Q4LE39 (ARI4B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
AT-rich interactive domain-containing protein 4B
Short name=ARID domain-containing protein 4B

Alternative name(s):
180 kDa Sin3-associated polypeptide
Short name=Sin3-associated polypeptide p180
Breast cancer-associated antigen BRCAA1
Histone deacetylase complex subunit SAP180
Retinoblastoma-binding protein 1-like 1

Gene names

Name:	ARID4B
Synonyms:	BRCAA1, RBBP1L1, RBP1L1, SAP180

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1312 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. Ref.2
Subunit structure	Component of a Sin3A corepressor complex consisting of SIN3A, SAP130, SUDS3/SAP45, SAP180, HDAC1 and HDAC2.
Subcellular location	Nucleus By similarity. Cytoplasm. Note: Cytoplasmic in breast cancer cells. Ref.1 Ref.3
Tissue specificity	Highly expressed in the testis and in breast, lung, colon, pancreatic and ovarian cancers. Expressed at low levels in the thymus, prostate and ovary. Ref.1 Ref.2 Ref.3
Domain	The C-terminus mediates interaction with mSin3A corepressor complex. Ref.2 The N-terminus is involved in transcriptional repression by HDAC-independent mechanisms. Ref.2 The ARID domain is involved in stabilizing the mSin3A corepressor complex on DNA. Ref.2
Sequence similarities	Contains 1 ARID domain.
Sequence caution	The sequence AAD41239.1 differs from that shown. Reason: Frameshift at positions 859, 869, 1287 and 1311. The sequence AAF23433.3 differs from that shown. Reason: Frameshift at positions 1287 and 1311. The sequence BAB14428.1 differs from that shown. Reason: Erroneous initiation. The sequence BAE06114.1 differs from that shown. Reason: Erroneous initiation. The sequence CAI13751.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
Ligand	DNA-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ETS1	P14921	2	EBI-2680990,EBI-913209

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q4LE39-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q4LE39-2)

The sequence of this isoform differs from the canonical sequence as follows:
     529-614: Missing.

Isoform 3 (identifier: Q4LE39-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1150-1153: TNSS → SAPH
     1154-1312: Missing.

