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Q4LDE5 (SVEP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1
Alternative name(s):
CCP module-containing protein 22
Polydom
Selectin-like osteoblast-derived protein
Short name=SEL-OB
Serologically defined breast cancer antigen NY-BR-38
Gene names
Name:SVEP1
Synonyms:C9orf13, CCP22, SELOB
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length3571 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in the cell attachment process By similarity.

Subcellular location

Secreted Potential. Cytoplasm. Membrane; Peripheral membrane protein Ref.1.

Tissue specificity

Present in mesenchymal primary cultured cell lysates (at protein level). Highly expressed in placenta. Also expressed in marrow stromal cell. Weakly or not expressed in other tissues. Ref.1 Ref.8

Post-translational modification

O-glycosylated with core 1 or possibly core 8 glycans. Ref.9

Sequence similarities

Contains 9 EGF-like domains.

Contains 2 HYR domains.

Contains 1 pentaxin domain.

Contains 34 Sushi (CCP/SCR) domains.

Contains 1 VWFA domain.

Sequence caution

The sequence AAG48257.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAG48257.1 differs from that shown. Reason: Frameshift at positions 2630, 2638 and 2655.

The sequence BAB14617.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAB55420.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence CAH73557.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence CAH73558.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAH74138.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence CAH74139.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI14068.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentCytoplasm
Membrane
Secreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainEGF-like domain
Repeat
Signal
Sushi
   LigandCalcium
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

chromatin binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q4LDE5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q4LDE5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     868-868: P → N
     869-3571: Missing.
Isoform 3 (identifier: Q4LDE5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-2074: Missing.
Isoform 4 (identifier: Q4LDE5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1547-3571: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 35713554Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1
PRO_0000320179

Regions

Domain83 – 264182VWFA
Domain376 – 43560Sushi 1
Domain436 – 49560Sushi 2
Domain496 – 56166Sushi 3
Domain560 – 64283HYR 1
Domain643 – 72482HYR 2
Domain725 – 78965Sushi 4
Domain1193 – 122937EGF-like 1
Domain1231 – 126737EGF-like 2; calcium-binding Potential
Domain1269 – 130537EGF-like 3; calcium-binding Potential
Domain1307 – 134337EGF-like 4; calcium-binding Potential
Domain1345 – 138137EGF-like 5; calcium-binding Potential
Domain1383 – 141937EGF-like 6; calcium-binding Potential
Domain1430 – 1623194Pentaxin
Domain1629 – 168759Sushi 5
Domain1688 – 174558Sushi 6
Domain1745 – 178440EGF-like 7; calcium-binding Potential
Domain1787 – 184458Sushi 7
Domain1845 – 190258Sushi 8
Domain1903 – 196058Sushi 9
Domain1961 – 201858Sushi 10
Domain2019 – 208062Sushi 11
Domain2081 – 214363Sushi 12
Domain2144 – 220158Sushi 13
Domain2202 – 226160Sushi 14
Domain2262 – 232059Sushi 15
Domain2321 – 237858Sushi 16
Domain2379 – 243759Sushi 17
Domain2438 – 249558Sushi 18
Domain2496 – 255358Sushi 19
Domain2554 – 261057Sushi 20
Domain2663 – 271452Sushi 21
Domain2715 – 277258Sushi 22
Domain2773 – 283058Sushi 23
Domain2831 – 288858Sushi 24
Domain2889 – 294658Sushi 25
Domain2947 – 300458Sushi 26
Domain3005 – 306157Sushi 27
Domain3062 – 311958Sushi 28
Domain3120 – 317859Sushi 29
Domain3179 – 323860Sushi 30
Domain3239 – 329658Sushi 31
Domain3297 – 335458Sushi 32
Domain3355 – 341359Sushi 33
Domain3414 – 347057Sushi 34
Domain3500 – 353233EGF-like 8
Domain3533 – 356432EGF-like 9
Region887 – 8948O-glycosylated at one site
Motif2845 – 28473Cell attachment site Potential

