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Protein
Submitted name:

TNC variant protein

Gene

TNC variant protein

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
TNC variant proteinImported
Gene namesi
Name:TNC variant proteinImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35103.

PTM / Processingi

Proteomic databases

PaxDbiQ4LE33.
PeptideAtlasiQ4LE33.
PRIDEiQ4LE33.

Expressioni

Gene expression databases

GenevisibleiQ4LE33. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000265131.

Structurei

3D structure databases

ProteinModelPortaliQ4LE33.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini218 – 24932EGF-likeInterPro annotationAdd
BLAST
Domaini312 – 34332EGF-likeInterPro annotationAdd
BLAST
Domaini405 – 43632EGF-likeInterPro annotationAdd
BLAST
Domaini498 – 52932EGF-likeInterPro annotationAdd
BLAST
Domaini591 – 62232EGF-likeInterPro annotationAdd
BLAST
Domaini657 – 74791Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini748 – 83689Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini837 – 92690Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini927 – 102296Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1023 – 110785Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1108 – 119790Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1199 – 128890Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1290 – 138293Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1383 – 147189Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1472 – 156392Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1565 – 165389Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1654 – 174390Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1744 – 183390Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1834 – 192087Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1921 – 200989Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini2007 – 2222216Fibrinogen C-terminalInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains fibrinogen C-terminal domain.SAAS annotation

Phylogenomic databases

eggNOGiKOG1225. Eukaryota.
KOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
HOGENOMiHOG000234355.
HOVERGENiHBG008949.
KOiK06252.

Family and domain databases

Gene3Di2.60.40.10. 15 hits.
3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR013111. EGF_extracell.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR033078. TNC.
[Graphical view]
PANTHERiPTHR19143:SF38. PTHR19143:SF38. 2 hits.
PfamiPF07974. EGF_2. 6 hits.
PF00147. Fibrinogen_C. 1 hit.
PF00041. fn3. 15 hits.
PF12661. hEGF. 3 hits.
[Graphical view]
SMARTiSM00181. EGF. 14 hits.
SM00186. FBG. 1 hit.
SM00060. FN3. 15 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 12 hits.
SSF56496. SSF56496. 1 hit.
PROSITEiPS00022. EGF_1. 15 hits.
PS01186. EGF_2. 15 hits.
PS50026. EGF_3. 5 hits.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50853. FN3. 15 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q4LE33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SLLCASKSPI LLKVRYPRAL EPQQHPAKPT STMGAMTQLL AGVFLAFLAL
60 70 80 90 100
ATEGGVLKKV IRHKRQSGVN ATLPEENQPV VFNHVYNIKL PVGSQCSVDL
110 120 130 140 150
ESASGEKDLA PPSEPSESFQ EHTVDGENQI VFTHRINIPR RACGCAAAPD
160 170 180 190 200
VKELLSRLEE LENLVSSLRE QCTAGAGCCL QPATGRLDTR PFCSGRGNFS
210 220 230 240 250
TEGCGCVCEP GWKGPNCSEP ECPGNCHLRG RCIDGQCICD DGFTGEDCSQ
260 270 280 290 300
LACPSDCNDQ GKCVNGVCIC FEGYAGADCS REICPVPCSE EHGTCVDGLC
310 320 330 340 350
VCHDGFAGDD CNKPLCLNNC YNRGRCVENE CVCDEGFTGE DCSELICPND
360 370 380 390 400
CFDRGRCING TCYCEEGFTG EDCGKPTCPH ACHTQGRCEE GQCVCDEGFA
410 420 430 440 450
GVDCSEKRCP ADCHNRGRCV DGRCECDDGF TGADCGELKC PNGCSGHGRC
460 470 480 490 500
VNGQCVCDEG YTGEDCSQLR CPNDCHSRGR CVEGKCVCEQ GFKGYDCSDM
510 520 530 540 550
SCPNDCHQHG RCVNGMCVCD DGYTGEDCRD RQCPRDCSNR GLCVDGQCVC
560 570 580 590 600
EDGFTGPDCA ELSCPNDCHG RGRCVNGQCV CHEGFMGKDC KEQRCPSDCH
610 620 630 640 650
GQGRCVDGQC ICHEGFTGLD CGQHSCPSDC NNLGQCVSGR CICNEGYSGE
660 670 680 690 700
DCSEVSPPKD LVVTEVTEET VNLAWDNEMR VTEYLVVYTP THEGGLEMQF
710 720 730 740 750
RVPGDQTSTI IRELEPGVEY FIRVFAILEN KKSIPVSARV ATYLPAPEGL
760 770 780 790 800
KFKSIKETSV EVEWDPLDIA FETWEIIFRN MNKEDEGEIT KSLRRPETSY
810 820 830 840 850
RQTGLAPGQE YEISLHIVKN NTRGPGLKRV TTTRLDAPSQ IEVKDVTDTT
860 870 880 890 900
ALITWFKPLA EIDGIELTYG IKDVPGDRTT IDLTEDENQY SIGNLKPDTE
910 920 930 940 950
YEVSLISRRG DMSSNPAKET FTTGLDAPRN LRRVSQTDNS ITLEWRNGKA
960 970 980 990 1000
AIDSYRIKYA PISGGDHAEV DVPKSQQATT KTTLTGLRPG TEYGIGVSAV
1010 1020 1030 1040 1050
KEDKESNPAT INAATELDTP KDLQVSETAE TSLTLLWKTP LAKFDRYRLN
1060 1070 1080 1090 1100
YSLPTGQWVG VQLPRNTTSY VLRGLEPGQE YNVLLTAEKG RHKSKPAHVK
1110 1120 1130 1140 1150
ASTEQAPELE NLTVTEVGWD GLRLNWTAAD QAYEHFIIQV QEANKVEAAR
1160 1170 1180 1190 1200
NLTVPGSLRA VDIPGLKAAT PYTVSIYGVI QGYRTPVLSA EASTGETPNL
1210 1220 1230 1240 1250
GEVVVAEVGW DALKLNWTAP EGAYEYFFIQ VQEADTVEAA QNLTVPGGLR
1260 1270 1280 1290 1300
STDLPGLKAA THYTITIRGV TQDFSTTPLS VEVLTEEVPD MGNLTVTEVS
1310 1320 1330 1340 1350
WDALRLNWTT PDGTYDQFTI QVQEADQVEE AHNLTVPGSL RSMEIPGLRA
1360 1370 1380 1390 1400
GTPYTVTLHG EVRGHSTRPL AVEVVTEDLP QLGDLAVSEV GWDGLRLNWT
1410 1420 1430 1440 1450
AADNAYEHFV IQVQEVNKVE AAQNLTLPGS LRAVDIPGLE AATPYRVSIY
1460 1470 1480 1490 1500
GVIRGYRTPV LSAEASTAKE PEIGNLNVSD ITPESFNLSW MATDGIFETF
1510 1520 1530 1540 1550
TIEIIDSNRL LETVEYNISG AERTAHISGL PPSTDFIVYL SGLAPSIRTK
1560 1570 1580 1590 1600
TISATATTEA LPLLENLTIS DINPYGFTVS WMASENAFDS FLVTVVDSGK
1610 1620 1630 1640 1650
LLDPQEFTLS GTQRKLELRG LITGIGYEVM VSGFTQGHQT KPLRAEIVTE
1660 1670 1680 1690 1700
AEPEVDNLLV SDATPDGFRL SWTADEGVFD NFVLKIRDTK KQSEPLEITL
1710 1720 1730 1740 1750
LAPERTRDIT GLREATEYEI ELYGISKGRR SQTVSAIATT AMGSPKEVIF
1760 1770 1780 1790 1800
SDITENSATV SWRAPTAQVE SFRITYVPIT GGTPSMVTVD GTKTQTRLVK
1810 1820 1830 1840 1850
LIPGVEYLVS IIAMKGFEES EPVSGSFTTA LDGPSGLVTA NITDSEALAR
1860 1870 1880 1890 1900
WQPAIATVDS YVISYTGEKV PEITRTVSGN TVEYALTDLE PATEYTLRIF
1910 1920 1930 1940 1950
AEKGPQKSST ITAKFTTDLD SPRDLTATEV QSETALLTWR PPRASVTGYL
1960 1970 1980 1990 2000
LVYESVDGTV KEVIVGPDTT SYSLADLSPS THYTAKIQAL NGPLRSNMIQ
2010 2020 2030 2040 2050
TIFTTIGLLY PFPKDCSQAM LNGDTTSGLY TIYLNGDKAE ALEVFCDMTS
2060 2070 2080 2090 2100
DGGGWIVFLR RKNGRENFYQ NWKAYAAGFG DRREEFWLGL DNLNKITAQG
2110 2120 2130 2140 2150
QYELRVDLRD HGETAFAVYD KFSVGDAKTR YKLKVEGYSG TAGDSMAYHN
2160 2170 2180 2190 2200
GRSFSTFDKD TDSAITNCAL SYKGAFWYRN CHRVNLMGRY GDNNHSQGVN
2210 2220 2230
WFHWKGHEHS IQFAEMKLRP SNFRNLEGRR KRA
Length:2,233
Mass (Da):244,404
Last modified:August 2, 2005 - v1
Checksum:i3AB15331FB1E92E7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB210038 mRNA. Translation: BAE06120.1.
RefSeqiNP_002151.2. NM_002160.3.
UniGeneiHs.143250.
Hs.734766.

