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Q4LE36

- Q4LE36_HUMAN

UniProt

Q4LE36 - Q4LE36_HUMAN

Protein
Submitted name:

ACLY variant protein

Gene

ACLY variant protein

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (02 Aug 2005)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei796 – 7961Tele-phosphohistidine intermediateUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. ATP citrate synthase activity Source: InterPro
    3. cofactor binding Source: InterPro
    4. succinate-CoA ligase (ADP-forming) activity Source: InterPro

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    ACLY variant proteinImported
    Gene namesi
    Name:ACLY variant proteinImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. mitochondrion Source: Ensembl
    3. nucleus Source: HPA
    4. plasma membrane Source: HPA

    PTM / Processingi

    Proteomic databases

    PRIDEiQ4LE36.

    Expressioni

    Gene expression databases

    ArrayExpressiQ4LE36.
    BgeeiQ4LE36.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-5001398.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4LE36.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG003318.

    Family and domain databases

    Gene3Di1.10.230.10. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.261. 2 hits.
    3.40.50.720. 1 hit.
    InterProiIPR014608. ATP-citrate_synthase.
    IPR013650. ATP-grasp_succ-CoA_synth-type.
    IPR013816. ATP_grasp_subdomain_2.
    IPR017440. Cit_synth/succinyl-CoA_lig_AS.
    IPR016143. Citrate_synth-like_sm_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR003781. CoA-bd.
    IPR005810. CoA_lig_alpha.
    IPR005811. CoA_ligase.
    IPR016040. NAD(P)-bd_dom.
    IPR017866. Succ-CoA_synthase_bsu_CS.
    IPR016102. Succinyl-CoA_synth-like.
    [Graphical view]
    PfamiPF08442. ATP-grasp_2. 1 hit.
    PF00285. Citrate_synt. 1 hit.
    PF02629. CoA_binding. 1 hit.
    PF00549. Ligase_CoA. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036511. ATP_citrt_syn. 1 hit.
    SUPFAMiSSF48256. SSF48256. 2 hits.
    SSF52210. SSF52210. 1 hit.
    PROSITEiPS01216. SUCCINYL_COA_LIG_1. 1 hit.
    PS00399. SUCCINYL_COA_LIG_2. 1 hit.
    PS01217. SUCCINYL_COA_LIG_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q4LE36-1 [UniParc]FASTAAdd to Basket

