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Protein

Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1

Gene

SVEP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the cell attachment process.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1
Alternative name(s):
CCP module-containing protein 22
Polydom
Selectin-like osteoblast-derived protein
Short name:
SEL-OB
Serologically defined breast cancer antigen NY-BR-38
Gene namesi
Name:SVEP1
Synonyms:C9orf13, CCP22, SELOB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:15985. SVEP1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi79987.
OpenTargetsiENSG00000165124.
PharmGKBiPA25971.

Polymorphism and mutation databases

BioMutaiSVEP1.
DMDMi296452942.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000032017918 – 3571Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1Add BLAST3554

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi186N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi378 ↔ 420By similarity
Disulfide bondi406 ↔ 433By similarity
Disulfide bondi438 ↔ 480By similarity
Disulfide bondi466 ↔ 493By similarity
Disulfide bondi498 ↔ 544By similarity
Disulfide bondi529 ↔ 559By similarity
Disulfide bondi727 ↔ 769By similarity
Disulfide bondi753 ↔ 787By similarity
Glycosylationi847N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1102N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1197 ↔ 1208By similarity
Disulfide bondi1202 ↔ 1217By similarity
Disulfide bondi1219 ↔ 1228By similarity
Disulfide bondi1235 ↔ 1246By similarity
Disulfide bondi1240 ↔ 1255By similarity
Disulfide bondi1257 ↔ 1266By similarity
Disulfide bondi1273 ↔ 1284By similarity
Disulfide bondi1278 ↔ 1293By similarity
Disulfide bondi1295 ↔ 1304By similarity
Disulfide bondi1311 ↔ 1322By similarity
Disulfide bondi1316 ↔ 1331By similarity
Disulfide bondi1333 ↔ 1342By similarity
Disulfide bondi1349 ↔ 1360By similarity
Disulfide bondi1354 ↔ 1369By similarity
Disulfide bondi1371 ↔ 1380By similarity
Disulfide bondi1387 ↔ 1398By similarity
Disulfide bondi1392 ↔ 1407By similarity
Disulfide bondi1409 ↔ 1418By similarity
Disulfide bondi1631 ↔ 1672By similarity
Disulfide bondi1658 ↔ 1685By similarity
Disulfide bondi1690 ↔ 1730By similarity
Disulfide bondi1716 ↔ 1743By similarity
Disulfide bondi1749 ↔ 1761By similarity
Disulfide bondi1755 ↔ 1770By similarity
Disulfide bondi1772 ↔ 1783By similarity
Disulfide bondi1789 ↔ 1829By similarity
Disulfide bondi1815 ↔ 1842By similarity
Disulfide bondi1847 ↔ 1887By similarity
Disulfide bondi1873 ↔ 1900By similarity
Disulfide bondi1905 ↔ 1945By similarity
Disulfide bondi1931 ↔ 1958By similarity
Disulfide bondi1963 ↔ 2003By similarity
Disulfide bondi1989 ↔ 2016By similarity
Disulfide bondi2021 ↔ 2061By similarity
Disulfide bondi2047 ↔ 2078By similarity
Disulfide bondi2083 ↔ 2126By similarity
Disulfide bondi2112 ↔ 2141By similarity
Disulfide bondi2146 ↔ 2186By similarity
Disulfide bondi2172 ↔ 2199By similarity
Disulfide bondi2204 ↔ 2245By similarity
Disulfide bondi2231 ↔ 2259By similarity
Disulfide bondi2264 ↔ 2304By similarity
Disulfide bondi2290 ↔ 2318By similarity
Disulfide bondi2323 ↔ 2363By similarity
Disulfide bondi2349 ↔ 2376By similarity
Disulfide bondi2381 ↔ 2422By similarity
Disulfide bondi2408 ↔ 2435By similarity
Disulfide bondi2440 ↔ 2480By similarity
Disulfide bondi2466 ↔ 2493By similarity
Disulfide bondi2498 ↔ 2538By similarity
Disulfide bondi2524 ↔ 2551By similarity
Disulfide bondi2556 ↔ 2596By similarity
Disulfide bondi2582 ↔ 2608By similarity
Disulfide bondi2685 ↔ 2712By similarity
Disulfide bondi2717 ↔ 2757By similarity
Disulfide bondi2743 ↔ 2770By similarity
Disulfide bondi2775 ↔ 2815By similarity
Disulfide bondi2801 ↔ 2828By similarity
Disulfide bondi2833 ↔ 2873By similarity
Disulfide bondi2859 ↔ 2886By similarity
Disulfide bondi2891 ↔ 2931By similarity
Disulfide bondi2917 ↔ 2944By similarity
Disulfide bondi2949 ↔ 2989By similarity
Disulfide bondi2975 ↔ 3002By similarity
Disulfide bondi3007 ↔ 3046By similarity
Glycosylationi3018N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi3032 ↔ 3059By similarity
Disulfide bondi3064 ↔ 3104By similarity
Disulfide bondi3090 ↔ 3117By similarity
Disulfide bondi3122 ↔ 3163By similarity
Disulfide bondi3148 ↔ 3176By similarity
Disulfide bondi3181 ↔ 3221By similarity
Glycosylationi3186N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi3207 ↔ 3236By similarity
Disulfide bondi3241 ↔ 3281By similarity
Disulfide bondi3267 ↔ 3294By similarity
Disulfide bondi3299 ↔ 3339By similarity
Disulfide bondi3325 ↔ 3352By similarity
Disulfide bondi3384 ↔ 3411By similarity
Disulfide bondi3416 ↔ 3456By similarity
Disulfide bondi3442 ↔ 3468By similarity
Disulfide bondi3504 ↔ 3514By similarity
Disulfide bondi3508 ↔ 3520By similarity
Disulfide bondi3522 ↔ 3531By similarity
Disulfide bondi3536 ↔ 3546By similarity
Disulfide bondi3540 ↔ 3552By similarity
Disulfide bondi3554 ↔ 3563By similarity