Genome annotation databases

GeneIDi3371.
KEGGihsa:3371.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB210038 mRNA. Translation: BAE06120.1.
RefSeqiNP_002151.2. NM_002160.3.
UniGeneiHs.143250.
Hs.734766.

3D structure databases

ProteinModelPortaliQ4LE33.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000265131.

Proteomic databases

PaxDbiQ4LE33.
PeptideAtlasiQ4LE33.
PRIDEiQ4LE33.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3371.
KEGGihsa:3371.

Organism-specific databases

CTDi3371.
PharmGKBiPA35103.

Phylogenomic databases

eggNOGiKOG1225. Eukaryota.
KOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
HOGENOMiHOG000234355.
HOVERGENiHBG008949.
KOiK06252.

Miscellaneous databases

ChiTaRSiTNC. human.
GenomeRNAii3371.

Gene expression databases

GenevisibleiQ4LE33. HS.

Family and domain databases

Gene3Di2.60.40.10. 15 hits.
3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR013111. EGF_extracell.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR033078. TNC.
[Graphical view]
PANTHERiPTHR19143:SF38. PTHR19143:SF38. 2 hits.
PfamiPF07974. EGF_2. 6 hits.
PF00147. Fibrinogen_C. 1 hit.
PF00041. fn3. 15 hits.
PF12661. hEGF. 3 hits.
[Graphical view]
SMARTiSM00181. EGF. 14 hits.
SM00186. FBG. 1 hit.
SM00060. FN3. 15 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 12 hits.
SSF56496. SSF56496. 1 hit.
PROSITEiPS00022. EGF_1. 15 hits.
PS01186. EGF_2. 15 hits.
PS50026. EGF_3. 5 hits.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50853. FN3. 15 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ4LE33_HUMAN
AccessioniPrimary (citable) accession number: Q4LE33
Entry historyi
Integrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: July 6, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.