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Protein

AT-rich interactive domain-containing protein 4B

Gene

ARID4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-3214815. HDACs deacetylate histones.
R-HSA-427413. NoRC negatively regulates rRNA expression.

Names & Taxonomyi

Protein namesi
Recommended name:
AT-rich interactive domain-containing protein 4B
Short name:
ARID domain-containing protein 4B
Alternative name(s):
180 kDa Sin3-associated polypeptide
Short name:
Sin3-associated polypeptide p180
Breast cancer-associated antigen BRCAA1
Histone deacetylase complex subunit SAP180
Retinoblastoma-binding protein 1-like 1
Gene namesi
Name:ARID4B
Synonyms:BRCAA1, RBBP1L1, RBP1L1, SAP180
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15550. ARID4B.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation
  • Cytoplasm 2 Publications

  • Note: Cytoplasmic in breast cancer cells.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51742.
OpenTargetsiENSG00000054267.
PharmGKBiPA134940494.

Polymorphism and mutation databases

BioMutaiARID4B.
DMDMi143955276.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002828631 – 1312AT-rich interactive domain-containing protein 4BAdd BLAST1312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei276PhosphoserineCombined sources1
Modified residuei295PhosphoserineBy similarity1
Modified residuei296PhosphoserineBy similarity1
Cross-linki429Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki440Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei483PhosphoserineCombined sources1
Modified residuei666PhosphoserineCombined sources1
Modified residuei675PhosphoserineCombined sources1
Modified residuei717PhosphoserineCombined sources1
Modified residuei778PhosphoserineCombined sources1
Modified residuei790PhosphoserineCombined sources1
Modified residuei793PhosphothreonineCombined sources1
Modified residuei1014PhosphoserineCombined sources1
Modified residuei1026PhosphothreonineCombined sources1
Modified residuei1029PhosphoserineCombined sources1
Modified residuei1150PhosphothreonineCombined sources1
Modified residuei1152PhosphoserineCombined sources1
Modified residuei1153PhosphoserineCombined sources1
Modified residuei1155PhosphoserineCombined sources1
Modified residuei1159PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ4LE39.
MaxQBiQ4LE39.
PaxDbiQ4LE39.
PeptideAtlasiQ4LE39.
PRIDEiQ4LE39.

PTM databases

iPTMnetiQ4LE39.
PhosphoSitePlusiQ4LE39.

Expressioni

Tissue specificityi

Highly expressed in the testis and in breast, lung, colon, pancreatic and ovarian cancers. Expressed at low levels in the thymus, prostate and ovary.3 Publications

Gene expression databases

BgeeiENSG00000054267.
ExpressionAtlasiQ4LE39. baseline and differential.
GenevisibleiQ4LE39. HS.

Organism-specific databases

HPAiHPA027333.
HPA053692.

Interactioni

Subunit structurei

Component of a Sin3A corepressor complex consisting of SIN3A, SAP130, SUDS3/SAP45, SAP180, HDAC1 and HDAC2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ETS1P149212EBI-2680990,EBI-913209

Protein-protein interaction databases

BioGridi119708. 34 interactors.
IntActiQ4LE39. 20 interactors.
STRINGi9606.ENSP00000264183.

Structurei

3D structure databases

ProteinModelPortaliQ4LE39.
SMRiQ4LE39.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini306 – 398ARIDPROSITE-ProRule annotationAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni465 – 473Antigenic epitope9
Regioni1130 – 1137Antigenic epitope8

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili728 – 754Sequence analysisAdd BLAST27
Coiled coili1231 – 1270Sequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi154 – 159Poly-Ser6
Compositional biasi268 – 567Glu-richAdd BLAST300
Compositional biasi1095 – 1101Poly-Ser7
Compositional biasi1271 – 1303Ser-richAdd BLAST33

Domaini

The C-terminus mediates interaction with mSin3A corepressor complex.1 Publication
The N-terminus is involved in transcriptional repression by HDAC-independent mechanisms.1 Publication
The ARID domain is involved in stabilizing the mSin3A corepressor complex on DNA.1 Publication

Sequence similaritiesi

Contains 1 ARID domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2744. Eukaryota.
KOG3001. Eukaryota.
ENOG410Y2AP. LUCA.
GeneTreeiENSGT00850000132287.
HOVERGENiHBG058247.
InParanoidiQ4LE39.
KOiK19195.
OMAiPCKECEN.
OrthoDBiEOG091G0EG4.
PhylomeDBiQ4LE39.
TreeFamiTF106427.