Post-translational modificationi

O-glycosylated with core 1 or possibly core 8 glycans.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ4LDE5.
PaxDbiQ4LDE5.
PeptideAtlasiQ4LDE5.
PRIDEiQ4LDE5.

PTM databases

iPTMnetiQ4LDE5.
PhosphoSitePlusiQ4LDE5.

Expressioni

Tissue specificityi

Present in mesenchymal primary cultured cell lysates (at protein level). Highly expressed in placenta. Also expressed in marrow stromal cell. Weakly or not expressed in other tissues.2 Publications

Gene expression databases

BgeeiENSG00000165124.
ExpressionAtlasiQ4LDE5. baseline and differential.
GenevisibleiQ4LDE5. HS.

Organism-specific databases

HPAiHPA020610.
HPA021520.

Interactioni

Protein-protein interaction databases

BioGridi123051. 4 interactors.
IntActiQ4LDE5. 13 interactors.
MINTiMINT-1197821.
STRINGi9606.ENSP00000384917.

Structurei

3D structure databases

ProteinModelPortaliQ4LDE5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 264VWFAPROSITE-ProRule annotationAdd BLAST182
Domaini376 – 435Sushi 1PROSITE-ProRule annotationAdd BLAST60
Domaini436 – 495Sushi 2PROSITE-ProRule annotationAdd BLAST60
Domaini496 – 561Sushi 3PROSITE-ProRule annotationAdd BLAST66
Domaini560 – 642HYR 1PROSITE-ProRule annotationAdd BLAST83
Domaini643 – 724HYR 2PROSITE-ProRule annotationAdd BLAST82
Domaini725 – 789Sushi 4PROSITE-ProRule annotationAdd BLAST65
Domaini1193 – 1229EGF-like 1PROSITE-ProRule annotationAdd BLAST37
Domaini1231 – 1267EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1269 – 1305EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1307 – 1343EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1345 – 1381EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1383 – 1419EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1430 – 1623PentaxinAdd BLAST194
Domaini1629 – 1687Sushi 5PROSITE-ProRule annotationAdd BLAST59
Domaini1688 – 1745Sushi 6PROSITE-ProRule annotationAdd BLAST58
Domaini1745 – 1784EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini1787 – 1844Sushi 7PROSITE-ProRule annotationAdd BLAST58
Domaini1845 – 1902Sushi 8PROSITE-ProRule annotationAdd BLAST58
Domaini1903 – 1960Sushi 9PROSITE-ProRule annotationAdd BLAST58
Domaini1961 – 2018Sushi 10PROSITE-ProRule annotationAdd BLAST58
Domaini2019 – 2080Sushi 11PROSITE-ProRule annotationAdd BLAST62
Domaini2081 – 2143Sushi 12PROSITE-ProRule annotationAdd BLAST63
Domaini2144 – 2201Sushi 13PROSITE-ProRule annotationAdd BLAST58
Domaini2202 – 2261Sushi 14PROSITE-ProRule annotationAdd BLAST60
Domaini2262 – 2320Sushi 15PROSITE-ProRule annotationAdd BLAST59
Domaini2321 – 2378Sushi 16PROSITE-ProRule annotationAdd BLAST58
Domaini2379 – 2437Sushi 17PROSITE-ProRule annotationAdd BLAST59
Domaini2438 – 2495Sushi 18PROSITE-ProRule annotationAdd BLAST58
Domaini2496 – 2553Sushi 19PROSITE-ProRule annotationAdd BLAST58
Domaini2554 – 2610Sushi 20PROSITE-ProRule annotationAdd BLAST57
Domaini2663 – 2714Sushi 21PROSITE-ProRule annotationAdd BLAST52
Domaini2715 – 2772Sushi 22PROSITE-ProRule annotationAdd BLAST58
Domaini2773 – 2830Sushi 23PROSITE-ProRule annotationAdd BLAST58
Domaini2831 – 2888Sushi 24PROSITE-ProRule annotationAdd BLAST58
Domaini2889 – 2946Sushi 25PROSITE-ProRule annotationAdd BLAST58
Domaini2947 – 3004Sushi 26PROSITE-ProRule annotationAdd BLAST58
Domaini3005 – 3061Sushi 27PROSITE-ProRule annotationAdd BLAST57
Domaini3062 – 3119Sushi 28PROSITE-ProRule annotationAdd BLAST58
Domaini3120 – 3178Sushi 29PROSITE-ProRule annotationAdd BLAST59
Domaini3179 – 3238Sushi 30PROSITE-ProRule annotationAdd BLAST60
Domaini3239 – 3296Sushi 31PROSITE-ProRule annotationAdd BLAST58
Domaini3297 – 3354Sushi 32PROSITE-ProRule annotationAdd BLAST58
Domaini3355 – 3413Sushi 33PROSITE-ProRule annotationAdd BLAST59
Domaini3414 – 3470Sushi 34PROSITE-ProRule annotationAdd BLAST57
Domaini3500 – 3532EGF-like 8PROSITE-ProRule annotationAdd BLAST33
Domaini3533 – 3564EGF-like 9PROSITE-ProRule annotationAdd BLAST32

