IKBKAP variant protein

Functionⁱ

GO - Biological processⁱ

regulation of transcription, DNA-templated Source: InterPro
tRNA wobble uridine modification Source: InterPro

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: IKBKAP variant proteinImported
Gene namesⁱ	Name:IKBKAP variant proteinImported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Subcellular locationⁱ

GO - Cellular componentⁱ

Elongator holoenzyme complex Source: InterPro

Complete GO annotation...

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	Q4LE38.
PeptideAtlas More...PeptideAtlasⁱ	Q4LE38.
PRIDEⁱ	Q4LE38.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000070061.

Bgeeⁱ

ENSG00000070061.

Family & Domainsⁱ

Phylogenomic databases

eggNOGⁱ	KOG1920. Eukaryota. COG5290. LUCA.
HOGENOMⁱ	HOG000007712.
HOVERGENⁱ	HBG019038.
KEGG Orthology (KO) More...KOⁱ	K11373.

Family and domain databases

Gene3Dⁱ	2.130.10.10. 2 hits.
InterProⁱ	View protein in InterPro IPR006849. Iki3. IPR015943. WD40/YVTN_repeat-like_dom.
PANTHERⁱ	PTHR12747. PTHR12747. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04762. IKI3. 1 hit.
PIRSFⁱ	PIRSF017233. IKAP. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Fragment.

Q4LE38-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
LYLSRGNHFI MRNLKLFRTL EFRDIQGPGN PQCFSLRTEQ GTVLIGSEHG 
        60         70         80         90        100
LIEVDPVSRE VKNEVSLVAE GFLPEDGSGR IVGVQDLLDQ ESVCVATASG 
       110        120        130        140        150
DVILCSLSTQ QLECVGSVAS GISVMSWSPD QELVLLATGQ QTLIMMTKDF 
       160        170        180        190        200
EPILEQQIHQ DDFGESKFIT VGWGRKETQF HGSEGRQAAF QMQMHESALP 
       210        220        230        240        250
WDDHRPQVTW RGDGQFFAVS VVCPETGARK VRVWNREFAL QSTSEPVAGL 
       260        270        280        290        300
GPALAWKPSG SLIASTQDKP NQQDIVFFEK NGLLHGHFTL PFLKDEVKVN 
       310        320        330        340        350
DLLWNADSSV LAVWLEDLQR EESSIPKTCV QLWTVGNYHW YLKQSLSFST 
       360        370        380        390        400
CGKSKIVSLM WDPVTPYRLH VLCQGWHYLA YDWHWTTDRS VGDNSSDLSN 
       410        420        430        440        450
VAVIDGNRVL VTVFRQTVVP PPMCTYQLLF PHPVNQVTFL AHPQKSNDLA 
       460        470        480        490        500
VLDASNQISV YKCGDCPSAD PTVKLGAVGG SGFKVCLRTP HLEKRYKIQF 
       510        520        530        540        550
ENNEDQDVNP LKLGLLTWIE EDVFLAVSHS EFSPRSVIHH LTAASSEMDE 
       560        570        580        590        600
EHGQLNVSSS AAVDGVIISL CCNSKTKSVV LQLADGQIFK YLWESPSLAI 
       610        620        630        640        650
KPWKNSGGFP VRFPYPCTQT ELAMIGEEEC VLGLTDRCRF FINDIEVASN 
       660        670        680        690        700
ITSFAVYDEF LLLTTHSHTC QCFCLRDASF KTLQAGLSSN HVSHGEVLRK 
       710        720        730        740        750
VERGSRIVTV VPQDTKLVLQ MPRGNLEVVH HRALVLAQIR KWLDKLMFKE 
       760        770        780        790        800
AFECMRKLRI NLNLIYDHNP KVFLGNVETF IKQIDSVNHI NLFFTELKEE 
       810        820        830        840        850
DVTKTMYPAP VTSSVYLSRD PDGNKIDLVC DAMRAVMESI NPHKYCLSIL 
       860        870        880        890        900
TSHVKKTTPE LEIVLQKVHE LQGNAPSDPD AVSAEEALKY LLHLVDVNEL 
       910        920        930        940        950
YDHSLGTYDF DLVLMVAEKS QKDPKEYLPF LNTLKKMETN YQRFTIDKYL 
       960        970        980        990       1000
KRYEKAIGHL SKCGPEYFPE CLNLIKDKNL YNEALKLYSP SSQQYQDISI 
      1010       1020       1030       1040       1050
AYGEHLMQEH MYEPAGLMFA RCGAHEKALS AFLTCGNWKQ ALCVAAQLNF 
      1060       1070       1080       1090       1100
TKDQLVGLGR TLAGKLVEQR KHIDAAMVLE ECAQDYEEAV LLLLEGAAWE 
      1110       1120       1130       1140       1150
EALRLVYKYN RLDIIETNVK PSILEAQKNY MAFLDSQTAT FSRHKKRLLV 
      1160       1170       1180       1190       1200
VRELKEQAQQ AGLDDEVPHG QESDLFSETS SVVSGSEMSG KYSHSNSRIS 
      1210       1220       1230       1240       1250
ARSSKNRRKA ERKKHSLKEG SPLEDLALLE ALSEVVQNTE NLKDEVYHIL 
      1260       1270       1280       1290       1300
KVLFLFEFDE QGRELQKAFE DTLQLMERSL PEIWTLTYQQ NSATPVLGPN 
      1310       1320       1330       1340 
STANSIMASY QQQKTSVPVL DAELFIPPKI NRRTQWKLSL LD