Isoform 4 (identifier: Q4LE39-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-319: Missing.
     1112-1122: ACTGQKRVKDA → GEKENVYVDLF
     1123-1312: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1312	1312	AT-rich interactive domain-containing protein 4B		PRO_0000282863
Regions
	Domain	306 – 398	93	ARID
	Region	465 – 473	9	Antigenic epitope
	Region	1130 – 1137	8	Antigenic epitope
	Coiled coil	728 – 754	27	Potential
	Coiled coil	1231 – 1270	40	Potential
	Compositional bias	154 – 159	6	Poly-Ser
	Compositional bias	268 – 567	300	Glu-rich
	Compositional bias	1095 – 1101	7	Poly-Ser
	Compositional bias	1271 – 1303	33	Ser-rich
Amino acid modifications
	Modified residue	666	1	Phosphoserine Ref.16
	Modified residue	675	1	Phosphoserine Ref.16 Ref.17
	Modified residue	710	1	Phosphoserine Ref.13
	Modified residue	712	1	Phosphoserine Ref.13
	Modified residue	713	1	Phosphoserine Ref.13
	Modified residue	717	1	Phosphoserine Ref.13
	Modified residue	778	1	Phosphoserine Ref.14
	Modified residue	790	1	Phosphoserine Ref.16 Ref.17 Ref.18
	Modified residue	793	1	Phosphothreonine Ref.16 Ref.17 Ref.18
	Modified residue	795	1	Phosphotyrosine Ref.17
	Modified residue	912	1	Phosphoserine Ref.16
	Modified residue	1014	1	Phosphoserine Ref.18
	Modified residue	1022	1	Phosphothreonine Ref.12 Ref.18
	Modified residue	1026	1	Phosphothreonine Ref.18
	Modified residue	1029	1	Phosphoserine Ref.12
	Modified residue	1150	1	Phosphothreonine Ref.16
	Modified residue	1152	1	Phosphoserine Ref.16
	Modified residue	1153	1	Phosphoserine Ref.16 Ref.17
	Modified residue	1155	1	Phosphoserine Ref.16 Ref.17
	Modified residue	1159	1	Phosphoserine Ref.16
	Modified residue	1256	1	Phosphoserine Ref.15
Natural variations
	Alternative sequence	1 – 319	319	Missing in isoform 4.		VSP_024230
	Alternative sequence	529 – 614	86	Missing in isoform 2.		VSP_024231
	Alternative sequence	1112 – 1122	11	ACTGQKRVKDA → GEKENVYVDLF in isoform 4.		VSP_024232
	Alternative sequence	1123 – 1312	190	Missing in isoform 4.		VSP_024233
	Alternative sequence	1150 – 1153	4	TNSS → SAPH in isoform 3.		VSP_024234
	Alternative sequence	1154 – 1312	159	Missing in isoform 3.		VSP_024235
Experimental info
	Sequence conflict	15	1	D → G in AAO63590. Ref.2
	Sequence conflict	79	1	V → A in AAO63590. Ref.2
	Sequence conflict	330	1	R → Q in AAF28341. Ref.1
	Sequence conflict	330	1	R → Q in AAF23433. Ref.3
	Sequence conflict	400	1	A → P in BAA89794. Ref.4
	Sequence conflict	436	1	I → IEFCGR in AAF23433. Ref.3
	Sequence conflict	437	1	K → Q in BAA89794. Ref.4
	Sequence conflict	559 – 561	3	DNN → ATI in BAA89794. Ref.4
	Sequence conflict	568	1	C → S in BAA89794. Ref.4
	Sequence conflict	575	1	V → A in BAA89794. Ref.4
	Sequence conflict	584	1	N → H in BAA89794. Ref.4
	Sequence conflict	605	1	L → S in AAF36964. Ref.9
	Sequence conflict	616	1	D → G in AAF36964. Ref.9
	Sequence conflict	813	1	D → G in AAO63590. Ref.2
	Sequence conflict	915 – 917	3	RLQ → LP in AAF23433. Ref.3
	Sequence conflict	940	1	L → R in AAF23433. Ref.3
	Sequence conflict	1000	1	K → E in AAF28341. Ref.1
	Sequence conflict	1000	1	K → E in AAF36964. Ref.9
	Sequence conflict	1001	1	T → Q in AAF23433. Ref.3
	Sequence conflict	1032	1	S → P in AAO63590. Ref.2
	Sequence conflict	1087	1	S → N in AAO63590. Ref.2
	Sequence conflict	1118	1	R → G in CAI46047. Ref.8
	Sequence conflict	1144	1	K → T in AAF23433. Ref.3
	Sequence conflict	1144	1	K → T in AAD41239. Ref.10
	Sequence conflict	1243 – 1244	2	IR → NQ in AAF23433. Ref.3
	Sequence conflict	1243 – 1244	2	IR → NQ in AAD41239. Ref.10
	Sequence conflict	1290	1	V → A in AAF28341. Ref.1
	Sequence conflict	1290	1	V → A in AAF36964. Ref.9