Amino acid modifications

Glycosylation1861N-linked (GlcNAc...) Potential
Glycosylation8471N-linked (GlcNAc...) Potential
Glycosylation11021N-linked (GlcNAc...) Potential
Glycosylation30181N-linked (GlcNAc...) Potential
Glycosylation31861N-linked (GlcNAc...) Potential
Disulfide bond378 ↔ 420 By similarity
Disulfide bond406 ↔ 433 By similarity
Disulfide bond438 ↔ 480 By similarity
Disulfide bond466 ↔ 493 By similarity
Disulfide bond498 ↔ 544 By similarity
Disulfide bond529 ↔ 559 By similarity
Disulfide bond727 ↔ 769 By similarity
Disulfide bond753 ↔ 787 By similarity
Disulfide bond1197 ↔ 1208 By similarity
Disulfide bond1202 ↔ 1217 By similarity
Disulfide bond1219 ↔ 1228 By similarity
Disulfide bond1235 ↔ 1246 By similarity
Disulfide bond1240 ↔ 1255 By similarity
Disulfide bond1257 ↔ 1266 By similarity
Disulfide bond1273 ↔ 1284 By similarity
Disulfide bond1278 ↔ 1293 By similarity
Disulfide bond1295 ↔ 1304 By similarity
Disulfide bond1311 ↔ 1322 By similarity
Disulfide bond1316 ↔ 1331 By similarity
Disulfide bond1333 ↔ 1342 By similarity
Disulfide bond1349 ↔ 1360 By similarity
Disulfide bond1354 ↔ 1369 By similarity
Disulfide bond1371 ↔ 1380 By similarity
Disulfide bond1387 ↔ 1398 By similarity
Disulfide bond1392 ↔ 1407 By similarity
Disulfide bond1409 ↔ 1418 By similarity
Disulfide bond1631 ↔ 1672 By similarity
Disulfide bond1658 ↔ 1685 By similarity
Disulfide bond1690 ↔ 1730 By similarity
Disulfide bond1716 ↔ 1743 By similarity
Disulfide bond1749 ↔ 1761 By similarity
Disulfide bond1755 ↔ 1770 By similarity
Disulfide bond1772 ↔ 1783 By similarity
Disulfide bond1789 ↔ 1829 By similarity
Disulfide bond1815 ↔ 1842 By similarity
Disulfide bond1847 ↔ 1887 By similarity
Disulfide bond1873 ↔ 1900 By similarity
Disulfide bond1905 ↔ 1945 By similarity
Disulfide bond1931 ↔ 1958 By similarity
Disulfide bond1963 ↔ 2003 By similarity
Disulfide bond1989 ↔ 2016 By similarity
Disulfide bond2021 ↔ 2061 By similarity
Disulfide bond2047 ↔ 2078 By similarity
Disulfide bond2083 ↔ 2126 By similarity
Disulfide bond2112 ↔ 2141 By similarity
Disulfide bond2146 ↔ 2186 By similarity
Disulfide bond2172 ↔ 2199 By similarity
Disulfide bond2204 ↔ 2245 By similarity
Disulfide bond2231 ↔ 2259 By similarity
Disulfide bond2264 ↔ 2304 By similarity
Disulfide bond2290 ↔ 2318 By similarity
Disulfide bond2323 ↔ 2363 By similarity
Disulfide bond2349 ↔ 2376 By similarity
Disulfide bond2381 ↔ 2422 By similarity
Disulfide bond2408 ↔ 2435 By similarity
Disulfide bond2440 ↔ 2480 By similarity
Disulfide bond2466 ↔ 2493 By similarity
Disulfide bond2498 ↔ 2538 By similarity
Disulfide bond2524 ↔ 2551 By similarity
Disulfide bond2556 ↔ 2596 By similarity
Disulfide bond2582 ↔ 2608 By similarity
Disulfide bond2685 ↔ 2712 By similarity
Disulfide bond2717 ↔ 2757 By similarity
Disulfide bond2743 ↔ 2770 By similarity
Disulfide bond2775 ↔ 2815 By similarity
Disulfide bond2801 ↔ 2828 By similarity
Disulfide bond2833 ↔ 2873 By similarity
Disulfide bond2859 ↔ 2886 By similarity
Disulfide bond2891 ↔ 2931 By similarity
Disulfide bond2917 ↔ 2944 By similarity
Disulfide bond2949 ↔ 2989 By similarity
Disulfide bond2975 ↔ 3002 By similarity
Disulfide bond3007 ↔ 3046 By similarity
Disulfide bond3032 ↔ 3059 By similarity
Disulfide bond3064 ↔ 3104 By similarity
Disulfide bond3090 ↔ 3117 By similarity
Disulfide bond3122 ↔ 3163 By similarity
Disulfide bond3148 ↔ 3176 By similarity
Disulfide bond3181 ↔ 3221 By similarity
Disulfide bond3207 ↔ 3236 By similarity
Disulfide bond3241 ↔ 3281 By similarity
Disulfide bond3267 ↔ 3294 By similarity
Disulfide bond3299 ↔ 3339 By similarity
Disulfide bond3325 ↔ 3352 By similarity
Disulfide bond3384 ↔ 3411 By similarity
Disulfide bond3416 ↔ 3456 By similarity
Disulfide bond3442 ↔ 3468 By similarity
Disulfide bond3504 ↔ 3514 By similarity
Disulfide bond3508 ↔ 3520 By similarity
Disulfide bond3522 ↔ 3531 By similarity
Disulfide bond3536 ↔ 3546 By similarity
Disulfide bond3540 ↔ 3552 By similarity
Disulfide bond3554 ↔ 3563 By similarity

