 QTNAHESKEW YHASLTRAQA EHMLMRVPRD GAFLVRKRNE PNSYAISFRA EGKIKHCRVQ 850 860 870 880 890 900 QEGQTVMLGN SEFDSLVDLI SYYEKHPLYR KMKLRYPINE EALEKIGTAE PDYGALYEGR 910 920 930 940 950 960 NPGFYVEANP MPTFKCAVKA LFDYKAQRED ELTFTKSAII QNVEKQEGGW WRGDYGGKKQ 970 980 990 1000 1010 1020 LWFPSNYVEE MVNPVALEPE REHLDENSPL GDLLRGVLDV PACQIAIRPE GKNNRLFVFS 1030 1040 1050 1060 1070 1080 ISMASVAHWS LDVAADSQEE LQDWVKKIRE VAQTADARLT EGKIMERRKK IALELSELVV 1090 1100 1110 1120 1130 1140 YCRPVPFDEE KIGTERACYR DMSSFPETKA EKYVNKAKGK KFLQYNRLQL SRIYPKGQRL 1150 1160 1170 1180 1190 1200 DSSNYDPLPM WICGSQLVAL NFQTPDKPMQ MNQALFMTGR HCGYVLQPST MRDEAFDPFD 1210 1220 1230 1240 1250 1260 KSSLRGLEPC AISIEVLGAR HLPKNGRGIV CPFVEIEVAG AEYDSTKQKT EFVVDNGLNP 1270 1280 1290 1300 1310 1320 VWPAKPFHFQ ISNPEFAFLR FVVYEEDMFS DQNFLAQATF PVKGLKTGYR AVPLKNNYSE 1330 1340 1350 1360 1370 1380 DLELASLLIK IDIFPAKENG DLSPFSGTSL RERGSDASGQ LFHGRAREGS FESRYQQPFE 1390 1400 1410 DFRISQEHLA DHFDSRERRA PRRTRVNGDN RL

References

[1]	"Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method." Nakajima D., Saito K., Yamakawa H., Kikuno R.F., Nakayama M., Ohara R., Okazaki N., Koga H., Nagase T., Ohara O. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Brain EMBL BAE06110.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB210028 mRNA. Translation: BAE06110.1.
IPI	IPI00383849.
RefSeq	NP_002651.2. NP_877963.1.
UniGene	Hs.268177
3D structure databases
SMR	Q4LE43. Positions 611-675, 664-780, 785-881, 912-974, 973-1055.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4LE43.
Proteomic databases
PRIDE	Q4LE43.
Genome annotation databases
Ensembl	ENST00000373271; ENSP00000362368; ENSG00000124181; Homo sapiens. [Genome view]
GeneID	5335.
KEGG	hsa:5335.
Organism-specific databases
CTD	5335.
HGNC	HGNC:9065. PLCG1.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q4LE43.
Gene expression databases
ArrayExpress	Q4LE43.
Bgee	Q4LE43.
Family and domain databases
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR018029. C2_membr_targeting. IPR018247. EF_Hand_1_Ca_BS. IPR018249. EF_HAND_2. IPR011993. PH_type. IPR015359. Phospholipase_C_EF-hand-like. IPR001192. Phospholipase_C_Pinositol-sp_C. IPR001711. Phospholipase_C_Pinositol-sp_Y. IPR017946. PLC-like_Pdiesterase_TIM-brl. IPR001849. Pleckstrin_homology. IPR000909. PLipase_C_PInositol-sp_X_dom. IPR000980. SH2. IPR001452. SH3_domain. IPR020473. SH3_region. [Graphical view]
Gene3D	G3DSA:2.30.29.30. PH_type. 1 hit. G3DSA:3.20.20.190. PLC-like_Pdiesterase_TIM-brl. 1 hit.
Pfam	PF00168. C2. 1 hit. PF09279. efhand_like. 1 hit. PF00169. PH. 1 hit. PF00388. PI-PLC-X. 1 hit. PF00387. PI-PLC-Y. 1 hit. PF00017. SH2. 2 hits. PF00018. SH3_1. 1 hit. [Graphical view]
PRINTS	PR00390. PHPHLIPASEC. PR00401. SH2DOMAIN. PR00452. SH3DOMAIN.
SMART	SM00239. C2. 1 hit. SM00233. PH. 3 hits. SM00148. PLCXc. 1 hit. SM00149. PLCYc. 1 hit. SM00252. SH2. 2 hits. SM00326. SH3. 1 hit. [Graphical view]
PROSITE	PS50004. C2. 1 hit. PS00018. EF_HAND_1. 1 hit. PS50222. EF_HAND_2. 1 hit. PS50003. PH_DOMAIN. 2 hits. PS50007. PIPLC_X_DOMAIN. 1 hit. PS50008. PIPLC_Y_DOMAIN. 1 hit. PS50001. SH2. 2 hits. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	20662.

Entry information

Entry name

Q4LE43_HUMAN

Accession

Primary (citable) accession number: Q4LE43

Entry history

Integrated into UniProtKB/TrEMBL:	August 2, 2005
Last sequence update:	August 2, 2005
Last modified:	February 9, 2010
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.