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 3, 2007. Version 2. Checksum: E4175FF80F5217EE	FASTA	1,312	147,809
	10 20 30 40 50 60 MKALDEPPYL TVGTDVSAKY RGAFCEAKIK TAKRLVKVKV TFRHDSSTVE VQDDHIKGPL 70 80 90 100 110 120 KVGAIVEVKN LDGAYQEAVI NKLTDASWYT VVFDDGDEKT LRRSSLCLKG ERHFAESETL 130 140 150 160 170 180 DQLPLTNPEH FGTPVIGKKT NRGRRSNHIP EEESSSSSSD EDEDDRKQID ELLGKVVCVD 190 200 210 220 230 240 YISLDKKKAL WFPALVVCPD CSDEIAVKKD NILVRSFKDG KFTSVPRKDV HEITSDTAPK 250 260 270 280 290 300 PDAVLKQAFE QALEFHKSRT IPANWKTELK EDSSSSEAEE EEEEEDDEKE KEDNSSEEEE 310 320 330 340 350 360 EIEPFPEERE NFLQQLYKFM EDRGTPINKR PVLGYRNLNL FKLFRLVHKL GGFDNIESGA 370 380 390 400 410 420 VWKQVYQDLG IPVLNSAAGY NVKCAYKKYL YGFEEYCRSA NIEFQMALPE KVVNKQCKEC 430 440 450 460 470 480 ENVKEIKVKE ENETEIKEIK MEEERNIIPR EEKPIEDEIE RKENIKPSLG SKKNLLESIP 490 500 510 520 530 540 THSDQEKEVN IKKPEDNENL DDKDDDTTRV DESLNIKVEA EEEKAKSGDE TNKEEDEDDE 550 560 570 580 590 600 EAEEEEEEEE EEEDEDDDDN NEEEEFECYP PGMKVQVRYG RGKNQKMYEA SIKDSDVEGG 610 620 630 640 650 660 EVLYLVHYCG WNVRYDEWIK ADKIVRPADK NVPKIKHRKK IKNKLDKEKD KDEKYSPKNC 670 680 690 700 710 720 KLRRLSKPPF QTNPSPEMVS KLDLTDAKNS DTAHIKSIEI TSILNGLQAS ESSAEDSEQE 730 740 750 760 770 780 DERGAQDMDN NGKEESKIDH LTNNRNDLIS KEEQNSSSLL EENKVHADLV ISKPVSKSPE 790 800 810 820 830 840 RLRKDIEVLS EDTDYEEDEV TKKRKDVKKD TTDKSSKPQI KRGKRRYCNT EECLKTGSPG 850 860 870 880 890 900 KKEEKAKNKE SLCMENSSNS SSDEDEEETK AKMTPTKKYN GLEEKRKSLR TTGFYSGFSE 910 920 930 940 950 960 VAEKRIKLLN NSDERLQNSR AKDRKDVWSS IQGQWPKKTL KELFSDSDTE AAASPPHPAP 970 980 990 1000 1010 1020 EEGVAEESLQ TVAEEESCSP SVELEKPPPV NVDSKPIEEK TVEVNDRKAE FPSSGSNSVL 1030 1040 1050 1060 1070 1080 NTPPTTPESP SSVTVTEGSR QQSSVTVSEP LAPNQEEVRS IKSETDSTIE VDSVAGELQD 1090 1100 1110 1120 1130 1140 LQSEGNSSPA GFDASVSSSS SNQPEPEHPE KACTGQKRVK DAQGGGSSSK KQKRSHKATV 1150 1160 1170 1180 1190 1200 VNNKKKGKGT NSSDSEELSA GESITKSQPV KSVSTGMKSH STKSPARTQS PGKCGKNGDK 1210 1220 1230 1240 1250 1260 DPDLKEPSNR LPKVYKWSFQ MSDLENMTSA ERITILQEKL QEIRKHYLSL KSEVASIDRR 1270 1280 1290 1300 1310 RKRLKKKERE SAATSSSSSS PSSSSITAAV MLTLAEPSMS SASQNGMSVE CR
	Isoform 2 [UniParc]. Checksum: 3ADAB4A897403AD9	FASTA	1,226	137,607
	10 20 30 40 50 60 MKALDEPPYL TVGTDVSAKY RGAFCEAKIK TAKRLVKVKV TFRHDSSTVE VQDDHIKGPL 70 80 90 100 110 120 KVGAIVEVKN LDGAYQEAVI NKLTDASWYT VVFDDGDEKT LRRSSLCLKG ERHFAESETL 130 140 150 160 170 180 DQLPLTNPEH FGTPVIGKKT NRGRRSNHIP EEESSSSSSD EDEDDRKQID ELLGKVVCVD 190 200 210 220 230 240 YISLDKKKAL WFPALVVCPD CSDEIAVKKD NILVRSFKDG KFTSVPRKDV HEITSDTAPK 250 260 270 280 290 300 PDAVLKQAFE QALEFHKSRT IPANWKTELK EDSSSSEAEE EEEEEDDEKE KEDNSSEEEE 310 320 330 340 350 360 EIEPFPEERE NFLQQLYKFM EDRGTPINKR PVLGYRNLNL FKLFRLVHKL