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni887 – 894O-glycosylated at one site8

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi2845 – 2847Cell attachment siteSequence analysis3

Sequence similaritiesi

Contains 9 EGF-like domains.PROSITE-ProRule annotation
Contains 2 HYR domains.PROSITE-ProRule annotation
Contains 1 pentaxin domain.Curated
Contains 34 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
KOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00760000118803.
HOVERGENiHBG108523.
InParanoidiQ4LDE5.
KOiK17495.
PhylomeDBiQ4LDE5.
TreeFamiTF342247.

Family and domain databases

CDDicd00033. CCP. 32 hits.
Gene3Di2.40.155.10. 1 hit.
2.60.120.200. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR023413. GFP-like.
IPR009030. Growth_fac_rcpt_.
IPR003410. HYR_dom.
IPR001759. Pentaxin-related.
IPR000436. Sushi_SCR_CCP_dom.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
IPR002035. VWF_A.
[Graphical view]
PfamiPF00008. EGF. 6 hits.
PF07645. EGF_CA. 1 hit.
PF07699. Ephrin_rec_like. 4 hits.
PF12661. hEGF. 1 hit.
PF02494. HYR. 2 hits.
PF00354. Pentaxin. 1 hit.
PF00084. Sushi. 33 hits.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00032. CCP. 34 hits.
SM00181. EGF. 10 hits.
SM00179. EGF_CA. 8 hits.
SM01411. Ephrin_rec_like. 4 hits.
SM00159. PTX. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF57184. SSF57184. 3 hits.
SSF57535. SSF57535. 33 hits.
PROSITEiPS00010. ASX_HYDROXYL. 6 hits.
PS00022. EGF_1. 9 hits.
PS01186. EGF_2. 11 hits.
PS50026. EGF_3. 9 hits.
PS01187. EGF_CA. 6 hits.
PS50825. HYR. 2 hits.
PS50923. SUSHI. 34 hits.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q4LDE5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWPRLAFCCW GLALVSGWAT FQQMSPSRNF SFRLFPETAP GAPGSIPAPP
60 70 80 90 100
APGDEAAGSR VERLGQAFRR RVRLLRELSE RLELVFLVDD SSSVGEVNFR
110 120 130 140 150
SELMFVRKLL SDFPVVPTAT RVAIVTFSSK NYVVPRVDYI STRRARQHKC
160 170 180 190 200
ALLLQEIPAI SYRGGGTYTK GAFQQAAQIL LHARENSTKV VFLITDGYSN
210 220 230 240 250
GGDPRPIAAS LRDSGVEIFT FGIWQGNIRE LNDMASTPKE EHCYLLHSFE
260 270 280 290 300
EFEALARRAL HEDLPSGSFI QDDMVHCSYL CDEGKDCCDR MGSCKCGTHT
310 320 330 340 350
GHFECICEKG YYGKGLQYEC TACPSGTYKP EGSPGGISSC IPCPDENHTS
360 370 380 390 400
PPGSTSPEDC VCREGYRASG QTCELVHCPA LKPPENGYFI QNTCNNHFNA
410 420 430 440 450
ACGVRCHPGF DLVGSSIILC LPNGLWSGSE SYCRVRTCPH LRQPKHGHIS
460 470 480 490 500
CSTREMLYKT TCLVACDEGY RLEGSDKLTC QGNSQWDGPE PRCVERHCST
510 520 530 540 550
FQMPKDVIIS PHNCGKQPAK FGTICYVSCR QGFILSGVKE MLRCTTSGKW
