Q4LDX3 (Q4LDX3_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Janus kinase 1 EMBL BAE02826.1

Gene names

Name:

JAK1 EMBL BAE02826.1

Organism

Homo sapiens (Human) EMBL BAE02826.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1141 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SAAS SAAS000980
Sequence similarities	Contains 1 protein kinase domain. SAAS SAAS008266

Ontologies

Keywords
Ligand	ATP-binding SAAS SAAS000980 Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase SAAS SAAS000980
PTM	Phosphoprotein RuleBase RU003493
Gene Ontology (GO)
Biological_process	intracellular protein kinase cascade Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoskeleton Inferred from electronic annotation. Source: InterPro membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW non-membrane spanning protein tyrosine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q4LDX3 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 716A1A8434BC8F0B	FASTA	1,141	131,690
	10 20 30 40 50 60 MAFCAKMRSS KKTEVNLEAP EPGVEVIFYL SDREPLRLGS GEYTAEELCI RAAQACRISP 70 80 90 100 110 120 LCHNLFALYD ENTKLWYAPN RTITVDDKMS LRLHYRMRFY FTNWHGTNDN EQSVWRHSPK 130 140 150 160 170 180 KQKNGYEKKK IPDATPLLDA SSLEYLFAQG QYDLVKCLAP IRDPKTEQDG HDIENECLGM 190 200 210 220 230 240 AVLAISHYAM MKKMQLPELP KDISYKRYIP ETLNKSIRQR NLLTRMRINN VFKDFLKEFN 250 260 270 280 290 300 NKTICDSSVS THDLKVKYLA TLETLTKHYG AEIFETSMLL ISSENEMNWF HSNDGGNVLY 310 320 330 340 350 360 YEVMVTGNLG IQWRHKPNVV SVEKEKNKLK RKKLENKHKK DEEKNKIREE WNNFSYFPEI 370 380 390 400 410 420 THIVIKESVV SINKQDNKKM ELKLSSHEEA LSFVSLVDGY FRLTADAHHY LCTDVAPPLI 430 440 450 460 470 480 VHNIQNGCHG PICTEYAINK LRQEGSEEGM SVLRWSCTDF DNILMTVTCF EKSEQVQGAQ 490 500 510 520 530 540 KQFKNFQIEV QKGRYSLHGS DRSFPSLGDL MSHLKKQILR TDNISFMLKR CCQPKPREIS 550 560 570 580 590 600 NLLVATKKAQ EWQPVYPMSQ LSFDRILKKD LVQGEHLGRG TRTHIYSGTL MDYKDDEGTS 610 620 630 640 650 660 EEKKIKVILK VLDPSHRDIS LAFFEAASMI RQVSHKHIVY LYGVCVRDVE NIMVEEFVEG 670 680 690 700 710 720 GPLDLFMHRK SDVLTTPWKF KVAKQLASAL SYLEDKDLVH GNVCTKNLLL AREGIDSECG 730 740 750 760 770 780 PFIKLSDPGI PITVLSRQEC IERIPWIAPE CVEDSKNLCV AADKWSFGTT LWEICYNGEI 790 800 810 820 830 840 PLKDKTLIEK ERFYESRCRP VTPSCKELAD LMTRCMNYDP NQRPFFRAIM RDINKLEEQN 850 860 870 880 890 900 PDIVSEKKPA TEVDPTHFEK RFLKRIRDLE EGHFGKVELC RYDPEDNTGE QVAVKSLKPE 910 920 930 940 950 960 SGGNHIADLK KEIEILRNLY HENIVKYKGI CTEDGGNGIK LIMEFLPSGS LKEYLPKNKN 970 980 990 1000 1010 1020 KINLKQQLKY AVQICKGMDY LGSRQYVHRD LAARNVLVES EHQVKIGDFG LTKAIETDKE 1030 1040 1050 1060 1070 1080 YYTVKDDRDS PKFGYAPECL MQSKFYIASD VWSFGVTLHE LLTYCDSDSS PMALFLKMIG 1090 1100 1110 1120 1130 1140 PTHGQMTVTR LVNTLKEGKR LPCPPNCPDE VYQLMRKCWE FQPSNRTSFQ NLIEGFEALL K

References

[1]	"The mutation in the ATP-binding region of JAK1, identified in human uterine leiomyosarcomas, results in defective interferon-gamma inducibility of TAP1 and LMP2." Hayashi T., Kobayashi Y., Kohsaka S., Sano K. Oncogene 25:4016-4026(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB219242 mRNA. Translation: BAE02826.1.
IPI	IPI00784013.
UniGene	Hs.207538.
3D structure databases
ProteinModelPortal	Q4LDX3.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4LDX3.
Proteomic databases
PRIDE	Q4LDX3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG006195.
Gene expression databases
ArrayExpress	Q4LDX3.
Family and domain databases
Gene3D	3.30.505.10. 1 hit.
InterPro	IPR019749. Band_41_domain. IPR019748. FERM_central. IPR000299. FERM_domain. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR000980. SH2. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2. IPR020776. Tyr_kinase_non-rcpt_Jak1. [Graphical view]
Pfam	PF07714. Pkinase_Tyr. 2 hits. [Graphical view]
PIRSF	PIRSF000636. TyrPK_Jak. 1 hit.
PRINTS	PR01823. JANUSKINASE. PR01824. JANUSKINASE1. PR00109. TYRKINASE.
SMART	SM00295. B41. 1 hit. SM00252. SH2. 1 hit. SM00219. TyrKc. 2 hits. [Graphical view]
SUPFAM	SSF47031. FERM_3-hlx. 1 hit. SSF56112. Kinase_like. 2 hits.
PROSITE	PS50057. FERM_3. 1 hit. PS50011. PROTEIN_KINASE_DOM. 2 hits. PS00109. PROTEIN_KINASE_TYR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	JAK1. human.

Entry information

Entry name

Q4LDX3_HUMAN

Accession

Primary (citable) accession number: Q4LDX3

Entry history

Integrated into UniProtKB/TrEMBL:	August 2, 2005
Last sequence update:	August 2, 2005
Last modified:	March 6, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.