    « Hide

    LPAAGVLRIL RGSSGLWKKR RARTSAETGR AGLSAAMSAK AISEQTGKEL     50
    LYKFICTTSA IQNRFKYARV TPDTDWARLL QDHPWLLSQN LVVKPDQLIK 100
    RRGKLGLVGV NLTLDGVKSW LKPRLGQEAT VGKATGFLKN FLIEPFVPHS 150
    QAEEFYVCIY ATREGDYVLF HHEGGVDVGD VDAKAQKLLV GVDEKLNPED 200
    IKKHLLVHAP EDKKEILASF ISGLFNFYED LYFTYLEINP LVVTKDGVYV 250
    LDLAAKVDAT ADYICKVKWG DIEFPPPFGR EAYPEEAYIA DLDAKSGASL 300
    KLTLLNPKGR IWTMVAGGGA SVVYSDTICD LGGVNELANY GEYSGAPSEQ 350
    QTYDYAKTIL SLMTREKHPD GKILIIGGSI ANFTNVAATF KGIVRAIRDY 400
    QGPLKEHEVT IFVRRGGPNY QEGLRVMGEV GKTTGIPIHV FGTETHMTAI 450
    VGMALGHRPI PNQPPTAAHT ANFLLNASGS TSTPAPSRTA SFSESRADEV 500
    APAKKAKPAM PQDSVPSPRS LQGKSTTLFS RHTKAIVWGM QTRAVQGMLD 550
    FDYVCSRDEP SVAAMVYPFT GDHKQKFYWG HKEILIPVFK NMADAMRKHP 600
    EVDVLINFAS LRSAYDSTME TMNYAQIRTI AIIAEGIPEA LTRKLIKKAD 650
    QKGVTIIGPA TVGGIKPGCF KIGNTGGMLD NILASKLYRP GSVAYVSRSG 700
    GMSNELNNII SRTTDGVYEG VAIGGDRYPG STFMDHVLRY QDTPGVKMIV 750
    VLGEIGGTEE YKICRGIKEG RLTKPIVCWC IGTCATMFSS EVQFGHAGAC 800
    ANQASETAVA KNQALKEAGV FVPRSFDELG EIIQSVYEDL VANGVIVPAQ 850
    EVPPPTVPMD YSWARELGLI RKPASFMTSI CDERGQELIY AGMPITEVFK 900
    EEMGIGGVLG LLWFQKRLPK YSCQFIEMCL MVTADHGPAV SGAHNTIICA 950
    RAGKDLVSSL TSGLLTIGDR FGGALDAAAK MFSKAFDSGI IPMEFVNKMK 1000
    KEGKLIMGIG HRVKSINNPD MRVQILKDYV RQHFPATPLL DYALEVEKIT 1050
    TSKKPNLILN VDGLIGVAFV DMLRNCGSFT REEADEYIDI GALNGIFVLG 1100
    RSMGFIGHYL DQKRLKQGLY RHPWDDISYV LPEHMSM 1137
    Length:1,137
    Mass (Da):124,557
    Last modified:August 2, 2005 - v1
    Checksum:iE634EE8F9AEDB882
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB210035 mRNA. Translation: BAE06117.1.
    UniGeneiHs.387567.

    Genome annotation databases

    UCSCiuc002hyi.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB210035 mRNA. Translation: BAE06117.1 .
    UniGenei Hs.387567.

    3D structure databases

    ProteinModelPortali Q4LE36.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-5001398.

    Proteomic databases

    PRIDEi Q4LE36.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi uc002hyi.3. human.

    Phylogenomic databases

    HOVERGENi HBG003318.

    Miscellaneous databases

    ChiTaRSi ACLY. human.

    Gene expression databases

    ArrayExpressi Q4LE36.
    Bgeei Q4LE36.

    Family and domain databases

    Gene3Di 1.10.230.10. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.261. 2 hits.
    3.40.50.720. 1 hit.
    InterProi IPR014608. ATP-citrate_synthase.
    IPR013650. ATP-grasp_succ-CoA_synth-type.
    IPR013816. ATP_grasp_subdomain_2.
    IPR017440. Cit_synth/succinyl-CoA_lig_AS.
    IPR016143. Citrate_synth-like_sm_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR003781. CoA-bd.
    IPR005810. CoA_lig_alpha.
    IPR005811. CoA_ligase.
    IPR016040. NAD(P)-bd_dom.
    IPR017866. Succ-CoA_synthase_bsu_CS.
    IPR016102. Succinyl-CoA_synth-like.
    [Graphical view ]
    Pfami PF08442. ATP-grasp_2. 1 hit.
    PF00285. Citrate_synt. 1 hit.
    PF02629. CoA_binding. 1 hit.
    PF00549. Ligase_CoA. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036511. ATP_citrt_syn. 1 hit.
    SUPFAMi SSF48256. SSF48256. 2 hits.
    SSF52210. SSF52210. 1 hit.
    PROSITEi PS01216. SUCCINYL_COA_LIG_1. 1 hit.
    PS00399. SUCCINYL_COA_LIG_2. 1 hit.
    PS01217. SUCCINYL_COA_LIG_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method."
      Nakajima D., Saito K., Yamakawa H., Kikuno R.F., Nakayama M., Ohara R., Okazaki N., Koga H., Nagase T., Ohara O.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: BrainImported.

    Entry informationi

    Entry nameiQ4LE36_HUMAN
    AccessioniPrimary (citable) accession number: Q4LE36
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 2, 2005
    Last sequence update: August 2, 2005
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.