Natural variations

Alternative sequence1 – 20742074Missing in isoform 3.
VSP_031625
Alternative sequence8681P → N in isoform 2.
VSP_031626
Alternative sequence869 – 35712703Missing in isoform 2.
VSP_031627
Alternative sequence1547 – 35712025Missing in isoform 4.
VSP_031628
Natural variant3321G → A. Ref.3
Corresponds to variant rs3818764 [ dbSNP | Ensembl ].
VAR_039153
Natural variant4281G → S.
Corresponds to variant rs10980419 [ dbSNP | Ensembl ].
VAR_039154
Natural variant5071V → I.
Corresponds to variant rs872665 [ dbSNP | Ensembl ].
VAR_039155
Natural variant5811Q → H.
Corresponds to variant rs10817033 [ dbSNP | Ensembl ].
VAR_039156
Natural variant6371I → V.
Corresponds to variant rs13286541 [ dbSNP | Ensembl ].
VAR_039157
Natural variant8991K → R.
Corresponds to variant rs10817025 [ dbSNP | Ensembl ].
VAR_039158
Natural variant11571I → V.
Corresponds to variant rs7038903 [ dbSNP | Ensembl ].
VAR_039159
Natural variant13301L → M.
Corresponds to variant rs10817021 [ dbSNP | Ensembl ].
VAR_039160
Natural variant14161K → Q.
Corresponds to variant rs1889323 [ dbSNP | Ensembl ].
VAR_039161
Natural variant14441M → L.
Corresponds to variant rs7863519 [ dbSNP | Ensembl ].
VAR_039162
Natural variant16481L → V.
Corresponds to variant rs7852962 [ dbSNP | Ensembl ].
VAR_039163
Natural variant18101E → A.
Corresponds to variant rs2986671 [ dbSNP | Ensembl ].
VAR_039164
Natural variant19531R → K.
Corresponds to variant rs17204832 [ dbSNP | Ensembl ].
VAR_039165
Natural variant26071T → A.
Corresponds to variant rs3802433 [ dbSNP | Ensembl ].
VAR_039166
Natural variant27501A → V. Ref.3
Corresponds to variant rs7030192 [ dbSNP | Ensembl ].
VAR_039167
Natural variant29221I → V.
Corresponds to variant rs16914996 [ dbSNP | Ensembl ].
VAR_039168
Natural variant31611F → I. Ref.6
Corresponds to variant rs3739451 [ dbSNP | Ensembl ].
VAR_039169
Natural variant32301P → T.
Corresponds to variant rs16914992 [ dbSNP | Ensembl ].
VAR_039170
Natural variant35591T → M.
Corresponds to variant rs17204533 [ dbSNP | Ensembl ].
VAR_039171

