ID   NANE_STAHJ              Reviewed;         223 AA.
AC   Q4L9T7;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   16-JUN-2009, entry version 27.
DE   RecName: Full=Putative N-acetylmannosamine-6-phosphate 2-epimerase;
DE            EC=5.1.3.9;
DE   AltName: Full=ManNAc-6-P epimerase;
GN   Name=nanE; OrderedLocusNames=SH0279;
OS   Staphylococcus haemolyticus (strain JCSC1435).
OC   Bacteria; Firmicutes; Bacillales; Staphylococcus.
OX   NCBI_TaxID=279808;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16237012; DOI=10.1128/JB.187.21.7292-7308.2005;
RA   Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y.,
RA   Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S.,
RA   Lee J.C., Hiramatsu K.;
RT   "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the
RT   extreme plasticity of its genome and the evolution of human-colonizing
RT   staphylococcal species.";
RL   J. Bacteriol. 187:7292-7308(2005).
CC   -!- FUNCTION: Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to
CC       N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (Potential).
CC   -!- CATALYTIC ACTIVITY: N-acyl-D-glucosamine 6-phosphate = N-acyl-D-
CC       mannosamine 6-phosphate.
CC   -!- PATHWAY: Amino-sugar metabolism; N-acetylneuraminic acid
CC       degradation; D-fructose 6-phosphate from N-acetylneuraminic acid:
CC       step 3/5.
CC   -!- SIMILARITY: Belongs to the nanE family.
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DR   EMBL; AP006716; BAE03588.1; -; Genomic_DNA.
DR   RefSeq; YP_252194.1; -.
DR   SMR; Q4L9T7; 1-221.
DR   GeneID; 3483961; -.
DR   GenomeReviews; AP006716_GR; SH0279.
DR   KEGG; sha:SH0279; -.
DR   NMPDR; fig|279808.3.peg.292; -.
DR   HOGENOM; Q4L9T7; -.
DR   OMA; Q4L9T7; YNTPELA.
DR   BioCyc; SHAE279808:SH0279-MON; -.
DR   GO; GO:0047465; F:N-acylglucosamine-6-phosphate 2-epimerase a...; IEA:EC.
DR   GO; GO:0006051; P:N-acetylmannosamine metabolic process; IEA:HAMAP.
DR   HAMAP; MF_01235; -; 1.
DR   InterPro; IPR007260; NanE.
DR   Pfam; PF04131; NanE; 1.
DR   ProDom; PD149806; TMP_synthase; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Complete proteome; Isomerase.
FT   CHAIN         1    223       Putative N-acetylmannosamine-6-phosphate
FT                                2-epimerase.
FT                                /FTId=PRO_0000301487.
SQ   SEQUENCE   223 AA;  24653 MW;  9371F0FB0AB2B24B CRC64;
     MLPNGLIVSC QALPDEPLHS SFIMSKMALA AYQGGAVGIR ANTKEDILAI REEVSLPVIG
     IVKRDYEGSN VFITATSKEV DELIESGCEV IALDATTQTR PKESLEELVH YIREKAPHVE
     IMADISTVEE AINADHLNFD YIGTTLRGYT SYTKGHILFE NDFEFLKEVL EKVNAKVIAE
     GNVITPEMYK KVSDLGVHCT VVGGAITRPK QITERFIEAV QQK
//