ID   PGCA_STAHJ              Reviewed;         548 AA.
AC   Q4L9R5;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   16-JUN-2009, entry version 30.
DE   RecName: Full=Phosphoglucomutase;
DE            Short=PGM;
DE            EC=5.4.2.2;
DE   AltName: Full=Alpha-phosphoglucomutase;
DE   AltName: Full=Glucose phosphomutase;
GN   Name=pgcA; OrderedLocusNames=SH0301;
OS   Staphylococcus haemolyticus (strain JCSC1435).
OC   Bacteria; Firmicutes; Bacillales; Staphylococcus.
OX   NCBI_TaxID=279808;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16237012; DOI=10.1128/JB.187.21.7292-7308.2005;
RA   Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y.,
RA   Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S.,
RA   Lee J.C., Hiramatsu K.;
RT   "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the
RT   extreme plasticity of its genome and the evolution of human-colonizing
RT   staphylococcal species.";
RL   J. Bacteriol. 187:7292-7308(2005).
CC   -!- FUNCTION: Catalyzes the interconversion between glucose-6-
CC       phosphate and alpha-glucose-1-phosphate. This is the first step in
CC       the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. a
CC       glycolipid found in the membrane, which is also used as a membrane
CC       anchor for lipoteichoic acid (LTA) (By similarity).
CC   -!- CATALYTIC ACTIVITY: Alpha-D-glucose 1-phosphate = alpha-D-glucose
CC       6-phosphate.
CC   -!- COFACTOR: Binds 1 magnesium ion per subunit (By similarity).
CC   -!- PATHWAY: Glycolipid metabolism; diglucosyl-diacylglycerol
CC       biosynthesis.
CC   -!- SIMILARITY: Belongs to the phosphohexose mutase family.
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DR   EMBL; AP006716; BAE03610.1; -; Genomic_DNA.
DR   RefSeq; YP_252216.1; -.
DR   GeneID; 3483980; -.
DR   GenomeReviews; AP006716_GR; SH0301.
DR   KEGG; sha:SH0301; -.
DR   NMPDR; fig|279808.3.peg.313; -.
DR   HOGENOM; Q4L9R5; -.
DR   OMA; Q4L9R5; PKIKCYY.
DR   BioCyc; SHAE279808:SH0301-MON; -.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004614; F:phosphoglucomutase activity; IEA:EC.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR005844; A-D-PHexomutase_a/b/a-I.
DR   InterPro; IPR016055; A-D-PHexomutase_a/b/a-I/II/III.
DR   InterPro; IPR005845; A-D-PHexomutase_a/b/a-II.
DR   InterPro; IPR005843; A-D-PHexomutase_C.
DR   InterPro; IPR016066; A-D-PHexomutase_CS.
DR   InterPro; IPR005841; A-D-PHexomutase_N.
DR   Gene3D; G3DSA:3.40.120.10; A-D-PHexomutase_a/b/a-I/II/III; 3.
DR   Pfam; PF02878; PGM_PMM_I; 1.
DR   Pfam; PF02879; PGM_PMM_II; 1.
DR   Pfam; PF00408; PGM_PMM_IV; 1.
DR   PRINTS; PR00509; PGMPMM.
DR   PROSITE; PS00710; PGM_PMM; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Complete proteome; Glucose metabolism;
KW   Isomerase; Magnesium; Metal-binding; Phosphoprotein.
FT   CHAIN         1    548       Phosphoglucomutase.
FT                                /FTId=PRO_0000308347.
FT   ACT_SITE    135    135       Phosphoserine intermediate (By
FT                                similarity).
FT   METAL       135    135       Magnesium; via phosphate group (By
FT                                similarity).
FT   METAL       288    288       Magnesium (By similarity).
FT   METAL       290    290       Magnesium (By similarity).
FT   METAL       292    292       Magnesium (By similarity).
SQ   SEQUENCE   548 AA;  62002 MW;  30DDFD65916EA473 CRC64;
     MKDNWMKYKD DSLVASFYDS QTTTFQEQGF ETELAFGTAG IRGQFGLGPG RLNRYTIQRL
     ALGIANYLKD KEDNPSIVIH YDIRHLSSEF AHIITQILTS KGIKVYLADV YKTTPQLSFA
     VRYLQTSAGI MITASHNPKD YNGIKVYGAD GAQLDEDTSL EVAQYINNLG NPLELNIDLN
     QELIEKNTFD LQEAVYDSYI NEITNLIGDI PQSDLKVVYT SLHGTGVPII PDVLKHLNFQ
     NVSLVELQCE LDPNFSSVKS ANPEEREAFD LAIQQAHDLE ANLIIATDPD VDRMGFVERD
     TNGQTYYFGG SEIGALLIKY LLEYTNVPNH SVVIQSIVSG ELGKRLAQQH EVTVKEVLIG
     FKHIAKAIRE LDDTESFLFA YEESYGYLAD DFVRDKDAIQ IVPLIIKYTS ILKNEGKTLH
     DALKEIHREV GQYRDKPMSK VFEGREGQQQ INALMDKLRR NIPDVIAGLK VIAVEDYETL
     KRNYKEDNTE EAISLPQANV IRILFKEGFI ALRPSGTEPK LKFYLSLNVD NFEQVSQDIY
     NYIFGDTE
//