GGFDNIESGA 370 380 390 400 410 420 VWKQVYQDLG IPVLNSAAGY NVKCAYKKYL YGFEEYCRSA NIEFQMALPE KVVNKQCKEC 430 440 450 460 470 480 ENVKEIKVKE ENETEIKEIK MEEERNIIPR EEKPIEDEIE RKENIKPSLG SKKNLLESIP 490 500 510 520 530 540 THSDQEKEVN IKKPEDNENL DDKDDDTTRV DESLNIKVEA EEEKAKSGYD EWIKADKIVR 550 560 570 580 590 600 PADKNVPKIK HRKKIKNKLD KEKDKDEKYS PKNCKLRRLS KPPFQTNPSP EMVSKLDLTD 610 620 630 640 650 660 AKNSDTAHIK SIEITSILNG LQASESSAED SEQEDERGAQ DMDNNGKEES KIDHLTNNRN 670 680 690 700 710 720 DLISKEEQNS SSLLEENKVH ADLVISKPVS KSPERLRKDI EVLSEDTDYE EDEVTKKRKD 730 740 750 760 770 780 VKKDTTDKSS KPQIKRGKRR YCNTEECLKT GSPGKKEEKA KNKESLCMEN SSNSSSDEDE 790 800 810 820 830 840 EETKAKMTPT KKYNGLEEKR KSLRTTGFYS GFSEVAEKRI KLLNNSDERL QNSRAKDRKD 850 860 870 880 890 900 VWSSIQGQWP KKTLKELFSD SDTEAAASPP HPAPEEGVAE ESLQTVAEEE SCSPSVELEK 910 920 930 940 950 960 PPPVNVDSKP IEEKTVEVND RKAEFPSSGS NSVLNTPPTT PESPSSVTVT EGSRQQSSVT 970 980 990 1000 1010 1020 VSEPLAPNQE EVRSIKSETD STIEVDSVAG ELQDLQSEGN SSPAGFDASV SSSSSNQPEP 1030 1040 1050 1060 1070 1080 EHPEKACTGQ KRVKDAQGGG SSSKKQKRSH KATVVNNKKK GKGTNSSDSE ELSAGESITK 1090 1100 1110 1120 1130 1140 SQPVKSVSTG MKSHSTKSPA RTQSPGKCGK NGDKDPDLKE PSNRLPKVYK WSFQMSDLEN 1150 1160 1170 1180 1190 1200 MTSAERITIL QEKLQEIRKH YLSLKSEVAS IDRRRKRLKK KERESAATSS SSSSPSSSSI 1210 1220 TAAVMLTLAE PSMSSASQNG MSVECR
	Isoform 3 [UniParc]. Checksum: 9C540DF507EBC220	FASTA	1,153	130,418
	10 20 30 40 50 60 MKALDEPPYL TVGTDVSAKY RGAFCEAKIK TAKRLVKVKV TFRHDSSTVE VQDDHIKGPL 70 80 90 100 110 120 KVGAIVEVKN LDGAYQEAVI NKLTDASWYT VVFDDGDEKT LRRSSLCLKG ERHFAESETL 130 140 150 160 170 180 DQLPLTNPEH FGTPVIGKKT NRGRRSNHIP EEESSSSSSD EDEDDRKQID ELLGKVVCVD 190 200 210 220 230 240 YISLDKKKAL WFPALVVCPD CSDEIAVKKD NILVRSFKDG KFTSVPRKDV HEITSDTAPK 250 260 270 280 290 300 PDAVLKQAFE QALEFHKSRT IPANWKTELK EDSSSSEAEE EEEEEDDEKE KEDNSSEEEE 310 320 330 340 350 360 EIEPFPEERE NFLQQLYKFM EDRGTPINKR PVLGYRNLNL FKLFRLVHKL GGFDNIESGA 370 380 390 400 410 420 VWKQVYQDLG IPVLNSAAGY NVKCAYKKYL YGFEEYCRSA NIEFQMALPE KVVNKQCKEC 430 440 450 460 470 480 ENVKEIKVKE ENETEIKEIK MEEERNIIPR EEKPIEDEIE RKENIKPSLG SKKNLLESIP 490 500 510 520 530 540 THSDQEKEVN IKKPEDNENL DDKDDDTTRV DESLNIKVEA EEEKAKSGDE TNKEEDEDDE 550 560 570 580 590 600 EAEEEEEEEE EEEDEDDDDN NEEEEFECYP PGMKVQVRYG RGKNQKMYEA SIKDSDVEGG 610 620 630 640 650 660 EVLYLVHYCG WNVRYDEWIK ADKIVRPADK NVPKIKHRKK IKNKLDKEKD KDEKYSPKNC 670 680 690 700 710 720 KLRRLSKPPF QTNPSPEMVS KLDLTDAKNS DTAHIKSIEI TSILNGLQAS ESSAEDSEQE 730 740 750 760 770 780 DERGAQDMDN NGKEESKIDH LTNNRNDLIS KEEQNSSSLL EENKVHADLV ISKPVSKSPE 790 800 810 820 830 840 RLRKDIEVLS EDTDYEEDEV TKKRKDVKKD TTDKSSKPQI KRGKRRYCNT EECLKTGSPG 850 860 870 880 890 900 KKEEKAKNKE SLCMENSSNS SSDEDEEETK