Q4LAL9 (CATD_CANFA) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 47.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Cathepsin D EC=3.4.23.5 | ||
| Gene names |
| ||
| Organism | Canis familiaris (Dog) (Canis lupus familiaris) | ||
| Taxonomic identifier | 9615 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis |
Protein attributes
| Sequence length | 410 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Acid protease active in intracellular protein breakdown. |
| Catalytic activity | Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin. |
| Subcellular location | Lysosome. Melanosome By similarity. |
| Sequence similarities | Belongs to the peptidase A1 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Lysosome |
| Coding sequence diversity | Polymorphism |
| Domain | Signal |
| Molecular function | Aspartyl protease Hydrolase Protease |
| PTM | Disulfide bond Glycoprotein Zymogen |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | proteolysis Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell melanosomeInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | aspartic-type endopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 18 | 18 | By similarity | ||||||||
| Propeptide | 19 – 64 | 46 | Activation peptide By similarity | PRO_0000045434 | |||||||
| Chain | 65 – 410 | 346 | Cathepsin D | PRO_0000045435 | |||||||
Sites | |||||||||||
| Active site | 97 | 1 | By similarity | ||||||||
| Active site | 293 | 1 | By similarity | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 134 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 261 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 91 ↔ 160 | By similarity | |||||||||
| Disulfide bond | 110 ↔ 117 | By similarity | |||||||||
| Disulfide bond | 284 ↔ 288 | By similarity | |||||||||
| Disulfide bond | 327 ↔ 364 | By similarity | |||||||||
Natural variations | |||||||||||
| Natural variant | 254 | 1 | K → T. Ref.1 | ||||||||
Sequences
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References
| [1] | "The canine CTSD gene as a candidate for late-onset neuronal ceroid lipofuscinosis." Woehlke A., Distl O., Droegemueller C. Anim. Genet. 36:530-532(2005) [PubMed: 16293139] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-254. Strain: Beagle. Tissue: Lung. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AM048627 mRNA. Translation: CAJ14973.1. |
| RefSeq | NP_001020792.1. NM_001025621.1. |
| UniGene | Cfa.17547. |
3D structure databases | |
| ProteinModelPortal | Q4LAL9. |
| SMR | Q4LAL9. Positions 65-161, 168-407. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q4LAL9. |
Protein family/group databases | |
| MEROPS | A01.009. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSCAFT00000015991; ENSCAFP00000014791; ENSCAFG00000010052. |
| GeneID | 483662. |
| KEGG | cfa:483662. |
Organism-specific databases | |
| CTD | 1509. |
Phylogenomic databases | |
| eggNOG | maNOG17543. |
| GeneTree | ENSGT00600000084042. |
| HOVERGEN | HBG000482. |
| InParanoid | Q4LAL9. |
| OMA | INEICER. |
| OrthoDB | EOG40GCR5. |
| PhylomeDB | Q4LAL9. |
Family and domain databases | |
| InterPro | IPR001461. Peptidase_A1. IPR021109. Peptidase_aspartic. IPR001969. Peptidase_aspartic_AS. IPR009007. Peptidase_aspartic_catalytic. IPR012848. Propep_A1. [Graphical view] |
| Gene3D | G3DSA:2.40.70.10. Pept_Aspartc_cat. 2 hits. |
| KO | K01379. |
| PANTHER | PTHR13683. Peptidase_A1. 1 hit. |
| Pfam | PF07966. A1_Propeptide. 1 hit. PF00026. Asp. 1 hit. [Graphical view] |
| PRINTS | PR00792. PEPSIN. |
| SUPFAM | SSF50630. Pept_Aspartic. 1 hit. |
| PROSITE | PS00141. ASP_PROTEASE. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CATD_CANFA | ||||||||
| Accession | Primary (citable) accession number: Q4LAL9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with