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Protein

Phosphoinositide phospholipase C

Gene

PLCG1 variant protein

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi287 – 298PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation, TransducerSAAS annotation
Biological processLipid degradationUniRule annotation, Lipid metabolism
LigandCalciumPROSITE-ProRule annotation

Enzyme and pathway databases

SignaLinkiQ4LE43

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phospholipase CUniRule annotation (EC:3.1.4.11UniRule annotation)
Gene namesi
Name:PLCG1 variant proteinImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33392

PTM / Processingi

Proteomic databases

PeptideAtlasiQ4LE43
PRIDEiQ4LE43

Expressioni

Gene expression databases

GenevisibleiQ4LE43 HS

Structurei

3D structure databases

ProteinModelPortaliQ4LE43
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini149 – 264PHInterPro annotationAdd BLAST116
Domaini274 – 309EF-handInterPro annotationAdd BLAST36
Domaini442 – 586PI-PLC X-boxInterPro annotationAdd BLAST145
Domaini672 – 779SH2InterPro annotationAdd BLAST108
Domaini790 – 878SH2InterPro annotationAdd BLAST89
Domaini913 – 973SH3InterPro annotationAdd BLAST61
Domaini1017 – 1053PHInterPro annotationAdd BLAST37
Domaini1075 – 1192PI-PLC Y-boxInterPro annotationAdd BLAST118
Domaini1197 – 1299C2InterPro annotationAdd BLAST103

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1264 Eukaryota
ENOG410XPXE LUCA
HOGENOMiHOG000230864
HOVERGENiHBG053611
KOiK01116

Family and domain databases

CDDicd09932 SH2_C-SH2_PLC_gamma_like, 1 hit
cd10341 SH2_N-SH2_PLC_gamma_like, 1 hit
cd11970 SH3_PLCgamma1, 1 hit
Gene3Di2.30.29.30, 1 hit
2.60.40.150, 1 hit
3.20.20.190, 2 hits
3.30.505.10, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR001192 PI-PLC_fam
IPR028380 PLC-gamma1
IPR035023 PLC-gamma_C-SH2
IPR035024 PLC-gamma_N-SH2
IPR017946 PLC-like_Pdiesterase_TIM-brl
IPR035724 PLCgamma1_SH3
IPR000909 PLipase_C_PInositol-sp_X_dom
IPR001711 PLipase_C_Pinositol-sp_Y
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR10336 PTHR10336, 1 hit
PTHR10336:SF52 PTHR10336:SF52, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF00388 PI-PLC-X, 1 hit
PF00387 PI-PLC-Y, 1 hit
PF00017 SH2, 2 hits
PF00018 SH3_1, 1 hit
PRINTSiPR00390 PHPHLIPASEC
PR00401 SH2DOMAIN
PR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00233 PH, 3 hits
SM00148 PLCXc, 1 hit
SM00149 PLCYc, 1 hit
SM00252 SH2, 2 hits
SM00326 SH3, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF50044 SSF50044, 1 hit
SSF51695 SSF51695, 2 hits
SSF55550 SSF55550, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS50003 PH_DOMAIN, 2 hits
PS50007 PIPLC_X_DOMAIN, 1 hit
PS50008 PIPLC_Y_DOMAIN, 1 hit
PS50001 SH2, 2 hits
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Fragment.