AKMTPTKKYN GLEEKRKSLR TTGFYSGFSE 910 920 930 940 950 960 VAEKRIKLLN NSDERLQNSR AKDRKDVWSS IQGQWPKKTL KELFSDSDTE AAASPPHPAP 970 980 990 1000 1010 1020 EEGVAEESLQ TVAEEESCSP SVELEKPPPV NVDSKPIEEK TVEVNDRKAE FPSSGSNSVL 1030 1040 1050 1060 1070 1080 NTPPTTPESP SSVTVTEGSR QQSSVTVSEP LAPNQEEVRS IKSETDSTIE VDSVAGELQD 1090 1100 1110 1120 1130 1140 LQSEGNSSPA GFDASVSSSS SNQPEPEHPE KACTGQKRVK DAQGGGSSSK KQKRSHKATV 1150 VNNKKKGKGS APH
	Isoform 4 [UniParc]. Checksum: AC58481D8DE15417	FASTA	803	91,140
	10 20 30 40 50 60 MEDRGTPINK RPVLGYRNLN LFKLFRLVHK LGGFDNIESG AVWKQVYQDL GIPVLNSAAG 70 80 90 100 110 120 YNVKCAYKKY LYGFEEYCRS ANIEFQMALP EKVVNKQCKE CENVKEIKVK EENETEIKEI 130 140 150 160 170 180 KMEEERNIIP REEKPIEDEI ERKENIKPSL GSKKNLLESI PTHSDQEKEV NIKKPEDNEN 190 200 210 220 230 240 LDDKDDDTTR VDESLNIKVE AEEEKAKSGD ETNKEEDEDD EEAEEEEEEE EEEEDEDDDD 250 260 270 280 290 300 NNEEEEFECY PPGMKVQVRY GRGKNQKMYE ASIKDSDVEG GEVLYLVHYC GWNVRYDEWI 310 320 330 340 350 360 KADKIVRPAD KNVPKIKHRK KIKNKLDKEK DKDEKYSPKN CKLRRLSKPP FQTNPSPEMV 370 380 390 400 410 420 SKLDLTDAKN SDTAHIKSIE ITSILNGLQA SESSAEDSEQ EDERGAQDMD NNGKEESKID 430 440 450 460 470 480 HLTNNRNDLI SKEEQNSSSL LEENKVHADL VISKPVSKSP ERLRKDIEVL SEDTDYEEDE 490 500 510 520 530 540 VTKKRKDVKK DTTDKSSKPQ IKRGKRRYCN TEECLKTGSP GKKEEKAKNK ESLCMENSSN 550 560 570 580 590 600 SSSDEDEEET KAKMTPTKKY NGLEEKRKSL RTTGFYSGFS EVAEKRIKLL NNSDERLQNS 610 620 630 640 650 660 RAKDRKDVWS SIQGQWPKKT LKELFSDSDT EAAASPPHPA PEEGVAEESL QTVAEEESCS 670 680 690 700 710 720 PSVELEKPPP VNVDSKPIEE KTVEVNDRKA EFPSSGSNSV LNTPPTTPES PSSVTVTEGS 730 740 750 760 770 780 RQQSSVTVSE PLAPNQEEVR SIKSETDSTI EVDSVAGELQ DLQSEGNSSP AGFDASVSSS 790 800 SSNQPEPEHP EKGEKENVYV DLF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"RBP1L1, a retinoblastoma-binding protein-related gene encoding an antigenic epitope abundantly expressed in human carcinomas and normal testis." Cao J.-N., Gao T.-W., Stanbridge E.J., Irie R. J. Natl. Cancer Inst. 93:1159-1165(2001) [PubMed: 11481388] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]	"Identification and characterization of three new components of the mSin3A corepressor complex." Fleischer T.C., Yun U.J., Ayer D.E. Mol. Cell. Biol. 23:3456-3467(2003) [PubMed: 12724404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, DOMAIN, TISSUE SPECIFICITY, IDENTIFICATION IN A MSIN3A COREPRESSOR COMPLEX WITH SIN3A; SAP130; SUDS3; ARID4B; HDAC1 AND HDAC2.
[3]	"Characterization of BRCAA1 and its novel antigen epitope identification." Cui D., Jin G., Gao T.W., Sun T., Tian F., Estrada G.G., Gao H., Sarai A. Cancer Epidemiol. Biomarkers Prev. 13:1136-1145(2004) [PubMed: 15247124] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[4]	"Rheumatoid arthritis antigenic protein similar to retinoblastoma binding protein 1 (RBP1)." Tanaka M. Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4). Tissue: Synovium.
