Q4L9E6 (CYSC_STAHJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylyl-sulfate kinase
EC=2.7.1.25

Alternative name(s):
APS kinase
ATP adenosine-5'-phosphosulfate 3'-phosphotransferase
Adenosine-5'-phosphosulfate kinase

Gene names

Name:	cysC
Ordered Locus Names:	SH0420

Organism

Staphylococcus haemolyticus (strain JCSC1435) [Complete proteome] [HAMAP]

Taxonomic identifier

279808 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	199 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the synthesis of activated sulfate. HAMAP MF_00065
Catalytic activity	ATP + adenylyl sulfate = ADP + 3'-phosphoadenylyl sulfate. HAMAP MF_00065
Pathway	Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3. HAMAP MF_00065
Sequence similarities	Belongs to the APS kinase family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	sulfate assimilation Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylylsulfate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 199	199	Adenylyl-sulfate kinase HAMAP MF_00065		PRO_1000009036
Regions
	Nucleotide binding	34 – 41	8	ATP By similarity
Sites
	Active site	108	1	Phosphoserine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4L9E6 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: A4DD7578D9F652AA	FASTA	199	22,491
	10 20 30 40 50 60 MSQSSNITWH DSEVTKSDRQ QQNGHKSVVI WFTGLSGSGK STVSVELEKA LFQLEKHSYR 70 80 90 100 110 120 LDGDNVRHGL NKNLGFSPED RKENIRRIGE VSKLLVDAGT IAITAFISPY RADRDEVREI 130 140 150 160 170 180 LEDGEFIEVY TECSVEACEQ RDPKGLYKKA RSGEIKEFTG ISASYEAPHQ PEITINTEHQ 190 SVEESVSTII EYLKNKEII

References

[1]

"Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species." Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K. J. Bacteriol. 187:7292-7308(2005) [PubMed: 16237012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JCSC1435.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006716 Genomic DNA. Translation: BAE03729.1.
RefSeq	YP_252335.1. NC_007168.1.
3D structure databases
HSSP	HSSP built from PDB template 1M7G based on UniProtKB Q12657.
ProteinModelPortal	Q4L9E6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4L9E6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000045708; EBSTAP00000044159; EBSTAG00000045705.
GeneID	3484075.
GenomeReviews	Gene locus SH0420 in contig AP006716_GR.
KEGG	sha:SH0420.
NMPDR	fig|279808.3.peg.489.
PATRIC	19616873. VBIStaHae67511_0413.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0529.
GeneTree	EBGT00050000026401.
HOGENOM	HBG309946.
OMA	AELGYHT.
PhylomeDB	Q4L9E6.
ProtClustDB	PRK03846.
Enzyme and pathway databases
BioCyc	SHAE279808:SH0420-MONOMER.
Family and domain databases
HAMAP	MF_00065. Adenylyl_sulf_kinase. [Tree]
InterPro	IPR002891. APS_kinase_C. [Graphical view]
KO	K00860.
Pfam	PF01583. APS_kinase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00455. ApsK. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CYSC_STAHJ

Accession

Primary (citable) accession number: Q4L9E6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 2, 2005
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program