Experimental info

Sequence conflict4291S → L in CAF04067. Ref.1
Sequence conflict4291S → L in BAB55420. Ref.3
Sequence conflict6041H → R in BAB14617. Ref.3
Sequence conflict8221F → L in BAB14617. Ref.3
Sequence conflict8421C → W in CAF04067. Ref.1
Sequence conflict8421C → W in BAB55420. Ref.3
Sequence conflict9801E → G in CAF04067. Ref.1
Sequence conflict9801E → G in BAB55420. Ref.3
Sequence conflict10631Y → C in CAF04067. Ref.1
Sequence conflict10631Y → C in BAB55420. Ref.3
Sequence conflict14421D → V in CAF04067. Ref.1
Sequence conflict14421D → V in BAB55420. Ref.3
Sequence conflict15461P → PGMF in CAF04067. Ref.1
Sequence conflict17751P → S in CAF04067. Ref.1
Sequence conflict21791K → E in CAD97901. Ref.6
Sequence conflict21891T → S in BAC11489. Ref.3
Sequence conflict22371S → P in BAC11489. Ref.3
Sequence conflict22461Q → H in BAC11489. Ref.3
Sequence conflict22591C → W in BAC11489. Ref.3
Sequence conflict22991D → G in CAD97988. Ref.6
Sequence conflict24541Q → R in BAC11489. Ref.3
Sequence conflict25191T → I in CAD97901. Ref.6
Sequence conflict26231D → A in AAG48257. Ref.7
Sequence conflict27051W → R in BAC11489. Ref.3
Sequence conflict27531D → G in BAC11489. Ref.3
Sequence conflict28331C → R in BAC11489. Ref.3
Sequence conflict28571Y → H in CAD97901. Ref.6
Sequence conflict30051C → F in BAC11489. Ref.3
Sequence conflict31861N → S in CAD97988. Ref.6
Sequence conflict33021P → Q in CAF04067. Ref.1
Sequence conflict33021P → Q in BAC11489. Ref.3
Sequence conflict33981C → Y in CAF04067. Ref.1
Sequence conflict33981C → Y in BAC11489. Ref.3
Sequence conflict35651R → G in CAD97988. Ref.6
Sequence conflict35671R → G in CAD97988. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: 8F52DE456CED5DED

FASTA3,571390,170
        10         20         30         40         50         60 
MWPRLAFCCW GLALVSGWAT FQQMSPSRNF SFRLFPETAP GAPGSIPAPP APGDEAAGSR 

        70         80         90        100        110        120 
VERLGQAFRR RVRLLRELSE RLELVFLVDD SSSVGEVNFR SELMFVRKLL SDFPVVPTAT 

       130        140        150        160        170        180 
RVAIVTFSSK NYVVPRVDYI STRRARQHKC ALLLQEIPAI SYRGGGTYTK GAFQQAAQIL 

       190        200        210        220        230        240 
LHARENSTKV VFLITDGYSN GGDPRPIAAS LRDSGVEIFT FGIWQGNIRE LNDMASTPKE 

       250        260        270        280        290        300 
EHCYLLHSFE EFEALARRAL HEDLPSGSFI QDDMVHCSYL CDEGKDCCDR MGSCKCGTHT 

       310        320        330        340        350        360 
GHFECICEKG YYGKGLQYEC TACPSGTYKP EGSPGGISSC IPCPDENHTS PPGSTSPEDC 

       370        380        390        400        410        420 
VCREGYRASG QTCELVHCPA LKPPENGYFI QNTCNNHFNA ACGVRCHPGF DLVGSSIILC 

       430        440        450        460        470        480 
LPNGLWSGSE SYCRVRTCPH LRQPKHGHIS CSTREMLYKT TCLVACDEGY RLEGSDKLTC 

       490        500        510        520        530        540 
QGNSQWDGPE PRCVERHCST FQMPKDVIIS PHNCGKQPAK FGTICYVSCR QGFILSGVKE 