Family and domain databases

Gene3Di1.10.150.60. 1 hit.
InterProiIPR028853. ARID4B.
IPR001606. ARID_dom.
IPR016197. Chromodomain-like.
IPR012603. RBB1NT.
IPR002999. Tudor.
IPR025995. Tudor-knot.
[Graphical view]
PANTHERiPTHR13964:SF24. PTHR13964:SF24. 1 hit.
PfamiPF01388. ARID. 1 hit.
PF08169. RBB1NT. 1 hit.
PF11717. Tudor-knot. 1 hit.
[Graphical view]
SMARTiSM00501. BRIGHT. 1 hit.
SM00333. TUDOR. 2 hits.
[Graphical view]
SUPFAMiSSF46774. SSF46774. 1 hit.
SSF54160. SSF54160. 1 hit.
PROSITEiPS51011. ARID. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q4LE39-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKALDEPPYL TVGTDVSAKY RGAFCEAKIK TAKRLVKVKV TFRHDSSTVE
60 70 80 90 100
VQDDHIKGPL KVGAIVEVKN LDGAYQEAVI NKLTDASWYT VVFDDGDEKT
110 120 130 140 150
LRRSSLCLKG ERHFAESETL DQLPLTNPEH FGTPVIGKKT NRGRRSNHIP
160 170 180 190 200
EEESSSSSSD EDEDDRKQID ELLGKVVCVD YISLDKKKAL WFPALVVCPD
210 220 230 240 250
CSDEIAVKKD NILVRSFKDG KFTSVPRKDV HEITSDTAPK PDAVLKQAFE
260 270 280 290 300
QALEFHKSRT IPANWKTELK EDSSSSEAEE EEEEEDDEKE KEDNSSEEEE
310 320 330 340 350
EIEPFPEERE NFLQQLYKFM EDRGTPINKR PVLGYRNLNL FKLFRLVHKL
360 370 380 390 400
GGFDNIESGA VWKQVYQDLG IPVLNSAAGY NVKCAYKKYL YGFEEYCRSA
410 420 430 440 450
NIEFQMALPE KVVNKQCKEC ENVKEIKVKE ENETEIKEIK MEEERNIIPR
460 470 480 490 500
EEKPIEDEIE RKENIKPSLG SKKNLLESIP THSDQEKEVN IKKPEDNENL
510 520 530 540 550
DDKDDDTTRV DESLNIKVEA EEEKAKSGDE TNKEEDEDDE EAEEEEEEEE
560 570 580 590 600
EEEDEDDDDN NEEEEFECYP PGMKVQVRYG RGKNQKMYEA SIKDSDVEGG
610 620 630 640 650
EVLYLVHYCG WNVRYDEWIK ADKIVRPADK NVPKIKHRKK IKNKLDKEKD
660 670 680 690 700
KDEKYSPKNC KLRRLSKPPF QTNPSPEMVS KLDLTDAKNS DTAHIKSIEI
710 720 730 740 750
TSILNGLQAS ESSAEDSEQE DERGAQDMDN NGKEESKIDH LTNNRNDLIS
760 770 780 790 800
KEEQNSSSLL EENKVHADLV ISKPVSKSPE RLRKDIEVLS EDTDYEEDEV
810 820 830 840 850
TKKRKDVKKD TTDKSSKPQI KRGKRRYCNT EECLKTGSPG KKEEKAKNKE
860 870 880 890 900
SLCMENSSNS SSDEDEEETK AKMTPTKKYN GLEEKRKSLR TTGFYSGFSE
910 920 930 940 950
VAEKRIKLLN NSDERLQNSR AKDRKDVWSS IQGQWPKKTL KELFSDSDTE
960 970 980 990 1000
AAASPPHPAP EEGVAEESLQ TVAEEESCSP SVELEKPPPV NVDSKPIEEK
1010 1020 1030 1040 1050
TVEVNDRKAE FPSSGSNSVL NTPPTTPESP SSVTVTEGSR QQSSVTVSEP
1060 1070 1080 1090 1100
LAPNQEEVRS IKSETDSTIE VDSVAGELQD LQSEGNSSPA GFDASVSSSS
1110 1120 1130 1140 1150
SNQPEPEHPE KACTGQKRVK DAQGGGSSSK KQKRSHKATV VNNKKKGKGT
1160 1170 1180 1190 1200
NSSDSEELSA GESITKSQPV KSVSTGMKSH STKSPARTQS PGKCGKNGDK
1210 1220 1230 1240 1250
DPDLKEPSNR LPKVYKWSFQ MSDLENMTSA ERITILQEKL QEIRKHYLSL
1260 1270 1280 1290 1300
KSEVASIDRR RKRLKKKERE SAATSSSSSS PSSSSITAAV MLTLAEPSMS
1310
SASQNGMSVE CR
Length:1,312
Mass (Da):147,809
Last modified:April 3, 2007 - v2
Checksum:iE4175FF80F5217EE
GO
Isoform 2 (identifier: Q4LE39-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     529-614: Missing.

