Reviewed, UniProtKB/Swiss-Prot Q4L9R5 (PGCA_STAHJ)

Names and origin

Protein names

Recommended name:
    Phosphoglucomutase
      Short name=PGM
    EC=5.4.2.2
Alternative name(s):
    Alpha-phosphoglucomutase
    Glucose phosphomutase

Gene names

Name:	pgcA
Ordered Locus Names:	SH0301

Organism

Staphylococcus haemolyticus (strain JCSC1435) [Complete proteome] [HAMAP]

Taxonomic identifier

279808 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	548 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the interconversion between glucose-6-phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. a glycolipid found in the membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA) By similarity.
Catalytic activity	Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Pathway	Glycolipid metabolism; diglucosyl-diacylglycerol biosynthesis.
Sequence similarities	Belongs to the phosphohexose mutase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoglucomutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 548	548	Phosphoglucomutase		PRO_0000308347
Sites
	Active site	135	1	Phosphoserine intermediate By similarity
	Metal binding	135	1	Magnesium; via phosphate group By similarity
	Metal binding	288	1	Magnesium By similarity
	Metal binding	290	1	Magnesium By similarity
	Metal binding	292	1	Magnesium By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4L9R5-1 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: 30DDFD65916EA473	FASTA	548	62,002
	10 20 30 40 50 60 MKDNWMKYKD DSLVASFYDS QTTTFQEQGF ETELAFGTAG IRGQFGLGPG RLNRYTIQRL 70 80 90 100 110 120 ALGIANYLKD KEDNPSIVIH YDIRHLSSEF AHIITQILTS KGIKVYLADV YKTTPQLSFA 130 140 150 160 170 180 VRYLQTSAGI MITASHNPKD YNGIKVYGAD GAQLDEDTSL EVAQYINNLG NPLELNIDLN 190 200 210 220 230 240 QELIEKNTFD LQEAVYDSYI NEITNLIGDI PQSDLKVVYT SLHGTGVPII PDVLKHLNFQ 250 260 270 280 290 300 NVSLVELQCE LDPNFSSVKS ANPEEREAFD LAIQQAHDLE ANLIIATDPD VDRMGFVERD 310 320 330 340 350 360 TNGQTYYFGG SEIGALLIKY LLEYTNVPNH SVVIQSIVSG ELGKRLAQQH EVTVKEVLIG 370 380 390 400 410 420 FKHIAKAIRE LDDTESFLFA YEESYGYLAD DFVRDKDAIQ IVPLIIKYTS ILKNEGKTLH 430 440 450 460 470 480 DALKEIHREV GQYRDKPMSK VFEGREGQQQ INALMDKLRR NIPDVIAGLK VIAVEDYETL 490 500 510 520 530 540 KRNYKEDNTE EAISLPQANV IRILFKEGFI ALRPSGTEPK LKFYLSLNVD NFEQVSQDIY NYIFGDTE

References

[1]

"Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species." Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K. J. Bacteriol. 187:7292-7308(2005) [PubMed: 16237012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP006716 Genomic DNA. Translation: BAE03610.1.
RefSeq	YP_252216.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3483980.
GenomeReviews	Gene locus SH0301 in contig AP006716_GR.
KEGG	sha:SH0301.
NMPDR	fig|279808.3.peg.313.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4L9R5.
OMA	Q4L9R5. PKIKCYY.
Enzyme and pathway databases
BioCyc	SHAE279808:SH0301-MON.
Family and domain databases
InterPro	IPR005844. A-D-PHexomutase_a/b/a-I. IPR016055. A-D-PHexomutase_a/b/a-I/II/III. IPR005845. A-D-PHexomutase_a/b/a-II. IPR005843. A-D-PHexomutase_C. IPR016066. A-D-PHexomutase_CS. IPR005841. A-D-PHexomutase_N. [Graphical view]
Gene3D	G3DSA:3.40.120.10. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
Pfam	PF02878. PGM_PMM_I. 1 hit. PF02879. PGM_PMM_II. 1 hit. PF00408. PGM_PMM_IV. 1 hit. [Graphical view]
PRINTS	PR00509. PGMPMM.
PROSITE	PS00710. PGM_PMM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGCA_STAHJ

Accession

Primary (citable) accession number: Q4L9R5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	August 2, 2005
Last modified:	June 16, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)