       550        560        570        580        590        600 
MLRCTTSGKW NVGVQAAVCK DVEAPQINCP KDIEAKTLEQ QDSANVTWQI PTAKDNSGEK 

       610        620        630        640        650        660 
VSVHVHPAFT PPYLFPIGDV AIVYTATDLS GNQASCIFHI KVIDAEPPVI DWCRSPPPVQ 

       670        680        690        700        710        720 
VSEKVHAASW DEPQFSDNSG AELVITRSHT QGDLFPQGET IVQYTATDPS GNNRTCDIHI 

       730        740        750        760        770        780 
VIKGSPCEIP FTPVNGDFIC TPDNTGVNCT LTCLEGYDFT EGSTDKYYCA YEDGVWKPTY 

       790        800        810        820        830        840 
TTEWPDCAKK RFANHGFKSF EMFYKAARCD DTDLMKKFSE AFETTLGKMV PSFCSDAEDI 

       850        860        870        880        890        900 
DCRLEENLTK KYCLEYNYDY ENGFAIGPGG WGAANRLDYS YDDFLDTVQE TATSIGNAKS 

       910        920        930        940        950        960 
SRIKRSAPLS DYKIKLIFNI TASVPLPDER NDTLEWENQQ RLLQTLETIT NKLKRTLNKD 

       970        980        990       1000       1010       1020 
PMYSFQLASE ILIADSNSLE TKKASPFCRP GSVLRGRMCV NCPLGTYYNL EHFTCESCRI 

      1030       1040       1050       1060       1070       1080 
GSYQDEEGQL ECKLCPSGMY TEYIHSRNIS DCKAQCKQGT YSYSGLETCE SCPLGTYQPK 

      1090       1100       1110       1120       1130       1140 
FGSRSCLSCP ENTSTVKRGA VNISACGVPC PEGKFSRSGL MPCHPCPRDY YQPNAGKAFC 

      1150       1160       1170       1180       1190       1200 
LACPFYGTTP FAGSRSITEC SSFSSTFSAA EESVVPPASL GHIKKRHEIS SQVFHECFFN 

      1210       1220       1230       1240       1250       1260 
PCHNSGTCQQ LGRGYVCLCP LGYTGLKCET DIDECSPLPC LNNGVCKDLV GEFICECPSG 

      1270       1280       1290       1300       1310       1320 
YTGQRCEENI NECSSSPCLN KGICVDGVAG YRCTCVKGFV GLHCETEVNE CQSNPCLNNA 

      1330       1340       1350       1360       1370       1380 
VCEDQVGGFL CKCPPGFLGT RCGKNVDECL SQPCKNGATC KDGANSFRCL CAAGFTGSHC 

      1390       1400       1410       1420       1430       1440 
ELNINECQSN PCRNQATCVD ELNSYSCKCQ PGFSGKRCET EQSTGFNLDF EVSGIYGYVM 

      1450       1460       1470       1480       1490       1500 
LDGMLPSLHA LTCTFWMKSS DDMNYGTPIS YAVDNGSDNT LLLTDYNGWV LYVNGREKIT 

      1510       1520       1530       1540       1550       1560 
NCPSVNDGRW HHIAITWTSA NGIWKVYIDG KLSDGGAGLS VGLPIPGGGA LVLGQEQDKK 

      1570       1580       1590       1600       1610       1620 
GEGFSPAESF VGSISQLNLW DYVLSPQQVK SLATSCPEEL SKGNVLAWPD FLSGIVGKVK 

      1630       1640       1650       1660       1670       1680 
IDSKSIFCSD CPRLGGSVPH LRTASEDLKP GSKVNLFCDP GFQLVGNPVQ YCLNQGQWTQ 

      1690       1700       1710       1720       1730       1740 
PLPHCERISC GVPPPLENGF HSADDFYAGS TVTYQCNNGY YLLGDSRMFC TDNGSWNGVS 

      1750       1760       1770       1780       1790       1800 
PSCLDVDECA VGSDCSEHAS CLNVDGSYIC SCVPPYTGDG KNCAEPIKCK APGNPENGHS 

