Q4LAL9 (CATD_CANFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cathepsin D
EC=3.4.23.5

Gene names

Name:

CTSD

Organism

Canis familiaris (Dog) (Canis lupus familiaris)

Taxonomic identifier

9615 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis

Protein attributes

Sequence length	410 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Acid protease active in intracellular protein breakdown.
Catalytic activity	Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.
Subcellular location	Lysosome. Melanosome By similarity.
Sequence similarities	Belongs to the peptidase A1 family.

Ontologies

Keywords
Cellular component	Lysosome
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Aspartyl protease Hydrolase Protease
PTM	Disulfide bond Glycoprotein Zymogen
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell melanosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aspartic-type endopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	By similarity
	Propeptide	19 – 64	46	Activation peptide By similarity		PRO_0000045434
	Chain	65 – 410	346	Cathepsin D		PRO_0000045435
Sites
	Active site	97	1	By similarity
	Active site	293	1	By similarity
Amino acid modifications
	Glycosylation	134	1	N-linked (GlcNAc...) Potential
	Glycosylation	261	1	N-linked (GlcNAc...) Potential
	Disulfide bond	91 ↔ 160		By similarity
	Disulfide bond	110 ↔ 117		By similarity
	Disulfide bond	284 ↔ 288		By similarity
	Disulfide bond	327 ↔ 364		By similarity
Natural variations
	Natural variant	254	1	K → T. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q4LAL9 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 1E97B7C15BAAF9CD	FASTA	410	44,320
	10 20 30 40 50 60 MQPPSLLLLV LGLLAAPAAA LVRIPLHKFT SVRRTMTELG GPVEDLIAKG PISKYAQGAP 70 80 90 100 110 120 AVTGGPIPEM LRNYMDAQYY GEIGIGTPPQ CFTVVFDTGS SNLWVPSIHC KLLDIACWIH 130 140 150 160 170 180 HKYNSGKSST YVKNGTSFDI HYGSGSLSGY LSQDTVSVPC KSALSGLAGI KVERQTFGEA 190 200 210 220 230 240 TKQPGITFIA AKFDGILGMA YPRISVNNVL PVFDNLMQQK LVEKNIFSFY LNRDPNAQPG 250 260 270 280 290 300 GELMLGGTDS KYYKGPLSYL NVTRKAYWQV HMEQVDVGSS LTLCKGGCEA IVDTGTSLIV 310 320 330 340 350 360 GPVDEVRELQ KAIGAVPLIQ GEYMIPCEKV STLPDVTLKL GGKLYKLSSE DYTLKVSQGG 370 380 390 400 410 KTICLSGFMG MDIPPPGGPL WILGDVFIGC YYTVFDRDQN RVGLAQATRL

References

[1]	"The canine CTSD gene as a candidate for late-onset neuronal ceroid lipofuscinosis." Woehlke A., Distl O., Droegemueller C. Anim. Genet. 36:530-532(2005) [PubMed: 16293139] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-254. Strain: Beagle. Tissue: Lung.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM048627 mRNA. Translation: CAJ14973.1.
RefSeq	NP_001020792.1. NM_001025621.1.
UniGene	Cfa.17547.
3D structure databases
ProteinModelPortal	Q4LAL9.
SMR	Q4LAL9. Positions 65-161, 168-407.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4LAL9.
Protein family/group databases
MEROPS	A01.009.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSCAFT00000015991; ENSCAFP00000014791; ENSCAFG00000010052.
GeneID	483662.
KEGG	cfa:483662.
Organism-specific databases
CTD	1509.
Phylogenomic databases
eggNOG	maNOG17543.
GeneTree	ENSGT00600000084042.
HOVERGEN	HBG000482.
InParanoid	Q4LAL9.
OMA	INEICER.
OrthoDB	EOG40GCR5.
PhylomeDB	Q4LAL9.
Family and domain databases
InterPro	IPR001461. Peptidase_A1. IPR021109. Peptidase_aspartic. IPR001969. Peptidase_aspartic_AS. IPR009007. Peptidase_aspartic_catalytic. IPR012848. Propep_A1. [Graphical view]
Gene3D	G3DSA:2.40.70.10. Pept_Aspartc_cat. 2 hits.
KO	K01379.
PANTHER	PTHR13683. Peptidase_A1. 1 hit.
Pfam	PF07966. A1_Propeptide. 1 hit. PF00026. Asp. 1 hit. [Graphical view]
PRINTS	PR00792. PEPSIN.
SUPFAM	SSF50630. Pept_Aspartic. 1 hit.
PROSITE	PS00141. ASP_PROTEASE. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CATD_CANFA

Accession

Primary (citable) accession number: Q4LAL9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	August 2, 2005
Last modified:	November 16, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program