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Protein
Submitted name:

ACLY variant protein

Gene

ACLY variant protein

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei796 – 7961Tele-phosphohistidine intermediateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
ACLY variant proteinImported
Gene namesi
Name:ACLY variant proteinImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ4LE36.

Expressioni

Gene expression databases

BgeeiQ4LE36.

Interactioni

Protein-protein interaction databases

MINTiMINT-5001398.

Structurei

3D structure databases

ProteinModelPortaliQ4LE36.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG003318.
KOiK01648.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
3.30.470.20. 1 hit.
3.40.50.261. 2 hits.
3.40.50.720. 1 hit.
InterProiIPR014608. ATP-citrate_synthase.
IPR013650. ATP-grasp_succ-CoA_synth-type.
IPR013816. ATP_grasp_subdomain_2.
IPR017440. Cit_synth/succinyl-CoA_lig_AS.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR003781. CoA-bd.
IPR005810. CoA_lig_alpha.
IPR005811. CoA_ligase.
IPR016040. NAD(P)-bd_dom.
IPR017866. Succ-CoA_synthase_bsu_CS.
IPR016102. Succinyl-CoA_synth-like.
[Graphical view]
PfamiPF08442. ATP-grasp_2. 1 hit.
PF00285. Citrate_synt. 1 hit.
PF02629. CoA_binding. 1 hit.
PF00549. Ligase_CoA. 1 hit.
[Graphical view]
PIRSFiPIRSF036511. ATP_citrt_syn. 1 hit.
SUPFAMiSSF48256. SSF48256. 2 hits.
SSF52210. SSF52210. 1 hit.
PROSITEiPS01216. SUCCINYL_COA_LIG_1. 1 hit.
PS00399. SUCCINYL_COA_LIG_2. 1 hit.
PS01217. SUCCINYL_COA_LIG_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q4LE36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LPAAGVLRIL RGSSGLWKKR RARTSAETGR AGLSAAMSAK AISEQTGKEL
60 70 80 90 100
LYKFICTTSA IQNRFKYARV TPDTDWARLL QDHPWLLSQN LVVKPDQLIK
110 120 130 140 150
RRGKLGLVGV NLTLDGVKSW LKPRLGQEAT VGKATGFLKN FLIEPFVPHS
160 170 180 190 200
QAEEFYVCIY ATREGDYVLF HHEGGVDVGD VDAKAQKLLV GVDEKLNPED
210 220 230 240 250
IKKHLLVHAP EDKKEILASF ISGLFNFYED LYFTYLEINP LVVTKDGVYV
260 270 280 290 300
LDLAAKVDAT ADYICKVKWG DIEFPPPFGR EAYPEEAYIA DLDAKSGASL
310 320 330 340 350
KLTLLNPKGR IWTMVAGGGA SVVYSDTICD LGGVNELANY GEYSGAPSEQ
360 370 380 390 400
QTYDYAKTIL SLMTREKHPD GKILIIGGSI ANFTNVAATF KGIVRAIRDY
410 420 430 440 450
QGPLKEHEVT IFVRRGGPNY QEGLRVMGEV GKTTGIPIHV FGTETHMTAI
460 470 480 490 500
VGMALGHRPI PNQPPTAAHT ANFLLNASGS TSTPAPSRTA SFSESRADEV
510 520 530 540 550
APAKKAKPAM PQDSVPSPRS LQGKSTTLFS RHTKAIVWGM QTRAVQGMLD
560 570 580 590 600
FDYVCSRDEP SVAAMVYPFT GDHKQKFYWG HKEILIPVFK NMADAMRKHP
610 620 630 640 650
EVDVLINFAS LRSAYDSTME TMNYAQIRTI AIIAEGIPEA LTRKLIKKAD
660 670 680 690 700
QKGVTIIGPA TVGGIKPGCF KIGNTGGMLD NILASKLYRP GSVAYVSRSG
710 720 730 740 750
GMSNELNNII SRTTDGVYEG VAIGGDRYPG STFMDHVLRY QDTPGVKMIV
760 770 780 790 800
VLGEIGGTEE YKICRGIKEG RLTKPIVCWC IGTCATMFSS EVQFGHAGAC
810 820 830 840 850
ANQASETAVA KNQALKEAGV FVPRSFDELG EIIQSVYEDL VANGVIVPAQ
860 870 880 890 900
EVPPPTVPMD YSWARELGLI RKPASFMTSI CDERGQELIY AGMPITEVFK
910 920 930 940 950
EEMGIGGVLG LLWFQKRLPK YSCQFIEMCL MVTADHGPAV SGAHNTIICA
960 970 980 990 1000
RAGKDLVSSL TSGLLTIGDR FGGALDAAAK MFSKAFDSGI IPMEFVNKMK
1010 1020 1030 1040 1050
KEGKLIMGIG HRVKSINNPD MRVQILKDYV RQHFPATPLL DYALEVEKIT
1060 1070 1080 1090 1100
TSKKPNLILN VDGLIGVAFV DMLRNCGSFT REEADEYIDI GALNGIFVLG
1110 1120 1130
RSMGFIGHYL DQKRLKQGLY RHPWDDISYV LPEHMSM
Length:1,137
Mass (Da):124,557
Last modified:August 2, 2005 - v1
Checksum:iE634EE8F9AEDB882
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB210035 mRNA. Translation: BAE06117.1.
RefSeqiNP_001290203.1. NM_001303274.1.
NP_001290204.1. NM_001303275.1.
UniGeneiHs.387567.

