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Protein

HTH-type transcriptional regulator ArcR

Gene

arcR

Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Positively regulates the expression of the arcABDCR operon under anaerobic conditions, thus playing an essential role in arginine catabolism. May also control the expression of genes encoding proteins which are involved in anaerobic metabolism. Can bind cyclic AMP (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi41 – 130cNMPAdd BLAST90
DNA bindingi189 – 208H-T-H motifBy similarityAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandcAMP, cAMP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSHAE279808:G1G27-344-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator ArcR
Gene namesi
Name:arcR
Ordered Locus Names:SH0369
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000543 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003494201 – 227HTH-type transcriptional regulator ArcRAdd BLAST227

Interactioni

Protein-protein interaction databases

STRINGi279808.SH0369

Structurei

3D structure databases

ProteinModelPortaliQ4L9J7
SMRiQ4L9J7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini156 – 227HTH crp-typeAdd BLAST72

Phylogenomic databases

eggNOGiENOG4105IJS Bacteria
COG0664 LUCA
HOGENOMiHOG000022896
KOiK21828
OMAiEYLCKNH
OrthoDBiPOG091H03PG

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF51206 SSF51206, 1 hit

Sequencei

Sequence statusi: Complete.

Q4L9J7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGKTYINNR DNDLSEGLKQ LASYLNIPTG VIQAFKSECF VRRYNKGQII
60 70 80 90 100
YYSSDQPTYV YLLLDGIVLR ETINEDGDAY RKLNKEQLLF PLNHLFRKIE
110 120 130 140 150
LNEMCTAITP CNVIGIPKDM LEYLCKNHDD IFVTLFEKLN NELELLMEYN
160 170 180 190 200
MALTTKLARE RIEKVLYYLC HAIGYDQDEF YEIKHIMTIQ LLSDLAGISR
210 220
ETTGHIVHEL KEEKKLIKNG KNWMVIK
Length:227
Mass (Da):26,542
Last modified:August 2, 2005 - v1
Checksum:i45851C0B0FDC1052
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA Translation: BAE03678.1
RefSeqiWP_011274695.1, NC_007168.1

Genome annotation databases

EnsemblBacteriaiBAE03678; BAE03678; SH0369
GeneIDi24247962
KEGGisha:SH0369

Similar proteinsi

Entry informationi

Entry nameiARCR_STAHJ
AccessioniPrimary (citable) accession number: Q4L9J7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: August 2, 2005
Last modified: April 25, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health