Q4LE43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ESSAGLRAGW VDRERRALPP PSRLRPRLRP VWGSRGAGAA GRRAGVLPTG
60 70 80 90 100
ARAPLFPAPK RGGASGQPRP AALRPRPVSA CRSRRRVPLV CRLSLSPNLS
110 120 130 140 150
RRRCACSRAV LACAAAAPSV GAMAGAASPC ANGCGPGAPS DAEVLHLCRS
160 170 180 190 200
LEVGTVMTLF YSKKSQRPER KTFQVKLETR QITWSRGADK IEGAIDIREI
210 220 230 240 250
KEIRPGKTSR DFDRYQEDPA FRPDQSHCFV ILYGMEFRLK TLSLQATSED
260 270 280 290 300
EVNMWIKGLT WLMEDTLQAP TPLQIERWLR KQFYSVDRNR EDRISAKDLK
310 320 330 340 350
NMLSQVNYRV PNMRFLRERL TDLEQRSGDI TYGQFAQLYR SLMYSAQKTM
360 370 380 390 400
DLPFLEASTL RAGERPELCR VSLPEFQQFL LDYQGELWAV DRLQVQEFML
410 420 430 440 450
SFLRDPLREI EEPYFFLDEF VTFLFSKENS VWNSQLDAVC PDTMNNPLSH
460 470 480 490 500
YWISSSHNTY LTGDQFSSES SLEAYARCLR MGCRCIELDC WDGPDGMPVI
510 520 530 540 550
YHGHTLTTKI KFSDVLHTIK EHAFVASEYP VILSIEDHCS IAQQRNMAQY
560 570 580 590 600
FKKVLGDTLL TKPVEISADG LPSPNQLKRK ILIKHKKLAE GSAYEEVPTS
610 620 630 640 650
MMYSENDISN SIKNGILYLE DPVNHEWYPH YFVLTSSKIY YSEETSSDQG
660 670 680 690 700
NEDEEEPKEV SSSTELHSNE KWFHGKLGAG RDGRHIAERL LTEYCIETGA
710 720 730 740 750
PDGSFLVRES ETFVGDYTLS FWRNGKVQHC RIHSRQDAGT PKFFLTDNLV
760 770 780 790 800
FDSLYDLITH YQQVPLRCNE FEMRLSEPVP QTNAHESKEW YHASLTRAQA
810 820 830 840 850
EHMLMRVPRD GAFLVRKRNE PNSYAISFRA EGKIKHCRVQ QEGQTVMLGN
860 870 880 890 900
SEFDSLVDLI SYYEKHPLYR KMKLRYPINE EALEKIGTAE PDYGALYEGR
910 920 930 940 950
NPGFYVEANP MPTFKCAVKA LFDYKAQRED ELTFTKSAII QNVEKQEGGW
960 970 980 990 1000
WRGDYGGKKQ LWFPSNYVEE MVNPVALEPE REHLDENSPL GDLLRGVLDV
1010 1020 1030 1040 1050
PACQIAIRPE GKNNRLFVFS ISMASVAHWS LDVAADSQEE LQDWVKKIRE
1060 1070 1080 1090 1100
VAQTADARLT EGKIMERRKK IALELSELVV YCRPVPFDEE KIGTERACYR
1110 1120 1130 1140 1150
DMSSFPETKA EKYVNKAKGK KFLQYNRLQL SRIYPKGQRL DSSNYDPLPM
1160 1170 1180 1190 1200
WICGSQLVAL NFQTPDKPMQ MNQALFMTGR HCGYVLQPST MRDEAFDPFD
1210 1220 1230 1240 1250
KSSLRGLEPC AISIEVLGAR HLPKNGRGIV CPFVEIEVAG AEYDSTKQKT
1260 1270 1280 1290 1300
EFVVDNGLNP VWPAKPFHFQ ISNPEFAFLR FVVYEEDMFS DQNFLAQATF
1310 1320 1330 1340 1350
PVKGLKTGYR AVPLKNNYSE DLELASLLIK IDIFPAKENG DLSPFSGTSL
1360 1370 1380 1390 1400
RERGSDASGQ LFHGRAREGS FESRYQQPFE DFRISQEHLA DHFDSRERRA
1410
PRRTRVNGDN RL
Length:1,412
Mass (Da):161,303
Last modified:August 2, 2005 - v1
Checksum:i6B3233E8A77FAD3D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB210028 mRNA Translation: BAE06110.1
RefSeqiNP_002651.2, NM_002660.2
NP_877963.1, NM_182811.1
UniGeneiHs.268177

Genome annotation databases

GeneIDi5335
KEGGihsa:5335

Similar proteinsi

Entry informationi

Entry nameiQ4LE43_HUMAN
AccessioniPrimary (citable) accession number: Q4LE43
Entry historyiIntegrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: March 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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Main funding by: National Institutes of Health