Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Arsenate reductase 1

Gene

arsC1

Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)].UniRule annotation

Catalytic activityi

Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H2O.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei10NucleophileUniRule annotation1
Active sitei82NucleophileUniRule annotation1
Active sitei89NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processArsenical resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Arsenate reductase 1UniRule annotation (EC:1.20.4.4UniRule annotation)
Gene namesi
Name:arsC1UniRule annotation
Ordered Locus Names:SH0101
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000543 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001625301 – 133Arsenate reductase 1Add BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi10 ↔ 82Redox-active; alternateUniRule annotation
Disulfide bondi82 ↔ 89Redox-active; alternateUniRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi279808.SH0101

Structurei

3D structure databases

ProteinModelPortaliQ4LAB5
SMRiQ4LAB5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the low molecular weight phosphotyrosine protein phosphatase family. Thioredoxin-coupled ArsC subfamily.UniRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4108UXE Bacteria
COG0394 LUCA
HOGENOMiHOG000273093
KOiK03741
OMAiCSHADSV
OrthoDBiPOG091H07DS

Family and domain databases

HAMAPiMF_01624 Arsenate_reduct, 1 hit
InterProiView protein in InterPro
IPR014064 Arsenate_reductase_ArsC
IPR023485 Ptyr_pPase
IPR036196 Ptyr_pPase_sf
PfamiView protein in Pfam
PF01451 LMWPc, 1 hit
SMARTiView protein in SMART
SM00226 LMWPc, 1 hit
SUPFAMiSSF52788 SSF52788, 1 hit
TIGRFAMsiTIGR02691 arsC_pI258_fam, 1 hit

Sequencei

Sequence statusi: Complete.

Q4LAB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKKTIYFIC SGNSCRSQMA EGWGKEILGE DWNVYSAGIE THGVNPKAIE
60 70 80 90 100
AMKEVDIDIS NHTSDLIDSD ILEQSDLVVT LCSDADDNCP ILPPNVKKEH
110 120 130
WGFDDPAGKE WPEFQRVRDE IGKRIQEFKE TLV
Length:133
Mass (Da):15,044
Last modified:August 2, 2005 - v1
Checksum:iB9BF03C2058BB337
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA Translation: BAE03410.1
RefSeqiWP_011274433.1, NC_007168.1

Genome annotation databases

EnsemblBacteriaiBAE03410; BAE03410; SH0101
GeneIDi24245919
KEGGisha:SH0101

Similar proteinsi

Entry informationi

Entry nameiARSC1_STAHJ
AccessioniPrimary (citable) accession number: Q4LAB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: August 2, 2005
Last modified: April 25, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health