560 570 580 590 600
NVGVQAAVCK DVEAPQINCP KDIEAKTLEQ QDSANVTWQI PTAKDNSGEK
610 620 630 640 650
VSVHVHPAFT PPYLFPIGDV AIVYTATDLS GNQASCIFHI KVIDAEPPVI
660 670 680 690 700
DWCRSPPPVQ VSEKVHAASW DEPQFSDNSG AELVITRSHT QGDLFPQGET
710 720 730 740 750
IVQYTATDPS GNNRTCDIHI VIKGSPCEIP FTPVNGDFIC TPDNTGVNCT
760 770 780 790 800
LTCLEGYDFT EGSTDKYYCA YEDGVWKPTY TTEWPDCAKK RFANHGFKSF
810 820 830 840 850
EMFYKAARCD DTDLMKKFSE AFETTLGKMV PSFCSDAEDI DCRLEENLTK
860 870 880 890 900
KYCLEYNYDY ENGFAIGPGG WGAANRLDYS YDDFLDTVQE TATSIGNAKS
910 920 930 940 950
SRIKRSAPLS DYKIKLIFNI TASVPLPDER NDTLEWENQQ RLLQTLETIT
960 970 980 990 1000
NKLKRTLNKD PMYSFQLASE ILIADSNSLE TKKASPFCRP GSVLRGRMCV
1010 1020 1030 1040 1050
NCPLGTYYNL EHFTCESCRI GSYQDEEGQL ECKLCPSGMY TEYIHSRNIS
1060 1070 1080 1090 1100
DCKAQCKQGT YSYSGLETCE SCPLGTYQPK FGSRSCLSCP ENTSTVKRGA
1110 1120 1130 1140 1150
VNISACGVPC PEGKFSRSGL MPCHPCPRDY YQPNAGKAFC LACPFYGTTP
1160 1170 1180 1190 1200
FAGSRSITEC SSFSSTFSAA EESVVPPASL GHIKKRHEIS SQVFHECFFN
1210 1220 1230 1240 1250
PCHNSGTCQQ LGRGYVCLCP LGYTGLKCET DIDECSPLPC LNNGVCKDLV
1260 1270 1280 1290 1300
GEFICECPSG YTGQRCEENI NECSSSPCLN KGICVDGVAG YRCTCVKGFV
1310 1320 1330 1340 1350
GLHCETEVNE CQSNPCLNNA VCEDQVGGFL CKCPPGFLGT RCGKNVDECL
1360 1370 1380 1390 1400
SQPCKNGATC KDGANSFRCL CAAGFTGSHC ELNINECQSN PCRNQATCVD
1410 1420 1430 1440 1450
ELNSYSCKCQ PGFSGKRCET EQSTGFNLDF EVSGIYGYVM LDGMLPSLHA
1460 1470 1480 1490 1500
LTCTFWMKSS DDMNYGTPIS YAVDNGSDNT LLLTDYNGWV LYVNGREKIT
1510 1520 1530 1540 1550
NCPSVNDGRW HHIAITWTSA NGIWKVYIDG KLSDGGAGLS VGLPIPGGGA
1560 1570 1580 1590 1600
LVLGQEQDKK GEGFSPAESF VGSISQLNLW DYVLSPQQVK SLATSCPEEL
1610 1620 1630 1640 1650
SKGNVLAWPD FLSGIVGKVK IDSKSIFCSD CPRLGGSVPH LRTASEDLKP
1660 1670 1680 1690 1700
GSKVNLFCDP GFQLVGNPVQ YCLNQGQWTQ PLPHCERISC GVPPPLENGF
1710 1720 1730 1740 1750
HSADDFYAGS TVTYQCNNGY YLLGDSRMFC TDNGSWNGVS PSCLDVDECA
1760 1770 1780 1790 1800
VGSDCSEHAS CLNVDGSYIC SCVPPYTGDG KNCAEPIKCK APGNPENGHS
1810 1820 1830 1840 1850
SGEIYTVGAE VTFSCQEGYQ LMGVTKITCL ESGEWNHLIP YCKAVSCGKP
1860 1870 1880 1890 1900
AIPENGCIEE LAFTFGSKVT YRCNKGYTLA GDKESSCLAN SSWSHSPPVC
1910 1920 1930 1940 1950
EPVKCSSPEN INNGKYILSG LTYLSTASYS CDTGYSLQGP SIIECTASGI
1960 1970 1980 1990 2000
WDRAPPACHL VFCGEPPAIK DAVITGNNFT FRNTVTYTCK EGYTLAGLDT
2010 2020 2030 2040 2050
IECLADGKWS RSDQQCLAVS CDEPPIVDHA SPETAHRLFG DIAFYYCSDG
2060 2070 2080 2090 2100
YSLADNSQLL CNAQGKWVPP EGQDMPRCIA HFCEKPPSVS YSILESVSKA
2110 2120 2130 2140 2150
KFAAGSVVSF KCMEGFVLNT SAKIECMRGG QWNPSPMSIQ CIPVRCGEPP
