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Protein

Adenylyl-sulfate kinase

Gene

cysC

Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the synthesis of activated sulfate.UniRule annotation

Catalytic activityi

ATP + adenylyl sulfate = ADP + 3'-phosphoadenylyl sulfate.UniRule annotation

Pathwayi: hydrogen sulfide biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes sulfite from sulfate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Sulfate adenylyltransferase (sat)
  2. Adenylyl-sulfate kinase (cysC)
  3. Phosphoadenosine phosphosulfate reductase (cysH)
This subpathway is part of the pathway hydrogen sulfide biosynthesis, which is itself part of Sulfur metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sulfite from sulfate, the pathway hydrogen sulfide biosynthesis and in Sulfur metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei108Phosphoserine intermediateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi34 – 41ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00140; UER00205.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylyl-sulfate kinaseUniRule annotation (EC:2.7.1.25UniRule annotation)
Alternative name(s):
APS kinaseUniRule annotation
ATP adenosine-5'-phosphosulfate 3'-phosphotransferaseUniRule annotation
Adenosine-5'-phosphosulfate kinaseUniRule annotation
Gene namesi
Name:cysCUniRule annotation
Ordered Locus Names:SH0420
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000543 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000090361 – 199Adenylyl-sulfate kinaseAdd BLAST199

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi279808.SH0420.

Structurei

3D structure databases

ProteinModelPortaliQ4L9E6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the APS kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108I67. Bacteria.
COG0529. LUCA.
HOGENOMiHOG000228204.
KOiK00860.
OMAiRQQDIIK.
OrthoDBiPOG091H04O4.

Family and domain databases

CDDicd02027. APSK. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00065. Adenylyl_sulf_kinase. 1 hit.
InterProiIPR002891. APS_kinase.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00455. apsK. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4L9E6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQSSNITWH DSEVTKSDRQ QQNGHKSVVI WFTGLSGSGK STVSVELEKA
60 70 80 90 100
LFQLEKHSYR LDGDNVRHGL NKNLGFSPED RKENIRRIGE VSKLLVDAGT
110 120 130 140 150
IAITAFISPY RADRDEVREI LEDGEFIEVY TECSVEACEQ RDPKGLYKKA
160 170 180 190
RSGEIKEFTG ISASYEAPHQ PEITINTEHQ SVEESVSTII EYLKNKEII
Length:199
Mass (Da):22,491
Last modified:August 2, 2005 - v1
Checksum:iA4DD7578D9F652AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA. Translation: BAE03729.1.
RefSeqiWP_011274746.1. NC_007168.1.

Genome annotation databases

EnsemblBacteriaiBAE03729; BAE03729; SH0420.
GeneIDi24247262.
KEGGisha:SH0420.
PATRICi19616873. VBIStaHae67511_0413.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA. Translation: BAE03729.1.
RefSeqiWP_011274746.1. NC_007168.1.

3D structure databases

ProteinModelPortaliQ4L9E6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi279808.SH0420.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAE03729; BAE03729; SH0420.
GeneIDi24247262.
KEGGisha:SH0420.
PATRICi19616873. VBIStaHae67511_0413.

Phylogenomic databases

eggNOGiENOG4108I67. Bacteria.
COG0529. LUCA.
HOGENOMiHOG000228204.
KOiK00860.
OMAiRQQDIIK.
OrthoDBiPOG091H04O4.

Enzyme and pathway databases

UniPathwayiUPA00140; UER00205.

Family and domain databases

CDDicd02027. APSK. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00065. Adenylyl_sulf_kinase. 1 hit.
InterProiIPR002891. APS_kinase.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00455. apsK. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCYSC_STAHJ
AccessioniPrimary (citable) accession number: Q4L9E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 2, 2005
Last modified: November 2, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.