Show »
Length:1,226
Mass (Da):137,607
Checksum:i3ADAB4A897403AD9
GO
Isoform 3 (identifier: Q4LE39-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1150-1153: TNSS → SAPH
     1154-1312: Missing.

Show »
Length:1,153
Mass (Da):130,418
Checksum:i9C540DF507EBC220
GO
Isoform 4 (identifier: Q4LE39-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-319: Missing.
     1112-1122: ACTGQKRVKDA → GEKENVYVDLF
     1123-1312: Missing.

Show »
Length:803
Mass (Da):91,140
Checksum:iAC58481D8DE15417
GO

Sequence cautioni

The sequence AAD41239 differs from that shown. Reason: Frameshift at positions 859, 869, 1287 and 1311.Curated
The sequence AAF23433 differs from that shown. Reason: Frameshift at positions 1287 and 1311.Curated
The sequence BAB14428 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE06114 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI13751 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15D → G in AAO63590 (PubMed:12724404).Curated1
Sequence conflicti79V → A in AAO63590 (PubMed:12724404).Curated1
Sequence conflicti330R → Q in AAF28341 (PubMed:11481388).Curated1
Sequence conflicti330R → Q in AAF23433 (PubMed:15247124).Curated1
Sequence conflicti400A → P in BAA89794 (Ref. 4) Curated1
Sequence conflicti436I → IEFCGR in AAF23433 (PubMed:15247124).Curated1
Sequence conflicti437K → Q in BAA89794 (Ref. 4) Curated1
Sequence conflicti559 – 561DNN → ATI in BAA89794 (Ref. 4) Curated3
Sequence conflicti568C → S in BAA89794 (Ref. 4) Curated1
Sequence conflicti575V → A in BAA89794 (Ref. 4) Curated1
Sequence conflicti584N → H in BAA89794 (Ref. 4) Curated1
Sequence conflicti605L → S in AAF36964 (Ref. 9) Curated1
Sequence conflicti616D → G in AAF36964 (Ref. 9) Curated1
Sequence conflicti813D → G in AAO63590 (PubMed:12724404).Curated1
Sequence conflicti915 – 917RLQ → LP in AAF23433 (PubMed:15247124).Curated3
Sequence conflicti940L → R in AAF23433 (PubMed:15247124).Curated1
Sequence conflicti1000K → E in AAF28341 (PubMed:11481388).Curated1
Sequence conflicti1000K → E in AAF36964 (Ref. 9) Curated1
Sequence conflicti1001T → Q in AAF23433 (PubMed:15247124).Curated1
Sequence conflicti1032S → P in AAO63590 (PubMed:12724404).Curated1
Sequence conflicti1087S → N in AAO63590 (PubMed:12724404).Curated1
Sequence conflicti1118R → G in CAI46047 (PubMed:17974005).Curated1
Sequence conflicti1144K → T in AAF23433 (PubMed:15247124).Curated1
Sequence conflicti1144K → T in AAD41239 (Ref. 10) Curated1
Sequence conflicti1243 – 1244IR → NQ in AAF23433 (PubMed:15247124).Curated2
Sequence conflicti1243 – 1244IR → NQ in AAD41239 (Ref. 10) Curated2
Sequence conflicti1290V → A in AAF28341 (PubMed:11481388).Curated1
Sequence conflicti1290V → A in AAF36964 (Ref. 9) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0242301 – 319Missing in isoform 4. 1 PublicationAdd BLAST319
Alternative sequenceiVSP_024231529 – 614Missing in isoform 2. 4 PublicationsAdd BLAST86
Alternative sequenceiVSP_0242321112 – 1122ACTGQKRVKDA → GEKENVYVDLF in isoform 4. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_0242331123 – 1312Missing in isoform 4. 1 PublicationAdd BLAST190
Alternative sequenceiVSP_0242341150 – 1153TNSS → SAPH in isoform 3. 1 Publication4
Alternative sequenceiVSP_0242351154 – 1312Missing in isoform 3. 1 PublicationAdd BLAST159