Genome annotation databases

GeneIDi47.
KEGGihsa:47.
UCSCiuc002hyi.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB210035 mRNA. Translation: BAE06117.1.
RefSeqiNP_001290203.1. NM_001303274.1.
NP_001290204.1. NM_001303275.1.
UniGeneiHs.387567.

3D structure databases

ProteinModelPortaliQ4LE36.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-5001398.

Chemistry

BindingDBiQ4LE36.

Proteomic databases

PRIDEiQ4LE36.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi47.
KEGGihsa:47.
UCSCiuc002hyi.3. human.

Organism-specific databases

CTDi47.

Phylogenomic databases

HOVERGENiHBG003318.
KOiK01648.

Miscellaneous databases

ChiTaRSiACLY. human.

Gene expression databases

BgeeiQ4LE36.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
3.30.470.20. 1 hit.
3.40.50.261. 2 hits.
3.40.50.720. 1 hit.
InterProiIPR014608. ATP-citrate_synthase.
IPR013650. ATP-grasp_succ-CoA_synth-type.
IPR013816. ATP_grasp_subdomain_2.
IPR017440. Cit_synth/succinyl-CoA_lig_AS.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR003781. CoA-bd.
IPR005810. CoA_lig_alpha.
IPR005811. CoA_ligase.
IPR016040. NAD(P)-bd_dom.
IPR017866. Succ-CoA_synthase_bsu_CS.
IPR016102. Succinyl-CoA_synth-like.
[Graphical view]
PfamiPF08442. ATP-grasp_2. 1 hit.
PF00285. Citrate_synt. 1 hit.
PF02629. CoA_binding. 1 hit.
PF00549. Ligase_CoA. 1 hit.
[Graphical view]
PIRSFiPIRSF036511. ATP_citrt_syn. 1 hit.
SUPFAMiSSF48256. SSF48256. 2 hits.
SSF52210. SSF52210. 1 hit.
PROSITEiPS01216. SUCCINYL_COA_LIG_1. 1 hit.
PS00399. SUCCINYL_COA_LIG_2. 1 hit.
PS01217. SUCCINYL_COA_LIG_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method."
    Nakajima D., Saito K., Yamakawa H., Kikuno R.F., Nakayama M., Ohara R., Okazaki N., Koga H., Nagase T., Ohara O.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiQ4LE36_HUMAN
AccessioniPrimary (citable) accession number: Q4LE36
Entry historyi
Integrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: May 27, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.