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Protein
Submitted name:

ITGA7 variant protein

Gene

ITGA7 variant protein

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IntegrinUniRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotation

Keywords - Biological processi

Cell adhesionUniRule annotationSAAS annotation

Enzyme and pathway databases

SignaLinkiQ4LE35.

Names & Taxonomyi

Protein namesi
Submitted name:
ITGA7 variant proteinImported
Gene namesi
Name:ITGA7 variant proteinImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1101 – 112323HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29943.

PTM / Processingi

Proteomic databases

PaxDbiQ4LE35.
PeptideAtlasiQ4LE35.
PRIDEiQ4LE35.

Expressioni

Gene expression databases

BgeeiENSG00000135424.
GenevisibleiQ4LE35. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000452120.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini534 – 1025492Integrin_alpha2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the integrin alpha chain family.UniRule annotationSAAS annotation
Contains FG-GAP repeats.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IPBB. Eukaryota.
ENOG410XVGZ. LUCA.
HOGENOMiHOG000015786.
HOVERGENiHBG108011.
KOiK06583.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
SUPFAMiSSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q4LE35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LAGAGAAGWR SGGRAGGLAG RTSGRRLKDQ RDFGDQRRAW GDLGLGACEI
60 70 80 90 100
SLAFAGSSRR DRPMAGARSR DPWGASGICY LFGSLLVELL FSRAVAFNLD
110 120 130 140 150
VMGALRKEGE PGSLFGFSVA LHRQLQPRPQ SWLLVGAPQA LALPGQQANR
160 170 180 190 200
TGGLFACPLS LEETDCYRVD IDQGADMQKE SKENQWLGVS VRSQGPGGKI
210 220 230 240 250
VTCAHRYEAR QRVDQILETR DMIGRCFVLS QDLAIRDELD GGEWKFCEGR
260 270 280 290 300
PQGHEQFGFC QQGTAAAFSP DSHYLLFGAP GTYNWKGLLF VTNIDSSDPD
310 320 330 340 350
QLVYKTLDPA DRLPGPAGDL ALNSYLGFSI DSGKGLVRAE ELSFVAGAPR
360 370 380 390 400
ANHKGAVVIL RKDSASRLVP EVMLSGERLT SGFGYSLAVA DLNSDGWPDL
410 420 430 440 450
IVGAPYFFER QEELGGAVYV YLNQGGHWAG ISPLRLCGSP DSMFGISLAV
460 470 480 490 500
LGDLNQDGFP DIAVGAPFDG DGKVFIYHGS SLGVVAKPSQ VLEGEAVGIK
510 520 530 540 550
SFGYSLSGSL DMDGNQYPDL LVGSLADTAV LFRARPILHV SHEVSIAPRS
560 570 580 590 600
IDLEQPNCAG GHSVCVDLRV CFSYIAVPSS YSPTVALDYV LDADTDRRLR
610 620 630 640 650
GQVPRVTFLS RNLEEPKHQA SGTVWLKHQH DRVCGDAMFQ LQENVKDKLR
660 670 680 690 700
AIVVTLSYSL QTPRLRRQAP GQGLPPVAPI LNAHQPSTQR AEIHFLKQGC
710 720 730 740 750
GEDKICQSNL QLVRARFCTR VSDTEFQPLP MDVDGTTALF ALSGQPVIGL
760 770 780 790 800
ELMVTNLPSD PAQPQADGDD AHEAQLLVML PDSLHYSGVR ALDPAEKPLC
810 820 830 840 850
LSNENASHVE CELGNPMKRG AQVTFYLILS TSGISIETTE LEVELLLATI
860 870 880 890 900
SEQELHPVSA RARVFIELPL SIAGMAIPQQ LFFSGVVRGE RAMQSERDVG
910 920 930 940 950
SKVKYEVTVS NQGQSLRTLG SAFLNIMWPH EIANGKWLLY PMQVELEGGQ
960 970 980 990 1000
GPGQKGLCSP RPNILHLDVD SRDRRRRELE PPEQQEPGER QEPSMSWWPV
1010 1020 1030 1040 1050
SSAEKKKNIT LDCARGTANC VVFSCPLYSF DRAAVLHVWG RLWNSTFLEE
1060 1070 1080 1090 1100
YSAVKSLEVI VRANITVKSS IKNLMLRDAS TVIPVMVYLD PMAVVAEGVP
1110 1120 1130 1140 1150
WWVILLAVLA GLLVLALLVL LLWKMGFFKR AKHPEATVPQ YHAVKIPRED
1160 1170 1180 1190 1200
RQQFKEEKTG TILRNNWGSP RREGPDAHPI LAADGHPELG PDGHPGPGTA
Length:1,200
Mass (Da):130,819
Last modified:August 2, 2005 - v1
Checksum:i540E87C8095F8EC2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB210036 mRNA. Translation: BAE06118.1.
RefSeqiNP_001138468.1. NM_001144996.1.
NP_001138469.1. NM_001144997.1.
NP_002197.2. NM_002206.2.
UniGeneiHs.524484.

Genome annotation databases

GeneIDi3679.
KEGGihsa:3679.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB210036 mRNA. Translation: BAE06118.1.
RefSeqiNP_001138468.1. NM_001144996.1.
NP_001138469.1. NM_001144997.1.
NP_002197.2. NM_002206.2.
UniGeneiHs.524484.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000452120.

Proteomic databases

PaxDbiQ4LE35.
PeptideAtlasiQ4LE35.
PRIDEiQ4LE35.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3679.
KEGGihsa:3679.

Organism-specific databases

CTDi3679.
PharmGKBiPA29943.

Phylogenomic databases

eggNOGiENOG410IPBB. Eukaryota.
ENOG410XVGZ. LUCA.
HOGENOMiHOG000015786.
HOVERGENiHBG108011.
KOiK06583.

Enzyme and pathway databases

SignaLinkiQ4LE35.

Miscellaneous databases

ChiTaRSiITGA7. human.
GenomeRNAii3679.

Gene expression databases

BgeeiENSG00000135424.
GenevisibleiQ4LE35. HS.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
SUPFAMiSSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ4LE35_HUMAN
AccessioniPrimary (citable) accession number: Q4LE35
Entry historyi
Integrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.