Length:1,342

Mass (Da):151,456

Last modified:August 2, 2005 - v1

Checksum:ⁱ58D6B7FB9A77110E

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	1	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB210033 mRNA. Translation: BAE06115.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_003631.2. NM_003640.4.
UniGeneⁱ	Hs.494738.

Genome annotation databases

GeneIDⁱ	8518.
KEGGⁱ	hsa:8518.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB210033 mRNA. Translation: BAE06115.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_003631.2. NM_003640.4.
UniGeneⁱ	Hs.494738.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PaxDbⁱ	Q4LE38.
PeptideAtlas More...PeptideAtlasⁱ	Q4LE38.
PRIDEⁱ	Q4LE38.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	8518.
KEGGⁱ	hsa:8518.

Organism-specific databases

CTDⁱ	8518.

CTDⁱ

8518.

Phylogenomic databases

eggNOGⁱ	KOG1920. Eukaryota. COG5290. LUCA.
HOGENOMⁱ	HOG000007712.
HOVERGENⁱ	HBG019038.
KEGG Orthology (KO) More...KOⁱ	K11373.

Miscellaneous databases

ChiTaRSⁱ	IKBKAP. human.
GenomeRNAiⁱ	8518.

Gene expression databases

Bgeeⁱ	ENSG00000070061.

Bgeeⁱ

ENSG00000070061.

Family and domain databases

Gene3Dⁱ	2.130.10.10. 2 hits.
InterProⁱ	View protein in InterPro IPR006849. Iki3. IPR015943. WD40/YVTN_repeat-like_dom.
PANTHERⁱ	PTHR12747. PTHR12747. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04762. IKI3. 1 hit.
PIRSFⁱ	PIRSF017233. IKAP. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q4LE38_HUMAN
Accessionⁱ	Q4LE38Primary (citable) accession number: Q4LE38
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	August 2, 2005
	Last sequence update:	August 2, 2005
	Last modified:	July 5, 2017
	This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

UniProtKB - Q4LE38 (Q4LE38_HUMAN)

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IKBKAP variant protein

Select a section on the left to see content.

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Proteomic databases

Expressionⁱ

Gene expression databases

Family & Domainsⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Experimental Info

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q4LE38 (Q4LE38_HUMAN)

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IKBKAP variant protein

IKBKAP variant protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