      1810       1820       1830       1840       1850       1860 
SGEIYTVGAE VTFSCQEGYQ LMGVTKITCL ESGEWNHLIP YCKAVSCGKP AIPENGCIEE 

      1870       1880       1890       1900       1910       1920 
LAFTFGSKVT YRCNKGYTLA GDKESSCLAN SSWSHSPPVC EPVKCSSPEN INNGKYILSG 

      1930       1940       1950       1960       1970       1980 
LTYLSTASYS CDTGYSLQGP SIIECTASGI WDRAPPACHL VFCGEPPAIK DAVITGNNFT 

      1990       2000       2010       2020       2030       2040 
FRNTVTYTCK EGYTLAGLDT IECLADGKWS RSDQQCLAVS CDEPPIVDHA SPETAHRLFG 

      2050       2060       2070       2080       2090       2100 
DIAFYYCSDG YSLADNSQLL CNAQGKWVPP EGQDMPRCIA HFCEKPPSVS YSILESVSKA 

      2110       2120       2130       2140       2150       2160 
KFAAGSVVSF KCMEGFVLNT SAKIECMRGG QWNPSPMSIQ CIPVRCGEPP SIMNGYASGS 

      2170       2180       2190       2200       2210       2220 
NYSFGAMVAY SCNKGFYIKG EKKSTCEATG QWSSPIPTCH PVSCGEPPKV ENGFLEHTTG 

      2230       2240       2250       2260       2270       2280 
RIFESEVRYQ CNPGYKSVGS PVFVCQANRH WHSESPLMCV PLDCGKPPPI QNGFMKGENF 

      2290       2300       2310       2320       2330       2340 
EVGSKVQFFC NEGYELVGDS SWTCQKSGKW NKKSNPKCMP AKCPEPPLLE NQLVLKELTT 

      2350       2360       2370       2380       2390       2400 
EVGVVTFSCK EGHVLQGPSV LKCLPSQQWN DSFPVCKIVL CTPPPLISFG VPIPSSALHF 

      2410       2420       2430       2440       2450       2460 
GSTVKYSCVG GFFLRGNSTT LCQPDGTWSS PLPECVPVEC PQPEEIPNGI IDVQGLAYLS 

      2470       2480       2490       2500       2510       2520 
TALYTCKPGF ELVGNTTTLC GENGHWLGGK PTCKAIECLK PKEILNGKFS YTDLHYGQTV 

      2530       2540       2550       2560       2570       2580 
TYSCNRGFRL EGPSALTCLE TGDWDVDAPS CNAIHCDSPQ PIENGFVEGA DYSYGAIIIY 

      2590       2600       2610       2620       2630       2640 
SCFPGFQVAG HAMQTCEESG WSSSIPTCMP IDCGLPPHID FGDCTKLKDD QGYFEQEDDM 

      2650       2660       2670       2680       2690       2700 
MEVPYVTPHP PYHLGAVAKT WENTKESPAT HSSNFLYGTM VSYTCNPGYE LLGNPVLICQ 

      2710       2720       2730       2740       2750       2760 
EDGTWNGSAP SCISIECDLP TAPENGFLRF TETSMGSAVQ YSCKPGHILA GSDLRLCLEN 

      2770       2780       2790       2800       2810       2820 
RKWSGASPRC EAISCKKPNP VMNGSIKGSN YTYLSTLYYE CDPGYVLNGT ERRTCQDDKN 

      2830       2840       2850       2860       2870       2880 
WDEDEPICIP VDCSSPPVSA NGQVRGDEYT FQKEIEYTCN EGFLLEGARS RVCLANGSWS 

      2890       2900       2910       2920       2930       2940 
GATPDCVPVR CATPPQLANG VTEGLDYGFM KEVTFHCHEG YILHGAPKLT CQSDGNWDAE 

      2950       2960       2970       2980       2990       3000 
IPLCKPVNCG PPEDLAHGFP NGFSFIHGGH IQYQCFPGYK LHGNSSRRCL SNGSWSGSSP 

