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Q4L9J7

- ARCR_STAHJ

UniProt

Q4L9J7 - ARCR_STAHJ

Protein

HTH-type transcriptional regulator ArcR

Gene

arcR

Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (02 Aug 2005)
      Previous versions | rss
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    Functioni

    Positively regulates the expression of the arcABDCR operon under anaerobic conditions, thus playing an essential role in arginine catabolism. May also control the expression of genes encoding proteins which are involved in anaerobic metabolism. Can bind cyclic AMP By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi41 – 13090cNMPAdd
    BLAST
    DNA bindingi189 – 20820H-T-H motifBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. cAMP binding Source: UniProtKB-KW
    2. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    cAMP, cAMP-binding, DNA-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSHAE279808:GJX7-371-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HTH-type transcriptional regulator ArcR
    Gene namesi
    Name:arcR
    Ordered Locus Names:SH0369
    OrganismiStaphylococcus haemolyticus (strain JCSC1435)
    Taxonomic identifieri279808 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000543: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 227227HTH-type transcriptional regulator ArcRPRO_0000349420Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi279808.SH0369.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4L9J7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini156 – 22772HTH crp-typeAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0664.
    HOGENOMiHOG000022896.
    OrthoDBiEOG6QRWC5.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    2.60.120.10. 1 hit.
    InterProiIPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR014710. RmlC-like_jellyroll.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q4L9J7-1 [UniParc]FASTAAdd to Basket

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    MAGKTYINNR DNDLSEGLKQ LASYLNIPTG VIQAFKSECF VRRYNKGQII    50
    YYSSDQPTYV YLLLDGIVLR ETINEDGDAY RKLNKEQLLF PLNHLFRKIE 100
    LNEMCTAITP CNVIGIPKDM LEYLCKNHDD IFVTLFEKLN NELELLMEYN 150
    MALTTKLARE RIEKVLYYLC HAIGYDQDEF YEIKHIMTIQ LLSDLAGISR 200
    ETTGHIVHEL KEEKKLIKNG KNWMVIK 227
    Length:227
    Mass (Da):26,542
    Last modified:August 2, 2005 - v1
    Checksum:i45851C0B0FDC1052
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006716 Genomic DNA. Translation: BAE03678.1.
    RefSeqiWP_011274695.1. NC_007168.1.
    YP_252284.1. NC_007168.1.

    Genome annotation databases

    EnsemblBacteriaiBAE03678; BAE03678; SH0369.
    GeneIDi3484042.
    KEGGisha:SH0369.
    PATRICi19616769. VBIStaHae67511_0361.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006716 Genomic DNA. Translation: BAE03678.1 .
    RefSeqi WP_011274695.1. NC_007168.1.
    YP_252284.1. NC_007168.1.

    3D structure databases

    ProteinModelPortali Q4L9J7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 279808.SH0369.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAE03678 ; BAE03678 ; SH0369 .
    GeneIDi 3484042.
    KEGGi sha:SH0369.
    PATRICi 19616769. VBIStaHae67511_0361.

    Phylogenomic databases

    eggNOGi COG0664.
    HOGENOMi HOG000022896.
    OrthoDBi EOG6QRWC5.

    Enzyme and pathway databases

    BioCyci SHAE279808:GJX7-371-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    2.60.120.10. 1 hit.
    InterProi IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR014710. RmlC-like_jellyroll.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species."
      Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K.
      J. Bacteriol. 187:7292-7308(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JCSC1435.

    Entry informationi

    Entry nameiARCR_STAHJ
    AccessioniPrimary (citable) accession number: Q4L9J7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: August 2, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3