2160 2170 2180 2190 2200
SIMNGYASGS NYSFGAMVAY SCNKGFYIKG EKKSTCEATG QWSSPIPTCH
2210 2220 2230 2240 2250
PVSCGEPPKV ENGFLEHTTG RIFESEVRYQ CNPGYKSVGS PVFVCQANRH
2260 2270 2280 2290 2300
WHSESPLMCV PLDCGKPPPI QNGFMKGENF EVGSKVQFFC NEGYELVGDS
2310 2320 2330 2340 2350
SWTCQKSGKW NKKSNPKCMP AKCPEPPLLE NQLVLKELTT EVGVVTFSCK
2360 2370 2380 2390 2400
EGHVLQGPSV LKCLPSQQWN DSFPVCKIVL CTPPPLISFG VPIPSSALHF
2410 2420 2430 2440 2450
GSTVKYSCVG GFFLRGNSTT LCQPDGTWSS PLPECVPVEC PQPEEIPNGI
2460 2470 2480 2490 2500
IDVQGLAYLS TALYTCKPGF ELVGNTTTLC GENGHWLGGK PTCKAIECLK
2510 2520 2530 2540 2550
PKEILNGKFS YTDLHYGQTV TYSCNRGFRL EGPSALTCLE TGDWDVDAPS
2560 2570 2580 2590 2600
CNAIHCDSPQ PIENGFVEGA DYSYGAIIIY SCFPGFQVAG HAMQTCEESG
2610 2620 2630 2640 2650
WSSSIPTCMP IDCGLPPHID FGDCTKLKDD QGYFEQEDDM MEVPYVTPHP
2660 2670 2680 2690 2700
PYHLGAVAKT WENTKESPAT HSSNFLYGTM VSYTCNPGYE LLGNPVLICQ
2710 2720 2730 2740 2750
EDGTWNGSAP SCISIECDLP TAPENGFLRF TETSMGSAVQ YSCKPGHILA
2760 2770 2780 2790 2800
GSDLRLCLEN RKWSGASPRC EAISCKKPNP VMNGSIKGSN YTYLSTLYYE
2810 2820 2830 2840 2850
CDPGYVLNGT ERRTCQDDKN WDEDEPICIP VDCSSPPVSA NGQVRGDEYT
2860 2870 2880 2890 2900
FQKEIEYTCN EGFLLEGARS RVCLANGSWS GATPDCVPVR CATPPQLANG
2910 2920 2930 2940 2950
VTEGLDYGFM KEVTFHCHEG YILHGAPKLT CQSDGNWDAE IPLCKPVNCG
2960 2970 2980 2990 3000
PPEDLAHGFP NGFSFIHGGH IQYQCFPGYK LHGNSSRRCL SNGSWSGSSP
3010 3020 3030 3040 3050
SCLPCRCSTP VIEYGTVNGT DFDCGKAARI QCFKGFKLLG LSEITCEADG
3060 3070 3080 3090 3100
QWSSGFPHCE HTSCGSLPMI PNAFISETSS WKENVITYSC RSGYVIQGSS
3110 3120 3130 3140 3150
DLICTEKGVW SQPYPVCEPL SCGSPPSVAN AVATGEAHTY ESEVKLRCLE
3160 3170 3180 3190 3200
GYTMDTDTDT FTCQKDGRWF PERISCSPKK CPLPENITHI LVHGDDFSVN
3210 3220 3230 3240 3250
RQVSVSCAEG YTFEGVNISV CQLDGTWEPP FSDESCSPVS CGKPESPEHG
3260 3270 3280 3290 3300
FVVGSKYTFE STIIYQCEPG YELEGNRERV CQENRQWSGG VAICKETRCE
3310 3320 3330 3340 3350
TPLEFLNGKA DIENRTTGPN VVYSCNRGYS LEGPSEAHCT ENGTWSHPVP
3360 3370 3380 3390 3400
LCKPNPCPVP FVIPENALLS EKEFYVDQNV SIKCREGFLL QGHGIITCNP
3410 3420 3430 3440 3450
DETWTQTSAK CEKISCGPPA HVENAIARGV HYQYGDMITY SCYSGYMLEG
3460 3470 3480 3490 3500
FLRSVCLENG TWTSPPICRA VCRFPCQNGG ICQRPNACSC PEGWMGRLCE
3510 3520 3530 3540 3550
EPICILPCLN GGRCVAPYQC DCPPGWTGSR CHTAVCQSPC LNGGKCVRPN
3560 3570
RCHCLSSWTG HNCSRKRRTG F
Length:3,571
Mass (Da):390,170
Last modified:May 18, 2010 - v3
Checksum:i8F52DE456CED5DED
GO
Isoform 2 (identifier: Q4LDE5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     868-868: P → N
     869-3571: Missing.

