Q4LE28 (Q4LE28_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
CREBBP variant protein EMBL BAE06125.1

Gene names

Name:

CREBBP variant protein EMBL BAE06125.1

Organism

Homo sapiens (Human) EMBL BAE06125.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	2472 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Domain	Bromodomain SAAS SAAS001487
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	histone acetyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	histone acetyltransferase activity Inferred from electronic annotation. Source: InterPro transcription coactivator activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAE06125.1

Sequences

	Sequence		Length	Mass (Da)
	Q4LE28 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 651694163EB07C29	FASTA	2,472	267,908
	10 20 30 40 50 60 LRGAVAVAEI WPPPPPPGLR PPSPSAPARP LAARARSSPS QPAGPPTPVR ALAGPAARAR 70 80 90 100 110 120 GCFREQVKMA ENLLDGPPNP KRAKLSSPGF SANDSTDFGS LFDLENDLPD ELIPNGGELG 130 140 150 160 170 180 LLNSGNLVPD AASKHKQLSE LLRGGSGSSI NPGIGNVSAS SPVQQGLGGQ AQGQPNSANM 190 200 210 220 230 240 ASLSAMGKSP LSQGDSSAPS LPKQAASTSG PTPAASQALN PQAQKQVGLA TSSPATSQTG 250 260 270 280 290 300 PGICMNANFN QTHPGLLNSN SGHSLINQAS QGQAQVMNGS LGAAGRGRGA GMPYPTPAMQ 310 320 330 340 350 360 GASSSVLAET LTQVSPQMTG HAGLNTAQAG GMAKMGITGN TSPFGQPFSQ AGGQPMGATG 370 380 390 400 410 420 VNPQLASKQS MVNSLPTFPT DIKNTSVTNV PNMSQMQTSV GIVPTQAIAT GPTADPEKRK 430 440 450 460 470 480 LIQQQLVLLL HAHKCQRREQ ANGEVRACSL PHCRTMKNVL NHMTHCQAGK ACQAILGSPA 490 500 510 520 530 540 SGIQNTIGSV GTGQQNATSL SNPNPIDPSS MQRAYAALGL PYMNQPQTQL QPQVPGQQPA 550 560 570 580 590 600 QPQTHQQMRT LNPLGNNPMN IPAGGITTDQ QPPNLISESA LPTSLGATNP LMNDGSNSGN 610 620 630 640 650 660 IGTLSTIPTA APPSSTGVRK GWHEHVTQDL RSHLVHKLVQ AIFPTPDPAA LKDRRMENLV 670 680 690 700 710 720 AYAKKVEGDM YESANSRDEY YHLLAEKIYK IQKELEEKRR SRLHKQGILG NQPALPAPGA 730 740 750 760 770 780 QPPVIPQAQP VRPPNGPLSL PVNRMQVSQG MNSFNPMSLG NVQLPQAPMG PRAASPMNHS 790 800 810 820 830 840 VQMNSMGSVP GMAISPSRMP QPPNMMGAHT NNMMAQAPAQ SQFLPQNQFP SSSGAMSVGM 850 860 870 880 890 900 GQPPAQTGVS QGQVPGAALP NPLNMLGPQA SQLPCPPVTQ SPLHPTPPPA STAAGMPSLQ 910 920 930 940 950 960 HTTPPGMTPP QPAAPTQPST PVSSSGQTPT PTPGSVPSAT QTQSTPTVQA AAQAQVTPQP 970 980 990 1000 1010 1020 QTPVQPPSVA TPQSSQQQPT PVHAQPPGTP LSQAAASIDN RVPTPSSVAS AETNSQQPGP 1030 1040 1050 1060 1070 1080 DVPVLEMKTE TQAEDTEPDP GESKGEPRSE MMEEDLQGAS QVKEETDIAE QKSEPMEVDE 1090 1100 1110 1120 1130 1140 KKPEVKVEVK EEEESSSNGT ASQSTSPSQP RKKIFKPEEL RQALMPTLEA LYRQDPESLP 1150 1160 1170 1180 1190 1200 FRQPVDPQLL GIPDYFDIVK NPMDLSTIKR KLDTGQYQEP WQYVDDVWLM FNNAWLYNRK 1210 1220 1230 1240 1250 1260 TSRVYKFCSK LAEVFEQEID PVMQSLGYCC GRKYEFSPQT LCCYGKQLCT IPRDAAYYSY 1270 1280 1290 1300 1310 1320 QNRYHFCEKC FTEIQGENVT LGDDPSQPQT TISKDQFEKK KNDTLDPEPF VDCKECGRKM 1330 1340 1350 1360 1370 1380 HQICVLHYDI IWPSGFVCDN CLKKTGRPRK ENKFSAKRLQ TTRLGNHLED RVNKFLRRQN 1390 1400 1410 1420 1430 1440 HPEAGEVFVR VVASSDKTVE VKPGMKSRFV DSGEMSESFP YRTKALFAFE EIDGVDVCFF 1450 1460 1470 1480 1490 1500 GMHVQEYGSD CPPPNTRRVY ISYLDSIHFF RPRCLRTAVY HEILIGYLEY VKKLGYVTGH 1510 1520 1530 1540 1550 1560 IWACPPSEGD DYIFHCHPPD QKIPKPKRLQ EWYKKMLDKA FAERIIHDYK DIFKQATEDR 1570 1580 1590 1600 1610 1620 LTSAKELPYF EGDFWPNVLE ESIKELEQEE EERKKEESTA ASETTEGSQG DSKNAKKKNN 1630 1640 1650 1660 1670 1680 KKTNKNKSSI SRANKKKPSM PNVSNDLSQK LYATMEKHKE VFFVIHLHAG PVINTLPPIV 1690 1700 1710 1720 1730 1740 DPDPLLSCDL MDGRDAFLTL ARDKHWEFSS LRRSKWSTLC MLVELHTQGQ DRFVYTCNEC 1750 1760 1770 1780 1790 1800 KHHVETRWHC TVCEDYDLCI NCYNTKSHAH KMVKWGLGLD DEGSSQGEPQ SKSPQESRRL 1810 1820 1830 1840 1850 1860 SIQRCIQSLV HACQCRNANC SLPSCQKMKR VVQHTKGCKR KTNGGCPVCK QLIALCCYHA 1870 1880 1890 1900 1910 1920 KHCQENKCPV PFCLNIKHKL RQQQIQHRLQ QAQLMRRRMA TMNTRNVPQQ SLPSPTSAPP 1930 1940 1950 1960 1970 1980 GTPTQQPSTP QTPQPPAQPQ PSPVSMSPAG FPSVARTQPP TTVSTGKPTS QVPAPPPPAQ 1990 2000 2010 2020 2030 2040 PPPAAVEAAR QIEREAQQQQ HLYRVNINNS MPPGRTGMGT PGSQMAPVSL NVPRPNQVSG 2050 2060 2070 2080 2090 2100 PVMPSMPPGQ WQQAPLPQQQ PMPGLPRPVI SMQAQAAVAG PRMPSVQPPR SISPSALQDL 2110 2120 2130 2140 2150 2160 LRTLKSPSSP QQQQQVLNIL KSNPQLMAAF IKQRTAKYVA NQPGMQPQPG LQSQPGMQPQ 2170 2180 2190 2200 2210 2220 PGMHQQPSLQ NLNAMQAGVP RPGVPPQQQA MGGLNPQGQA LNIMNPGHNP NMASMNPQYR 2230 2240 2250 2260 2270 2280 EMLRRQLLQQ QQQQQQQQQQ QQQQQQGSAG MAGGMAGHGQ FQQPQGPGGY PPAMQQQQRM 2290 2300 2310 2320 2330 2340 QQHLPLQGSS MGQMAAQMGQ LGQMGQPGLG ADSTPNIQQA LQQRILQQQQ MKQQIGSPGQ 2350 2360 2370 2380 2390 2400 PNPMSPQQHM LSGQPQASHL PGQQIATSLS NQVRSPAPVQ SPRPQSQPPH SSPSPRIQPQ 2410 2420 2430 2440 2450 2460 PSPHHVSPQT GSPHPGLAVT MASSIDQGHL GNPEQSAMLP QLNTPSRSAL SSELSLVGDT 2470 TGDTLEKFVE GL