[5]	"Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method." Nakajima D., Saito K., Yamakawa H., Kikuno R.F., Nakayama M., Ohara R., Okazaki N., Koga H., Nagase T., Ohara O. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[6]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-651 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-424. Tissue: Hippocampus, Kidney and Lung.
[8]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1149 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1147-1312. Tissue: Adipose tissue and Testis.
[9]	"Human breast carcinoma-associated antigen isoform I." Cao J., Irie R.F., Stanbridge E.J. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 440-1312 (ISOFORM 1).
[10]	"Human Rb binding protein homolog gene, partial CDS." Liu T., Tao J., Zhang J., Li W., Ye M., Zhou J., Wu J., Shen Y., Yu M., Chen S., Mao M., Chen Z. Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 547-1312.
[11]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 828-1312.
[12]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1022 AND SER-1029, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-710; SER-712; SER-713 AND SER-717, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[14]	"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-778, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[15]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1256, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[16]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-666; SER-675; SER-790; THR-793; SER-912; THR-1150; SER-1152; SER-1153; SER-1155 AND SER-1159, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[17]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-675; SER-790; THR-793; TYR-795; SER-1153 AND SER-1155, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[18]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-790; THR-793; SER-1014; THR-1022 AND THR-1026, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[19]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF214114 mRNA. Translation: AAF28341.2. AY220790 mRNA. Translation: AAO63590.1. AF208045 mRNA. Translation: AAF23433.3. Frameshift. AB030181 mRNA. Translation: BAA89794.1. AB210032 mRNA. Translation: BAE06114.1. Different initiation. AL391994, AL133418 Genomic DNA. Translation: CAI13747.2. AL391994 Genomic DNA. Translation: CAI13749.1. AL391994, AL133418 Genomic DNA. Translation: CAI13751.1. Sequence problems. AL133418, AL391994 Genomic DNA. Translation: CAI22961.2. AL133418, AL391994 Genomic