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF214114 mRNA. Translation: AAF28341.2.
AY220790 mRNA. Translation: AAO63590.1.
AF208045 mRNA. Translation: AAF23433.3. Frameshift.
AB030181 mRNA. Translation: BAA89794.1.
AB210032 mRNA. Translation: BAE06114.1. Different initiation.
AL391994, AL133418 Genomic DNA. Translation: CAI13747.2.
AL391994 Genomic DNA. Translation: CAI13749.1.
AL391994, AL133418 Genomic DNA. Translation: CAI13751.1. Sequence problems.
AL133418, AL391994 Genomic DNA. Translation: CAI22961.2.
AL133418, AL391994 Genomic DNA. Translation: CAI22962.1.
BC048959 mRNA. Translation: AAH48959.1. Different termination.
BC062536 mRNA. Translation: AAH62536.1. Different termination.
BC104632 mRNA. Translation: AAI04633.1. Different termination.
BC130418 mRNA. Translation: AAI30419.1.
BX648820 mRNA. Translation: CAI46047.1.
AL133594 mRNA. Translation: CAB63731.1.
AF227899 mRNA. Translation: AAF36964.1.
AF083249 mRNA. Translation: AAD41239.1. Frameshift.
AK023144 mRNA. Translation: BAB14428.1. Different initiation.
CCDSiCCDS31060.1. [Q4LE39-2]
CCDS31061.1. [Q4LE39-1]
PIRiT43497.
RefSeqiNP_001193723.1. NM_001206794.1. [Q4LE39-1]
NP_057458.4. NM_016374.5. [Q4LE39-1]
NP_112739.2. NM_031371.3. [Q4LE39-2]
XP_011542514.1. XM_011544212.2. [Q4LE39-1]
UniGeneiHs.575782.

Genome annotation databases

EnsembliENST00000264183; ENSP00000264183; ENSG00000054267. [Q4LE39-1]
ENST00000349213; ENSP00000264184; ENSG00000054267. [Q4LE39-2]
ENST00000366603; ENSP00000355562; ENSG00000054267. [Q4LE39-1]
ENST00000421364; ENSP00000394663; ENSG00000054267. [Q4LE39-3]
GeneIDi51742.
KEGGihsa:51742.
UCSCiuc001hwq.3. human. [Q4LE39-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF214114 mRNA. Translation: AAF28341.2.
AY220790 mRNA. Translation: AAO63590.1.
AF208045 mRNA. Translation: AAF23433.3. Frameshift.
AB030181 mRNA. Translation: BAA89794.1.
AB210032 mRNA. Translation: BAE06114.1. Different initiation.
AL391994, AL133418 Genomic DNA. Translation: CAI13747.2.
AL391994 Genomic DNA. Translation: CAI13749.1.
AL391994, AL133418 Genomic DNA. Translation: CAI13751.1. Sequence problems.
AL133418, AL391994 Genomic DNA. Translation: CAI22961.2.
AL133418, AL391994 Genomic DNA. Translation: CAI22962.1.
BC048959 mRNA. Translation: AAH48959.1. Different termination.
BC062536 mRNA. Translation: AAH62536.1. Different termination.
BC104632 mRNA. Translation: AAI04633.1. Different termination.
BC130418 mRNA. Translation: AAI30419.1.
BX648820 mRNA. Translation: CAI46047.1.
AL133594 mRNA. Translation: CAB63731.1.
AF227899 mRNA. Translation: AAF36964.1.
AF083249 mRNA. Translation: AAD41239.1. Frameshift.
AK023144 mRNA. Translation: BAB14428.1. Different initiation.
CCDSiCCDS31060.1. [Q4LE39-2]
CCDS31061.1. [Q4LE39-1]
PIRiT43497.
RefSeqiNP_001193723.1. NM_001206794.1. [Q4LE39-1]
NP_057458.4. NM_016374.5. [Q4LE39-1]
NP_112739.2. NM_031371.3. [Q4LE39-2]
XP_011542514.1. XM_011544212.2. [Q4LE39-1]
UniGeneiHs.575782.