Show »
Length:868
Mass (Da):96,134
Checksum:i516974CD450855FD
GO
Isoform 3 (identifier: Q4LDE5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2074: Missing.

Show »
Length:1,497
Mass (Da):163,559
Checksum:i98D8650DB3B69DD4
GO
Isoform 4 (identifier: Q4LDE5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1547-3571: Missing.

Note: No experimental confirmation available.
Show »
Length:1,546
Mass (Da):170,093
Checksum:iB304C96189C62CD1
GO

Sequence cautioni

The sequence AAG48257 differs from that shown. Reason: Frameshift at positions 2630, 2638 and 2655.Curated
The sequence AAG48257 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14617 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB55420 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAH73557 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAH73558 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAH74138 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAH74139 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI14068 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti429S → L in CAF04067 (PubMed:16206243).Curated1
Sequence conflicti429S → L in BAB55420 (PubMed:14702039).Curated1
Sequence conflicti604H → R in BAB14617 (PubMed:14702039).Curated1
Sequence conflicti822F → L in BAB14617 (PubMed:14702039).Curated1
Sequence conflicti842C → W in CAF04067 (PubMed:16206243).Curated1
Sequence conflicti842C → W in BAB55420 (PubMed:14702039).Curated1
Sequence conflicti980E → G in CAF04067 (PubMed:16206243).Curated1
Sequence conflicti980E → G in BAB55420 (PubMed:14702039).Curated1
Sequence conflicti1063Y → C in CAF04067 (PubMed:16206243).Curated1
Sequence conflicti1063Y → C in BAB55420 (PubMed:14702039).Curated1
Sequence conflicti1442D → V in CAF04067 (PubMed:16206243).Curated1
Sequence conflicti1442D → V in BAB55420 (PubMed:14702039).Curated1
Sequence conflicti1546P → PGMF in CAF04067 (PubMed:16206243).Curated1
Sequence conflicti1775P → S in CAF04067 (PubMed:16206243).Curated1
Sequence conflicti2179K → E in CAD97901 (PubMed:17974005).Curated1
Sequence conflicti2189T → S in BAC11489 (PubMed:14702039).Curated1
Sequence conflicti2237S → P in BAC11489 (PubMed:14702039).Curated1
Sequence conflicti2246Q → H in BAC11489 (PubMed:14702039).Curated1
Sequence conflicti2259C → W in BAC11489 (PubMed:14702039).Curated1
Sequence conflicti2299D → G in CAD97988 (PubMed:17974005).Curated1
Sequence conflicti2454Q → R in BAC11489 (PubMed:14702039).Curated1
Sequence conflicti2519T → I in CAD97901 (PubMed:17974005).Curated1
Sequence conflicti2623D → A in AAG48257 (PubMed:12747765).Curated1
Sequence conflicti2705W → R in BAC11489 (PubMed:14702039).Curated1
Sequence conflicti2753D → G in BAC11489 (PubMed:14702039).Curated1
Sequence conflicti2833C → R in BAC11489 (PubMed:14702039).Curated1
Sequence conflicti2857Y → H in CAD97901 (PubMed:17974005).Curated1
Sequence conflicti3005C → F in BAC11489 (PubMed:14702039).Curated1
Sequence conflicti3186N → S in CAD97988 (PubMed:17974005).Curated1
Sequence conflicti3302P → Q in CAF04067 (PubMed:16206243).Curated1
Sequence conflicti3302P → Q in BAC11489 (PubMed:14702039).Curated1
Sequence conflicti3398C → Y in CAF04067 (PubMed:16206243).Curated1
Sequence conflicti3398C → Y in BAC11489 (PubMed:14702039).Curated1
Sequence conflicti3565R → G in CAD97988 (PubMed:17974005).Curated1
Sequence conflicti3567R → G in CAD97988 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039153332G → A.1 PublicationCorresponds to variant rs3818764dbSNPEnsembl.1
Natural variantiVAR_039154428G → S.Corresponds to variant rs10980419dbSNPEnsembl.1
Natural variantiVAR_039155507V → I.Corresponds to variant rs872665dbSNPEnsembl.1
Natural variantiVAR_039156581Q → H.Corresponds to variant rs10817033dbSNPEnsembl.1
Natural variantiVAR_039157637I → V.Corresponds to variant rs13286541dbSNPEnsembl.1
Natural variantiVAR_039158899K → R.Corresponds to variant rs10817025dbSNPEnsembl.1
Natural variantiVAR_0391591157I → V.Corresponds to variant rs7038903dbSNPEnsembl.1
Natural variantiVAR_0391601330L → M.Corresponds to variant rs10817021dbSNPEnsembl.1
Natural variantiVAR_0391611416K → Q.Corresponds to variant rs1889323dbSNPEnsembl.1
Natural variantiVAR_0391621444M → L.Corresponds to variant rs7863519dbSNPEnsembl.1
Natural variantiVAR_0391631648L → V.Corresponds to variant rs7852962dbSNPEnsembl.1
Natural variantiVAR_0391641810E → A.Corresponds to variant rs2986671dbSNPEnsembl.1
Natural variantiVAR_0391651953R → K.Corresponds to variant rs17204832dbSNPEnsembl.1
Natural variantiVAR_0391662607T → A.Corresponds to variant rs3802433dbSNPEnsembl.1
Natural variantiVAR_0391672750A → V.1 PublicationCorresponds to variant rs7030192dbSNPEnsembl.1
Natural variantiVAR_0391682922I → V.Corresponds to variant rs16914996dbSNPEnsembl.1
Natural variantiVAR_0391693161F → I.1 PublicationCorresponds to variant rs3739451dbSNPEnsembl.1
Natural variantiVAR_0391703230P → T.Corresponds to variant rs16914992dbSNPEnsembl.1
Natural variantiVAR_0391713559T → M.Corresponds to variant rs17204533dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0316251 – 2074Missing in isoform 3. 2 PublicationsAdd BLAST2074
Alternative sequenceiVSP_031626868P → N in isoform 2. 2 Publications1
Alternative sequenceiVSP_031627869 – 3571Missing in isoform 2. 2 PublicationsAdd BLAST2703
Alternative sequenceiVSP_0316281547 – 3571Missing in isoform 4. 1 PublicationAdd BLAST2025