DNA. Translation: CAI22962.1. BC048959 mRNA. Translation: AAH48959.1. Different termination. BC062536 mRNA. Translation: AAH62536.1. Different termination. BC104632 mRNA. Translation: AAI04633.1. Different termination. BC130418 mRNA. Translation: AAI30419.1. BX648820 mRNA. Translation: CAI46047.1. AL133594 mRNA. Translation: CAB63731.1. AF227899 mRNA. Translation: AAF36964.1. AF083249 mRNA. Translation: AAD41239.1. Frameshift. AK023144 mRNA. Translation: BAB14428.1. Different initiation.
IPI	IPI00302917. IPI00328828. IPI00647132. IPI00647647.
PIR	T43497.
RefSeq	NP_001193723.1. NM_001206794.1. NP_057458.4. NM_016374.5. NP_112739.2. NM_031371.3.
UniGene	Hs.533633. Hs.575782.
3D structure databases
HSSP	HSSP built from PDB template 1IG6 based on UniProtKB Q14865.
ProteinModelPortal	Q4LE39.
SMR	Q4LE39. Positions 8-130, 166-279, 308-400.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q4LE39. 9 interactions.
STRING	Q4LE39.
PTM databases
PhosphoSite	Q4LE39.
Polymorphism databases
DMDM	143955276.
Proteomic databases
PRIDE	Q4LE39.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000264183; ENSP00000264183; ENSG00000054267. ENST00000366603; ENSP00000355562; ENSG00000054267.
GeneID	51742.
KEGG	hsa:51742.
UCSC	uc001hwq.1. human. uc001hwr.1. human. uc001hws.2. human. uc001hwt.2. human.
Organism-specific databases
CTD	51742.
GeneCards	GC01M235295.
H-InvDB	HIX0001712.
HGNC	HGNC:15550. ARID4B.
HPA	HPA027333.
MIM	609696. gene.
neXtProt	NX_Q4LE39.
PharmGKB	PA134940494.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00510000046413.
HOVERGEN	HBG058247.
InParanoid	Q4LE39.
OMA	NGMSVEC.
PhylomeDB	Q4LE39.
Gene expression databases
ArrayExpress	Q4LE39.
Bgee	Q4LE39.
Genevestigator	Q4LE39.
Family and domain databases
InterPro	IPR001606. ARID/BRIGHT_DNA-bd. IPR000953. Chromo_domain/shadow. IPR016197. Chromodomain-like. IPR012603. RBB1NT. IPR002999. Tudor. [Graphical view]
Gene3D	G3DSA:1.10.150.60. ARID. 1 hit.
Pfam	PF01388. ARID. 1 hit. PF08169. RBB1NT. 1 hit. [Graphical view]
SMART	SM00501. BRIGHT. 1 hit. SM00298. CHROMO. 1 hit. SM00333. TUDOR. 2 hits. [Graphical view]
SUPFAM	SSF46774. ARID. 1 hit. SSF54160. Chromodomain-like. 1 hit.
PROSITE	PS51011. ARID. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	55820.
SOURCE	Search...

Entry information

Entry name

ARI4B_HUMAN

Accession

Primary (citable) accession number: Q4LE39
Secondary accession number(s): A1L465 , Q3MHV4, Q5HY99, Q5T2C2, Q5T2C3, Q5T2C4, Q5T2C5, Q5T2C6, Q6P600, Q86UX1, Q86WR4, Q9H915, Q9NYU3, Q9NZB6, Q9NZG4, Q9P2W4, Q9UF62, Q9Y6E1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	April 3, 2007
Last modified:	January 25, 2012
This is version 65 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.