SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q4LE36

- Q4LE36_HUMAN

UniProt

Q4LE36 - Q4LE36_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name: ACLY variant protein
Gene
ACLY variant protein
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei796 – 7961Tele-phosphohistidine intermediate By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. ATP citrate synthase activity Source: InterPro
  3. cofactor binding Source: InterPro
  4. succinate-CoA ligase (ADP-forming) activity Source: InterPro

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
ACLY variant proteinImported
Gene namesi
Name:ACLY variant proteinImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. mitochondrion Source: Ensembl
  3. nucleus Source: HPA
  4. plasma membrane Source: HPA
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ4LE36.

Expressioni

Gene expression databases

ArrayExpressiQ4LE36.
BgeeiQ4LE36.

Interactioni

Protein-protein interaction databases

MINTiMINT-5001398.

Structurei

3D structure databases

ProteinModelPortaliQ4LE36.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG003318.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
3.30.470.20. 1 hit.
3.40.50.261. 2 hits.
3.40.50.720. 1 hit.
InterProiIPR014608. ATP-citrate_synthase.
IPR013650. ATP-grasp_succ-CoA_synth-type.
IPR013816. ATP_grasp_subdomain_2.
IPR017440. Cit_synth/succinyl-CoA_lig_AS.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR003781. CoA-bd.
IPR005810. CoA_lig_alpha.
IPR005811. CoA_ligase.
IPR016040. NAD(P)-bd_dom.
IPR017866. Succ-CoA_synthase_bsu_CS.
IPR016102. Succinyl-CoA_synth-like.
[Graphical view]
PfamiPF08442. ATP-grasp_2. 1 hit.
PF00285. Citrate_synt. 1 hit.
PF02629. CoA_binding. 1 hit.
PF00549. Ligase_CoA. 1 hit.
[Graphical view]
PIRSFiPIRSF036511. ATP_citrt_syn. 1 hit.
SUPFAMiSSF48256. SSF48256. 2 hits.
SSF52210. SSF52210. 1 hit.
PROSITEiPS01216. SUCCINYL_COA_LIG_1. 1 hit.
PS00399. SUCCINYL_COA_LIG_2. 1 hit.
PS01217. SUCCINYL_COA_LIG_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q4LE36-1 [UniParc]FASTAAdd to Basket

« Hide

LPAAGVLRIL RGSSGLWKKR RARTSAETGR AGLSAAMSAK AISEQTGKEL     50
LYKFICTTSA IQNRFKYARV TPDTDWARLL QDHPWLLSQN LVVKPDQLIK 100
RRGKLGLVGV NLTLDGVKSW LKPRLGQEAT VGKATGFLKN FLIEPFVPHS 150
QAEEFYVCIY ATREGDYVLF HHEGGVDVGD VDAKAQKLLV GVDEKLNPED 200
IKKHLLVHAP EDKKEILASF ISGLFNFYED LYFTYLEINP LVVTKDGVYV 250
LDLAAKVDAT ADYICKVKWG DIEFPPPFGR EAYPEEAYIA DLDAKSGASL 300
KLTLLNPKGR IWTMVAGGGA SVVYSDTICD LGGVNELANY GEYSGAPSEQ 350
QTYDYAKTIL SLMTREKHPD GKILIIGGSI ANFTNVAATF KGIVRAIRDY 400
QGPLKEHEVT IFVRRGGPNY QEGLRVMGEV GKTTGIPIHV FGTETHMTAI 450
VGMALGHRPI PNQPPTAAHT ANFLLNASGS TSTPAPSRTA SFSESRADEV 500
APAKKAKPAM PQDSVPSPRS LQGKSTTLFS RHTKAIVWGM QTRAVQGMLD 550
FDYVCSRDEP SVAAMVYPFT GDHKQKFYWG HKEILIPVFK NMADAMRKHP 600
EVDVLINFAS LRSAYDSTME TMNYAQIRTI AIIAEGIPEA LTRKLIKKAD 650
QKGVTIIGPA TVGGIKPGCF KIGNTGGMLD NILASKLYRP GSVAYVSRSG 700
GMSNELNNII SRTTDGVYEG VAIGGDRYPG STFMDHVLRY QDTPGVKMIV 750
VLGEIGGTEE YKICRGIKEG RLTKPIVCWC IGTCATMFSS EVQFGHAGAC 800
ANQASETAVA KNQALKEAGV FVPRSFDELG EIIQSVYEDL VANGVIVPAQ 850
EVPPPTVPMD YSWARELGLI RKPASFMTSI CDERGQELIY AGMPITEVFK 900
EEMGIGGVLG LLWFQKRLPK YSCQFIEMCL MVTADHGPAV SGAHNTIICA 950
RAGKDLVSSL TSGLLTIGDR FGGALDAAAK MFSKAFDSGI IPMEFVNKMK 1000
KEGKLIMGIG HRVKSINNPD MRVQILKDYV RQHFPATPLL DYALEVEKIT 1050
TSKKPNLILN VDGLIGVAFV DMLRNCGSFT REEADEYIDI GALNGIFVLG 1100
RSMGFIGHYL DQKRLKQGLY RHPWDDISYV LPEHMSM 1137
Length:1,137
Mass (Da):124,557
Last modified:August 2, 2005 - v1
Checksum:iE634EE8F9AEDB882
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB210035 mRNA. Translation: BAE06117.1.
UniGeneiHs.387567.

Genome annotation databases

UCSCiuc002hyi.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB210035 mRNA. Translation: BAE06117.1 .
UniGenei Hs.387567.

3D structure databases

ProteinModelPortali Q4LE36.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-5001398.

Proteomic databases

PRIDEi Q4LE36.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi uc002hyi.3. human.

Phylogenomic databases

HOVERGENi HBG003318.

Miscellaneous databases

ChiTaRSi ACLY. human.

Gene expression databases

ArrayExpressi Q4LE36.
Bgeei Q4LE36.

Family and domain databases

Gene3Di 1.10.230.10. 1 hit.
3.30.470.20. 1 hit.
3.40.50.261. 2 hits.
3.40.50.720. 1 hit.
InterProi IPR014608. ATP-citrate_synthase.
IPR013650. ATP-grasp_succ-CoA_synth-type.
IPR013816. ATP_grasp_subdomain_2.
IPR017440. Cit_synth/succinyl-CoA_lig_AS.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR003781. CoA-bd.
IPR005810. CoA_lig_alpha.
IPR005811. CoA_ligase.
IPR016040. NAD(P)-bd_dom.
IPR017866. Succ-CoA_synthase_bsu_CS.
IPR016102. Succinyl-CoA_synth-like.
[Graphical view ]
Pfami PF08442. ATP-grasp_2. 1 hit.
PF00285. Citrate_synt. 1 hit.
PF02629. CoA_binding. 1 hit.
PF00549. Ligase_CoA. 1 hit.
[Graphical view ]
PIRSFi PIRSF036511. ATP_citrt_syn. 1 hit.
SUPFAMi SSF48256. SSF48256. 2 hits.
SSF52210. SSF52210. 1 hit.
PROSITEi PS01216. SUCCINYL_COA_LIG_1. 1 hit.
PS00399. SUCCINYL_COA_LIG_2. 1 hit.
PS01217. SUCCINYL_COA_LIG_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method."
    Nakajima D., Saito K., Yamakawa H., Kikuno R.F., Nakayama M., Ohara R., Okazaki N., Koga H., Nagase T., Ohara O.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiQ4LE36_HUMAN
AccessioniPrimary (citable) accession number: Q4LE36
Entry historyi
Integrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: July 9, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi