Q4L9T7 (NANE_STAHJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative N-acetylmannosamine-6-phosphate 2-epimerase
EC=5.1.3.9

Alternative name(s):
ManNAc-6-P epimerase

Gene names

Name:	nanE
Ordered Locus Names:	SH0279

Organism

Staphylococcus haemolyticus (strain JCSC1435) [Complete proteome] [HAMAP]

Taxonomic identifier

279808 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	223 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) Potential. HAMAP MF_01235
Catalytic activity	N-acyl-D-glucosamine 6-phosphate = N-acyl-D-mannosamine 6-phosphate. HAMAP MF_01235
Pathway	Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 3/5. HAMAP MF_01235
Sequence similarities	Belongs to the nanE family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	N-acetylmannosamine metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	N-acylglucosamine-6-phosphate 2-epimerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 223	223	Putative N-acetylmannosamine-6-phosphate 2-epimerase HAMAP MF_01235		PRO_0000301487

Sequences

	Sequence		Length	Mass (Da)
	Q4L9T7 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 9371F0FB0AB2B24B	FASTA	223	24,653
	10 20 30 40 50 60 MLPNGLIVSC QALPDEPLHS SFIMSKMALA AYQGGAVGIR ANTKEDILAI REEVSLPVIG 70 80 90 100 110 120 IVKRDYEGSN VFITATSKEV DELIESGCEV IALDATTQTR PKESLEELVH YIREKAPHVE 130 140 150 160 170 180 IMADISTVEE AINADHLNFD YIGTTLRGYT SYTKGHILFE NDFEFLKEVL EKVNAKVIAE 190 200 210 220 GNVITPEMYK KVSDLGVHCT VVGGAITRPK QITERFIEAV QQK

References

[1]

"Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species." Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K. J. Bacteriol. 187:7292-7308(2005) [PubMed: 16237012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JCSC1435.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006716 Genomic DNA. Translation: BAE03588.1.
RefSeq	YP_252194.1. NC_007168.1.
3D structure databases
HSSP	HSSP built from PDB template 1YXY based on UniProtKB P65522.
ProteinModelPortal	Q4L9T7.
SMR	Q4L9T7. Positions 1-221.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4L9T7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000044315; EBSTAP00000042766; EBSTAG00000044313.
GeneID	3483961.
GenomeReviews	Gene locus SH0279 in contig AP006716_GR.
KEGG	sha:SH0279.
NMPDR	fig|279808.3.peg.292.
PATRIC	19616587. VBIStaHae67511_0270.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3010.
GeneTree	EBGT00050000025172.
HOGENOM	HBG296941.
OMA	CQALEDE.
PhylomeDB	Q4L9T7.
ProtClustDB	PRK01130.
Enzyme and pathway databases
BioCyc	SHAE279808:SH0279-MONOMER.
Family and domain databases
HAMAP	MF_01235. ManNAc6P_epimer. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR007260. NanE. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01788.
Pfam	PF04131. NanE. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NANE_STAHJ

Accession

Primary (citable) accession number: Q4L9T7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	August 2, 2005
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program