Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Multicopper oxidase mco

Gene

mco

Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

May be involved in copper homeostasis and oxidative stress response.By similarity

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi107Copper 1; type 2By similarity1
Metal bindingi109Copper 2; type 3By similarity1
Metal bindingi147Copper 2; type 3By similarity1
Metal bindingi149Copper 3; type 3By similarity1
Metal bindingi375Copper 4; type 1By similarity1
Metal bindingi378Copper 1; type 2By similarity1
Metal bindingi380Copper 3; type 3By similarity1
Metal bindingi428Copper 3; type 3By similarity1
Metal bindingi429Copper 4; type 1By similarity1
Metal bindingi430Copper 2; type 3By similarity1
Metal bindingi434Copper 4; type 1By similarity1
Metal bindingi439Copper 4; type 1By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Multicopper oxidase mco (EC:1.-.-.-)
Gene namesi
Name:mco
Ordered Locus Names:SH0106
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000543 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003369981 – 447Multicopper oxidase mcoAdd BLAST447

Interactioni

Protein-protein interaction databases

STRINGi279808.SH0106.

Structurei

3D structure databases

ProteinModelPortaliQ4LAB0.
SMRiQ4LAB0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated

Phylogenomic databases

eggNOGiENOG4107STQ. Bacteria.
COG2132. LUCA.
HOGENOMiHOG000096435.
OrthoDBiPOG091H07T5.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view]
PfamiPF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4LAB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNMKEDKKN TMDMTNMKHH DERKKLNSSQ GKNEIIFPEV AESKKDNNGY
60 70 80 90 100
KNYTLKAQKG KTEFYKNNFS NTLGYNGNLL GPTLKLKKGD KVKIKLINNL
110 120 130 140 150
DENTTFHWHG LEVNGKVDGG PSQVIKPGKE KTIKFEVNQD SATLWYHPHP
160 170 180 190 200
SPNTAKQVYN GLSGLLYIED SKKNNYPSNY GKNDLPIIIQ DKTFVSKKLN
210 220 230 240 250
YSKTKDEDGT QGDTVLVNGI VNPKLTAKEE KIRLRLLNGS NARDLNLKLS
260 270 280 290 300
NNQSFEYIAS DGGQLKNAKK LKEINLAPSE RKEIVIDLSK MKGEKVSLVD
310 320 330 340 350
NDKTVILPIS NKEKSSNKSN TPKVSKKIKL EGMNDNVTIN GNKFDPNRID
360 370 380 390 400
FTQKLNQKEV WEIENVKDKM GGMKHPFHIH GTQFKVLSVD GEKPPKDMRG
410 420 430 440
KKDVISLEPG QKAKIEVVFK NTGTYMFHCH ILEHEDNGMM GQIKVTN
Length:447
Mass (Da):50,620
Last modified:May 20, 2008 - v2
Checksum:i89B13A2E70EBFD11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA. Translation: BAE03415.1.
RefSeqiWP_011274438.1. NC_007168.1.

Genome annotation databases

EnsemblBacteriaiBAE03415; BAE03415; SH0106.
GeneIDi24246056.
KEGGisha:SH0106.
PATRICi19616249. VBIStaHae67511_0102.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA. Translation: BAE03415.1.
RefSeqiWP_011274438.1. NC_007168.1.

3D structure databases

ProteinModelPortaliQ4LAB0.
SMRiQ4LAB0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi279808.SH0106.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAE03415; BAE03415; SH0106.
GeneIDi24246056.
KEGGisha:SH0106.
PATRICi19616249. VBIStaHae67511_0102.

Phylogenomic databases

eggNOGiENOG4107STQ. Bacteria.
COG2132. LUCA.
HOGENOMiHOG000096435.
OrthoDBiPOG091H07T5.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view]
PfamiPF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMCO_STAHJ
AccessioniPrimary (citable) accession number: Q4LAB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: November 2, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.