ID   BETA_STAHJ              Reviewed;         568 AA.
AC   Q4L9D7;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   16-JUN-2009, entry version 31.
DE   RecName: Full=Choline dehydrogenase;
DE            Short=CHD;
DE            Short=CDH;
DE            EC=1.1.99.1;
GN   Name=betA; OrderedLocusNames=SH0429;
OS   Staphylococcus haemolyticus (strain JCSC1435).
OC   Bacteria; Firmicutes; Bacillales; Staphylococcus.
OX   NCBI_TaxID=279808;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16237012; DOI=10.1128/JB.187.21.7292-7308.2005;
RA   Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y.,
RA   Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S.,
RA   Lee J.C., Hiramatsu K.;
RT   "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the
RT   extreme plasticity of its genome and the evolution of human-colonizing
RT   staphylococcal species.";
RL   J. Bacteriol. 187:7292-7308(2005).
CC   -!- FUNCTION: Can catalyze the oxidation of choline to betaine
CC       aldehyde and betaine aldehyde to glycine betaine (By similarity).
CC   -!- CATALYTIC ACTIVITY: Choline + acceptor = betaine aldehyde +
CC       reduced acceptor.
CC   -!- COFACTOR: FAD (By similarity).
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis
CC       via choline pathway; betaine aldehyde from choline (cytochrome c
CC       reductase route): step 1/1.
CC   -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
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DR   EMBL; AP006716; BAE03738.1; -; Genomic_DNA.
DR   RefSeq; YP_252344.1; -.
DR   GeneID; 3482376; -.
DR   GenomeReviews; AP006716_GR; SH0429.
DR   KEGG; sha:SH0429; -.
DR   NMPDR; fig|279808.3.peg.518; -.
DR   HOGENOM; Q4L9D7; -.
DR   OMA; Q4L9D7; AGRSDYP.
DR   BioCyc; SHAE279808:SH0429-MON; -.
DR   GO; GO:0008812; F:choline dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0050660; F:FAD binding; IEA:InterPro.
DR   GO; GO:0006066; P:cellular alcohol metabolic process; IEA:InterPro.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from c...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00750; -; 1.
DR   InterPro; IPR011533; Choline_dehydrogenase.
DR   InterPro; IPR012132; GMC_OxRdtase.
DR   InterPro; IPR000172; GMC_OxRdtase_N.
DR   InterPro; IPR007867; GMC_OxRtase_C.
DR   Pfam; PF05199; GMC_oxred_C; 1.
DR   Pfam; PF00732; GMC_oxred_N; 1.
DR   PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR   TIGRFAMs; TIGR01810; betA; 1.
DR   PROSITE; PS00623; GMC_OXRED_1; 1.
DR   PROSITE; PS00624; GMC_OXRED_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; FAD; Flavoprotein; Oxidoreductase.
FT   CHAIN         1    568       Choline dehydrogenase.
FT                                /FTId=PRO_0000205603.
FT   NP_BIND       8     37       FAD (Probable).
FT   ACT_SITE    473    473       By similarity.
SQ   SEQUENCE   568 AA;  63553 MW;  AAE7A8FC49494CA7 CRC64;
     MSKKNSYDYV IIGGGSAGSV LGNRLTEDKD KEVLVLEAGR SDYPWDLFIQ MPAALMFPSG
     NRFYDWIYQT EEEPHMGRKV DHARGKVLGG SSSINGMIYQ RGNPMDYEGW AEPEGMESWD
     FAHCLPYFKR LEKTYGATPF DQFRGHHGPI KLKRGPATNP LFKSFFDAGV EAGYHKTKDV
     NGYRQEGFGP FDSQVHNGRR VSASRAYLHP AMKRKNLTVK TRAFVTKIHF DGNKATGVTF
     KRNGRYHTVD AGEVILSGGA FNTPQLLQLS GIGDAEFLKS KGIEPRMHLP GVGENFEDHL
     EVYIQHECKE PVSLQPSLDV KRMPWIGLQW IFARKGAAAS NHFEGGAFVR SNNQVAYPNL
     MFHFLPIAVR YDGQKAPVAH GYQVHVGPMY SNSRGSLKIK SKDPFEKPSI VFNYLSTKED
     EQEWVEAIRV ARNILAQKAM DPYNGGEISP GPSVQTDEEI LDWVRRDGET ALHPSCSAKM
     GPASDPMSVV DPLTMKVHGM ENLRVVDASA MPRTTNGNIH APVLMLAEKA ADIIRGKKPL
     EPQYVDYYKH GVSDENAGAM EFDPYYQH
//