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Protein

Phosphoinositide phospholipase C

Gene

PLCG1 variant protein

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation, TransducerSAAS annotation

Keywords - Biological processi

Lipid degradationUniRule annotation, Lipid metabolism

Enzyme and pathway databases

SignaLinkiQ4LE43.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phospholipase CUniRule annotation (EC:3.1.4.11UniRule annotation)
Gene namesi
Name:PLCG1 variant proteinImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33392.

PTM / Processingi

Proteomic databases

PaxDbiQ4LE43.
PeptideAtlasiQ4LE43.
PRIDEiQ4LE43.

Expressioni

Gene expression databases

GenevisibleiQ4LE43. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000244007.

Structurei

3D structure databases

ProteinModelPortaliQ4LE43.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini149 – 264PHInterPro annotationAdd BLAST116
Domaini274 – 309EF-handInterPro annotationAdd BLAST36
Domaini442 – 586PI-PLC X-boxInterPro annotationAdd BLAST145
Domaini672 – 779SH2InterPro annotationAdd BLAST108
Domaini790 – 878SH2InterPro annotationAdd BLAST89
Domaini913 – 973SH3InterPro annotationAdd BLAST61
Domaini1017 – 1053PHInterPro annotationAdd BLAST37
Domaini1075 – 1192PI-PLC Y-boxInterPro annotationAdd BLAST118
Domaini1197 – 1299C2InterPro annotationAdd BLAST103

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation
Contains 1 PI-PLC X-box domain.UniRule annotation
Contains 1 PI-PLC Y-box domain.UniRule annotation
Contains 1 SH3 domain.UniRule annotation
Contains 3 PH domains.UniRule annotation

