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Protein

Cathepsin D

Gene

CTSD

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Acid protease active in intracellular protein breakdown.

Catalytic activityi

Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei97 – 971PROSITE-ProRule annotation
Active sitei293 – 2931PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Enzyme and pathway databases

ReactomeiR-CFA-1442490. Collagen degradation.
R-CFA-2132295. MHC class II antigen presentation.

Protein family/group databases

MEROPSiA01.009.

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin D (EC:3.4.23.5)
Gene namesi
Name:CTSD
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 18

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818By similarityAdd
BLAST
Propeptidei19 – 6446Activation peptideBy similarityPRO_0000045434Add
BLAST
Chaini65 – 410346Cathepsin DPRO_0000045435Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi91 ↔ 160By similarity
Disulfide bondi110 ↔ 117By similarity
Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence analysis
Glycosylationi261 – 2611N-linked (GlcNAc...)Sequence analysis
Disulfide bondi284 ↔ 288By similarity
Disulfide bondi327 ↔ 364By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ4LAL9.
PRIDEiQ4LAL9.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000014791.

Structurei

3D structure databases

ProteinModelPortaliQ4LAL9.
SMRiQ4LAL9. Positions 65-161, 168-407.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini79 – 405327Peptidase A1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated
Contains 1 peptidase A1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
GeneTreeiENSGT00760000118929.
HOGENOMiHOG000197681.
HOVERGENiHBG000482.
InParanoidiQ4LAL9.
KOiK01379.
OMAiKVERQVF.
OrthoDBiEOG7HQN88.
TreeFamiTF314990.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR033144. Cathepsin_D.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PTHR13683:SF230. PTHR13683:SF230. 1 hit.
PfamiPF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4LAL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPPSLLLLV LGLLAAPAAA LVRIPLHKFT SVRRTMTELG GPVEDLIAKG
60 70 80 90 100
PISKYAQGAP AVTGGPIPEM LRNYMDAQYY GEIGIGTPPQ CFTVVFDTGS
110 120 130 140 150
SNLWVPSIHC KLLDIACWIH HKYNSGKSST YVKNGTSFDI HYGSGSLSGY
160 170 180 190 200
LSQDTVSVPC KSALSGLAGI KVERQTFGEA TKQPGITFIA AKFDGILGMA
210 220 230 240 250
YPRISVNNVL PVFDNLMQQK LVEKNIFSFY LNRDPNAQPG GELMLGGTDS
260 270 280 290 300
KYYKGPLSYL NVTRKAYWQV HMEQVDVGSS LTLCKGGCEA IVDTGTSLIV
310 320 330 340 350
GPVDEVRELQ KAIGAVPLIQ GEYMIPCEKV STLPDVTLKL GGKLYKLSSE
360 370 380 390 400
DYTLKVSQGG KTICLSGFMG MDIPPPGGPL WILGDVFIGC YYTVFDRDQN
410
RVGLAQATRL
Length:410
Mass (Da):44,320
Last modified:August 2, 2005 - v1
Checksum:i1E97B7C15BAAF9CD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti254 – 2541K → T.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM048627 mRNA. Translation: CAJ14973.1.
RefSeqiNP_001020792.1. NM_001025621.1.
UniGeneiCfa.17547.

Genome annotation databases

EnsembliENSCAFT00000015991; ENSCAFP00000014791; ENSCAFG00000010052.
GeneIDi483662.
KEGGicfa:483662.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM048627 mRNA. Translation: CAJ14973.1.
RefSeqiNP_001020792.1. NM_001025621.1.
UniGeneiCfa.17547.

3D structure databases

ProteinModelPortaliQ4LAL9.
SMRiQ4LAL9. Positions 65-161, 168-407.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000014791.

Protein family/group databases

MEROPSiA01.009.

Proteomic databases

PaxDbiQ4LAL9.
PRIDEiQ4LAL9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000015991; ENSCAFP00000014791; ENSCAFG00000010052.
GeneIDi483662.
KEGGicfa:483662.

Organism-specific databases

CTDi1509.

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
GeneTreeiENSGT00760000118929.
HOGENOMiHOG000197681.
HOVERGENiHBG000482.
InParanoidiQ4LAL9.
KOiK01379.
OMAiKVERQVF.
OrthoDBiEOG7HQN88.
TreeFamiTF314990.

Enzyme and pathway databases

ReactomeiR-CFA-1442490. Collagen degradation.
R-CFA-2132295. MHC class II antigen presentation.

Miscellaneous databases

NextBioi20858024.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR033144. Cathepsin_D.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PTHR13683:SF230. PTHR13683:SF230. 1 hit.
PfamiPF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The canine CTSD gene as a candidate for late-onset neuronal ceroid lipofuscinosis."
    Woehlke A., Distl O., Droegemueller C.
    Anim. Genet. 36:530-532(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-254.
    Strain: Beagle.
    Tissue: Lung.

Entry informationi

Entry nameiCATD_CANLF
AccessioniPrimary (citable) accession number: Q4LAL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: August 2, 2005
Last modified: April 13, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.