      3010       3020       3030       3040       3050       3060 
SCLPCRCSTP VIEYGTVNGT DFDCGKAARI QCFKGFKLLG LSEITCEADG QWSSGFPHCE 

      3070       3080       3090       3100       3110       3120 
HTSCGSLPMI PNAFISETSS WKENVITYSC RSGYVIQGSS DLICTEKGVW SQPYPVCEPL 

      3130       3140       3150       3160       3170       3180 
SCGSPPSVAN AVATGEAHTY ESEVKLRCLE GYTMDTDTDT FTCQKDGRWF PERISCSPKK 

      3190       3200       3210       3220       3230       3240 
CPLPENITHI LVHGDDFSVN RQVSVSCAEG YTFEGVNISV CQLDGTWEPP FSDESCSPVS 

      3250       3260       3270       3280       3290       3300 
CGKPESPEHG FVVGSKYTFE STIIYQCEPG YELEGNRERV CQENRQWSGG VAICKETRCE 

      3310       3320       3330       3340       3350       3360 
TPLEFLNGKA DIENRTTGPN VVYSCNRGYS LEGPSEAHCT ENGTWSHPVP LCKPNPCPVP 

      3370       3380       3390       3400       3410       3420 
FVIPENALLS EKEFYVDQNV SIKCREGFLL QGHGIITCNP DETWTQTSAK CEKISCGPPA 

      3430       3440       3450       3460       3470       3480 
HVENAIARGV HYQYGDMITY SCYSGYMLEG FLRSVCLENG TWTSPPICRA VCRFPCQNGG 

      3490       3500       3510       3520       3530       3540 
ICQRPNACSC PEGWMGRLCE EPICILPCLN GGRCVAPYQC DCPPGWTGSR CHTAVCQSPC 

      3550       3560       3570 
LNGGKCVRPN RCHCLSSWTG HNCSRKRRTG F 

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Isoform 2 [UniParc].

Checksum: 516974CD450855FD
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FASTA86896,134
Isoform 3 [UniParc].

Checksum: 98D8650DB3B69DD4
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FASTA1,497163,559
Isoform 4 [UniParc].

Checksum: B304C96189C62CD1
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FASTA1,546170,093

References

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[1]"Molecular and cellular characterization of SEL-OB/SVEP1 in osteogenic cells in vivo and in vitro."
Shur I., Socher R., Hameiri M., Fried A., Benayahu D.
J. Cell. Physiol. 206:420-427(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]Han J., Fang Y., Yan J., Ye Q.
Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
Tissue: Mammary gland.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 195-3571 (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 318-868 (ISOFORM 2), VARIANTS ALA-332 AND VAL-2750.
Tissue: Placenta.
[4]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Placenta.
[6]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2131-3571, VARIANT ILE-3161.
Tissue: Colon endothelium.
[7]"Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression."
Scanlan M.J., Gout I., Gordon C.M., Williamson B., Stockert E., Gure A.O., Jaeger D., Chen Y.-T., Mackay A., O'Hare M.J., Old L.J.
Cancer Immun. 1:4-4(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2269-2756.
Tissue: Mammary gland.
[8]"Polydom: a secreted protein with pentraxin, complement control protein, epidermal growth factor and von Willebrand factor A domains."
Gilges D., Vinit M.-A., Callebaut I., Coulombel L., Cacheux V., Romeo P.-H., Vigon I.
Biochem. J. 352:49-59(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[9]"Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
Halim A., Nilsson J., Ruetschi U., Hesse C., Larson G.
Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION, STRUCTURE OF CARBOHYDRATES, IDENTIFICATION BY MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ619977 mRNA. Translation: CAF04067.1.
AY916667 mRNA. Translation: AAX12481.1.
AK023591 mRNA. Translation: BAB14617.1. Different initiation.
AK075235 mRNA. Translation: BAC11489.1.
AK027870 mRNA. Translation: BAB55420.1. Different initiation.
AL158158 Genomic DNA. Translation: CAI14071.1.
AL592463, AL354982 Genomic DNA. Translation: CAH73557.1. Different initiation.
AL592463, AL158158, AL354982 Genomic DNA. Translation: CAH73558.1. Sequence problems.
AL354982, AL592463 Genomic DNA. Translation: CAH74138.1. Different initiation.
AL354982, AL158158, AL592463 Genomic DNA. Translation: CAH74139.1. Sequence problems.
AL158158, AL354982, AL592463 Genomic DNA. Translation: CAI14068.1. Sequence problems.
BC030816 mRNA. Translation: AAH30816.1.
BX537918 mRNA. Translation: CAD97901.1.
BX538049 mRNA. Translation: CAD97988.1.
AF308289 mRNA. Translation: AAG48257.1. Sequence problems.
RefSeqNP_699197.3. NM_153366.3.
UniGeneHs.522334.
Hs.726867.

