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Protein

Cathepsin D

Gene

CTSD

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation.By similarity

Catalytic activityi

Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei97PROSITE-ProRule annotation1
Active sitei293PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Enzyme and pathway databases

ReactomeiR-CFA-1442490. Collagen degradation.
R-CFA-2132295. MHC class II antigen presentation.
R-CFA-6798695. Neutrophil degranulation.

Protein family/group databases

MEROPSiA01.009.

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin D (EC:3.4.23.5)
Gene namesi
Name:CTSD
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 18

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
PropeptideiPRO_000004543419 – 64Activation peptideBy similarityAdd BLAST46
ChainiPRO_000004543565 – 410Cathepsin DAdd BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi91 ↔ 160By similarity
Disulfide bondi110 ↔ 117By similarity
Glycosylationi134N-linked (GlcNAc...)Sequence analysis1
Glycosylationi261N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi284 ↔ 288By similarity
Disulfide bondi327 ↔ 364By similarity

Post-translational modificationi

N- and O-glycosylated.By similarity
Undergoes proteolytic cleavage and activation by ADAM30.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ4LAL9.
PRIDEiQ4LAL9.

Interactioni

Subunit structurei

Consists of a light chain and a heavy chain. Interacts with ADAM30; this leads to activation of CTSD.By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000014791.

Structurei

3D structure databases

ProteinModelPortaliQ4LAL9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini79 – 405Peptidase A1PROSITE-ProRule annotationAdd BLAST327

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated
Contains 1 peptidase A1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
GeneTreeiENSGT00760000118929.
HOGENOMiHOG000197681.
HOVERGENiHBG000482.
InParanoidiQ4LAL9.
KOiK01379.
OMAiKVERQVF.
OrthoDBiEOG091G0JP7.
TreeFamiTF314990.

Family and domain databases

CDDicd05490. Cathepsin_D2. 1 hit.
Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR033736. Cathepsin_chordata.
IPR033144. Cathepsin_D.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PTHR13683:SF230. PTHR13683:SF230. 1 hit.
PfamiPF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4LAL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPPSLLLLV LGLLAAPAAA LVRIPLHKFT SVRRTMTELG GPVEDLIAKG
60 70 80 90 100
PISKYAQGAP AVTGGPIPEM LRNYMDAQYY GEIGIGTPPQ CFTVVFDTGS
110 120 130 140 150
SNLWVPSIHC KLLDIACWIH HKYNSGKSST YVKNGTSFDI HYGSGSLSGY
160 170 180 190 200
LSQDTVSVPC KSALSGLAGI KVERQTFGEA TKQPGITFIA AKFDGILGMA
210 220 230 240 250
YPRISVNNVL PVFDNLMQQK LVEKNIFSFY LNRDPNAQPG GELMLGGTDS
260 270 280 290 300
KYYKGPLSYL NVTRKAYWQV HMEQVDVGSS LTLCKGGCEA IVDTGTSLIV
310 320 330 340 350
GPVDEVRELQ KAIGAVPLIQ GEYMIPCEKV STLPDVTLKL GGKLYKLSSE
360 370 380 390 400
DYTLKVSQGG KTICLSGFMG MDIPPPGGPL WILGDVFIGC YYTVFDRDQN
410
RVGLAQATRL
Length:410
Mass (Da):44,320
Last modified:August 2, 2005 - v1
Checksum:i1E97B7C15BAAF9CD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti254K → T.1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM048627 mRNA. Translation: CAJ14973.1.
RefSeqiNP_001020792.1. NM_001025621.1.
UniGeneiCfa.17547.

Genome annotation databases

EnsembliENSCAFT00000015991; ENSCAFP00000014791; ENSCAFG00000010052.
GeneIDi483662.
KEGGicfa:483662.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM048627 mRNA. Translation: CAJ14973.1.
RefSeqiNP_001020792.1. NM_001025621.1.
UniGeneiCfa.17547.

3D structure databases

ProteinModelPortaliQ4LAL9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000014791.

Protein family/group databases

MEROPSiA01.009.

Proteomic databases

PaxDbiQ4LAL9.
PRIDEiQ4LAL9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000015991; ENSCAFP00000014791; ENSCAFG00000010052.
GeneIDi483662.
KEGGicfa:483662.

Organism-specific databases

CTDi1509.

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
GeneTreeiENSGT00760000118929.
HOGENOMiHOG000197681.
HOVERGENiHBG000482.
InParanoidiQ4LAL9.
KOiK01379.
OMAiKVERQVF.
OrthoDBiEOG091G0JP7.
TreeFamiTF314990.

Enzyme and pathway databases

ReactomeiR-CFA-1442490. Collagen degradation.
R-CFA-2132295. MHC class II antigen presentation.
R-CFA-6798695. Neutrophil degranulation.

Family and domain databases

CDDicd05490. Cathepsin_D2. 1 hit.
Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR033736. Cathepsin_chordata.
IPR033144. Cathepsin_D.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PTHR13683:SF230. PTHR13683:SF230. 1 hit.
PfamiPF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCATD_CANLF
AccessioniPrimary (citable) accession number: Q4LAL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: August 2, 2005
Last modified: November 30, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.