References

[1]	"Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method." Nakajima D., Saito K., Yamakawa H., Kikuno R.F., Nakayama M., Ohara R., Okazaki N., Koga H., Nagase T., Ohara O. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Brain EMBL BAE06125.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB210043 mRNA. Translation: BAE06125.1.
IPI	IPI01009314.
RefSeq	NP_001073315.1. NM_001079846.1. NP_004371.2. NM_004380.2.
UniGene	Hs.459759.
3D structure databases
ProteinModelPortal	Q4LE28.
SMR	Q4LE28. Positions 409-473, 617-703, 1111-1227, 1353-1588, 1641-1780, 1793-1884, 2095-2141.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4LE28.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1387.
KEGG	hsa:1387.
UCSC	uc002cvw.1. human.
Organism-specific databases
CTD	1387.
PharmGKB	PA26866.
Phylogenomic databases
GeneTree	ENSGT00550000074306.
HOVERGEN	HBG000185.
Gene expression databases
ArrayExpress	Q4LE28.
Bgee	Q4LE28.
Family and domain databases
InterPro	IPR001487. Bromodomain. IPR018359. Bromodomain_CS. IPR010303. DUF902_CREBbp. IPR013178. Histone_H3-K56_AcTrfase_RTT109. IPR003101. KIX. IPR009110. Nuc_rcpt_coact. IPR014744. Nuc_rcpt_coact_CREBbp. IPR000197. Znf_TAZ. IPR000433. Znf_ZZ. [Graphical view]
Gene3D	G3DSA:1.20.920.10. Bromodomain. 1 hit. G3DSA:1.10.246.20. KIX. 1 hit. G3DSA:1.10.1630.10. Nuc_rcpt_coact_CREBbp. 1 hit. G3DSA:1.20.1020.10. Znf_TAZ. 2 hits.
KO	K04498.
Pfam	PF00439. Bromodomain. 1 hit. PF09030. Creb_binding. 1 hit. PF06001. DUF902. 1 hit. PF08214. KAT11. 1 hit. PF02172. KIX. 1 hit. PF02135. zf-TAZ. 2 hits. PF00569. ZZ. 1 hit. [Graphical view]
PRINTS	PR00503. BROMODOMAIN.
SMART	SM00297. BROMO. 1 hit. SM00551. ZnF_TAZ. 2 hits. SM00291. ZnF_ZZ. 1 hit. [Graphical view]
SUPFAM	SSF47370. Bromodomain. 1 hit. SSF47040. KIX. 1 hit. SSF69125. Nuc_recept_coact. 1 hit. SSF57933. TAZ_finger. 2 hits.
PROSITE	PS00633. BROMODOMAIN_1. 1 hit. PS50014. BROMODOMAIN_2. 1 hit. PS50952. KIX. 1 hit. PS50134. ZF_TAZ. 2 hits. PS01357. ZF_ZZ_1. 1 hit. PS50135. ZF_ZZ_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	5635.

Entry information

Entry name

Q4LE28_HUMAN

Accession

Primary (citable) accession number: Q4LE28

Entry history

Integrated into UniProtKB/TrEMBL:	August 2, 2005
Last sequence update:	August 2, 2005
Last modified:	January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.