Reviewed, UniProtKB/Swiss-Prot Q4L9Y4 (MTLD_STAHJ)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
    EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	SH0232

Organism

Staphylococcus haemolyticus (strain JCSC1435) [Complete proteome] [HAMAP]

Taxonomic identifier

279808 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 367	367	Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196		PRO_1000011816
Regions
	Nucleotide binding	3 – 14	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4L9Y4-1 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: ECC9EF1D8614487F	FASTA	367	41,093
	10 20 30 40 50 60 MKAVHFGAGN IGRGFIGYIL SDNNIDVTFA DVNEEIINAL DNEGAYNVIL ANEEKTTTRV 70 80 90 100 110 120 TGVSAINSGQ LSDELKQAIL EADIITTAVG VNILPIIAKS FAPVLKEKEN HVNIVACENA 130 140 150 160 170 180 IMATDTLKEA ILDITGPLGD NIHFANSAVD RIVPLQKNDN ILDVMVEPFF EWVVEKDAWY 190 200 210 220 230 240 GEELEHIKYV DDLTPYIERK LLTVNTGHAL LAYAGRFYGR DTVLDAVKDE AIVADLRQVL 250 260 270 280 290 300 GETSEYIVDN FSFTKEEQAA YVEKIIGRFE NPYLSDEVTR VGRGTIRKIG PKDRIIKPLS 310 320 330 340 350 360 YLYENNLRRK GLLKAAALLL KYDDMNDKET IEMREYIDAH GVKAFLQEYA KINDRLADEI VAVYEDL

References

[1]

"Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species." Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K. J. Bacteriol. 187:7292-7308(2005) [PubMed: 16237012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP006716 Genomic DNA. Translation: BAE03541.1.
RefSeq	YP_252147.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3482068.
GenomeReviews	Gene locus SH0232 in contig AP006716_GR.
KEGG	sha:SH0232.
NMPDR	fig|279808.3.peg.245.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4L9Y4.
OMA	Q4L9Y4. VDRIVPN.
Enzyme and pathway databases
BioCyc	SHAE279808:SH0232-MON.
Family and domain databases
HAMAP	MF_00196. [Tree]
InterPro	IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR000669. Mannitol_DH_core. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_STAHJ

Accession

Primary (citable) accession number: Q4L9Y4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 2, 2005
Last modified:	June 16, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)