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ619977 mRNA. Translation: CAF04067.1.
AY916667 mRNA. Translation: AAX12481.1.
AK023591 mRNA. Translation: BAB14617.1. Different initiation.
AK075235 mRNA. Translation: BAC11489.1.
AK027870 mRNA. Translation: BAB55420.1. Different initiation.
AL158158 Genomic DNA. Translation: CAI14071.1.
AL592463, AL354982 Genomic DNA. Translation: CAH73557.1. Different initiation.
AL592463, AL158158, AL354982 Genomic DNA. Translation: CAH73558.1. Sequence problems.
AL354982, AL592463 Genomic DNA. Translation: CAH74138.1. Different initiation.
AL354982, AL158158, AL592463 Genomic DNA. Translation: CAH74139.1. Sequence problems.
AL158158, AL354982, AL592463 Genomic DNA. Translation: CAI14068.1. Sequence problems.
BC030816 mRNA. Translation: AAH30816.1.
BX537918 mRNA. Translation: CAD97901.1.
BX538049 mRNA. Translation: CAD97988.1.
AF308289 mRNA. Translation: AAG48257.1. Sequence problems.
CCDSiCCDS48004.1. [Q4LDE5-1]
RefSeqiNP_699197.3. NM_153366.3. [Q4LDE5-1]
UniGeneiHs.522334.
Hs.726867.

