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Q4L9J7 (ARCR_STAHJ) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
HTH-type transcriptional regulator ArcR
Gene names
Name:arcR
Ordered Locus Names:SH0369
OrganismStaphylococcus haemolyticus (strain JCSC1435) [Complete proteome] [HAMAP]
Taxonomic identifier279808 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length227 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Positively regulates the expression of the arcABDCR operon under anaerobic conditions, thus playing an essential role in arginine catabolism. May also control the expression of genes encoding proteins which are involved in anaerobic metabolism. Can bind cyclic AMP By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Contains 1 cyclic nucleotide-binding domain.

Contains 1 HTH crp-type DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentCytoplasm
   LigandcAMP
cAMP-binding
DNA-binding
Nucleotide-binding
   Molecular functionActivator
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

cAMP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 227227HTH-type transcriptional regulator ArcR
PRO_0000349420

Regions

Domain156 – 22772HTH crp-type
Nucleotide binding41 – 13090cNMP
DNA binding189 – 20820H-T-H motif By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4L9J7 [UniParc].

Last modified August 2, 2005. Version 1.
Checksum: 45851C0B0FDC1052

FASTA22726,542
        10         20         30         40         50         60 
MAGKTYINNR DNDLSEGLKQ LASYLNIPTG VIQAFKSECF VRRYNKGQII YYSSDQPTYV 

        70         80         90        100        110        120 
YLLLDGIVLR ETINEDGDAY RKLNKEQLLF PLNHLFRKIE LNEMCTAITP CNVIGIPKDM 

       130        140        150        160        170        180 
LEYLCKNHDD IFVTLFEKLN NELELLMEYN MALTTKLARE RIEKVLYYLC HAIGYDQDEF 

       190        200        210        220 
YEIKHIMTIQ LLSDLAGISR ETTGHIVHEL KEEKKLIKNG KNWMVIK 

« Hide

References

[1]"Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species."
Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K.
J. Bacteriol. 187:7292-7308(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JCSC1435.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP006716 Genomic DNA. Translation: BAE03678.1.
RefSeqYP_252284.1. NC_007168.1.

3D structure databases

ProteinModelPortalQ4L9J7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING279808.SH0369.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAE03678; BAE03678; SH0369.
GeneID3484042.
KEGGsha:SH0369.
PATRIC19616769. VBIStaHae67511_0361.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0664.
HOGENOMHOG000022896.
OMARETTGHI.
OrthoDBEOG6QRWC5.
ProtClustDBCLSK886120.

Enzyme and pathway databases

BioCycSHAE279808:GJX7-371-MONOMER.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR014710. RmlC-like_jellyroll.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00027. cNMP_binding. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 1 hit.
ProtoNetSearch...

Entry information

Entry nameARCR_STAHJ
AccessionPrimary (citable) accession number: Q4L9J7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: August 2, 2005
Last modified: February 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families