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Q4L9Y4 (MTLD_STAHJ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Mannitol-1-phosphate 5-dehydrogenase
EC=1.1.1.17
Gene names
Name:mtlD
Ordered Locus Names:SH0232
OrganismStaphylococcus haemolyticus (strain JCSC1435) [Complete proteome] [HAMAP]
Taxonomic identifier279808 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196

Sequence similarities

Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

mannitol-1-phosphate 5-dehydrogenase activity

Inferred from electronic annotation. Source: EC

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 367367Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196
PRO_1000011816

Regions

Nucleotide binding3 – 1412NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4L9Y4 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: ECC9EF1D8614487F

FASTA36741,093
        10         20         30         40         50         60 
MKAVHFGAGN IGRGFIGYIL SDNNIDVTFA DVNEEIINAL DNEGAYNVIL ANEEKTTTRV 

        70         80         90        100        110        120 
TGVSAINSGQ LSDELKQAIL EADIITTAVG VNILPIIAKS FAPVLKEKEN HVNIVACENA 

       130        140        150        160        170        180 
IMATDTLKEA ILDITGPLGD NIHFANSAVD RIVPLQKNDN ILDVMVEPFF EWVVEKDAWY 

       190        200        210        220        230        240 
GEELEHIKYV DDLTPYIERK LLTVNTGHAL LAYAGRFYGR DTVLDAVKDE AIVADLRQVL 

       250        260        270        280        290        300 
GETSEYIVDN FSFTKEEQAA YVEKIIGRFE NPYLSDEVTR VGRGTIRKIG PKDRIIKPLS 

       310        320        330        340        350        360 
YLYENNLRRK GLLKAAALLL KYDDMNDKET IEMREYIDAH GVKAFLQEYA KINDRLADEI 


VAVYEDL

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References

[1]"Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species."
Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K.
J. Bacteriol. 187:7292-7308(2005) [PubMed: 16237012] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JCSC1435.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP006716 Genomic DNA. Translation: BAE03541.1.
RefSeqYP_252147.1. NC_007168.1.

3D structure databases

ProteinModelPortalQ4L9Y4.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ4L9Y4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000045792; EBSTAP00000044243; EBSTAG00000045789.
GeneID3482068.
GenomeReviewsGene locus SH0232 in contig AP006716_GR.
KEGGsha:SH0232.
NMPDRfig|279808.3.peg.245.
PATRIC19616495. VBIStaHae67511_0224.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0246.
GeneTreeEBGT00050000024485.
HOGENOMHBG568825.
OMAFANTAVD.
PhylomeDBQ4L9Y4.
ProtClustDBPRK02318.

Enzyme and pathway databases

BioCycSHAE279808:SH0232-MONOMER.

Family and domain databases

HAMAPMF_00196. Mannitol_dehydrog.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR023028. Mannitol_1_phos_5_DH.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR023027. Mannitol_DH_CS.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00009.
PfamPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSPR00084. MTLDHDRGNASE.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
PROSITEPS00974. MANNITOL_DHGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTLD_STAHJ
AccessionPrimary (citable) accession number: Q4L9Y4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 2, 2005
Last modified: January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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