Genome annotation databases

EnsembliENST00000374461; ENSP00000363585; ENSG00000165124. [Q4LDE5-2]
ENST00000374469; ENSP00000363593; ENSG00000165124. [Q4LDE5-1]
GeneIDi79987.
KEGGihsa:79987.
UCSCiuc010mtz.4. human. [Q4LDE5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ619977 mRNA. Translation: CAF04067.1.
AY916667 mRNA. Translation: AAX12481.1.
AK023591 mRNA. Translation: BAB14617.1. Different initiation.
AK075235 mRNA. Translation: BAC11489.1.
AK027870 mRNA. Translation: BAB55420.1. Different initiation.
AL158158 Genomic DNA. Translation: CAI14071.1.
AL592463, AL354982 Genomic DNA. Translation: CAH73557.1. Different initiation.
AL592463, AL158158, AL354982 Genomic DNA. Translation: CAH73558.1. Sequence problems.
AL354982, AL592463 Genomic DNA. Translation: CAH74138.1. Different initiation.
AL354982, AL158158, AL592463 Genomic DNA. Translation: CAH74139.1. Sequence problems.
AL158158, AL354982, AL592463 Genomic DNA. Translation: CAI14068.1. Sequence problems.
BC030816 mRNA. Translation: AAH30816.1.
BX537918 mRNA. Translation: CAD97901.1.
BX538049 mRNA. Translation: CAD97988.1.
AF308289 mRNA. Translation: AAG48257.1. Sequence problems.
CCDSiCCDS48004.1. [Q4LDE5-1]
RefSeqiNP_699197.3. NM_153366.3. [Q4LDE5-1]
UniGeneiHs.522334.
Hs.726867.

3D structure databases

ProteinModelPortaliQ4LDE5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123051. 4 interactors.
IntActiQ4LDE5. 13 interactors.
MINTiMINT-1197821.
STRINGi9606.ENSP00000384917.

PTM databases

iPTMnetiQ4LDE5.
PhosphoSitePlusiQ4LDE5.

Polymorphism and mutation databases

BioMutaiSVEP1.
DMDMi296452942.

Proteomic databases

MaxQBiQ4LDE5.
PaxDbiQ4LDE5.
PeptideAtlasiQ4LDE5.
PRIDEiQ4LDE5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374461; ENSP00000363585; ENSG00000165124. [Q4LDE5-2]
ENST00000374469; ENSP00000363593; ENSG00000165124. [Q4LDE5-1]
GeneIDi79987.
KEGGihsa:79987.
UCSCiuc010mtz.4. human. [Q4LDE5-1]

Organism-specific databases

CTDi79987.
DisGeNETi79987.
GeneCardsiSVEP1.
H-InvDBHIX0008277.
HIX0035094.
HGNCiHGNC:15985. SVEP1.
HPAiHPA020610.
HPA021520.
MIMi611691. gene.
neXtProtiNX_Q4LDE5.
OpenTargetsiENSG00000165124.
PharmGKBiPA25971.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
KOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00760000118803.
HOVERGENiHBG108523.
InParanoidiQ4LDE5.
KOiK17495.
PhylomeDBiQ4LDE5.
TreeFamiTF342247.

Miscellaneous databases

ChiTaRSiSVEP1. human.
GenomeRNAii79987.
PROiQ4LDE5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165124.
ExpressionAtlasiQ4LDE5. baseline and differential.
GenevisibleiQ4LDE5. HS.

Family and domain databases

CDDicd00033. CCP. 32 hits.
Gene3Di2.40.155.10. 1 hit.
2.60.120.200. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR023413. GFP-like.
IPR009030. Growth_fac_rcpt_.
IPR003410. HYR_dom.
IPR001759. Pentaxin-related.
IPR000436. Sushi_SCR_CCP_dom.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
IPR002035. VWF_A.
[Graphical view]
PfamiPF00008. EGF. 6 hits.
PF07645. EGF_CA. 1 hit.
PF07699. Ephrin_rec_like. 4 hits.
PF12661. hEGF. 1 hit.
PF02494. HYR. 2 hits.
PF00354. Pentaxin. 1 hit.
PF00084. Sushi. 33 hits.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00032. CCP. 34 hits.
SM00181. EGF. 10 hits.
SM00179. EGF_CA. 8 hits.
SM01411. Ephrin_rec_like. 4 hits.
SM00159. PTX. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF57184. SSF57184. 3 hits.
SSF57535. SSF57535. 33 hits.
PROSITEiPS00010. ASX_HYDROXYL. 6 hits.
PS00022. EGF_1. 9 hits.
PS01186. EGF_2. 11 hits.
PS50026. EGF_3. 9 hits.
PS01187. EGF_CA. 6 hits.
PS50825. HYR. 2 hits.
PS50923. SUSHI. 34 hits.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSVEP1_HUMAN
AccessioniPrimary (citable) accession number: Q4LDE5
Secondary accession number(s): Q0P675
, Q5D213, Q5T938, Q5VTE4, Q5VTE5, Q7Z387, Q7Z3G3, Q8NBT9, Q96JU7, Q9H284, Q9H8J9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.