3D structure databases

ProteinModelPortalQ4LDE5.
SMRQ4LDE5. Positions 79-255, 313-563, 1195-1420, 1445-3563.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123051. 4 interactions.
IntActQ4LDE5. 12 interactions.
MINTMINT-1197821.

PTM databases

PhosphoSiteQ4LDE5.

Polymorphism databases

DMDM296452942.

Proteomic databases

PaxDbQ4LDE5.
PRIDEQ4LDE5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000297826; ENSP00000297826; ENSG00000165124. [Q4LDE5-3]
ENST00000401783; ENSP00000384917; ENSG00000165124. [Q4LDE5-1]
GeneID79987.
KEGGhsa:79987.
UCSCuc004beu.2. human. [Q4LDE5-2]
uc010mty.3. human. [Q4LDE5-3]
uc010mtz.3. human. [Q4LDE5-1]
uc010mua.1. human. [Q4LDE5-4]

Organism-specific databases

CTD79987.
GeneCardsGC09M113127.
H-InvDBHIX0008277.
HIX0035094.
HGNCHGNC:15985. SVEP1.
HPAHPA020610.
HPA021520.
MIM611691. gene.
neXtProtNX_Q4LDE5.
PharmGKBPA25971.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG12793.
HOVERGENHBG108523.
KOK17495.
OMAIDCRLED.
OrthoDBEOG7BS48H.
PhylomeDBQ4LDE5.
TreeFamTF342247.

Gene expression databases

ArrayExpressQ4LDE5.
BgeeQ4LDE5.
GenevestigatorQ4LDE5.

Family and domain databases

Gene3D2.40.155.10. 1 hit.
2.60.120.200. 1 hit.
3.40.50.410. 1 hit.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR023413. GFP_like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR003410. Hyalin.
IPR001759. Pentaxin.
IPR000436. Sushi_SCR_CCP.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
IPR002035. VWF_A.
[Graphical view]
PfamPF00008. EGF. 5 hits.
PF07645. EGF_CA. 1 hit.
PF07699. GCC2_GCC3. 4 hits.
PF12661. hEGF. 1 hit.
PF02494. HYR. 2 hits.
PF00354. Pentaxin. 1 hit.
PF00084. Sushi. 32 hits.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSPR00895. PENTAXIN.
SMARTSM00032. CCP. 34 hits.
SM00181. EGF. 4 hits.
SM00179. EGF_CA. 6 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF57184. SSF57184. 3 hits.
SSF57535. SSF57535. 33 hits.
PROSITEPS00010. ASX_HYDROXYL. 6 hits.
PS00022. EGF_1. 9 hits.
PS01186. EGF_2. 11 hits.
PS50026. EGF_3. 9 hits.
PS01187. EGF_CA. 6 hits.
PS50825. HYR. 2 hits.
PS50923. SUSHI. 34 hits.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi79987.
NextBio70034.
PROQ4LDE5.
SOURCESearch...

Entry information

Entry nameSVEP1_HUMAN
AccessionPrimary (citable) accession number: Q4LDE5
Secondary accession number(s): Q0P675 expand/collapse secondary AC list , Q5D213, Q5T938, Q5VTE4, Q5VTE5, Q7Z387, Q7Z3G3, Q8NBT9, Q96JU7, Q9H284, Q9H8J9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 18, 2010
Last modified: April 16, 2014
This is version 90 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM