Reviewed, UniProtKB/Swiss-Prot Q4L9E6 (CYSC_STAHJ)

Names and origin

Protein names

Recommended name:
    Adenylyl-sulfate kinase
    EC=2.7.1.25
Alternative name(s):
    APS kinase
    Adenosine-5'-phosphosulfate kinase
    ATP adenosine-5'-phosphosulfate 3'-phosphotransferase

Gene names

Name:	cysC
Ordered Locus Names:	SH0420

Organism

Staphylococcus haemolyticus (strain JCSC1435) [Complete proteome] [HAMAP]

Taxonomic identifier

279808 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	199 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the synthesis of activated sulfate. HAMAP MF_00065
Catalytic activity	ATP + adenylyl sulfate = ADP + 3'-phosphoadenylyl sulfate. HAMAP MF_00065
Pathway	Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3. HAMAP MF_00065
Sequence similarities	Belongs to the APS kinase family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	sulfate assimilation Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP adenylylsulfate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 199	199	Adenylyl-sulfate kinase HAMAP MF_00065		PRO_1000009036
Regions
	Nucleotide binding	34 – 41	8	ATP By similarity
Sites
	Active site	108	1	Phosphoserine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4L9E6-1 [UniParc]. Last modified August 2, 2005. Version 1. Checksum: A4DD7578D9F652AA	FASTA	199	22,491
	10 20 30 40 50 60 MSQSSNITWH DSEVTKSDRQ QQNGHKSVVI WFTGLSGSGK STVSVELEKA LFQLEKHSYR 70 80 90 100 110 120 LDGDNVRHGL NKNLGFSPED RKENIRRIGE VSKLLVDAGT IAITAFISPY RADRDEVREI 130 140 150 160 170 180 LEDGEFIEVY TECSVEACEQ RDPKGLYKKA RSGEIKEFTG ISASYEAPHQ PEITINTEHQ 190 SVEESVSTII EYLKNKEII

References

[1]

"Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species." Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K. J. Bacteriol. 187:7292-7308(2005) [PubMed: 16237012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP006716 Genomic DNA. Translation: BAE03729.1.
RefSeq	YP_252335.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3484075.
GenomeReviews	Gene locus SH0420 in contig AP006716_GR.
KEGG	sha:SH0420.
NMPDR	fig|279808.3.peg.489.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4L9E6.
OMA	Q4L9E6. IITITAF.
Enzyme and pathway databases
BioCyc	SHAE279808:SH0420-MON.
Family and domain databases
HAMAP	MF_00065. [Tree]
InterPro	IPR002891. APS_kinase_C. [Graphical view]
Pfam	PF01583. APS_kinase. 1 hit. [Graphical view]
ProDom	PD002350. APS_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00455. apsK. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CYSC_STAHJ

Accession

Primary (citable) accession number: Q4L9E6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 2, 2005
Last modified:	June 16, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)