Keywords - Domaini

SH3 domainUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1264. Eukaryota.
ENOG410XPXE. LUCA.
HOGENOMiHOG000230864.
HOVERGENiHBG053611.
KOiK01116.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
2.30.29.30. 3 hits.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
3.30.505.10. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001192. PI-PLC_fam.
IPR028380. PLC-gamma1.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
IPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 2 hits.
PTHR10336:SF52. PTHR10336:SF52. 2 hits.
PfamiPF00168. C2. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF00017. SH2. 2 hits.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00390. PHPHLIPASEC.
PR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 3 hits.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
SM00252. SH2. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF51695. SSF51695. 2 hits.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
PS50001. SH2. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q4LE43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ESSAGLRAGW VDRERRALPP PSRLRPRLRP VWGSRGAGAA GRRAGVLPTG
60 70 80 90 100
ARAPLFPAPK RGGASGQPRP AALRPRPVSA CRSRRRVPLV CRLSLSPNLS
110 120 130 140 150
RRRCACSRAV LACAAAAPSV GAMAGAASPC ANGCGPGAPS DAEVLHLCRS
160 170 180 190 200
LEVGTVMTLF YSKKSQRPER KTFQVKLETR QITWSRGADK IEGAIDIREI
210 220 230 240 250
KEIRPGKTSR DFDRYQEDPA FRPDQSHCFV ILYGMEFRLK TLSLQATSED
260 270 280 290 300
EVNMWIKGLT WLMEDTLQAP TPLQIERWLR KQFYSVDRNR EDRISAKDLK
310 320 330 340 350
NMLSQVNYRV PNMRFLRERL TDLEQRSGDI TYGQFAQLYR SLMYSAQKTM
360 370 380 390 400
DLPFLEASTL RAGERPELCR VSLPEFQQFL LDYQGELWAV DRLQVQEFML
410 420 430 440 450
SFLRDPLREI EEPYFFLDEF VTFLFSKENS VWNSQLDAVC PDTMNNPLSH
460 470 480 490 500
YWISSSHNTY LTGDQFSSES SLEAYARCLR MGCRCIELDC WDGPDGMPVI
510 520 530 540 550
YHGHTLTTKI KFSDVLHTIK EHAFVASEYP VILSIEDHCS IAQQRNMAQY
560 570 580 590 600
FKKVLGDTLL TKPVEISADG LPSPNQLKRK ILIKHKKLAE GSAYEEVPTS
610 620 630 640 650
MMYSENDISN SIKNGILYLE DPVNHEWYPH YFVLTSSKIY YSEETSSDQG
660 670 680 690 700
NEDEEEPKEV SSSTELHSNE KWFHGKLGAG RDGRHIAERL LTEYCIETGA
710 720 730 740 750
PDGSFLVRES ETFVGDYTLS FWRNGKVQHC RIHSRQDAGT PKFFLTDNLV
760 770 780 790 800
FDSLYDLITH YQQVPLRCNE FEMRLSEPVP QTNAHESKEW YHASLTRAQA
810 820 830 840 850
EHMLMRVPRD GAFLVRKRNE PNSYAISFRA EGKIKHCRVQ QEGQTVMLGN
860 870 880 890 900
SEFDSLVDLI SYYEKHPLYR KMKLRYPINE EALEKIGTAE PDYGALYEGR
910 920 930 940 950
NPGFYVEANP MPTFKCAVKA LFDYKAQRED ELTFTKSAII QNVEKQEGGW
960 970 980 990 1000
WRGDYGGKKQ LWFPSNYVEE MVNPVALEPE REHLDENSPL GDLLRGVLDV
1010 1020 1030 1040 1050
PACQIAIRPE GKNNRLFVFS ISMASVAHWS LDVAADSQEE LQDWVKKIRE
1060 1070 1080 1090 1100
VAQTADARLT EGKIMERRKK IALELSELVV YCRPVPFDEE KIGTERACYR
1110 1120 1130 1140 1150
DMSSFPETKA EKYVNKAKGK KFLQYNRLQL SRIYPKGQRL DSSNYDPLPM
1160 1170 1180 1190 1200
WICGSQLVAL NFQTPDKPMQ MNQALFMTGR HCGYVLQPST MRDEAFDPFD
1210 1220 1230 1240 1250
KSSLRGLEPC AISIEVLGAR HLPKNGRGIV CPFVEIEVAG AEYDSTKQKT
1260 1270 1280 1290 1300
EFVVDNGLNP VWPAKPFHFQ ISNPEFAFLR FVVYEEDMFS DQNFLAQATF
1310 1320 1330 1340 1350
PVKGLKTGYR AVPLKNNYSE DLELASLLIK IDIFPAKENG DLSPFSGTSL
1360 1370 1380 1390 1400
RERGSDASGQ LFHGRAREGS FESRYQQPFE DFRISQEHLA DHFDSRERRA
1410
PRRTRVNGDN RL
Length:1,412
Mass (Da):161,303
Last modified:August 2, 2005 - v1
Checksum:i6B3233E8A77FAD3D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB210028 mRNA. Translation: BAE06110.1.
RefSeqiNP_002651.2. NM_002660.2.
NP_877963.1. NM_182811.1.
UniGeneiHs.268177.

Genome annotation databases

GeneIDi5335.
KEGGihsa:5335.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB210028 mRNA. Translation: BAE06110.1.
RefSeqiNP_002651.2. NM_002660.2.
NP_877963.1. NM_182811.1.
UniGeneiHs.268177.

3D structure databases

ProteinModelPortaliQ4LE43.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000244007.

Proteomic databases

PaxDbiQ4LE43.
PeptideAtlasiQ4LE43.
PRIDEiQ4LE43.

Protocols and materials databases

DNASUi5335.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5335.
KEGGihsa:5335.

Organism-specific databases

CTDi5335.
PharmGKBiPA33392.

Phylogenomic databases

eggNOGiKOG1264. Eukaryota.
ENOG410XPXE. LUCA.
HOGENOMiHOG000230864.
HOVERGENiHBG053611.
KOiK01116.

Enzyme and pathway databases

SignaLinkiQ4LE43.

Miscellaneous databases

ChiTaRSiPLCG1. human.
GenomeRNAii5335.

Gene expression databases

GenevisibleiQ4LE43. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
2.30.29.30. 3 hits.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
3.30.505.10. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001192. PI-PLC_fam.
IPR028380. PLC-gamma1.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
IPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 2 hits.
PTHR10336:SF52. PTHR10336:SF52. 2 hits.
PfamiPF00168. C2. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF00017. SH2. 2 hits.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00390. PHPHLIPASEC.
PR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 3 hits.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
SM00252. SH2. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF51695. SSF51695. 2 hits.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
PS50001. SH2. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ4LE43_HUMAN
AccessioniPrimary (citable) accession number: Q4LE43
Entry historyi
Integrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: September 7, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.