3D structure databases

ProteinModelPortaliQ4LE39.
SMRiQ4LE39.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119708. 34 interactors.
IntActiQ4LE39. 20 interactors.
STRINGi9606.ENSP00000264183.

PTM databases

iPTMnetiQ4LE39.
PhosphoSitePlusiQ4LE39.

Polymorphism and mutation databases

BioMutaiARID4B.
DMDMi143955276.

Proteomic databases

EPDiQ4LE39.
MaxQBiQ4LE39.
PaxDbiQ4LE39.
PeptideAtlasiQ4LE39.
PRIDEiQ4LE39.

Protocols and materials databases

DNASUi51742.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264183; ENSP00000264183; ENSG00000054267. [Q4LE39-1]
ENST00000349213; ENSP00000264184; ENSG00000054267. [Q4LE39-2]
ENST00000366603; ENSP00000355562; ENSG00000054267. [Q4LE39-1]
ENST00000421364; ENSP00000394663; ENSG00000054267. [Q4LE39-3]
GeneIDi51742.
KEGGihsa:51742.
UCSCiuc001hwq.3. human. [Q4LE39-1]

Organism-specific databases

CTDi51742.
DisGeNETi51742.
GeneCardsiARID4B.
HGNCiHGNC:15550. ARID4B.
HPAiHPA027333.
HPA053692.
MIMi609696. gene.
neXtProtiNX_Q4LE39.
OpenTargetsiENSG00000054267.
PharmGKBiPA134940494.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2744. Eukaryota.
KOG3001. Eukaryota.
ENOG410Y2AP. LUCA.
GeneTreeiENSGT00850000132287.
HOVERGENiHBG058247.
InParanoidiQ4LE39.
KOiK19195.
OMAiPCKECEN.
OrthoDBiEOG091G0EG4.
PhylomeDBiQ4LE39.
TreeFamiTF106427.

Enzyme and pathway databases

ReactomeiR-HSA-3214815. HDACs deacetylate histones.
R-HSA-427413. NoRC negatively regulates rRNA expression.

Miscellaneous databases

ChiTaRSiARID4B. human.
GeneWikiiARID4B.
GenomeRNAii51742.
PROiQ4LE39.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000054267.
ExpressionAtlasiQ4LE39. baseline and differential.
GenevisibleiQ4LE39. HS.

Family and domain databases

Gene3Di1.10.150.60. 1 hit.
InterProiIPR028853. ARID4B.
IPR001606. ARID_dom.
IPR016197. Chromodomain-like.
IPR012603. RBB1NT.
IPR002999. Tudor.
IPR025995. Tudor-knot.
[Graphical view]
PANTHERiPTHR13964:SF24. PTHR13964:SF24. 1 hit.
PfamiPF01388. ARID. 1 hit.
PF08169. RBB1NT. 1 hit.
PF11717. Tudor-knot. 1 hit.
[Graphical view]
SMARTiSM00501. BRIGHT. 1 hit.
SM00333. TUDOR. 2 hits.
[Graphical view]
SUPFAMiSSF46774. SSF46774. 1 hit.
SSF54160. SSF54160. 1 hit.
PROSITEiPS51011. ARID. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARI4B_HUMAN
AccessioniPrimary (citable) accession number: Q4LE39
Secondary accession number(s): A1L465
, Q3MHV4, Q5HY99, Q5T2C2, Q5T2C3, Q5T2C4, Q5T2C5, Q5T2C6, Q6P600, Q86UX1, Q86WR4, Q9H915, Q9NYU3, Q9NZB6, Q9NZG4, Q9P2W4, Q9UF62, Q9Y6E1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: November 30, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.